{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T09:05:43Z","timestamp":1777626343984,"version":"3.51.4"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1185180"],"award-info":[{"award-number":["1185180"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jns-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.jns.2022.120439","type":"journal-article","created":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T12:22:38Z","timestamp":1664540558000},"page":"120439","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Cerebrospinal fluid neurofilament light chain differentiates behavioural variant frontotemporal dementia progressors from non-progressors"],"prefix":"10.1016","volume":"442","author":[{"given":"Dhamidhu","family":"Eratne","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Keem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Courtney","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Walterfang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Farrand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha","family":"Loi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy","family":"Kelso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Cadwallader","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel F.","family":"Berkovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiao-Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin L.","family":"Masters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Collins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Santillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis","family":"Velakoulis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jns.2022.120439_bb0005","first-page":"1","article-title":"Time to diagnosis in younger-onset dementia and the impact of a specialist diagnostic service","author":"Loi","year":"2020","journal-title":"Int. Psychogeriatr."},{"key":"10.1016\/j.jns.2022.120439_bb0010","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1002\/gps.4430","article-title":"Time to diagnosis in young-onset dementia and its determinants: the INSPIRED study","volume":"31","author":"Draper","year":"2016","journal-title":"International Journal of Geriatric Psychiatry"},{"key":"10.1016\/j.jns.2022.120439_bb0015","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1097\/WAD.0b013e3181a6bebc","article-title":"Missed and delayed diagnosis of dementia in primary care: prevalence and contributing factors","volume":"23","author":"Bradford","year":"2009","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"10.1016\/j.jns.2022.120439_bb0020","doi-asserted-by":"crossref","first-page":"126","DOI":"10.4088\/JCP.10m06382oli","article-title":"The diagnostic challenge of psychiatric symptoms in neurodegenerative disease: rates of and risk factors for prior psychiatric diagnosis in patients with early neurodegenerative disease","volume":"72","author":"Woolley","year":"2011","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jns.2022.120439_bb0025","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.4088\/JCP.15m09844","article-title":"Identifying specific clinical symptoms of behavioral variant frontotemporal dementia versus differential psychiatric disorders in patients presenting with a late-onset frontal lobe syndrome","volume":"77","author":"Dols","year":"2016","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jns.2022.120439_bb0030","doi-asserted-by":"crossref","first-page":"e1197","DOI":"10.4088\/JCP.16m11078","article-title":"The diagnostic challenge of the late-onset frontal lobe syndrome: clinical predictors for primary psychiatric disorders versus behavioral variant frontotemporal dementia","volume":"78","author":"Vijverberg","year":"2017","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jns.2022.120439_bb0035","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1159\/000444849","article-title":"Diagnostic accuracy of the frontotemporal dementia consensus criteria in the late-onset frontal lobe syndrome","volume":"41","author":"Vijverberg","year":"2016","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"10.1016\/j.jns.2022.120439_bb0040","doi-asserted-by":"crossref","DOI":"10.1177\/0004867414529477","article-title":"Comparing neurocognition in severe chronic schizophrenia and frontotemporal dementia","author":"Chan","year":"2014","journal-title":"Australian and New Zealand Journal of Psychiatry"},{"key":"10.1016\/j.jns.2022.120439_bb0045","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1192\/bjp.bp.108.057034","article-title":"Frontotemporal dementia presenting as schizophrenia-like psychosis in young people: Clinicopathological series and review of cases","volume":"194","author":"Velakoulis","year":"2009","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.jns.2022.120439_bb0050","first-page":"64","article-title":"Psychiatric diagnoses underlying the phenocopy syndrome of behavioural variant frontotemporal dementia","volume":"87","author":"Gossink","year":"2016","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.jns.2022.120439_bb0055","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1093\/brain\/awaa018","article-title":"Recommendations to distinguish behavioural variant frontotemporal dementia from psychiatric disorders","volume":"143","author":"Ducharme","year":"2020","journal-title":"Brain"},{"key":"10.1016\/j.jns.2022.120439_bb0060","article-title":"The diagnostic challenge of young-onset dementia syndromes and primary psychiatric diseases: results from a retrospective 20-year cross-sectional study","author":"Tsoukra","year":"2021","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"10.1016\/j.jns.2022.120439_bb0065","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1177\/0891988720924708","article-title":"The behavioral variant frontotemporal dementia Phenocopy syndrome: a review","volume":"34","author":"Power","year":"2021","journal-title":"J. Geriatr. Psychiatry Neurol."