{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T03:53:26Z","timestamp":1784865206216,"version":"3.55.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T00:00:00Z","timestamp":1623715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013870","name":"Epilepsiatutkimussaatio","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013870","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007639","name":"Maire Taponen Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007639","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jns-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.jns.2021.117542","type":"journal-article","created":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T22:25:34Z","timestamp":1623968734000},"page":"117542","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Status epilepticus: Practice variation and adherence to treatment guideline in a large community hospital"],"prefix":"10.1016","volume":"427","author":[{"given":"Joni J.","family":"Sairanen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Mari","family":"Kantanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harri T.","family":"Hypp\u00f6l\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reetta K.","family":"K\u00e4lvi\u00e4inen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jns.2021.117542_bb0005","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S1474-4422(15)00042-3","article-title":"Status epilepticus in adults","volume":"14","author":"Betjemann","year":"2015","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jns.2021.117542_bb0010","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s12028-012-9695-z","article-title":"Neurocritical care society status Epilepticus guideline writing committee, guidelines for the evaluation and management of status Epilepticus","volume":"17","author":"Brophy","year":"2012","journal-title":"Neurocrit. Care."},{"key":"10.1016\/j.jns.2021.117542_bb0015","doi-asserted-by":"crossref","first-page":"48","DOI":"10.5698\/1535-7597-16.1.48","article-title":"Evidence-based guideline: treatment of convulsive status Epilepticus in children and adults: report of the guideline Committee of the American Epilepsy Society","volume":"16","author":"Glauser","year":"2016","journal-title":"Epilepsy Curr."},{"key":"10.1016\/j.jns.2021.117542_bb0020","author":"K\u00e4lvi\u00e4inen"},{"key":"10.1016\/j.jns.2021.117542_bb0025","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/ana.24986","article-title":"Timing is everything: where status epilepticus treatment fails","volume":"82","author":"Hill","year":"2017","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.jns.2021.117542_bb0030","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1111\/epi.13121","article-title":"A definition and classification of status epilepticus \u2013 report of the ILAE task force on classification of status Epilepticus","volume":"56","author":"Trinka","year":"2015","journal-title":"Epilepsia."},{"key":"10.1016\/j.jns.2021.117542_bb0035","first-page":"122","article-title":"Advancements in the critical care management of status epilepticus","volume":"23","author":"Bauerschmidt","year":"2017","journal-title":"Curr. Opin. Crit. Care"},{"key":"10.1016\/j.jns.2021.117542_bb0040","doi-asserted-by":"crossref","first-page":"106288","DOI":"10.1016\/j.yebeh.2019.04.041","article-title":"Management of prolonged epileptic seizures and status epilepticus in palliative care patients","volume":"101","author":"K\u00e4lvi\u00e4inen","year":"2019","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.jns.2021.117542_bb0045","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s12028-014-0016-6","article-title":"Factors related to delays in pre-hospital management of status epilepticus","volume":"22","author":"K\u00e4mppi","year":"2015","journal-title":"Neurocrit. Care."},{"key":"10.1016\/j.jns.2021.117542_bb0050","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s13049-019-0605-7","article-title":"Treatment delay in status epilepticus - more effective prehospital symptom recognition warranted","volume":"27","author":"Sairanen","year":"2019","journal-title":"Scand. J. Trauma Resusc. Emerg. Med."},{"key":"10.1016\/j.jns.2021.117542_bb0055","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.jns.2016.10.004","article-title":"Latency to treatment of status epilepticus is associated with mortality and functional status","volume":"370","author":"Cheng","year":"2016","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.jns.2021.117542_bb0060","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jns.2017.09.031","article-title":"Impact of non-guideline-based treatment of status epilepticus","volume":"382","author":"Braun","year":"2017","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.jns.2021.117542_bb0065","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/ana.25416","article-title":"Factors predicting cessation of status epilepticus in clinical practice: data from a prospective observational registry (SENSE)","volume":"85","author":"Kellinghaus","year":"2019","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.jns.2021.117542_bb0070","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s00415-015-7992-0","article-title":"Association of seizure duration and outcome in refractory status epilepticus","volume":"263","author":"Mad\u017ear","year":"2016","journal-title":"J. Neurol."},{"key":"10.1016\/j.jns.2021.117542_bb0075","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1212\/WNL.0000000000000009","article-title":"Anesthetic drugs in status epilepticus: risk or rescue? A 6-year cohort study","volume":"82","author":"Sutter","year":"2014","journal-title":"Neurology."