{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:06:19Z","timestamp":1790795179873,"version":"4.1.0"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100017932","name":"Western University of Health Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017932","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jns-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.jns.2021.117558","type":"journal-article","created":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T03:28:06Z","timestamp":1624591686000},"page":"117558","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"special_numbering":"C","title":["An amyotrophic lateral sclerosis hot spot in the French Alps associated with genotoxic fungi"],"prefix":"10.1016","volume":"427","author":[{"given":"E.","family":"Lagrange","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.P.","family":"Vernoux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Reis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Palmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Camu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.S.","family":"Spencer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jns.2021.117558_bb0005","doi-asserted-by":"crossref","DOI":"10.1038\/s41586-021-03477-4","article-title":"Somatic mutation landscapes at single-molecule resolution","author":"Abascal","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.jns.2021.117558_bb0010","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S0021-9673(01)87720-7","article-title":"Thin-layer spectrofluorometric microanalysis of monomethylhydrazine in Gyromitra esculenta","volume":"287","author":"Andary","year":"1984","journal-title":"J. Chromatogr."},{"key":"10.1016\/j.jns.2021.117558_bb0015","author":"Anon"},{"key":"10.1016\/j.jns.2021.117558_bb0020","author":"Anon"},{"key":"10.1016\/j.jns.2021.117558_bb0025","doi-asserted-by":"crossref","first-page":"12408","DOI":"10.1038\/ncomms12408","article-title":"Projected increase in amyotrophic lateral sclerosis from 2015 to 2040","volume":"7","author":"Arthur","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jns.2021.117558_bb0030","series-title":"Toxicological Profile for Hydrazines. Atlanta, Georgia: Agency for Toxic Substances and Disease Registry","author":"ATSDR","year":"1997"},{"key":"10.1016\/j.jns.2021.117558_bb0035","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.3390\/toxins2122837","article-title":"The cyanobacteria derived toxin beta-N-methylamino-L-alanine and amyotrophic lateral sclerosis","volume":"2","author":"Banack","year":"2010","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.jns.2021.117558_bb0040","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1159\/000443146","article-title":"Environmental risk factors and amyotrophic lateral sclerosis: an umbrella review and critical assessment of current evidence from systematic reviews and meta-analyses of observational studies","volume":"46","author":"Belbasis","year":"2016","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.jns.2021.117558_bb0045","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0304-3835(92)90175-U","article-title":"Methylation of rat and mouse DNA by the mushroom poison gyromitrin and its metabolite monomethylhydrazine","volume":"61","author":"Bergman","year":"1992","journal-title":"Cancer Lett."},{"key":"10.1016\/j.jns.2021.117558_bb0050","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/BF01973825","article-title":"N-Methyl-N-formylhydrazine: a toxic and mutagenic inhibitor of the intestinal diamine oxidase","volume":"14","author":"Biega\u0144ski","year":"1984","journal-title":"Agents Actions"},{"key":"10.1016\/j.jns.2021.117558_bb0055","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1001\/archneur.1982.00510230003001","article-title":"A new hypothesis of the etiology of amyotrophic lateral sclerosis. The DNA hypothesis","volume":"39","author":"Bradley","year":"1982","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.jns.2021.117558_bb0060","doi-asserted-by":"crossref","first-page":"557","DOI":"10.3109\/00498258009033790","article-title":"Indications for nitrosamide formation from the mushroom poison gyromitrin by rat liver microsomes","volume":"10","author":"Braun","year":"1980","journal-title":"Xenobiotica"},{"key":"10.1016\/j.jns.2021.117558_bb0065","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0300-483X(79)80022-0","article-title":"Renal functional response to the mushroom poison gyromitrin","volume":"13","author":"Braun","year":"1979","journal-title":"Toxicology"},{"key":"10.1016\/j.jns.2021.117558_bb0070","series-title":"Rapport d\u2019investigation de suspicions d\u2019agr\u00e9gats de scl\u00e9roses lat\u00e9rales amyotrophiques (SLA) en Savoie et en Is\u00e8re (2013-2015)","author":"Chappert","year":"2017"},{"key":"10.1016\/j.jns.2021.117558_bb0075","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/S1474-4422(17)30401-5","article-title":"Novel genes associated with amyotrophic lateral sclerosis: diagnostic and clinical implications","volume":"17","author":"Chia","year":"2018","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jns.2021.117558_bb0080","first-page":"136","article-title":"The