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J. Neurosci."},{"key":"10.1016\/j.jns.2021.117541_bb0365","doi-asserted-by":"crossref","first-page":"4274","DOI":"10.1073\/pnas.0306147101","article-title":"Disruption of communication between peripheral and central trigeminovascular neurons mediates the antimigraine action of 5HT 1B\/1D receptor agonists","volume":"101","author":"Levy","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jns.2021.117541_bb0370","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1097\/NEN.0000000000000105","article-title":"Mast cells, neovascularization, and microhemorrhages are associated with saccular intracranial artery aneurysm wall remodelling","volume":"73","author":"Ollikainen","year":"2014","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.jns.2021.117541_bb0375","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1750-3639.2007.00092.x","article-title":"Stroke induces histamine accumulation and mast cell degranulation in the neonatal rat brain","volume":"18","author":"Biran","year":"2008","journal-title":"Brain Pathol."},{"key":"10.1016\/j.jns.2021.117541_bb0380","doi-asserted-by":"crossref","first-page":"3107","DOI":"10.1161\/STROKEAHA.109.549691","article-title":"Mast cells are early responders after hypoxia-ischemia in immature rat brain","volume":"40","author":"Jin","year":"2009","journal-title":"Stroke."},{"key":"10.1016\/j.jns.2021.117541_bb0385","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0031-6997(24)01328-0","article-title":"International Union of Pharmacology. XIII. Classification of histamine receptors","volume":"49","author":"Hill","year":"1997","journal-title":"Pharmacol Rev."},{"key":"10.1016\/j.jns.2021.117541_bb0390","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.1991.71.1.1","article-title":"Histaminergic transmission in the mammalian brain","volume":"71","author":"Schwartz","year":"1991","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.jns.2021.117541_bb0395","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nrd1631","article-title":"The histamine H3 receptor: from gene cloning to H3 receptor drugs","volume":"4","author":"Leurs","year":"2005","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jns.2021.117541_bb0400","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/cne.902290208","article-title":"Fine structure of histaminergic neurons in the caudal magnocellular nucleus of the rat as demonstrated by immunocytochemistry using histidine decarboxylase as a marker","volume":"229","author":"Hayashi","year":"1984","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.jns.2021.117541_bb0405","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1111\/j.1471-4159.1971.tb00014.x","article-title":"The subcellular localization of histamine and histamine methyltransferase in rat brain","volume":"18","author":"Kuhar","year":"1971","journal-title":"J. Neurochem."},{"key":"10.1016\/j.jns.2021.117541_bb0410","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/cne.902520207","article-title":"Histaminergic neurons in the rat brain: correlative immunocytochemistry, Golgi impregnation, electron microscopy","volume":"252","author":"Wouterlood","year":"1986","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.jns.2021.117541_bb0415","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0006-8993(75)90935-X","article-title":"Histamine synthesis in the developing rat brain: evidence for a multiple compartmentation","volume":"83","author":"Martres","year":"1975","journal-title":"Brain Res."},{"key":"10.1016\/j.jns.2021.117541_bb0420","doi-asserted-by":"crossref","first-page":"5166","DOI":"10.1073\/pnas.93.10.5166","article-title":"Distinct pharmacological properties and distribution in neurons and endocrine cells of two isoforms of the human vesicular monoamine transporter","volume":"93","author":"Erickson","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jns.2021.117541_bb0425","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1016\/0028-3908(95)00148-Y","article-title":"Transport of histamine by vesicular monoamine transporter-2","volume":"34","author":"Merickel","year":"1995","journal-title":"Neuropharmacology."},{"issue":"3","key":"10.1016\/j.jns.2021.117541_bb0430","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1152\/physrev.00043.2007","article-title":"Histamine in the nervous system","volume":"88","author":"Haas","year":"2008","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.jns.2021.117541_bb0435","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S0306-4522(00)00230-X","article-title":"Histamine H(1) receptors in patients with Alzheimer\u2019s disease assessed by positron emission tomography","volume":"99","author":"Higuchi","year":"2000","journal-title":"Neuroscience."},{"key":"10.1016\/j.jns.2021.117541_bb0440","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.neulet.2003.10.061","article-title":"Age-related changes in histamine receptor mRNA levels in the mouse brain","volume":"355","author":"Terao","year":"2004","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.jns.2021.117541_bb0445","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1097\/00001756-199205000-00014","article-title":"Age-dependent decrease in histamine H1 receptor in human brains revealed by PET","volume":"3","author":"Yanai","year":"1992","journal-title":"Neuroreport."