},{"key":"10.1016\/j.jns.2022.120439_bb0070","doi-asserted-by":"crossref","first-page":"S636","DOI":"10.1016\/j.eurpsy.2017.01.1046","article-title":"Phenocopy frontotemporal dementia: a case series from a National Memory Clinic and a review of the literature","volume":"41","author":"Power","year":"2017","journal-title":"Eur psychiatr"},{"key":"10.1016\/j.jns.2022.120439_bb0075","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1136\/jnnp.2008.163873","article-title":"Can progressive and non-progressive behavioural variant frontotemporal dementia be distinguished at presentation?","volume":"80","author":"Hornberger","year":"2009","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.jns.2022.120439_bb0080","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1212\/01.wnl.0000334299.72023.c8","article-title":"Executive function in progressive and nonprogressive behavioral variant frontotemporal dementia","volume":"71","author":"Hornberger","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2022.120439_bb0085","doi-asserted-by":"crossref","DOI":"10.1186\/s12883-018-1060-1","article-title":"The behavioural variant frontotemporal dementia phenocopy syndrome is a distinct entity - evidence from a longitudinal study","volume":"18","author":"Devenney","year":"2018","journal-title":"BMC Neurol."},{"key":"10.1016\/j.jns.2022.120439_bb0090","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1001\/jamaneurol.2015.2061","article-title":"Progression in behavioral variant frontotemporal dementia: a longitudinal study","volume":"72","author":"Devenney","year":"2015","journal-title":"JAMA Neurology"},{"key":"10.1016\/j.jns.2022.120439_bb0095","article-title":"Phenocopy or variant: a longitudinal study of very slowly progressive frontotemporal dementia","author":"Brodtmann","year":"2013","journal-title":"Case Reports"},{"key":"10.1016\/j.jns.2022.120439_bb0100","first-page":"757","article-title":"Novel cerebrospinal fluid biomarkers of axonal degeneration in frontotemporal dementia","volume":"1","author":"Mattsson","year":"2008","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.jns.2022.120439_bb0105","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1007\/s00330-016-4490-4","article-title":"Functional connectivity and microstructural white matter changes in phenocopy frontotemporal dementia","volume":"27","author":"Meijboom","year":"2017","journal-title":"Eur. Radiol."},{"key":"10.1016\/j.jns.2022.120439_bb0110","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1136\/jnnp-2011-301883","article-title":"Atypical, slowly progressive behavioural variant frontotemporal dementia associated with C9ORF72 hexanucleotide expansion","volume":"83","author":"Khan","year":"2012","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.jns.2022.120439_bb0115","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1080\/13554794.2014.951058","article-title":"Clinical heterogeneity of the C9orf72 genetic mutation in frontotemporal dementia","volume":"21","author":"Devenney","year":"2015","journal-title":"Neurocase"},{"key":"10.1016\/j.jns.2022.120439_bb0120","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.nicl.2016.03.019","article-title":"Structural and functional brain abnormalities place phenocopy frontotemporal dementia (FTD) in the FTD spectrum","volume":"11","author":"Steketee","year":"2016","journal-title":"NeuroImage: Clinical"},{"key":"10.1016\/j.jns.2022.120439_bb0125","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1136\/jnnp-2015-312826","article-title":"The bvFTD phenocopy syndrome: a clinicopathological report","volume":"87","author":"Devenney","year":"2016","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.jns.2022.120439_bb0130","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1093\/brain\/awr179","article-title":"Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia","volume":"134","author":"Rascovsky","year":"2011","journal-title":"Brain"},{"key":"10.1016\/j.jns.2022.120439_bb0135","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/j.jagp.2015.04.002","article-title":"Identifying bvFTD within the wide Spectrum of late onset frontal lobe syndrome: a clinical approach","volume":"23","author":"Krudop","year":"2015","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.jns.2022.120439_bb0140","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/s41582-018-0058-z","article-title":"Neurofilaments as biomarkers in neurological disorders","volume":"14","author":"Khalil","year":"2018","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.jns.2022.120439_bb0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/cshperspect.a018309","article-title":"Neurofilaments and neurofilament proteins in health and disease","volume":"9","author":"Yuan","year":"2017","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.jns.2022.120439_bb0150","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1001\/jamaneurol.2019.1534","article-title":"Diagnostic value of cerebrospinal fluid Neurofilament light protein in neurology: a systematic review and Meta-analysis","volume":"76","author":"Bridel","year":"2019","journal-title":"JAMA Neurology"},{"key":"10.1016\/j.jns.2022.120439_bb0155","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1136\/jnnp-2018-320106","article-title":"Neurofilament light chain as a biomarker in neurological disorders","volume":"90","author":"Gaetani","year":"2019","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.jns.2022.120439_bb0160","doi-asserted-by":"crossref","first-page":"3400","DOI":"10.1038\/s41467-021-23620-z","article-title":"A multicentre validation study of the diagnostic value of plasma neurofilament light","volume":"12","author":"Ashton","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jns.2022.120439_bb0165","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1177\/0004867419857811","article-title":"A pilot study of the utility of cerebrospinal fluid neurofilament light chain in differentiating neurodegenerative from psychiatric disorders: a \u2018C-reactive protein\u2019 for psychiatrists and