{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T20:18:10Z","timestamp":1783541890436,"version":"3.55.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100005725","name":"CHDI Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jns-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.jns.2019.116523","type":"journal-article","created":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T19:40:46Z","timestamp":1571168446000},"page":"116523","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"special_numbering":"C","title":["Mild cognitive impairment and dementia in motor manifest Huntington's disease: Classification and prevalence"],"prefix":"10.1016","volume":"408","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1223-7577","authenticated-orcid":false,"given":"Parunyou","family":"Julayanont","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaus R.","family":"McFarland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth M.","family":"Heilman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jns.2019.116523_bb0005","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/00005053-197401000-00008","article-title":"Neuropsychological and emotional correlates of Huntington\u2019s chorea","volume":"158","author":"Boll","year":"1974","journal-title":"J. Nerv. Ment. Dis."},{"key":"10.1016\/j.jns.2019.116523_bb0010","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1365-2796.2004.01388.x","article-title":"Mild cognitive impairment as a diagnostic entity","volume":"256","author":"Petersen","year":"2004","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.jns.2019.116523_bb0015","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1001\/archneurol.2009.266","article-title":"Mild cognitive impairment: ten years later","volume":"66","author":"Petersen","year":"2009","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.jns.2019.116523_bb0020","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1212\/01.WNL.0000065888.88988.6E","article-title":"Evidence for more widespread cerebral pathology in early HD: an MRI-based morphometric analysis","volume":"60","author":"Rosas","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2019.116523_bb0025","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1093\/arclin\/acx086","article-title":"The neuropsychology of Huntington\u2019s disease","volume":"32","author":"Snowden","year":"2017","journal-title":"Arch. Clin. Neuropsychol."},{"key":"10.1016\/j.jns.2019.116523_bb0030","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1159\/000481172","article-title":"Huntington\u2019s disease: premotor phase","volume":"17","author":"Ramos","year":"2017","journal-title":"Neurodegener. Dis."},{"key":"10.1016\/j.jns.2019.116523_bb0035","first-page":"1715","article-title":"fMRI biomarker of early neuronal dysfunction in presymptomatic Huntington\u2019s disease","volume":"25","author":"Paulsen","year":"2004","journal-title":"Am. J. Neuroradiol."},{"key":"10.1016\/j.jns.2019.116523_bb0040","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1093\/brain\/awm210","article-title":"Dorsolateral prefrontal cortex dysfunction in presymptomatic Huntington\u2019s disease: evidence from event-related fMRI","volume":"130","author":"Wolf","year":"2007","journal-title":"Brain J. Neurol."},{"key":"10.1016\/j.jns.2019.116523_bb0045","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1017\/S1355617707071214","article-title":"fMRI detection of early neural dysfunction in preclinical Huntington\u2019s disease","volume":"13","author":"Zimbelman","year":"2007","journal-title":"J. Int. Neuropsychol. Soc."},{"key":"10.1016\/j.jns.2019.116523_bb0050","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jns.2005.07.007","article-title":"Executive dysfunction in early stages of Huntington\u2019s disease is associated with striatal and insular atrophy: a neuropsychological and voxel-based morphometric study","volume":"239","author":"Peinemann","year":"2005","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.jns.2019.116523_bb0055","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1093\/cercor\/bhh185","article-title":"Landwehrmeyer GB (2005) thalamic atrophy in Huntington\u2019s disease co-varies with cognitive performance: a morphometric MRI analysis","volume":"15","author":"Kassubek","year":"1991","journal-title":"Cereb Cortex N Y N"},{"key":"10.1016\/j.jns.2019.116523_bb0060","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/0028-3932(85)90080-6","article-title":"Memory disorders associated with Huntington\u2019s disease: verbal recall, verbal recognition and procedural memory","volume":"23","author":"Butters","year":"1985","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.jns.2019.116523_bb0065","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1467-9450.1994.tb00931.x","article-title":"Characteristic patterns of verbal memory function in patients with Huntington\u2019s disease","volume":"35","author":"Lundervold","year":"1994","journal-title":"Scand. J. Psychol."},{"key":"10.1016\/j.jns.2019.116523_bb0070","doi-asserted-by":"crossref","first-page":"A52","DOI":"10.1136\/jnnp-2016-314597.146","article-title":"Verbal memory in huntington\u2019s disease: a longitudinal study","volume":"87","author":"Ho","year":"2016","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.jns.2019.116523_bb0075","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1093\/arclin\/15.4.361","article-title":"Recall and recognition in Huntington\u2019s disease","volume":"15","author":"Lang","year":"2000","journal-title":"Arch. Clin. Neuropsychol."},{"key":"10.1016\/j.jns.2019.116523_bb0080","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1016\/j.neuropsychologia.2006.01.015","article-title":"Episodic memory impairment in Huntington\u2019s disease: a meta-analysis","volume":"44","author":"Montoya","year":"2006","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.jns.2019.116523_bb0085","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1212\/WNL.0b013e3181eccfa2","article-title":"Mild cognitive impairment in prediagnosed Huntington disease","volume":"75","author":"Duff","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2019.116523_bb0090","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1159\/000091523","article-title":"Cognitive impairment related to apathy in early Huntington\u2019s disease","volume":"21","author":"Baudic","year":"2006","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"10.1016\/j.jns.2019.116523_bb0095","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/mds.870110204","article-title":"Unified Huntington\u2019s disease rating scale: reliability and consistency","volume":"11","author":"Huntington Study Group","year":"1996","journal-title":"Mov. Disord."