{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T03:49:07Z","timestamp":1788320947700,"version":"build-2803163510"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jns-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.jns.2021.120023","type":"journal-article","created":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T19:52:21Z","timestamp":1633377141000},"page":"120023","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Intrathecal inflammatory responses in the absence of SARS-CoV-2 nucleic acid in the CSF of COVID-19 hospitalized patients"],"prefix":"10.1016","volume":"430","author":[{"given":"Erica","family":"Normandin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn B.","family":"Holroyd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah I.","family":"Collens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bennett M.","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine J.","family":"Siddle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon","family":"Adams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Rudy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac H.","family":"Solomon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melis N.","family":"Anahtar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob E.","family":"Lemieux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca A.","family":"Trombetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"Kivisakk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven E.","family":"Arnold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otto","family":"Rapalino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne L.","family":"Piantadosi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pritha","family":"Sen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric S.","family":"Rosenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Branda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pardis C.","family":"Sabeti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shibani S.","family":"Mukerji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jns.2021.120023_bb0005","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1001\/jamaneurol.2020.1127","article-title":"Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China","volume":"77","author":"Mao","year":"2020","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.jns.2021.120023_bb0010","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1056\/NEJMc2008597","article-title":"Neurologic features in severe SARS-CoV-2 infection","volume":"382","author":"Helms","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jns.2021.120023_bb0015","doi-asserted-by":"crossref","first-page":"116884","DOI":"10.1016\/j.jns.2020.116884","article-title":"The neurology of COVID-19 revisited: a proposal from the environmental neurology specialty Group of the World Federation of Neurology to implement international neurological registries [online]","author":"Rom\u00e1n","year":"2020","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.jns.2021.120023_bb0020","doi-asserted-by":"crossref","first-page":"e1060","DOI":"10.1212\/WNL.0000000000009937","article-title":"Neurologic manifestations in hospitalized patients with COVID-19: the ALBACOVID registry","volume":"95","author":"Romero-S\u00e1nchez","year":"2020","journal-title":"Neurology."},{"key":"10.1016\/j.jns.2021.120023_bb0025","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1056\/NEJMc1509458","article-title":"Human coronavirus OC43 associated with fatal encephalitis","volume":"375","author":"Morfopoulou","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jns.2021.120023_bb0030","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1086\/444461","article-title":"Detection of severe acute respiratory syndrome coronavirus in the brain: potential role of the chemokine mig in pathogenesis","volume":"41","author":"Xu","year":"2005","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.jns.2021.120023_bb0035","doi-asserted-by":"crossref","first-page":"8913","DOI":"10.1128\/JVI.74.19.8913-8921.2000","article-title":"Neuroinvasion by human respiratory coronaviruses","volume":"74","author":"Arbour","year":"2000","journal-title":"J. Virol."},{"key":"10.1016\/j.jns.2021.120023_bb0040","doi-asserted-by":"crossref","first-page":"135528","DOI":"10.1016\/j.neulet.2020.135528","article-title":"What can we learn from brain autopsies in COVID-19?","volume":"742","author":"Mukerji","year":"2021","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.jns.2021.120023_bb0045","first-page":"421","article-title":"Cerebrospinal fluid in COVID-19: a systematic review of the literature","author":"Lewis","year":"2021","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.jns.2021.120023_bb0050","doi-asserted-by":"crossref","unstructured":"Bernard-Valnet R, Pizzarotti B, Anichini A, et al. Two patients with acute meningo-encephalitis concomitant to SARS-CoV-2 infection [online]. Accessed at: https:\/\/doi.org\/10.1101\/2020.04.17.20060251.","DOI":"10.1101\/2020.04.17.20060251"},{"key":"10.1016\/j.jns.2021.120023_bb0055","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.3201\/eid2609.202122","article-title":"Encephalopathy and encephalitis associated with cerebrospinal fluid cytokine alterations and coronavirus disease, Atlanta, Georgia, USA, 2020","volume":"26","author":"Benameur","year":"2020","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.jns.2021.120023_bb0060","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.bbi.2020.07.007","article-title":"Creutzfeldt-Jakob disease in a man with COVID-19: SARS-CoV-2-accelerated neurodegeneration?","volume":"89","author":"Young","year":"2020","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jns.2021.120023_bb0065","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.bbi.2020.05.022","article-title":"Plasmapheresis treatment in COVID-19-related autoimmune meningoencephalitis: case series","volume":"87","author":"Dogan","year":"2020","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jns.2021.120023_bb0070","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1002\/jmv.25888","article-title":"Concomitant neurological symptoms observed in a patient diagnosed with coronavirus disease 2019","volume":"92","author":"Yin","year":"2020","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.jns.2021.120023_bb0075","doi-asserted-by":"crossref","first-page":"e43","DOI":"10.1111\/ene.14298","article-title":"Two patients with acute meningoencephalitis concomitant with SARS-CoV-2 infection","volume":"27","author":"Bernard-Valnet","year":"2020","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.jns.2021.120023_bb0080","author":"Blueprint"},{"key":"10.1016\/j.jns.2021.120023_bb0085","author":"CDC"},{"key":"10.1016\/j.jns.2021.120023_bb0090","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1186\/s13059-014-0519-7","article-title":"Enhanced methods for unbiased deep sequencing of Lassa and Ebola RNA viruses from clinical and biological samples","volume":"15","author":"Matranga","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.jns.2021.120023_bb0095","doi-asserted-by":"crossref","first-page":"238","DOI":"10.3201\/eid2701.203448","article-title":"Fatal case of chronic Jamestown canyon virus encephalitis diagnosed by metagenomic sequencing in patient receiving rituximab [online]","author":"Solomon","year":"2021","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.jns.2021.120023_bb0100","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1093\/cid\/cix792","article-title":"Rapid detection of Powassan virus in a patient with encephalitis by metagenomic sequencing","volume":"66","author":"Piantadosi","year":"2018","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.jns.2021.120023_bb0105","doi-asserted-by":"crossref","first-page":"R46","DOI":"10.1186\/gb-2014-15-3-r46","article-title":"Kraken: ultrafast metagenomic sequence classification using exact alignments","volume":"15","author":"Wood","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.jns.2021.120023_bb0110","first-page":"371","article-title":"Phylogenetic analysis of SARS-CoV-2 in Boston highlights the impact of superspreading events","author":"Lemieux","year":"2021","journal-title":"Science [online serial]"},{"key":"10.1016\/j.jns.2021.120023_bb0115","doi-asserted-by":"crossref","first-page":"4121","DOI":"10.1093\/bioinformatics\/bty407","article-title":"Nextstrain: real-time tracking of pathogen evolution","volume":"34","author":"Hadfield","year":"2018","journal-title":"Bioinformatics."},{"key":"10.1016\/j.jns.2021.120023_bb0120","doi-asserted-by":"crossref","DOI":"10.1093\/ve\/vex042","article-title":"TreeTime: maximum-likelihood phylodynamic analysis","author":"Sagulenko","year":"2018","journal-title":"Virus Evol."},{"key":"10.1016\/j.jns.2021.120023_bb0125","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1093\/bioinformatics\/btw313","article-title":"Complex heatmaps reveal patterns and correlations in multidimensional genomic data","volume":"32","author":"Gu","year":"2016","journal-title":"Bioinformatics."},{"key":"10.1016\/j.jns.2021.120023_bb0130","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1101\/gr.238170.118","article-title":"Laboratory validation of a clinical metagenomic sequencing assay for pathogen detection in cerebrospinal fluid","volume":"29","author":"Miller","year":"2019","journal-title":"Genome Res."},{"key":"10.1016\/j.jns.2021.120023_bb0135","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/S1473-3099(18)30245-7","article-title":"Incidence, aetiology, and sequelae of viral meningitis in UK adults: a multicentre prospective observational cohort study","author":"McGill","year":"2018","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.jns.2021.120023_bb0140","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.cell.2020.09.032","article-title":"Structural and functional analysis of the D614G SARS-CoV-2 spike protein variant","volume":"183","author":"Yurkovetskiy","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.jns.2021.120023_bb0145","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1093\/infdis\/jiaa363","article-title":"Serum cytokine and chemokine profile in relation to the severity of coronavirus disease 2019 in China","volume":"222","author":"Chi","year":"2020","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jns.2021.120023_bb0150","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1080\/22221751.2020.1770129","article-title":"Profiling serum cytokines in COVID-19 patients reveals IL-6 and IL-10 are disease severity predictors","author":"Han","year":"2020","journal-title":"Emerg. Microb. Infect."