},{"issue":"1","key":"10.1016\/j.jns.2021.117541_bb0450","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0006-8993(84)90811-4","article-title":"Distribution of the histaminergic neuron system in the central nervous system of rats; a fluorescent immunohistochemical analysis with histidine decarboxylase as a marker","volume":"295","author":"Watanabe","year":"1984","journal-title":"Brain Res."},{"key":"10.1016\/j.jns.2021.117541_bb0455","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.pharmthera.2017.02.039","article-title":"The roles of histamine and its receptor ligands in central nervous system disorders: an update","volume":"175","author":"Hu","year":"2017","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.jns.2021.117541_bb0460","first-page":"222","article-title":"Neuromodulaci\u00f3n: una nueva funci\u00f3n para la histamina","volume":"6","author":"Arias-Monta\u00f1o","year":"1995","journal-title":"Rev. Biomed."},{"key":"10.1016\/j.jns.2021.117541_bb0465","doi-asserted-by":"crossref","first-page":"17","DOI":"10.4049\/jimmunol.176.1.17","article-title":"A key regulatory role for histamine in experimental autoimmune encephalomyelitis: disease exacerbation in histidine decarboxylase- deficient mice","volume":"176","author":"Musio","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.jns.2021.117541_bb0470","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S1471-4906(03)00233-3","article-title":"Involvement of both \u201callergic\u201d and \u201cautoimmune\u201d mechanisms in EAE, MS and other autoimmune diseases","volume":"24","author":"Pedotti","year":"2003","journal-title":"Trends Immunol."},{"key":"10.1016\/j.jns.2021.117541_bb0475","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1126\/science.1072810","article-title":"Identification of Bphs, an autoimmune disease locus, as histamine receptor H1","volume":"297","author":"Ma","year":"2002","journal-title":"Science."},{"key":"10.1016\/j.jns.2021.117541_bb0480","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/S0002-9440(10)63176-8","article-title":"Attenuation of Th1 effector cell responses and susceptibility to experimental allergic encephalomyelitis in histamine H2 receptor knockout mice is due to dysregulation of cytokine production by antigen-presenting cells","volume":"164","author":"Teuscher","year":"2004","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jns.2021.117541_bb0485","doi-asserted-by":"crossref","first-page":"10146","DOI":"10.1073\/pnas.0702291104","article-title":"Central histamine H3 receptor signaling negatively regulates susceptibility to autoimmune inflammatory disease of the CNS","volume":"104","author":"Teuscher","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jns.2021.117541_bb0490","first-page":"462","article-title":"The histamine H4 receptor as a new therapeutic target for inflammation","volume":"26","author":"De Esch","year":"2005","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.jns.2021.117541_bb0495","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/ni1078","article-title":"Elaborate interactions between the immune and nervous systems","volume":"5","author":"Steinman","year":"2004","journal-title":"Nat. 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Neurosci."},{"key":"10.1016\/j.jns.2021.117541_bb0515","first-page":"100","article-title":"Histamina y comunicaci\u00f3n intercelular: 99 a\u00f1os de historia","volume":"20","author":"Ramos-Jim\u00e9nez","year":"2009","journal-title":"Rev. Biomed."},{"key":"10.1016\/j.jns.2021.117541_bb0520","first-page":"94","article-title":"Isoformas del receptor a histamina H3 humano: generaci\u00f3n, expresi\u00f3n en el sistema nervioso central (SNC) e implicaciones funcionales","volume":"152","author":"Garc\u00eda-G\u00e1lvez","year":"2016","journal-title":"Gac. Med. Mex."},{"key":"10.1016\/j.jns.2021.117541_bb0525","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.brainres.2008.11.018","article-title":"Localization of histamine H4 receptors in the central nervous system of human and rat","volume":"1250","author":"Strakhova","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.jns.2021.117541_bb0530","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1111\/j.1476-5381.2012.02049.x","article-title":"Histamine H4 receptor antagonists as potent modulators of mammalian vestibular primary neuron excitability","volume":"167","author":"Desmadryl","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jns.2021.117541_bb0535","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/bph.12256","article-title":"Postsynaptic mechanisms underlying the excitatory action of histamine on medial vestibular nucleus neurons in rats","volume":"170","author":"Zhang","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jns.2021.117541_bb0540","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.neuroscience.2011.06.002","article-title":"Histamine H1, H3 and H4 receptors are involved in pruritus","volume":"190","author":"Rossbach","year":"2011","journal-title":"Neuroscience."