{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T15:03:15Z","timestamp":1789570995244,"version":"build-2803163510"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T00:00:00Z","timestamp":1658966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jns-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.jns.2022.120359","type":"journal-article","created":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T11:17:07Z","timestamp":1659007027000},"page":"120359","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Retinal microvascular function is associated with the cerebral microcirculation as determined by intravoxel incoherent motion MRI"],"prefix":"10.1016","volume":"440","author":[{"given":"Maud","family":"van Dinther","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulien H.M.","family":"Voorter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda T.","family":"Schram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tos T.J.M.","family":"Berendschot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfons J.H.M.","family":"Houben","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carroll A.B.","family":"Webers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"van Oostenbrugge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter H.","family":"Backes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Staals","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacobus F.A.","family":"Jansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.jns.2022.120359_bb0005","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S1474-4422(13)70060-7","article-title":"Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging","volume":"12","author":"Wardlaw","year":"2013","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jns.2022.120359_bb0010","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.nicl.2018.08.030","article-title":"Intravoxel incoherent motion MRI in neurological and cerebrovascular diseases","volume":"20","author":"Paschoal","year":"2018","journal-title":"Neuroimage Clin."},{"issue":"1","key":"10.1016\/j.jns.2022.120359_bb0015","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/mrm.1910270116","article-title":"The capillary network: a link between IVIM and classical perfusion","volume":"27","author":"Le Bihan","year":"1992","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.jns.2022.120359_bb0020","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.nicl.2017.01.017","article-title":"Simultaneous investigation of microvasculature and parenchyma in cerebral small vessel disease using intravoxel incoherent motion imaging","volume":"14","author":"Wong","year":"2017","journal-title":"Neuroimage Clin."},{"issue":"3","key":"10.1016\/j.jns.2022.120359_bb0025","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1161\/STROKEAHA.116.015084","article-title":"Intravoxel incoherent motion imaging in small vessel disease: microstructural integrity and microvascular perfusion related to cognition","volume":"48","author":"Zhang","year":"2017","journal-title":"Stroke."},{"issue":"1","key":"10.1016\/j.jns.2022.120359_bb0030","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0039-6257(01)00234-X","article-title":"Retinal microvascular abnormalities and their relationship with hypertension, cardiovascular disease, and mortality","volume":"46","author":"Wong","year":"2001","journal-title":"Surv. Ophthalmol."},{"issue":"1","key":"10.1016\/j.jns.2022.120359_bb0035","doi-asserted-by":"crossref","first-page":"6320","DOI":"10.1038\/s41598-019-42534-x","article-title":"Retinal microvasculature and cerebral small vessel disease in the Lothian birth cohort 1936 and mild stroke study","volume":"9","author":"McGrory","year":"2019","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.jns.2022.120359_bb0040","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/j.1747-4949.2010.00483.x","article-title":"Retinal arteriolar geometry is associated with cerebral white matter hyperintensities on magnetic resonance imaging","volume":"5","author":"Doubal","year":"2010","journal-title":"Int. J. Stroke"},{"issue":"20","key":"10.1016\/j.jns.2022.120359_bb0045","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1212\/WNL.0b013e3181a60a71","article-title":"Differences in retinal vessels support a distinct vasculopathy causing lacunar stroke","volume":"72","author":"Doubal","year":"2009","journal-title":"Neurology."},{"issue":"1","key":"10.1016\/j.jns.2022.120359_bb0050","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.neuron.2017.07.030","article-title":"The neurovascular unit coming of age: a journey through neurovascular coupling in health and disease","volume":"96","author":"Iadecola","year":"2017","journal-title":"Neuron."