role of vitamin B6 in the toxicity of hydrazines","volume":"166","author":"Cornish","year":"1969","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.jns.2021.117558_bb0085","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1007\/s12640-018-9980-5","article-title":"Fungal neurotoxins and sporadic amyotrophic lateral sclerosis","volume":"35","author":"French","year":"2019","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.jns.2021.117558_bb0090","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0278-6915(91)90062-C","article-title":"Chemical oxidation and metabolism of N-methyl-N-formylhydrazine. Evidence for diazenium and radical intermediates","volume":"29","author":"Gannett","year":"1991","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jns.2021.117558_bb0095","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1016\/0006-2952(93)90451-2","article-title":"Carbon-centered free radical formation during the metabolism of hydrazine derivatives by neutrophils","volume":"45","author":"Gamberine","year":"1993","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jns.2021.117558_bb0100","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1212\/WNL.35.2.193","article-title":"Disappearance of high-incidence amyotrophic lateral sclerosis and parkinsonism-dementia on Guam","volume":"35","author":"Garruto","year":"1985","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2021.117558_bb0105","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1016\/j.scitotenv.2010.01.009","volume":"408","author":"Goodnow","year":"2010","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jns.2021.117558_bb0110","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/bjc.1974.217","article-title":"Morphological and biochemical effects of 1,2-dimethylhydrazine and 1-methylhydrazine in rats and mice","volume":"30","author":"Hawks","year":"1974","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.jns.2021.117558_bb0115","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/bjc.1974.218","article-title":"The alkylation of nucleic acids of rat and mouse in vivo by the carcinogen 1,2-dimethylhydrazine","volume":"3","author":"Hawks","year":"1974","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.jns.2021.117558_bb0120","series-title":"Gyromitra Mushroom Toxicity. StatPearls [Internet]","author":"Horowitz","year":"2020"},{"key":"10.1016\/j.jns.2021.117558_bb0125","author":"INPN"},{"key":"10.1016\/j.jns.2021.117558_bb0130","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0041-0101(03)00238-1","article-title":"Cytotoxic fungi--an overview","volume":"42","author":"Karlson-Stiber","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.jns.2021.117558_bb0135","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0020911","article-title":"The cycad genotoxin MAM modulates brain cellular pathways involved in neurodegenerative disease and cancer in a DNA damage-linked manner","volume":"6","author":"Kisby","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jns.2021.117558_bb0140","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1212\/WNL.42.7.1336","article-title":"Content of the neurotoxins cycasin (methylazoxymethanol beta-D-glucoside) and BMAA (beta-N-methylamino-L-alanine) in cycad flour prepared by Guam Chamorros","volume":"42","author":"Kisby","year":"1992","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2021.117558_bb0145","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/bdrc.21052","article-title":"Animal models of brain maldevelopment induced by cycad plant genotoxins","volume":"99","author":"Kisby","year":"2013","journal-title":"Birth Defects Res. C Embryo Today."},{"key":"10.1016\/j.jns.2021.117558_bb0150","series-title":"Abstract: RISE-2017, Council d\u2019Europe, December, Strasbourg, France","article-title":"High-incidence cluster of ALS in the French Alps: common environment and multiple exposures","author":"Lagrange","year":"2017"},{"issue":"Suppl. S1","key":"10.1016\/j.jns.2021.117558_bb0155","first-page":"180","article-title":"The cyanotoxin BMAA and increased incidence in ALS clusters: a public health concern in France","volume":"19","author":"Lagrange","year":"2018","journal-title":"Amyotroph. Lateral Scler. Frontotemporal Degener"},{"key":"10.1016\/j.jns.2021.117558_bb0160","doi-asserted-by":"crossref","first-page":"482","DOI":"10.3390\/toxins12080482","article-title":"Warning on false or true morels and button mushrooms with potential toxicity linked to hydrazinic toxins: an update","volume":"12","author":"Lagrange","year":"2020","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.jns.2021.117558_bb0165","doi-asserted-by":"crossref","first-page":"116589","DOI":"10.1016\/j.jns.2019.116589","article-title":"Plasma from some patients with Amyotrophic Lateral Sclerosis exhibits elevated formaldehyde levels","volume":"409","author":"Lee","year":"2020","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.jns.2021.117558_bb0175","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1021\/ac60343a046","article-title":"Chemical studies on tobacco smoke. Quantitative