neurologists?","volume":"54","author":"Eratne","year":"2020","journal-title":"Aust. N. Z. J. Psychiatry"},{"key":"10.1016\/j.jns.2022.120439_bb0170","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1177\/0004867419893431","article-title":"Cerebrospinal fluid neurofilament light chain is elevated in Niemann\u2013Pick type C compared to psychiatric disorders and healthy controls and may be a marker of treatment response","volume":"54","author":"Eratne","year":"2020","journal-title":"Aust. N. Z. J. Psychiatry"},{"key":"10.1016\/j.jns.2022.120439_bb0175","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1212\/WNL.0000000000001015","article-title":"CSF neurofilament light differs in neurodegenerative diseases and predicts severity and survival","volume":"83","author":"Skillback","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2022.120439_bb0180","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1159\/000099473","article-title":"CSF neurofilaments in frontotemporal dementia compared with early onset Alzheimer\u2019s disease and controls","volume":"23","author":"Pijnenburg","year":"2007","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"10.1016\/j.jns.2022.120439_bb0185","first-page":"730","article-title":"The diagnostic performance of neurofilament light chain in CSF and blood for Alzheimer\u2019s disease, frontotemporal dementia, and amyotrophic lateral sclerosis: a systematic review and meta-analysis","volume":"11","author":"Forgrave","year":"2019","journal-title":"Alzheimer\u2019s & Dementia: Diagnosis, Assessment & Disease Monitoring"},{"key":"10.1016\/j.jns.2022.120439_bb0190","article-title":"The role of neurofilament light chain in frontotemporal dementia: a meta-analysis","author":"Karantali","year":"2020","journal-title":"Aging Clinical and Experimental Research"},{"key":"10.1016\/j.jns.2022.120439_bb0195","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1007\/s00415-019-09567-8","article-title":"Serum neurofilament light chain is a discriminative biomarker between frontotemporal lobar degeneration and primary psychiatric disorders","volume":"267","author":"Katisko","year":"2020","journal-title":"J. Neurol."},{"key":"10.1016\/j.jns.2022.120439_bb0200","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.jpsychires.2019.03.019","article-title":"Neurofilament light chain as a blood biomarker to differentiate psychiatric disorders from behavioural variant frontotemporal dementia","volume":"113","author":"Al Shweiki","year":"2019","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.jns.2022.120439_bb0205","article-title":"Plasma neurofilament light chain protein is not increased in treatment-resistant schizophrenia and first-degree relatives","author":"Eratne","year":"2021","journal-title":"Aust N Z J Psychiatry"},{"key":"10.1016\/j.jns.2022.120439_bb0210","first-page":"alz.12549","article-title":"Cerebrospinal fluid neurofilament light chain differentiates primary psychiatric disorders from rapidly progressive, Alzheimer\u2019s disease and frontotemporal disorders in clinical settings","author":"Eratne","year":"2022","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.jns.2022.120439_bb0215","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1080\/j.1440-1614.2006.01923.x","article-title":"The NUCOG: validity and reliability of a brief cognitive screening tool in neuropsychiatric patients","volume":"40","author":"Walterfang","year":"2006","journal-title":"Aust. N. Z. J. Psychiatry"},{"key":"10.1016\/j.jns.2022.120439_bb0220","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.neuron.2011.09.010","article-title":"A Hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD","volume":"72","author":"Renton","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.jns.2022.120439_bb0225","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.neuron.2011.09.011","article-title":"Expanded GGGGCC Hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS","volume":"72","author":"DeJesus-Hernandez","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.jns.2022.120439_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.jns.2020.117260","article-title":"The clinical utility of exome sequencing and extended bioinformatic analyses in adolescents and adults with a broad range of neurological phenotypes: an Australian perspective","volume":"420","author":"Eratne","year":"2021","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.jns.2022.120439_bb0235","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.3233\/JAD-190332","article-title":"Psychiatric Phenocopy syndrome of behavioral frontotemporal dementia: behavioral and cognitive fingerprint","volume":"72","author":"Buss\u00e8","year":"2019","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.jns.2022.120439_bb0240","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/jnnp-2015-312972","article-title":"Neurofilament light chain in FTD is elevated not only in cerebrospinal fluid, but also in serum","volume":"87","author":"Wilke","year":"2016","journal-title":"J. Neurol. Neurosurg. Psychiatry"}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X2200301X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X2200301X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:29:00Z","timestamp":1777422540000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X2200301X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":48,"alternative-id":["S0022510X2200301X"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2022.120439","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.01.14.22269323","asserted-by":"object"}]},"ISSN":["0022-510X"],"issn-type":[{"value":"0022-510X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cerebrospinal fluid neurofilament light chain differentiates behavioural variant frontotemporal dementia progressors from non-progressors","name":"articletitle","label":"Article Title"},{"value":"Journal of the Neurological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jns.2022.120439","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"120439"}}