{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:02:46Z","timestamp":1791806566511,"version":"4.3.4"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100018749","name":"Korea Brain Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018749","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["23-BR-02-04"],"award-info":[{"award-number":["23-BR-02-04"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["23-BR-03-02"],"award-info":[{"award-number":["23-BR-03-02"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["2021R1C1C1008688"],"award-info":[{"award-number":["2021R1C1C1008688"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["23-BR-02-05"],"award-info":[{"award-number":["23-BR-02-05"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jns-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.jns.2024.122885","type":"journal-article","created":{"date-parts":[[2024,1,13]],"date-time":"2024-01-13T18:01:50Z","timestamp":1705168910000},"page":"122885","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Identification and characterization of novel ERBB4 variant associated with sporadic amyotrophic lateral sclerosis (ALS)"],"prefix":"10.1016","volume":"457","author":[{"given":"Younghwi","family":"Kwon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minsung","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Mi","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinrye","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho-Won","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Sung","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung-Jun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jns.2024.122885_bb0005","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.bbadis.2006.01.004","article-title":"Genetics of familial and sporadic amyotrophic lateral sclerosis","volume":"1762","author":"Gros-Louis","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jns.2024.122885_bb0010","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1212\/WNL.0000000000003686","article-title":"Genetic testing in ALS: a survey of current practices","volume":"88","author":"Vajda","year":"2017","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2024.122885_bb0015","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1097\/WCO.0000000000000862","article-title":"Cognitive and behavioural impairment in amyotrophic lateral sclerosis","volume":"33","author":"Pender","year":"2020","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.jns.2024.122885_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2021.135898","article-title":"Cognitive and behavioural impairment in amyotrophic lateral sclerosis: a landmark of the disease? A mini review of longitudinal studies","volume":"754","author":"Consonni","year":"2021","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.jns.2024.122885_bb0025","doi-asserted-by":"crossref","first-page":"e984","DOI":"10.1212\/WNL.0000000000008063","article-title":"Cognitive impairment across ALS clinical stages in a population-based cohort","volume":"93","author":"Chi\u00f2","year":"2019","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2024.122885_bb0030","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1080\/21678421.2016.1267768","article-title":"Amyotrophic lateral sclerosis - frontotemporal spectrum disorder (ALS-FTSD): revised diagnostic criteria","volume":"18","author":"Strong","year":"2017","journal-title":"Amyotr. Later. Scler. Frontotemporal. Degener."},{"key":"10.1016\/j.jns.2024.122885_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2020.105063","article-title":"Neuroimaging in genetic frontotemporal dementia and amyotrophic lateral sclerosis","volume":"145","author":"Hakkinen","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.jns.2024.122885_bb0040","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.47.6_Suppl_4.233S","article-title":"The pharmacology and mechanism of action of riluzole","volume":"47","author":"Doble","year":"1996","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2024.122885_bb0045","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S1474-4422(18)30091-7","article-title":"Riluzole, disease stage and survival in ALS","volume":"17","author":"Dharmadasa","year":"2018","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jns.2024.122885_bb0050","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.freeradbiomed.2009.11.018","article-title":"Oxidative stress in ALS: key role in motor neuron injury and therapeutic target","volume":"48","author":"Barber","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jns.2024.122885_bb0055","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s10072-019-04055-3","article-title":"Effect of edaravone therapy in Korean amyotrophic lateral sclerosis (ALS) patients","volume":"41","author":"Park","year":"2020","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.jns.2024.122885_bb0060","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1056\/NEJMoa1916945","article-title":"Trial of sodium Phenylbutyrate-Taurursodiol for amyotrophic lateral sclerosis","volume":"383","author":"Paganoni","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jns.2024.122885_bb0065","first-page":"22","article-title":"New drug approved for ALS","volume":"123","author":"Aschenbrenner","year":"2023","journal-title":"Am. J. Nurs."},{"key":"10.1016\/j.jns.2024.122885_bb0070","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/S1474-4422(18)30054-1","article-title":"Stage at which riluzole treatment prolongs survival in patients with amyotrophic lateral sclerosis: a retrospective analysis of data from a dose-ranging study","volume":"17","author":"Fang","year":"2018","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jns.2024.122885_bb0075","doi-asserted-by":"crossref","first-page":"343","DOI":"10.2217\/nmt-2020-0033","article-title":"Riluzole for the treatment of amyotrophic lateral sclerosis","volume":"10","author":"Saitoh","year":"2020","journal-title":"Neurodegener. Disease Manage."},{"key":"10.1016\/j.jns.2024.122885_bb0080","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1002\/mus.27724","article-title":"Early initiation of riluzole may improve absolute survival in amyotrophic lateral sclerosis","volume":"66","author":"Thakore","year":"2022","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.jns.2024.122885_bb0085","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1001\/jamaneurol.2021.4893","article-title":"Safety and effectiveness of long-term intravenous Administration of Edaravone for treatment of patients with amyotrophic lateral sclerosis","volume":"79","author":"Witzel","year":"2022","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.jns.2024.122885_bb0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/14737175.2023.2174018","article-title":"An evaluation of the combination of sodium phenylbutyrate and taurursodiol for the treatment of amyotrophic lateral sclerosis","volume":"23","author":"Sun","year":"2023","journal-title":"Expert. Rev. Neurother."