analysis of hydrazine in tobacco and cigarette smoke","volume":"46","author":"Liu","year":"1974","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jns.2021.117558_bb0180","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1097\/WCO.0000000000000730","article-title":"Epidemiology of amyotrophic lateral sclerosis: an update of recent literature","volume":"32","author":"Longinetti","year":"2019","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.jns.2021.117558_bb0185","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1159\/000493386","article-title":"Amyotrophic lateral sclerosis descriptive epidemiology: the origin of geographic difference","volume":"52","author":"Logroscino","year":"2019","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.jns.2021.117558_bb0190","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1034\/j.1600-0404.2001.00361.x","article-title":"Mortality from amyotrophic lateral sclerosis in Finland, 1986-1995","volume":"104","author":"Maasilta","year":"2001","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.jns.2021.117558_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2020.12.025","article-title":"p53 is a central regulator driving neurodegeneration caused by C9orf72 poly(PR)","author":"Maor-Nof","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.jns.2021.117558_bb0200","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/j.1600-0404.1994.tb02698.x","article-title":"Rising mortality from motor neurone disease in Sweden 1961-1990: the relative role of increased population life expectancy and environmental factors","volume":"90","author":"Neilson","year":"1994","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.jns.2021.117558_bb0205","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1007\/BF00900964","article-title":"Rising amyotrophic lateral sclerosis mortality in France 1968-1990: increased life expectancy and inter-disease competition as an explanation","volume":"241","author":"Neilson","year":"1994","journal-title":"J. Neurol."},{"key":"10.1016\/j.jns.2021.117558_bb0210","series-title":"Fascinated by Fungi. First Nature","author":"O\u2019Reilly","year":"2011"},{"key":"10.1016\/j.jns.2021.117558_bb0215","series-title":"Neuropathology of Dementing Disorders","first-page":"268","article-title":"Amyotrophic lateral sclerosis-parkinsonism-dementia of Guam","author":"Perl","year":"1998"},{"key":"10.1016\/j.jns.2021.117558_bb0220","doi-asserted-by":"crossref","DOI":"10.1007\/s12640-020-00320-y","article-title":"Formaldehyde and brain disorders: a meta-analysis and bioinformatics approach","author":"Rana","year":"2021","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.jns.2021.117558_bb0225","author":"Richermoz"},{"key":"10.1016\/j.jns.2021.117558_bb0230","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1136\/jnnp.61.2.131","article-title":"Neuroepidemiology of amyotrophic lateral sclerosis: clues to aetiology and pathogenesis","volume":"61","author":"Rom\u00e1n","year":"1996","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.jns.2021.117558_bb0235","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1093\/aje\/kwg090","article-title":"Spatial clustering of amyotrophic lateral sclerosis in Finland at place of birth and place of death","volume":"157","author":"Sabel","year":"2003","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.jns.2021.117558_bb0240","doi-asserted-by":"crossref","first-page":"365","DOI":"10.3109\/15563651003698034","article-title":"Can morels (Morchella sp.) induce a toxic neurological syndrome?","volume":"48","author":"Saviuc","year":"2010","journal-title":"Clin. Toxicol. (Phila)"},{"key":"10.1016\/j.jns.2021.117558_bb0245","first-page":"103","article-title":"Formaldehyde determination in tobacco smoke--studies under experimental and actual conditions","volume":"189","author":"Schaller","year":"1989","journal-title":"Zentralbl. Hyg. Umweltmed."},{"key":"10.1016\/j.jns.2021.117558_bb0250","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1007\/s10654-017-0249-8","article-title":"Occupational formaldehyde and amyotrophic lateral sclerosis","volume":"32","author":"Seals","year":"2017","journal-title":"Eur. J. Epidemiol."},{"key":"10.1016\/j.jns.2021.117558_bb0255","first-page":"3693","article-title":"Oxidation of methylhydrazines to mutagenic methylating derivatives and inducers of the adaptive response of Escherichia coli to alkylation damage","volume":"52","author":"Sedgwick","year":"1992","journal-title":"Cancer Res."