},{"issue":"1\u20132","key":"10.1016\/j.jns.2022.120359_bb0055","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.jns.2012.05.041","article-title":"Retinal vasoreactivity as a marker for chronic ischemic white matter disease?","volume":"322","author":"Bettermann","year":"2012","journal-title":"J. Neurol. Sci."},{"issue":"18","key":"10.1016\/j.jns.2022.120359_bb0060","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1161\/CIRCULATIONAHA.116.023446","article-title":"Prediabetes and type 2 diabetes are associated with generalized microvascular dysfunction: the Maastricht study","volume":"134","author":"Sorensen","year":"2016","journal-title":"Circulation."},{"issue":"9559","key":"10.1016\/j.jns.2022.120359_bb0065","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0140-6736(07)60198-6","article-title":"The eye in hypertension","volume":"369","author":"Wong","year":"2007","journal-title":"Lancet."},{"issue":"5","key":"10.1016\/j.jns.2022.120359_bb0070","doi-asserted-by":"crossref","first-page":"876","DOI":"10.2337\/dc14-2043","article-title":"On the interplay of microvasculature, parenchyma, and memory in type 2 diabetes","volume":"38","author":"van Bussel","year":"2015","journal-title":"Diabetes Care"},{"issue":"6","key":"10.1016\/j.jns.2022.120359_bb0075","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s10654-014-9889-0","article-title":"The Maastricht study: an extensive phenotyping study on determinants of type 2 diabetes, its complications and its comorbidities","volume":"29","author":"Schram","year":"2014","journal-title":"Eur. J. Epidemiol."},{"issue":"10","key":"10.1016\/j.jns.2022.120359_bb0080","first-page":"1653","article-title":"Fluid-attenuated inversion recovery preparation: not an improvement over conventional diffusion-weighted imaging at 3T in acute ischemic stroke","volume":"25","author":"Simon","year":"2004","journal-title":"AJNR Am. J. Neuroradiol."},{"issue":"3","key":"10.1016\/j.jns.2022.120359_bb0085","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0896-6273(02)00569-X","article-title":"Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain","volume":"33","author":"Fischl","year":"2002","journal-title":"Neuron."},{"key":"10.1016\/j.jns.2022.120359_bb0090","series-title":"17th Annual Meeting of Intl Soc Mag Reson Med","article-title":"ExploreDTI: A graphical toolbox for processing, analyzing, and visualizing diffusion MR data","year":"2009"},{"issue":"1","key":"10.1016\/j.jns.2022.120359_bb0095","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/jcbfm.2012.125","article-title":"Combined arterial spin labeling and diffusion-weighted imaging for noninvasive estimation of capillary volume fraction and permeability-surface product in the human brain","volume":"33","author":"Hales","year":"2013","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"3","key":"10.1016\/j.jns.2022.120359_bb0100","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1002\/jmri.24195","article-title":"Measuring brain perfusion with intravoxel incoherent motion (IVIM): initial clinical experience","volume":"39","author":"Federau","year":"2014","journal-title":"J. Magn. Reson. Imaging"},{"issue":"9","key":"10.1016\/j.jns.2022.120359_bb0105","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1093\/aje\/kwaa023","article-title":"Microvascular phenotyping in the Maastricht study: design and Main findings, 2010-2018","volume":"189","author":"Li","year":"2020","journal-title":"Am. J. Epidemiol."},{"issue":"3","key":"10.1016\/j.jns.2022.120359_bb0110","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1076\/ceyr.27.3.143.16049","article-title":"Revised formulas for summarizing retinal vessel diameters","volume":"27","author":"Knudtson","year":"2003","journal-title":"Curr. Eye Res."},{"issue":"1","key":"10.1016\/j.jns.2022.120359_bb0115","doi-asserted-by":"crossref","first-page":"H1","DOI":"10.1152\/ajpheart.00581.2016","article-title":"Functional vascular contributions to cognitive impairment and dementia: mechanisms and consequences of cerebral autoregulatory dysfunction, endothelial impairment, and neurovascular uncoupling in aging","volume":"312","author":"Toth","year":"2017","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"7","key":"10.1016\/j.jns.2022.120359_bb0120","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S1474-4422(10)70104-6","article-title":"Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges","volume":"9","author":"Pantoni","year":"2010","journal-title":"Lancet Neurol."