},{"key":"10.1016\/j.jns.2021.117542_bb0080","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.seizure.2019.12.026","article-title":"Outcome of status epilepticus and the predictive value of the EMSE and STESS scores: a prospective study","volume":"75","author":"Sairanen","year":"2020","journal-title":"Seizure"},{"key":"10.1016\/j.jns.2021.117542_bb0085","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/nrneurol.2013.154","article-title":"Outcome predictors for status epilepticus\u2014what really counts","volume":"9","author":"Sutter","year":"2013","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.jns.2021.117542_bb0090","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.seizure.2018.04.005","article-title":"Outcomes of deviation from treatment guidelines in status epilepticus: a systematic review","volume":"58","author":"Uppal","year":"2018","journal-title":"Seizure."},{"key":"10.1016\/j.jns.2021.117542_bb0095","doi-asserted-by":"crossref","first-page":"7724","DOI":"10.1523\/JNEUROSCI.4944-04.2005","article-title":"Trafficking of GABA(a) receptors, loss of inhibition, and a mechanism for pharmacoresistance in status epilepticus","volume":"25","author":"Naylor","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jns.2021.117542_bb0100","doi-asserted-by":"crossref","first-page":"e3203","DOI":"10.1212\/WNL.0000000000010913","article-title":"Prehospital midazolam use and outcomes among patients with out-of-hospital status epilepticus","volume":"95","author":"Guterman","year":"2020","journal-title":"Neurology."},{"key":"10.1016\/j.jns.2021.117542_bb0105","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1111\/epi.16825","article-title":"Patterns of benzodiazepine underdosing in the established status Epilepticus treatment trial","volume":"62","author":"Sathe","year":"2021","journal-title":"Epilepsia."},{"key":"10.1016\/j.jns.2021.117542_bb0110","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1056\/NEJMoa002141","article-title":"A comparison of lorazepam, diazepam, and placebo for the treatment of out-of-hospital status epilepticus","volume":"345","author":"Alldredge","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jns.2021.117542_bb0115","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.yebeh.2015.02.030","article-title":"Nonintravenous midazolam versus intravenous or rectal diazepam for the treatment of early status epilepticus: a systematic review with meta-analysis","volume":"49","author":"Brigo","year":"2015","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.jns.2021.117542_bb0120","doi-asserted-by":"crossref","DOI":"10.1002\/ams2.582","article-title":"Japan resuscitation council (JRC) Neuroresuscitation task force and the guidelines editorial committee, comparison of diazepam and lorazepam for the emergency treatment of adult status epilepticus: a systemic review and meta-analysis","volume":"7","author":"Kobata","year":"2020","journal-title":"Acute Med. Surg."},{"key":"10.1016\/j.jns.2021.117542_bb0125","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1056\/NEJMoa1107494","article-title":"Intramuscular versus intravenous therapy for prehospital status epilepticus","volume":"366","author":"Silbergleit","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jns.2021.117542_bb0130","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1007\/s40263-019-00652-0","article-title":"Intravenous brivaracetam in the treatment of status epilepticus: a systematic review","volume":"33","author":"Brigo","year":"2019","journal-title":"CNS Drugs."},{"key":"10.1016\/j.jns.2021.117542_bb0135","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S1474-4422(15)00296-3","article-title":"SAMUKeppra investigators, Prehospital treatment with levetiracetam plus clonazepam or placebo plus clonazepam in status epilepticus (SAMUKeppra): a randomised, double-blind, phase 3 trial","volume":"15","author":"Navarro","year":"2016","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jns.2021.117542_bb0140","doi-asserted-by":"crossref","first-page":"106466","DOI":"10.1016\/j.yebeh.2019.106466","article-title":"Intravenous antiepileptic drugs in adults with benzodiazepine-resistant convulsive status epilepticus: a systematic review and network meta-analysis","volume":"101","author":"Brigo","year":"2019","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.jns.2021.117542_bb0145","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/S0140-6736(20)30611-5","volume":"395","author":"Chamberlain","year":"2020","journal-title":"Lancet."},{"key":"10.1016\/j.jns.2021.117542_bb0150","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.yebeh.2018.07.004","article-title":"Perampanel in the treatment of status epilepticus: a systematic review of the literature","volume":"86","author":"Brigo","year":"2018","journal-title":"Epilepsy Behav."}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X21002367?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X21002367?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T15:58:42Z","timestamp":1758383922000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X21002367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":30,"alternative-id":["S0022510X21002367"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2021.117542","relation":{},"ISSN":["0022-510X"],"issn-type":[{"value":"0022-510X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Status epilepticus: Practice variation and adherence to treatment guideline in a large community hospital","name":"articletitle","label":"Article Title"},{"value":"Journal of the Neurological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jns.2021.117542","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"117542"}}