},{"key":"10.1016\/j.jns.2019.116523_bb0100","first-page":"167","article-title":"Normative data stratified by age and education for two measures of verbal fluency: FAS and animal naming","volume":"14","author":"Rees","year":"1999","journal-title":"Arch. Clin. Neuropsychol."},{"key":"10.1016\/j.jns.2019.116523_bb0105","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0887-6177(03)00039-8","article-title":"Trail making test a and B: normative data stratified by age and education","volume":"19","author":"Tombaugh","year":"2004","journal-title":"Arch. Clin. Neuropsychol."},{"key":"10.1016\/j.jns.2019.116523_bb0110","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1017\/S0317167100015997","article-title":"Normative data for the Stroop color word test for a north American population","volume":"40","author":"Morrow","year":"2013","journal-title":"Can J Neurol Sci"},{"key":"10.1016\/j.jns.2019.116523_bb0115","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1076\/clin.12.1.43.1726","article-title":"Hopkins verbal learning test\u2013revised: normative data and analysis of inter-form and test-retest reliability","volume":"12","author":"Benedict","year":"1998","journal-title":"Clin. Neuropsychol."},{"key":"10.1016\/j.jns.2019.116523_bb0120","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1002\/mds.22953","article-title":"Cognitive and functional decline in Huntington\u2019s disease: dementia criteria revisited","volume":"25","author":"Peavy","year":"2010","journal-title":"Mov. Disord."},{"key":"10.1016\/j.jns.2019.116523_bb0125","series-title":"Operational Manual: Guidelines for Classifying National Education Programmes and Related Qualifications","first-page":"2015","author":"Secretary-General of the OECD (2015) ISCED","year":"2011"},{"key":"10.1016\/j.jns.2019.116523_bb0130","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1001\/archneur.1997.00550210019008","article-title":"Cognitive manifestations of Huntington disease in relation to genetic structure and clinical onset","volume":"54","author":"Jason","year":"1997","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.jns.2019.116523_bb0135","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3233\/JHD-140109","article-title":"Unawareness of deficits in Huntington\u2019s disease","volume":"3","author":"Sitek","year":"2014","journal-title":"J Huntingt Dis"},{"key":"10.1016\/j.jns.2019.116523_bb0140","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/pcn.12006","article-title":"Self-awareness of executive dysfunction in Huntington\u2019s disease: comparison with Parkinson\u2019s disease and cervical dystonia","volume":"67","author":"Sitek","year":"2013","journal-title":"Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.jns.2019.116523_bb0145","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1001\/archneur.58.2.273","article-title":"Progression of symptoms in the early and middle stages of Huntington disease","volume":"58","author":"Kirkwood","year":"2001","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.jns.2019.116523_bb0150","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1080\/13803390490510149","article-title":"Frontal lobe damage and tests of executive processing: a meta-analysis of the category test, Stroop test, and trail-making test","volume":"26","author":"Demakis","year":"2010","journal-title":"J. Clin. Exp. Neuropsychol."},{"key":"10.1016\/j.jns.2019.116523_bb0155","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1136\/jnnp.2010.208264","article-title":"Longitudinal change in regional brain volumes in prodromal Huntington disease","volume":"82","author":"Aylward","year":"2011","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.jns.2019.116523_bb0160","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S1474-4422(13)70088-7","article-title":"Predictors of phenotypic progression and disease onset in premanifest and early-stage Huntington\u2019s disease in the TRACK-HD study: analysis of 36-month observational data","volume":"12","author":"Tabrizi","year":"2013","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jns.2019.116523_bb0165","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1002\/hbm.22214","article-title":"Regionally selective atrophy of subcortical structures in prodromal HD as revealed by statistical shape analysis","volume":"35","author":"Younes","year":"2014","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.jns.2019.116523_bb0170","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.cortex.2017.07.017","article-title":"Cognitive decline in Huntington\u2019s disease expansion gene carriers","volume":"95","author":"Baake","year":"2017","journal-title":"Cortex"},{"key":"10.1016\/j.jns.2019.116523_bb0175","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1002\/mds.25075","article-title":"The incidence and prevalence of Huntington\u2019s disease: a systematic review and meta-analysis","volume":"27","author":"Pringsheim","year":"2012","journal-title":"Mov. Disord."},{"key":"10.1016\/j.jns.2019.116523_bb0180","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1159\/000444020","article-title":"The frequency of Huntington disease and Huntington disease-like 2 in the south African population","volume":"46","author":"Baine","year":"2016","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.jns.2019.116523_bb0185","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1093\/brain\/123.7.1349","article-title":"Visual object and visuospatial cognition in Huntington\u2019s disease: implications for information processing in corticostriatal circuits","volume":"123","author":"Lawrence","year":"2000","journal-title":"Brain"},{"key":"10.1016\/j.jns.2019.116523_bb0190","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1017\/S1355617716000321","article-title":"Visuospatial processing deficits linked to posterior brain regions in Premanifest and early stage Huntington\u2019s disease","volume":"22","author":"Labuschagne","year":"2016","journal-title":"J. Int. Neuropsychol. Soc."}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X19304551?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X19304551?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T15:48:05Z","timestamp":1758383285000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X19304551"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":38,"alternative-id":["S0022510X19304551"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2019.116523","relation":{},"ISSN":["0022-510X"],"issn-type":[{"value":"0022-510X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mild cognitive impairment and dementia in motor manifest Huntington's disease: Classification and prevalence","name":"articletitle","label":"Article Title"},{"value":"Journal of the Neurological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jns.2019.116523","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116523"}}