{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:38:01Z","timestamp":1791959881758,"version":"4.3.4"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jns-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.jns.2021.117565","type":"journal-article","created":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T10:48:38Z","timestamp":1625309318000},"page":"117565","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Increased telomere length in patients with frontotemporal dementia syndrome"],"prefix":"10.1016","volume":"428","author":[{"given":"Eun-Joo","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong-Ho","family":"Koh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jungsoon","family":"Ha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duk L.","family":"Na","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Won","family":"Seo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee-Jin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Won","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Hong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jee Hoon","family":"Roh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay C.","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Jin","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na-Yeon","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jee H.","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Won","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee-Jin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kee Hyung","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Hye","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SangYun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Ho","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byeong C.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Eun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyuk Sung","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Hee","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong-Hwa","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jns.2021.117565_bb0005","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.3233\/JAD-171087","article-title":"Progress and challenges in frontotemporal dementia research: a 20-year review","volume":"62","author":"Hodges","year":"2018","journal-title":"J. Alzheimers Dis."},{"issue":"10004","key":"10.1016\/j.jns.2021.117565_bb0010","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1016\/S0140-6736(15)00461-4","article-title":"Frontotemporal dementia","volume":"386","author":"Bang","year":"2015","journal-title":"Lancet."},{"issue":"18","key":"10.1016\/j.jns.2021.117565_bb0015","doi-asserted-by":"crossref","first-page":"6622","DOI":"10.1073\/pnas.85.18.6622","article-title":"A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes","volume":"85","author":"Moyzis","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.jns.2021.117565_bb0020","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.biochi.2007.07.008","article-title":"Protection against chromosome degradation at the telomeres","volume":"90","author":"Grandin","year":"2008","journal-title":"Biochimie."},{"issue":"6","key":"10.1016\/j.jns.2021.117565_bb0025","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1111\/j.1468-1331.2011.03655.x","article-title":"Telomere length shortening in patients with dementia with Lewy bodies","volume":"19","author":"Kume","year":"2012","journal-title":"Eur. J. Neurol."},{"issue":"1","key":"10.1016\/j.jns.2021.117565_bb0030","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s12017-012-8207-9","article-title":"Telomere shortening and Alzheimer\u2019s disease","volume":"15","author":"Cai","year":"2013","journal-title":"NeuroMolecular Med."},{"issue":"2","key":"10.1016\/j.jns.2021.117565_bb0035","doi-asserted-by":"crossref","first-page":"e92","DOI":"10.1176\/appi.neuropsych.13100240","article-title":"Reduced telomere length in neurodegenerative disorders may suggest shared biology","volume":"27","author":"Kota","year":"2015","journal-title":"J. Neuropsychiatr. Clin. Neurosci."},{"issue":"5","key":"10.1016\/j.jns.2021.117565_bb0040","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.tins.2014.02.010","article-title":"Telomere shortening in neurological disorders: an abundance of unanswered questions","volume":"37","author":"Eitan","year":"2014","journal-title":"Trends Neurosci."},{"issue":"5","key":"10.1016\/j.jns.2021.117565_bb0045","doi-asserted-by":"crossref","first-page":"4407","DOI":"10.18632\/aging.102893","article-title":"Telomere shortening reflecting physical aging is associated with cognitive decline and dementia conversion in mild cognitive impairment due to Alzheimer\u2019s disease","volume":"12","author":"Koh","year":"2020","journal-title":"Aging (Albany NY)"},{"issue":"1","key":"10.1016\/j.jns.2021.117565_bb0050","doi-asserted-by":"crossref","first-page":"3640","DOI":"10.1038\/s41598-020-60457-w","article-title":"Uncovering pathophysiological changes in frontotemporal dementia using serum lipids","volume":"10","author":"Phan","year":"2020","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.jns.2021.117565_bb0055","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/s41582-019-0231-z","article-title":"Neuroinflammation in frontotemporal dementia","volume":"15","author":"Bright","year":"2019","journal-title":"Nat. Rev. Neurol."},{"issue":"2","key":"10.1016\/j.jns.2021.117565_bb0060","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1097\/WCO.0000000000000665","article-title":"Immunological signatures in frontotemporal lobar degeneration","volume":"32","author":"Sirkis","year":"2019","journal-title":"Curr. Opin. Neurol."},{"issue":"Pt 11","key":"10.1016\/j.jns.2021.117565_bb0065","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1093\/brain\/awn234","article-title":"Development of methodology for conducting clinical trials in frontotemporal lobar degeneration","volume":"131","author":"Knopman","year":"2008","journal-title":"Brain."