},{"issue":"1","key":"10.1016\/j.jns.2022.120359_bb0125","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/jon.12412","article-title":"Impaired retinal vasoreactivity: an early marker of stroke risk in diabetes","volume":"27","author":"Bettermann","year":"2017","journal-title":"J. Neuroimaging"},{"issue":"1","key":"10.1016\/j.jns.2022.120359_bb0130","doi-asserted-by":"crossref","first-page":"e63","DOI":"10.1111\/aos.14232","article-title":"Retinal vascular fractal dimension and cerebral blood flow, a pilot study","volume":"98","author":"Nadal","year":"2020","journal-title":"Acta Ophthalmol."},{"key":"10.1016\/j.jns.2022.120359_bb0135","doi-asserted-by":"crossref","first-page":"259","DOI":"10.2147\/VHRM.S190470","article-title":"Small vessel disease to subcortical dementia: a dynamic model, which interfaces aging, cholinergic dysregulation and the neurovascular unit","volume":"15","author":"Caruso","year":"2019","journal-title":"Vasc. Health Risk Manag."},{"issue":"8","key":"10.1016\/j.jns.2022.120359_bb0140","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1007\/s00330-015-3655-x","article-title":"Caveat of measuring perfusion indexes using intravoxel incoherent motion magnetic resonance imaging in the human brain","volume":"25","author":"Wu","year":"2015","journal-title":"Eur. Radiol."},{"issue":"3","key":"10.1016\/j.jns.2022.120359_bb0145","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1148\/radiol.12120584","article-title":"Quantitative measurement of brain perfusion with intravoxel incoherent motion MR imaging","volume":"265","author":"Federau","year":"2012","journal-title":"Radiology."},{"issue":"1","key":"10.1016\/j.jns.2022.120359_bb0150","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1097\/RCT.0000000000000640","article-title":"Measuring cerebral hypoperfusion induced by hyperventilation challenge with Intravoxel incoherent motion magnetic resonance imaging in healthy volunteers","volume":"42","author":"Pavilla","year":"2018","journal-title":"J. Comput. Assist. Tomogr."},{"issue":"9","key":"10.1016\/j.jns.2022.120359_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.crad.2016.04.019","article-title":"Intravoxel incoherent motion diffusion-weighted imaging in stroke patients: initial clinical experience","volume":"71","author":"Yao","year":"2016","journal-title":"Clin. Radiol."},{"key":"10.1016\/j.jns.2022.120359_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2019.116228","article-title":"Effect of intravoxel incoherent motion on diffusion parameters in normal brain","volume":"204","author":"Vieni","year":"2020","journal-title":"Neuroimage."},{"issue":"6","key":"10.1016\/j.jns.2022.120359_bb0165","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1002\/jmri.27272","article-title":"Preliminary assessment of Intravoxel incoherent motion diffusion-weighted MRI (IVIM-DWI) metrics in Alzheimer\u2019s disease","volume":"52","author":"Bergamino","year":"2020","journal-title":"J. Magn. Reson. Imaging"},{"issue":"7","key":"10.1016\/j.jns.2022.120359_bb0170","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1136\/bjo.2003.033548","article-title":"Reduced response of retinal vessel diameters to flicker stimulation in patients with diabetes","volume":"88","author":"Garh\u00f6fer","year":"2004","journal-title":"Br. J. Ophthalmol."},{"issue":"1","key":"10.1016\/j.jns.2022.120359_bb0175","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1136\/bjo.88.1.54","article-title":"Flicker observation light induces diameter response in retinal arterioles: a clinical methodological study","volume":"88","author":"Nagel","year":"2004","journal-title":"Br. J. Ophthalmol."},{"issue":"2","key":"10.1016\/j.jns.2022.120359_bb0180","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/s00347-005-1254-y","article-title":"Variance of retinal vessel diameter response to flicker light. A methodical clinical study","volume":"103","author":"Nagel","year":"2006","journal-title":"Ophthalmologe."}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X22002210?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X22002210?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T16:00:22Z","timestamp":1758384022000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X22002210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":36,"alternative-id":["S0022510X22002210"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2022.120359","relation":{},"ISSN":["0022-510X"],"issn-type":[{"value":"0022-510X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Retinal microvascular function is associated with the cerebral microcirculation as determined by intravoxel incoherent motion MRI","name":"articletitle","label":"Article Title"},{"value":"Journal of the Neurological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jns.2022.120359","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"120359"}}