},{"key":"10.1016\/j.jns.2021.120023_bb0155","series-title":"Neurology-Neuroimmunology Neuroinflammation [online serial]","first-page":"7","article-title":"Anti--SARS-CoV-2 antibodies in the CSF, blood-brain barrier dysfunction, and neurological outcome: studies in 8 stuporous and comatose patients","author":"Alexopoulos","year":"2020"},{"key":"10.1016\/j.jns.2021.120023_bb0160","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/S1474-4422(20)30221-0","article-title":"Neurological associations of COVID-19","volume":"19","author":"Ellul","year":"2020","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jns.2021.120023_bb0165","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1136\/jnnp.57.8.897","article-title":"Cerebrospinal fluid in the diagnosis of multiple sclerosis: a consensus report","volume":"57","author":"Andersson","year":"1994","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.jns.2021.120023_bb0170","doi-asserted-by":"crossref","first-page":"e294","DOI":"10.1212\/WNL.0000000000010977","article-title":"CSF biomarkers in patients with COVID-19 and neurologic symptoms: a case series","volume":"96","author":"Ed\u00e9n","year":"2021","journal-title":"Neurology."},{"key":"10.1016\/j.jns.2021.120023_bb0175","doi-asserted-by":"crossref","first-page":"E242","DOI":"10.1148\/radiol.2020202222","article-title":"Brain MRI findings in severe COVID-19: a retrospective observational study","volume":"297","author":"Kremer","year":"2020","journal-title":"Radiology."},{"key":"10.1016\/j.jns.2021.120023_bb0180","series-title":"Neurology - Neuroimmunology Neuroinflammation","first-page":"e821","article-title":"Increased CSF levels of IL-1\u03b2, IL-6, and ACE in SARS-CoV-2\u2013associated encephalitis [online]","author":"Bodro","year":"2020"},{"key":"10.1016\/j.jns.2021.120023_bb0185","doi-asserted-by":"crossref","first-page":"104438","DOI":"10.1016\/j.jcv.2020.104438","article-title":"Validation of SARS-CoV-2 detection across multiple specimen types","volume":"128","author":"Perchetti","year":"2020","journal-title":"J. Clin. Virol."},{"key":"10.1016\/j.jns.2021.120023_bb0190","series-title":"Brain, Behavior, and Immunity","first-page":"149","article-title":"SARS-CoV-2 detected in cerebrospinal fluid by PCR in a case of COVID-19 encephalitis [online]","author":"Huang","year":"2020"},{"key":"10.1016\/j.jns.2021.120023_bb0195","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ijid.2020.03.062","article-title":"A first case of meningitis\/encephalitis associated with SARS-Coronavirus-2","volume":"94","author":"Moriguchi","year":"2020","journal-title":"Int. J. Infect. Dis."},{"key":"10.1016\/j.jns.2021.120023_bb0200","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1212\/WNL.0000000000010250","article-title":"Acute necrotizing encephalopathy with SARS-CoV-2 RNA confirmed in cerebrospinal fluid","volume":"95","author":"Virhammar","year":"2020","journal-title":"Neurology."},{"key":"10.1016\/j.jns.2021.120023_bb0205","doi-asserted-by":"crossref","first-page":"3154","DOI":"10.1007\/s00415-020-09996-w","article-title":"First case of SARS-COV-2 sequencing in cerebrospinal fluid of a patient with suspected demyelinating disease","volume":"267","author":"Domingues","year":"2020","journal-title":"J. Neurol."},{"key":"10.1016\/j.jns.2021.120023_bb0210","doi-asserted-by":"crossref","first-page":"101642","DOI":"10.1016\/j.tmaid.2020.101642","article-title":"Sars-Cov-2: underestimated damage to nervous system","volume":"36","author":"Zhou","year":"2020","journal-title":"Travel Med. Infect. Dis."},{"key":"10.1016\/j.jns.2021.120023_bb0215","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1002\/ana.20959","article-title":"West Nile virus neuroinvasive disease","volume":"60","author":"Davis","year":"2006","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.jns.2021.120023_bb0220","doi-asserted-by":"crossref","first-page":"100288","DOI":"10.1016\/j.xcrm.2021.100288","article-title":"Divergent and self-reactive immune responses in the CNS of COVID-19 patients with neurological symptoms","volume":"2","author":"Song","year":"2021","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.jns.2021.120023_bb0225","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.bbi.2020.12.022","article-title":"High frequency of cerebrospinal fluid autoantibodies in COVID-19 patients with neurological symptoms","volume":"93","author":"Franke","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jns.2021.120023_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopsych.2021.03.033","article-title":"Remission