{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T02:09:03Z","timestamp":1777860543400,"version":"3.51.4"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jns-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.jns.2020.117284","type":"journal-article","created":{"date-parts":[[2020,12,20]],"date-time":"2020-12-20T10:10:50Z","timestamp":1608459050000},"page":"117284","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Width of the third ventricle as a highly-sensitive biomarker in chronic progressive neuro-Beh\u00e7et's disease"],"prefix":"10.1016","volume":"421","author":[{"given":"Sunao","family":"Takahashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuo","family":"Sanjo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shohei","family":"Miyamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaaki","family":"Hattori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Oyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ukihide","family":"Tateishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takanori","family":"Yokota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jns.2020.117284_bb0005","doi-asserted-by":"crossref","first-page":"10196","DOI":"10.1038\/s41598-017-09938-z","article-title":"Distinct clinical features between acute and chronic progressive parenchymal neuro-Beh\u00e7et disease: meta-analysis","volume":"7","author":"Ishido","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jns.2020.117284_bb0010","doi-asserted-by":"crossref","first-page":"621","DOI":"10.3109\/s10165-010-0332-4","article-title":"An attack of acute neuro-Beh\u00e7et\u2019s disease during the course of chronic progressive neuro-Beh\u00e7et\u2019s disease: report of two cases","volume":"20","author":"Matsui","year":"2010","journal-title":"Mod. Rheumatol."},{"key":"10.1016\/j.jns.2020.117284_bb0015","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/mds.21834","article-title":"Ataxia and cerebellar atrophy \u2013 A novel manifestation of neuro-Beh\u00e7et disease?","volume":"23","author":"Gardner","year":"2008","journal-title":"Mov. Disord."},{"key":"10.1016\/j.jns.2020.117284_bb0020","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s00296-006-0171-y","article-title":"A possible variant of neuro-Beh\u00e7et disease presenting chronic progressive ataxia without mucocutaneo-ocular symptoms","volume":"27","author":"Hirose","year":"2006","journal-title":"Rheumatol. Int."},{"key":"10.1016\/j.jns.2020.117284_bb0025","first-page":"1015","article-title":"CNS involvement in neuro-Beh\u00e7et syndrome: an MR study","volume":"20","author":"Ko\u00e7er","year":"1999","journal-title":"Am. J. Neuroradiol."},{"key":"10.1016\/j.jns.2020.117284_bb0030","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jns.2008.10.003","article-title":"Delayed diagnosis of a neuroBeh\u00e7et patient with only brainstem and cerebellar atrophy: literature review","volume":"277","author":"Taskapilioglu","year":"2009","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.jns.2020.117284_bb0035","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1007\/s00508-013-0364-9","article-title":"Cortical and cerebellar atrophy, but no lesion in a patient with neuro-Beh\u00e7et's disease","volume":"125","author":"Varoglu","year":"2013","journal-title":"Wien. Klin. Wochenschr."},{"key":"10.1016\/j.jns.2020.117284_bb0040","doi-asserted-by":"crossref","first-page":"e142","DOI":"10.1111\/1756-185X.12013","article-title":"Magnetic resonance imaging findings and outcome of neuro-Beh\u00e7et\u2019s disease: the predictive factors","volume":"15","author":"Farahangiz","year":"2012","journal-title":"Int. J. Rheum. Dis."},{"key":"10.1016\/j.jns.2020.117284_bb0045","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jns.2013.11.020","article-title":"Quantitative analysis of brainstem atrophy on magnetic resonance imaging in chronic progressive neuro-Beh\u00e7et\u2019s disease","volume":"337","author":"Kikuchi","year":"2014","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.jns.2020.117284_bb0050","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1093\/brain\/122.11.2171","article-title":"Clinical patterns of neurological involvement in Beh\u00e7et's disease: evaluation of 200 patients. The Neuro-Beh\u00e7et Study Group","volume":"122","author":"Akman-Demir","year":"1999","journal-title":"Brain"},{"key":"10.1016\/j.jns.2020.117284_bb0055","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.clineuro.2009.08.002","article-title":"Neuro-Behcet's disease presenting with amnesia and frontal dysfunction","volume":"111","author":"Mimura","year":"2009","journal-title":"Clin. Neurol. Neurosurg."},{"key":"10.1016\/j.jns.2020.117284_bb0060","doi-asserted-by":"crossref","first-page":"116831","DOI":"10.1016\/j.jns.2020.116831","article-title":"Laboratory and clinical correlates of brain atrophy in Neuro-Beh\u00e7et\u2019s disease","volume":"414","author":"G\u0215nd\u0215z","year":"2020","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.jns.2020.117284_bb0065","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1001\/archneur.61.2.226","article-title":"Prediction of neuropsychological impairment in multiple sclerosis: comparison of conventional magnetic resonance imaging measures of atrophy and lesion burden","volume":"61","author":"Benedict","year":"2004","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.jns.2020.117284_bb0070","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/jdv.12107","article-title":"The International Criteria for Beh\u00e7et's Disease (ICBD): a collaborative study of 27 countries on the sensitivity and specificity of the new criteria","volume":"28","author":"International Team for the Revision of the International Criteria for Beh\u00e7et's Disease (ITR-ICBD)","year":"2014","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.jns.2020.117284_bb0075","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s004150050317","article-title":"Neuropsychological follow-up of 12 patients with neuro-Beh\u00e7et disease","volume":"246","author":"Oktem-Tan\u00f6r","year":"1999","journal-title":"J. Neurol."},{"key":"10.1016\/j.jns.2020.117284_bb0080","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1007\/s12149-013-0768-7","article-title":"Prediction of outcomes in MCI with (123)I-IMP-CBF SPECT: a multicenter prospective cohort study","volume":"27","author":"Ito","year":"2013","journal-title":"Ann. Nucl. Med."