},{"key":"10.1016\/j.jns.2021.117558_bb0260","author":"SEELAPLAGNE"},{"key":"10.1016\/j.jns.2021.117558_bb0265","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1212\/WNL.55.9.1262","article-title":"Increasing mortality from amyotrophic lateral sclerosis in Norway?","volume":"55","author":"Seljeseth","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2021.117558_bb0270","series-title":"Rapport d\u2019investigation de suspicions d\u2019agr\u00e9gats de Scl\u00e9roses Lat\u00e9rales Amyotrophiques (SLA) en Savoie et en Is\u00e8re (2013-2015)","author":"SPF","year":"2017"},{"key":"10.1016\/j.jns.2021.117558_bb0275","first-page":"11","article-title":"Lead and arsenic in Morchella esculenta fruitbodies collected in lead arsenate contaminated apple orchards in the northeastern United States: a preliminary study","volume":"3","author":"Shavit","year":"2010","journal-title":"Fungi"},{"key":"10.1016\/j.jns.2021.117558_bb0280","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jns.2018.05.017","article-title":"Formaldehyde, DNA damage, ALS and related neurodegenerative diseases","volume":"391","author":"Spencer","year":"2018","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.jns.2021.117558_bb0285","doi-asserted-by":"crossref","first-page":"754","DOI":"10.3389\/fneur.2019.00754","article-title":"Hypothesis: etiologic and molecular mechanistic leads for sporadic neurodegenerative diseases based on experience with western Pacific ALS\/PDC","volume":"10","author":"Spencer","year":"2019","journal-title":"Front. Neurol."},{"key":"10.1016\/j.jns.2021.117558_bb0290","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.neurol.2019.04.007","article-title":"ALS and environment: clues from spatial clustering?","volume":"175","author":"Spencer","year":"2019","journal-title":"Rev. Neurol."},{"key":"10.1016\/j.jns.2021.117558_bb0295","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.neuro.2016.03.017","article-title":"Seeking environmental causes of neurodegenerative disease and envisioning primary prevention","volume":"56","author":"Spencer","year":"2016","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.jns.2021.117558_bb0300","doi-asserted-by":"crossref","first-page":"117185","DOI":"10.1016\/j.jns.2020.117185","article-title":"Western Pacific ALS-PDC: evidence implicating cycad genotoxins","volume":"419","author":"Spencer","year":"2020","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.jns.2021.117558_bb0305","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0232-1513(88)80060-4","article-title":"The question of carcinogenic effects of hydrazine","volume":"33","author":"Steinhoff","year":"1988","journal-title":"Exp. Pathol."},{"key":"10.1016\/j.jns.2021.117558_bb0310","doi-asserted-by":"crossref","first-page":"3476","DOI":"10.3390\/w12123476","article-title":"Determining the relevant scale to analyze the quality of regional groundwater resources while combining groundwater bodies, physicochemical and biological databases in southeastern France","volume":"12","author":"Tiouiouine","year":"2020","journal-title":"Water"},{"key":"10.1016\/j.jns.2021.117558_bb0315","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1080\/15287397909529744","article-title":"Hepatocarcinogenesis by hydrazine mycotoxins of edible mushrooms","volume":"5","author":"Toth","year":"1979","journal-title":"J. Toxicol. Environ. Health"},{"key":"10.1016\/j.jns.2021.117558_bb0325","first-page":"392","article-title":"Comparison of the content of toxic principle in the false morels - Gyromitra gigas, Gyromitra fastigiata and Gyromitra esculenta [botanical identification]","volume":"4","author":"Viernstein","year":"1982","journal-title":"Nutrition"},{"key":"10.1016\/j.jns.2021.117558_bb0330","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1136\/jnnp-2017-317724","article-title":"Euro-MOTOR consortium multicentre, cross-cultural, population-based, case-control study of physical activity as risk factor for amyotrophic lateral sclerosis","volume":"89","author":"Visser","year":"2018","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.jns.2021.117558_bb0335","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1038\/s41467-020-15912-7","article-title":"Mutational signatures are jointly shaped by DNA damage and repair","volume":"11","author":"Volkova","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jns.2021.117558_bb0340","doi-asserted-by":"crossref","first-page":"171","DOI":"10.4103\/2152-7806.169561","article-title":"A comprehensive review of amyotrophic lateral sclerosis","volume":"6","author":"Zarei","year":"2015","journal-title":"Surg. Neurol. Int."},{"key":"10.1016\/j.jns.2021.117558_bb0345","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1600-0404.1996.tb00039.x","article-title":"Motor neuron disease on Guam: geographic and familial occurrence, 1956\u201385","volume":"94","author":"Zhang","year":"1996","journal-title":"Acta Neurol. Scand."}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X21002525?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X21002525?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T15:59:09Z","timestamp":1758383949000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X21002525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":67,"alternative-id":["S0022510X21002525"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2021.117558","relation":{},"ISSN":["0022-510X"],"issn-type":[{"value":"0022-510X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An amyotrophic lateral sclerosis hot spot in the French Alps associated with genotoxic fungi","name":"articletitle","label":"Article Title"},{"value":"Journal of the Neurological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jns.2021.117558","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"117558"}}