of subacute psychosis in a COVID-19 patient with an antineuronal autoantibody after treatment with intravenous immunoglobulin","author":"McAlpine","year":"2021","journal-title":"Biol. Psychiatry [online serial]"},{"key":"10.1016\/j.jns.2021.120023_bb0235","doi-asserted-by":"crossref","DOI":"10.1007\/s00415-021-10542-5","article-title":"Palilalia as a prominent feature of anti-NMDA receptor encephalitis in a woman with COVID-19","author":"McHattie","year":"2021","journal-title":"J. Neurol. [online serial]"},{"key":"10.1016\/j.jns.2021.120023_bb0240","doi-asserted-by":"crossref","DOI":"10.1007\/s00381-021-05155-2","article-title":"Pediatric anti-NMDA receptor encephalitis associated with COVID-19","author":"Sarigecili","year":"2021","journal-title":"Childs Nerv. Syst. [online serial]"},{"key":"10.1016\/j.jns.2021.120023_bb0245","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.seizure.2020.07.006","article-title":"Anti-NMDA receptor encephalitis presenting as new onset refractory status epilepticus in COVID-19","volume":"81","author":"Monti","year":"2020","journal-title":"Seizure."},{"key":"10.1016\/j.jns.2021.120023_bb0250","first-page":"7","article-title":"Increased CSF levels of IL-1\u03b2, IL-6, and ACE in SARS-CoV-2-associated encephalitis","author":"Bodro","year":"2020","journal-title":"Neurol. Neuroimmunol. Neuroinflamm. [online serial]"},{"key":"10.1016\/j.jns.2021.120023_bb0255","article-title":"Cerebrospinal fluid in COVID-19 neurological complications: no cytokine storm or neuroinflammation","author":"Garcia","year":"2021","journal-title":"medRxiv [online serial]"},{"key":"10.1016\/j.jns.2021.120023_bb0260","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.ccell.2021.01.007","article-title":"Inflammatory leptomeningeal cytokines mediate COVID-19 neurologic symptoms in cancer patients","volume":"39","author":"Remsik","year":"2021","journal-title":"Cancer Cell"},{"issue":"6","key":"10.1016\/j.jns.2021.120023_bb0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2020.102537","article-title":"The role of cytokines including interleukin-6 in COVID-19 induced pneumonia and macrophage activation syndrome-like disease","volume":"19","author":"McGonagle","year":"2020","journal-title":"Autoimmun. Rev."},{"issue":"5","key":"10.1016\/j.jns.2021.120023_bb0270","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1093\/infdis\/jiaa753","article-title":"Severe acute respiratory syndrome coronavirus 2\u2013induced immune activation and death of monocyte-derived human macrophages and dendritic cells","volume":"223","author":"Zheng","year":"2021","journal-title":"The Journal of infectious diseases"},{"key":"10.1016\/j.jns.2021.120023_bb0275","doi-asserted-by":"crossref","first-page":"752","DOI":"10.3389\/fphys.2020.00752","article-title":"The potential beneficial effect of EPA and DHA supplementation managing cytokine storm in coronavirus disease","volume":"11","author":"Szab\u00f3","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.jns.2021.120023_bb0280","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1128\/CMR.17.4.942-964.2004","article-title":"Role of microglia in central nervous system infections","volume":"17","author":"Rock","year":"2004","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.jns.2021.120023_bb0285","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci6010006","article-title":"The effects of hypoxia and inflammation on synaptic signaling in the CNS","volume":"6","author":"Mukandala","year":"2016","journal-title":"Brain Sci."},{"key":"10.1016\/j.jns.2021.120023_bb0290","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.bbi.2017.04.013","article-title":"Hypoxia augments LPS-induced inflammation and triggers high altitude cerebral edema in mice","volume":"64","author":"Zhou","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jns.2021.120023_bb0295","doi-asserted-by":"crossref","DOI":"10.3174\/ajnr.A6966","article-title":"Clinical, imaging, and lab correlates of severe COVID-19 leukoencephalopathy","author":"Rapalino","year":"2021","journal-title":"AJNR Am. J. Neuroradiol."}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X21027258?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X21027258?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T15:57:04Z","timestamp":1758383824000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X21027258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":59,"alternative-id":["S0022510X21027258"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2021.120023","relation":{},"ISSN":["0022-510X"],"issn-type":[{"value":"0022-510X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intrathecal inflammatory responses in the absence of SARS-CoV-2 nucleic acid in the CSF of COVID-19 hospitalized patients","name":"articletitle","label":"Article Title"},{"value":"Journal of the Neurological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jns.2021.120023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"120023"}}