{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T14:42:28Z","timestamp":1764859348270,"version":"3.44.0"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T00:00:00Z","timestamp":1654560000000},"content-version":"am","delay-in-days":310,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000049","name":"NIA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jns-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.jns.2021.117516","type":"journal-article","created":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T11:23:55Z","timestamp":1622460235000},"page":"117516","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Use of coffee grounds to test olfaction for predicting cognitive dysfunction and decline"],"prefix":"10.1016","volume":"427","author":[{"given":"Alexander J.","family":"Rajic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter S.","family":"Pressman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan H.","family":"Woodcock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidi J.","family":"Chial","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher M.","family":"Filley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jns.2021.117516_bb0005","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jalz.2010.07.001","article-title":"An economic evaluation of early assessment for Alzheimer\u2019s disease in the United Kingdom","volume":"8","author":"Getsios","year":"2012","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.jns.2021.117516_bb0010","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3233\/JAD-150685","article-title":"Excess costs associated with possible misdiagnosis of Alzheimer\u2019s disease among patients with vascular dementia in a UK CPRD population","volume":"53","author":"Happich","year":"2016","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"10.1016\/j.jns.2021.117516_bb0015","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1212\/WNL.0b013e3182918ca6","article-title":"Amyloid imaging and CSF biomarkers in predicting cognitive impairment up to 7.5 years later","volume":"80","author":"Roe","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2021.117516_bb0020","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1093\/ageing\/afs008","article-title":"Validation and diagnostic accuracy of the Alzheimer\u2019s questionnaire","volume":"41","author":"Malek-Ahmadi","year":"2012","journal-title":"Age Ageing"},{"key":"10.1016\/j.jns.2021.117516_bb0025","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1176\/appi.ajp.157.9.1399","article-title":"Olfactory deficits in patients with mild cognitive impairment predict Alzheimer\u2019s disease at follow-up","volume":"157","author":"Devanand","year":"2000","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jns.2021.117516_bb0030","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.neurobiolaging.2006.11.014","article-title":"Olfaction in patients with mild cognitive impairment and Alzheimer\u2019s disease","volume":"29","author":"Djordjevic","year":"2008","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.jns.2021.117516_bb0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuropsychologia.2016.03.004","article-title":"Long-term episodic memory decline is associated with olfactory deficits only in carriers of ApoE-\u03b54","volume":"85","author":"Olofsson","year":"2016","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.jns.2021.117516_bb0040","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1001\/jamaneurol.2015.2952","article-title":"Association between olfactory dysfunction and amnestic mild cognitive impairment and Alzheimer disease dementia","volume":"73","author":"Roberts","year":"2016","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.jns.2021.117516_bb0045","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1017\/S1355617713001409","article-title":"Olfactory impairment and subjective olfactory complaints independently predict conversion to dementia: a longitudinal, population-based study","volume":"20","author":"Stanciu","year":"2014","journal-title":"J. Int. Neuropsychol. Soc."},{"key":"10.1016\/j.jns.2021.117516_bb0050","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1212\/CPJ.0000000000000293","article-title":"Validation of olfactory deficit as a biomarker of Alzheimer disease","volume":"7","author":"Woodward","year":"2017","journal-title":"Neurol. Clin. Pract."},{"key":"10.1016\/j.jns.2021.117516_bb0055","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/jgs.15048","article-title":"Olfactory dysfunction predicts subsequent dementia in older U.S. adults","volume":"66","author":"Adams","year":"2018","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.jns.2021.117516_bb0060","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/cne.903460306","article-title":"Central olfactory connections in the macaque monkey","volume":"346","author":"Carmichael","year":"1994","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.jns.2021.117516_bb0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0064735","article-title":"Diagnostic value of the impairment of olfaction in Parkinson\u2019s disease","volume":"8","author":"Casjens","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jns.2021.117516_bb0070","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1186\/s12883-014-0168-1","article-title":"The brain structural and cognitive basis of odor identification deficits in mild cognitive impairment and Alzheimer\u2019s disease","volume":"14","author":"Kjelvik","year":"2014","journal-title":"BMC Neurol."},{"key":"10.1016\/j.jns.2021.117516_bb0075","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1177\/1533317514539033","article-title":"Odor identification in frontotemporal lobar degeneration subtypes","volume":"29","author":"Magerova","year":"2014","journal-title":"Am. J. Alzheimers Dis. Other Dement."},{"key":"10.1016\/j.jns.2021.117516_bb0080","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1093\/brain\/awt019","article-title":"A cortical pathway to olfactory naming: evidence from primary progressive aphasia","volume":"136","author":"Olofsson","year":"2013","journal-title":"Brain"},{"key":"10.1016\/j.jns.2021.117516_bb0085","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/0031-9384(84)90269-5","article-title":"Development of the University of Pennsylvania Smell Identification Test: a standardized microencapsulated test of olfactory function","volume":"32","author":"Doty","year":"1984","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.jns.2021.117516_bb0090","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1007\/s40520-017-0865-x","article-title":"Trajectory and variability characterization of the Montreal cognitive assessment in older adults","volume":"30","author":"Malek-Ahmadi","year":"2018","journal-title":"Aging Clin. Exp. Res."},{"key":"10.1016\/j.jns.2021.117516_bb0095","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1177\/1073191118771516","article-title":"The AVERT MoCA data: scoring reliability in a large multicenter trial","volume":"27","author":"Cumming","year":"2020","journal-title":"Assessment"},{"key":"10.1016\/j.jns.2021.117516_bb0100","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1212\/WNL.0b013e31828726f5","article-title":"Alzheimer disease in the United States (2010-2050) estimated using the 2010 census","volume":"80","author":"Hebert","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2021.117516_bb0105","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.mcna.2013.01.002","article-title":"Clinical trials in predementia stages of Alzheimer disease","volume":"97","author":"Pillai","year":"2013","journal-title":"Med. Clin. North Am."},{"key":"10.1016\/j.jns.2021.117516_bb0110","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/1471-2377-14-101","article-title":"Early intervention in Alzheimer\u2019s disease: a health economic study of the effects of diagnostic timing","volume":"14","author":"Barnett","year":"2014","journal-title":"BMC Neurol."}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X21002100?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X21002100?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T15:56:32Z","timestamp":1758383792000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X21002100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":22,"alternative-id":["S0022510X21002100"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2021.117516","relation":{},"ISSN":["0022-510X"],"issn-type":[{"type":"print","value":"0022-510X"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Use of coffee grounds to test olfaction for predicting cognitive dysfunction and decline","name":"articletitle","label":"Article Title"},{"value":"Journal of the Neurological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jns.2021.117516","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"117516"}}