{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T18:03:03Z","timestamp":1785607383402,"version":"3.56.0"},"reference-count":18,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T00:00:00Z","timestamp":1724976000000},"content-version":"am","delay-in-days":364,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jns-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.jns.2023.120775","type":"journal-article","created":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T11:14:04Z","timestamp":1692962044000},"page":"120775","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Clinical characteristics and intracranial arterial lesions of non-young adult ischemic stroke patients with RNF213 p.R4810K variant"],"prefix":"10.1016","volume":"452","author":[{"given":"Shiori","family":"Ogura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Ohara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eijirou","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Ashida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Maezono-Kandori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misaki","family":"Hanya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuko","family":"Mizuta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiki","family":"Mizuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jns.2023.120775_bb0005","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/jhg.2010.132","article-title":"A genome-wide association study identifies RNF213 as the first Moyamoya disease gene","volume":"56","author":"Kamada","year":"2011","journal-title":"J. Hum. Genet."},{"issue":"7","key":"10.1016\/j.jns.2023.120775_bb0010","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0022542","article-title":"Identification of RNF213 as a susceptibility gene for moyamoya disease and its possible role in vascular development","volume":"6","author":"Liu","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jns.2023.120775_bb0015","doi-asserted-by":"crossref","first-page":"13191","DOI":"10.1038\/srep13191","article-title":"Moyamoya disease susceptibility gene RNF213 links inflammatory and angiogenic signals in endothelial cells","volume":"5","author":"Ohkubo","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jns.2023.120775_bb0020","doi-asserted-by":"crossref","first-page":"16161","DOI":"10.1038\/srep16161","article-title":"Neuromuscular regulation in zebrafish by a large AAA+ ATPase\/ubiquitin ligase, mysterin\/RNF213","volume":"5","author":"Kotani","year":"2015","journal-title":"Sci. Rep."},{"issue":"10","key":"10.1016\/j.jns.2023.120775_bb0025","doi-asserted-by":"crossref","first-page":"2894","DOI":"10.1161\/STROKEAHA.113.002477","article-title":"Genetic variant RNF213 c.14576G>a in various phenotypes of intracranial major artery stenosis\/occlusion","volume":"44","author":"Miyawaki","year":"2013","journal-title":"Stroke."},{"issue":"8","key":"10.1016\/j.jns.2023.120775_bb0030","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1161\/STROKEAHA.120.030012","article-title":"Luminal and wall changes in intracranial arterial lesions for predicting stroke occurrence","volume":"51","author":"Kim","year":"2020","journal-title":"Stroke."},{"issue":"6","key":"10.1016\/j.jns.2023.120775_bb0035","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0156607","article-title":"A polymorphism in RNF213 is a susceptibility gene for intracranial atherosclerosis","volume":"11","author":"Bang","year":"2016","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.jns.2023.120775_bb0040","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1161\/CIRCULATIONAHA.118.038439","article-title":"Moyamoya disease susceptibility variant RNF213 p.R4810K increases the risk of ischemic stroke attributable to large-artery atherosclerosis","volume":"139","author":"Okazaki","year":"2019","journal-title":"Circulation."},{"issue":"1","key":"10.1016\/j.jns.2023.120775_bb0045","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1161\/01.STR.24.1.35","article-title":"Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of org 10172 in acute stroke treatment","volume":"24","author":"Adams","year":"1993","journal-title":"Stroke."},{"issue":"5","key":"10.1016\/j.jns.2023.120775_bb0050","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.jstrokecerebrovasdis.2015.01.005","article-title":"Genetic analysis of RNF213 c.14576G>a variant in nonatherosclerotic quasi-moyamoya disease","volume":"24","author":"Miyawaki","year":"2015","journal-title":"J. Stroke Cerebrovasc. Dis."},{"issue":"3","key":"10.1016\/j.jns.2023.120775_bb0055","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1159\/000508301","article-title":"Are genetic variants associated with the location of cerebral arterial lesions in stroke patients?","volume":"49","author":"Kim","year":"2020","journal-title":"Cerebrovasc. Dis."},{"issue":"2","key":"10.1016\/j.jns.2023.120775_bb0060","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s10143-018-0994-5","article-title":"Progress in moyamoya disease","volume":"43","author":"Shang","year":"2020","journal-title":"Neurosurg. Rev."},{"issue":"1","key":"10.1016\/j.jns.2023.120775_bb0065","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1177\/159101990300900105","article-title":"Moyamoya disease is a progressive occlusive arteriopathy of the primitive internal carotid artery","volume":"9","author":"Komiyama","year":"2003","journal-title":"Interv. Neuroradiol."},{"issue":"4","key":"10.1016\/j.jns.2023.120775_bb0070","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1007\/s12975-019-00743-6","article-title":"Moyamoya disease and spectrums of RNF213 vasculopathy","volume":"11","author":"Bang","year":"2020","journal-title":"Transl. Stroke Res."},{"issue":"2","key":"10.1016\/j.jns.2023.120775_bb0075","doi-asserted-by":"crossref","first-page":"65","DOI":"10.5853\/jos.2014.16.2.65","article-title":"Genetics and biomarkers of Moyamoya disease: significance of RNF213 as a susceptibility gene","volume":"16","author":"Fujimura","year":"2014","journal-title":"J. Stroke."},{"key":"10.1016\/j.jns.2023.120775_bb0080","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.brainres.2014.11.014","article-title":"Enhanced post-ischemic angiogenesis in mice lacking RNF213; a susceptibility gene for moyamoya disease","volume":"1594","author":"Ito","year":"2015","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.jns.2023.120775_bb0085","doi-asserted-by":"crossref","first-page":"3607","DOI":"10.1038\/s41598-018-22064-8","article-title":"Dysregulation of RNF213 promotes cerebral hypoperfusion","volume":"8","author":"Morimoto","year":"2018","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.jns.2023.120775_bb0090","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1161\/STROKEAHA.110.608471","article-title":"Increased thyroid function and elevated thyroid autoantibodies in pediatric patients with moyamoya disease: a case-control study","volume":"42","author":"Li","year":"2011","journal-title":"Stroke."}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X23002368?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X23002368?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T16:03:37Z","timestamp":1758384217000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X23002368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":18,"alternative-id":["S0022510X23002368"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2023.120775","relation":{},"ISSN":["0022-510X"],"issn-type":[{"value":"0022-510X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical characteristics and intracranial arterial lesions of non-young adult ischemic stroke patients with RNF213 p.R4810K variant","name":"articletitle","label":"Article Title"},{"value":"Journal of the Neurological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jns.2023.120775","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"120775"}}