},{"issue":"Pt 9","key":"10.1016\/j.jns.2021.117565_bb0070","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1093\/brain\/awr179","article-title":"Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia","volume":"134","author":"Rascovsky","year":"2011","journal-title":"Brain."},{"issue":"11","key":"10.1016\/j.jns.2021.117565_bb0075","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1212\/WNL.0b013e31821103e6","article-title":"Classification of primary progressive aphasia and its variants","volume":"76","author":"Gorno-Tempini","year":"2011","journal-title":"Neurology."},{"issue":"2","key":"10.1016\/j.jns.2021.117565_bb0080","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1159\/000360278","article-title":"Clinical and neuropsychological characteristics of a Nationwide Hospital-based registry of Frontotemporal dementia patients in Korea: a CREDOS-FTD study","volume":"4","author":"Kim","year":"2014","journal-title":"Dement Geriatr. Cogn. Dis. Extra."},{"issue":"6274","key":"10.1016\/j.jns.2021.117565_bb0085","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/345458a0","article-title":"Telomeres shorten during ageing of human fibroblasts","volume":"345","author":"Harley","year":"1990","journal-title":"Nature."},{"issue":"4","key":"10.1016\/j.jns.2021.117565_bb0090","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/ng.2528","article-title":"Identification of seven loci affecting mean telomere length and their association with disease","volume":"45","author":"Codd","year":"2013","journal-title":"Nat. Genet."},{"issue":"24","key":"10.1016\/j.jns.2021.117565_bb0095","doi-asserted-by":"crossref","first-page":"5385","DOI":"10.1093\/hmg\/dds382","article-title":"Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans","volume":"21","author":"Mangino","year":"2012","journal-title":"Hum. Mol. Genet."},{"issue":"3\u20134","key":"10.1016\/j.jns.2021.117565_bb0100","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1080\/21678421.2019.1586951","article-title":"Telomere length is greater in ALS than in controls: a whole genome sequencing study","volume":"20","author":"Al Khleifat","year":"2019","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener."},{"key":"10.1016\/j.jns.2021.117565_bb0105","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.neurobiolaging.2018.06.031","article-title":"Analysis of frontotemporal dementia, amyotrophic lateral sclerosis, and other dementia-related genes in 107 Korean patients with frontotemporal dementia","volume":"72","author":"Kim","year":"2018","journal-title":"Neurobiol. Aging"},{"issue":"1\u20132","key":"10.1016\/j.jns.2021.117565_bb0110","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.mrfmmm.2011.08.011","article-title":"Maintaining the end: roles of telomere proteins in end-protection, telomere replication and length regulation","volume":"730","author":"Stewart","year":"2012","journal-title":"Mutat. Res."},{"issue":"8","key":"10.1016\/j.jns.2021.117565_bb0115","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1093\/gerona\/glw053","article-title":"Meta-analysis of telomere length in Alzheimer\u2019s disease","volume":"71","author":"Forero","year":"2016","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.jns.2021.117565_bb0120","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.exger.2016.01.002","article-title":"Telomere length in Parkinson\u2019s disease: a meta-analysis","volume":"75","author":"Forero","year":"2016","journal-title":"Exp. Gerontol."},{"issue":"2","key":"10.1016\/j.jns.2021.117565_bb0125","doi-asserted-by":"crossref","first-page":"382","DOI":"10.18632\/aging.100904","article-title":"Telomere shortening leads to earlier age of onset in ALS mice","volume":"8","author":"Linkus","year":"2016","journal-title":"Aging (Albany NY)"},{"issue":"10","key":"10.1016\/j.jns.2021.117565_bb0130","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/jhg.2014.72","article-title":"Telomerase expression in amyotrophic lateral sclerosis (ALS) patients","volume":"59","author":"De Felice","year":"2014","journal-title":"J. Hum. Genet."},{"key":"10.1016\/j.jns.2021.117565_bb0135","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/nyas.12638","article-title":"Frontotemporal dementia: a bridge between dementia and neuromuscular disease","volume":"1338","author":"Ng","year":"2015","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"5","key":"10.1016\/j.jns.2021.117565_bb0140","first-page":"2615","article-title":"Alternative lengthening of telomeres can be maintained by preferential elongation of lagging strands","volume":"45","author":"Min","year":"2017","journal-title":"Nucleic Acids Res."},{"issue":"5","key":"10.1016\/j.jns.2021.117565_bb0145","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/nrg2763","article-title":"Alternative lengthening of telomeres: models, mechanisms and implications","volume":"11","author":"Cesare","year":"2010","journal-title":"Nat. Rev. Genet."},{"issue":"5193","key":"10.1016\/j.jns.2021.117565_bb0150","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1126\/science.7605428","article-title":"Specific association of human telomerase activity with immortal cells and cancer","volume":"266","author":"Kim","year":"1994","journal-title":"Science."}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X21002598?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X21002598?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T15:55:49Z","timestamp":1758383749000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X21002598"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":30,"alternative-id":["S0022510X21002598"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2021.117565","relation":{},"ISSN":["0022-510X"],"issn-type":[{"value":"0022-510X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increased telomere length in patients with frontotemporal dementia syndrome","name":"articletitle","label":"Article Title"},{"value":"Journal of the Neurological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jns.2021.117565","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"117565"}}