},{"key":"10.1016\/j.jns.2021.117541_bb0545","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1124\/jpet.103.061754","article-title":"A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties","volume":"309","author":"Thurmond","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.jns.2021.117541_bb0550","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1111\/bjd.14995","article-title":"Histamine metabolism and transport are deranged in human keratinocytes in oral lichen planus","volume":"176","author":"Salem","year":"2017","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jns.2021.117541_bb0555","doi-asserted-by":"crossref","first-page":"7907","DOI":"10.4049\/jimmunol.179.11.7907","article-title":"Functional expession of H4 histamine receptor in human natural killer cells, monocytes, and dendritic cells","volume":"179","author":"Damaj","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.jns.2021.117541_bb0560","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/bph.14524","article-title":"Histamine pharmacology: from sir Henry dale to the 21st century","volume":"177","author":"Tiligada","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jns.2021.117541_bb0565","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.jaci.2011.09.005","article-title":"Histamine and H1-antihistamines: celebrating a century of progress","volume":"128","author":"Simons","year":"2011","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.jns.2021.117541_bb0570","first-page":"1002","article-title":"Participation of H1 and H2 histamine receptors in physiological vasodilator responses","volume":"231","author":"Powell","year":"1976","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.jns.2021.117541_bb0575","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1038\/302832a0","article-title":"Auto-inhibition of brain histamine release mediated by a novel class (H3) of histamine receptor","volume":"302","author":"Arrang","year":"1983","journal-title":"Nature."},{"key":"10.1016\/j.jns.2021.117541_bb0580","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1006\/bbrc.2000.4008","article-title":"Molecular cloning and characterization of a new human histamine receptor, HH4R","volume":"279","author":"Nakamura","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jns.2021.117541_bb0585","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/S0026-895X(24)12232-8","article-title":"Cloning, expression, and pharmacological characterization of a novel human histamine receptor","volume":"59","author":"Zhu","year":"2001","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.jns.2021.117541_bb0590","doi-asserted-by":"crossref","unstructured":"Panula P., Chazot P.L., Cowart M., Gutzmer R., Leurs R., Liu W.L.S., Stark H., Robin L. Thurmond, and Helmut L. Haas. International union of basic and clinical pharmacology. XCVIII. histamine receptors. Pharmacol. 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Immunol."},{"issue":"10S","key":"10.1016\/j.jns.2021.117541_bb0605","article-title":"The effects of SENS-111, a new H4R antagonist, on vertigo induced by caloric test in healthy volunteers (HV) is related to plasma concentrations","volume":"38","author":"Attali","year":"2016","journal-title":"Clin. 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Neurosci."},{"key":"10.1016\/j.jns.2021.117541_bb0625","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1002\/eji.201141859","article-title":"Combinatorial roles for histamine H1-H2 and H3-H4 receptors in autoimmune inflammatory disease of the central nervous system","volume":"42","author":"Saligrama","year":"2012","journal-title":"Eur. J. 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Rev."},{"issue":"Suppl","key":"10.1016\/j.jns.2021.117541_bb0640","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/nn944","article-title":"Sleeping with the hypothalamus: emerging therapeutic targets for sleep disorders","volume":"5","author":"Mignot","year":"2002","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jns.2021.117541_bb0645","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1124\/mol.62.2.389","article-title":"Behavioral characterization of mice lacking histamine H(3) receptors","volume":"62","author":"Toyota","year":"2002","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.jns.2021.117541_bb0650","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1111\/j.1476-5381.1994.tb14883.x","article-title":"Role of histamine in rodent antinociception","volume":"111","author":"Malmberg-Aiello","year":"1994","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jns.2021.117541_bb0655","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.pbb.2007.07.014","article-title":"Activation of peripheral and spinal histamine H(3) receptors inhibits formalin-induced inflammation and nociception, respectively","volume":"88","author":"Cannon","year":"2007","journal-title":"Pharmacol. Biochem. 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