},{"key":"10.1016\/j.jns.2020.117284_bb0085","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/jmri.20665","article-title":"Characterization of cortical thickness and ventricular width in normal aging: a morphometric study at 3 tesla","volume":"24","author":"Preul","year":"2006","journal-title":"J. Magn. Reson. Imaging"},{"key":"10.1016\/j.jns.2020.117284_bb0090","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jns.2015.01.005","article-title":"Retrospective analysis of long-term outcome of chronic progressive neurological manifestations in Behcet's disease","volume":"349","author":"Hirohata","year":"2015","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.jns.2020.117284_bb0095","doi-asserted-by":"crossref","first-page":"405","DOI":"10.3109\/s10165-011-0533-5","article-title":"Clinical characteristics of neuro-Behcet\u2019s disease in Japan: a multicenter retrospective analysis","volume":"22","author":"Hirohata","year":"2012","journal-title":"Mod. Rheumatol."},{"key":"10.1016\/j.jns.2020.117284_bb0100","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jns.2007.09.041","article-title":"Histopathology of central nervous system lesions in Beh\u00e7et's disease","volume":"267","author":"Hirohata","year":"2008","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.jns.2020.117284_bb0105","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1212\/01.WNL.0000130192.12100.8D","article-title":"Neuro-Behcet disease with predominant involvement of the brainstem","volume":"63","author":"Mirsattari","year":"2004","journal-title":"Neurology."},{"key":"10.1016\/j.jns.2020.117284_bb0110","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1006\/clin.1996.4268","article-title":"Cerebrospinal fluid interleukin-6 in progressive neuro-Beh\u00e7et\u2019s syndrome","volume":"82","author":"Hirohata","year":"1997","journal-title":"Clin. Immunol. Immunopathol."},{"key":"10.1016\/j.jns.2020.117284_bb0115","doi-asserted-by":"crossref","first-page":"10061","DOI":"10.1073\/pnas.90.21.10061","article-title":"Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6","volume":"90","author":"Campbell","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jns.2020.117284_bb0120","doi-asserted-by":"crossref","first-page":"18460","DOI":"10.1073\/pnas.0809850105","article-title":"IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells","volume":"105","author":"Korn","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jns.2020.117284_bb0125","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/cei.12271","article-title":"Neuromyelitis optica: clinical features, immunopathogenesis and treatment","volume":"176","author":"Jarius","year":"2014","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jns.2020.117284_bb0130","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/nyas.12118","article-title":"Immunology of neuromyelitis optica: a T cell-B cell collaboration","volume":"1283","author":"Mitsdoerffer","year":"2013","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.jns.2020.117284_bb0135","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1111\/cei.12733","article-title":"Prediction of disease severity in neuromyelitis optica by the levels of interleukin (IL)-6 produced during remission phase","volume":"183","author":"Barros","year":"2016","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jns.2020.117284_bb0140","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1177\/1352458510379247","article-title":"Cytokine and chemokine profiles in neuromyelitis optica: significance of interleukin-6","volume":"16","author":"Uzawa","year":"2010","journal-title":"Mult. Scler."},{"key":"10.1016\/j.jns.2020.117284_bb0145","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s00401-017-1682-1","article-title":"Pathogenic implications of cerebrospinal fluid barrier pathology in neuromyelitis optica","volume":"133","author":"Guo","year":"2017","journal-title":"Acta Neuropathol."},{"issue":"1","key":"10.1016\/j.jns.2020.117284_bb0150","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/ana.23721","article-title":"Cognitive impairment and cortical degeneration in neuromyelitis optica","volume":"73","author":"Saji","year":"2013","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.jns.2020.117284_bb0155","first-page":"77","article-title":"Clinicopathological study on a case of neuro-Beh\u00e7et's disease: in special reference to MRI, SPECT and neuropathological findings","volume":"48","author":"Arai","year":"1994","journal-title":"Jpn. J. Psychiatry Neurol."},{"key":"10.1016\/j.jns.2020.117284_bb0160","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1552-6569.2002.tb00144.x","article-title":"Decreased cerebral blood flow in neuro-Beh\u00e7et\u2019s syndrome patients with neuropsychiatric manifestations and normal magnetic resonance imaging--a preliminary report","volume":"12","author":"Huang","year":"2002","journal-title":"J. Neuroimaging"},{"key":"10.1016\/j.jns.2020.117284_bb0165","doi-asserted-by":"crossref","first-page":"15775","DOI":"10.1523\/JNEUROSCI.3539-11.2011","article-title":"Rich-club organization of the human connectome","volume":"31","author":"van den Heuvel","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jns.2020.117284_bb0170","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jns.2004.02.021","article-title":"Cognitive impairment in Beh\u00e7et\u2019s disease patients without overt neurological involvement","volume":"220","author":"Monastero","year":"2004","journal-title":"J. Neurol. Sci."}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X20306201?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X20306201?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T15:51:50Z","timestamp":1758383510000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X20306201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":34,"alternative-id":["S0022510X20306201"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2020.117284","relation":{},"ISSN":["0022-510X"],"issn-type":[{"value":"0022-510X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Width of the third ventricle as a highly-sensitive biomarker in chronic progressive neuro-Beh\u00e7et's disease","name":"articletitle","label":"Article Title"},{"value":"Journal of the Neurological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jns.2020.117284","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"117284"}}