{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T19:56:04Z","timestamp":1770839764271,"version":"3.50.1"},"reference-count":14,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jns-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.jns.2020.116940","type":"journal-article","created":{"date-parts":[[2020,5,30]],"date-time":"2020-05-30T07:46:05Z","timestamp":1590824765000},"page":"116940","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Valproate impact and sex-dependent seizure remission in patients with idiopathic generalized epilepsy"],"prefix":"10.1016","volume":"415","author":[{"given":"Emanuele","family":"Cerulli Irelli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Cocchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Morano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Casciato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Fanella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariarita","family":"Albini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giacomo","family":"Fisco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca A.","family":"Barone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biagio","family":"Orlando","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Addolorata","family":"Mascia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Manfredi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinane","family":"Fattouch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna T.","family":"Giallonardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giancarlo","family":"Di Gennaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Di Bonaventura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.jns.2020.116940_bb0005","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1111\/j.1528-1167.2012.03723.x","article-title":"The prognosis of idiopathic generalized epilepsy","volume":"53","author":"Seneviratne","year":"2012","journal-title":"Epilepsia."},{"issue":"9566","key":"10.1016\/j.jns.2020.116940_bb0010","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/S0140-6736(07)60461-9","article-title":"The SANAD study of effectiveness of valproate, lamotrigine, or topiramate for generalised and unclassifiable epilepsy: an unblinded randomised controlled trial","volume":"369","author":"Marson","year":"2007","journal-title":"Lancet."},{"issue":"2","key":"10.1016\/j.jns.2020.116940_bb0015","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/S1474-4422(15)00314-2","article-title":"Valproic acid after five decades of use in epilepsy: time to reconsider the indications of a time-honoured drug","volume":"15","author":"Tomson","year":"2016","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jns.2020.116940_bb0020","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.seizure.2019.07.001","article-title":"Valproate utilisation trends among girls and women from 2013 to 2018","volume":"70","author":"Puteikis","year":"2019","journal-title":"Seizure."},{"issue":"7","key":"10.1016\/j.jns.2020.116940_bb0025","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1111\/epi.13021","article-title":"Valproate in the treatment of epilepsy in girls and women of childbearing potential","volume":"56","author":"Tomson","year":"2015","journal-title":"Epilepsia."},{"issue":"1","key":"10.1016\/j.jns.2020.116940_bb0030","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/epi.16407","article-title":"Doing without valproate in women of childbearing potential with idiopathic generalized epilepsy: implications on seizure outcome","volume":"61","author":"Cerulli Irelli","year":"2020","journal-title":"Epilepsia."},{"issue":"4","key":"10.1016\/j.jns.2020.116940_bb0035","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/epi.13709","article-title":"ILAE classification of the epilepsies: position paper of the ILAE commission for classification and terminology","volume":"58","author":"Scheffer","year":"2017","journal-title":"Epilepsia."},{"issue":"Suppl. 9","key":"10.1016\/j.jns.2020.116940_bb0040","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1528-1167.2005.00314.x","article-title":"Syndromes of idiopathic generalized epilepsies not recognized by the international league against epilepsy","volume":"46","author":"Panayiotopoulos","year":"2005","journal-title":"Epilepsia."},{"issue":"5","key":"10.1016\/j.jns.2020.116940_bb0045","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0987-7053(02)00343-X","article-title":"Eyelid myoclonia with absences: an overlooked epileptic syndrome?","volume":"32","author":"Striano","year":"2002","journal-title":"Neurophysiol. Clin."},{"issue":"5","key":"10.1016\/j.jns.2020.116940_bb0050","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1212\/WNL.51.5.1256","article-title":"Is the underlying cause of epilepsy a major prognostic factor for recurrence?","volume":"51","author":"Semah","year":"1998","journal-title":"Neurology."},{"key":"10.1016\/j.jns.2020.116940_bb0055","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.seizure.2019.06.021","article-title":"Outcomes of low-dose valproic acid treatment in patients with juvenile myoclonic epilepsy","volume":"70","author":"G\u00fcrer","year":"2019","journal-title":"Seizure."},{"issue":"5","key":"10.1016\/j.jns.2020.116940_bb0060","doi-asserted-by":"crossref","first-page":"e20","DOI":"10.1111\/ane.12216","article-title":"Low-dose sodium valproate in the treatment of idiopathic generalized epilepsies","volume":"129","author":"Mir\u00f3","year":"2014","journal-title":"Acta Neurol. Scand."},{"issue":"8","key":"10.1016\/j.jns.2020.116940_bb0065","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1093\/brain\/awh200","article-title":"Course and prognosis of childhood epilepsy: 5-year follow-up of the Dutch study of epilepsy in childhood","volume":"127","author":"Arts","year":"2004","journal-title":"Brain"},{"issue":"12","key":"10.1016\/j.jns.2020.116940_bb0070","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1046\/j.1528-1157.2001.21101.x","article-title":"Two-year remission and subsequent relapse in children with newly diagnosed epilepsy","volume":"42","author":"Berg","year":"2001","journal-title":"Epilepsia."}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X2030277X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X2030277X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T15:52:39Z","timestamp":1758383559000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X2030277X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":14,"alternative-id":["S0022510X2030277X"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2020.116940","relation":{},"ISSN":["0022-510X"],"issn-type":[{"value":"0022-510X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Valproate impact and sex-dependent seizure remission in patients with idiopathic generalized epilepsy","name":"articletitle","label":"Article Title"},{"value":"Journal of the Neurological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jns.2020.116940","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116940"}}