},{"key":"10.1016\/j.jns.2024.122885_bb0095","doi-asserted-by":"crossref","first-page":"1170996","DOI":"10.3389\/fnins.2023.1170996","article-title":"Recent progress of the genetics of amyotrophic lateral sclerosis and challenges of gene therapy","volume":"17","author":"Wang","year":"2023","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.jns.2024.122885_bb0100","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a024125","article-title":"Genetics of amyotrophic lateral sclerosis","volume":"8","author":"Ghasemi","year":"2018","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.jns.2024.122885_bb0105","doi-asserted-by":"crossref","first-page":"684","DOI":"10.3389\/fnins.2020.00684","article-title":"Multifaceted genes in amyotrophic lateral sclerosis-frontotemporal dementia","volume":"14","author":"Ranganathan","year":"2020","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.jns.2024.122885_bb0110","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.ajhg.2013.09.008","article-title":"ERBB4 mutations that disrupt the neuregulin-ErbB4 pathway cause amyotrophic lateral sclerosis type 19","volume":"93","author":"Takahashi","year":"2013","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.jns.2024.122885_bb0115","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1080\/08977190802312844","article-title":"EGFR family: structure physiology signalling and therapeutic targets","volume":"26","author":"Burgess","year":"2008","journal-title":"Growth Factors"},{"key":"10.1016\/j.jns.2024.122885_bb0120","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26237376","article-title":"A review of HER4 (ErbB4) kinase, its impact on cancer, and its inhibitors","volume":"26","author":"El-Gamal","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.jns.2024.122885_bb0125","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.semcdb.2010.09.011","article-title":"ErbB signaling in cardiac development and disease","volume":"21","author":"Sanchez-Soria","year":"2010","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.jns.2024.122885_bb0130","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.phrs.2013.11.002","article-title":"The ErbB\/HER family of protein-tyrosine kinases and cancer","volume":"79","author":"Roskoski","year":"2014","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jns.2024.122885_bb0135","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3389\/fncel.2013.00004","article-title":"ErbB1-4-dependent EGF\/neuregulin signals and their cross talk in the central nervous system: pathological implications in schizophrenia and Parkinson\u2019s disease","volume":"7","author":"Iwakura","year":"2013","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.jns.2024.122885_bb0140","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.neuron.2014.06.007","article-title":"Neuregulin-ERBB signaling in the nervous system and neuropsychiatric diseases","volume":"83","author":"Mei","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.jns.2024.122885_bb0145","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.nbd.2017.07.001","article-title":"Ablating ErbB4 in PV neurons attenuates synaptic and cognitive deficits in an animal model of Alzheimer\u2019s disease","volume":"106","author":"Zhang","year":"2017","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.jns.2024.122885_bb0150","first-page":"E3129","article-title":"ErbB2 regulates autophagic flux to modulate the proteostasis of APP-CTFs in Alzheimer\u2019s disease","volume":"114","author":"Wang","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jns.2024.122885_bb0155","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1093\/jnen\/62.1.42","article-title":"Neuregulin-1 and erbB4 immunoreactivity is associated with neuritic plaques in Alzheimer disease brain and in a transgenic model of Alzheimer disease","volume":"62","author":"Chaudhury","year":"2003","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.jns.2024.122885_bb0160","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0165-5728(99)00201-5","article-title":"Neuregulin and erbB receptor expression in normal and diseased human white matter","volume":"100","author":"Cannella","year":"1999","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jns.2024.122885_bb0165","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.nbd.2018.12.021","article-title":"Decreased circulating ErbB4 ectodomain fragments as a read-out of impaired signaling function in amyotrophic lateral sclerosis","volume":"124","author":"Lopez-Font","year":"2019","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.jns.2024.122885_bb0170","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/neup.12558","article-title":"Altered immunoreactivity of ErbB4, a causative gene product for ALS19, in the spinal cord of patients with sporadic ALS","volume":"39","author":"Takahashi","year":"2019","journal-title":"Neuropathology"},{"key":"10.1016\/j.jns.2024.122885_bb0175","doi-asserted-by":"crossref","first-page":"535","DOI":"10.3233\/JAD-191230","article-title":"ErbB4 mutation that decreased NRG1-ErbB4 signaling involved in the pathogenesis of amyotrophic lateral sclerosis\/frontotemporal dementia","volume":"74","author":"Sun","year":"2020","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.jns.2024.122885_bb0180","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/s41431-020-00767-9","article-title":"Genetic analysis of ALS cases in the isolated island population of Malta","volume":"29","author":"Borg","year":"2021","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.jns.2024.122885_bb0185","doi-asserted-by":"crossref","unstructured":"A. Al Khleifat, A. Iacoangeli, J. van Vugt, H. Bowles, M. Moisse, R.A.J. Zwamborn, R.A.A. van der Spek, A. Shatunov, J. Cooper-Knock, S. Topp, R. Byrne, C. Gellera, V. Lopez, A.R. Jones, S. Opie-Martin, A. Vural, Y. Campos, W. van Rheenen, B. Kenna, K.R. Van Eijk, K. Kenna, M. Weber, B. Smith, I. Fogh, V. Silani, K.E. Morrison, R. Dobson, M.A. van Es, R.L. McLaughlin, P. Vourc'h, A. Chio, P. Corcia, M. de Carvalho, M. Gotkine, M.P. Panades, J.S. Mora, P.J. Shaw, J.E. Landers, J.D. Glass, C.E. Shaw, N. Basak, O. Hardiman, W. Robberecht, P. Van Damme, L.H. van den Berg, J.H. Veldink, and A. Al-Chalabi, Structural variation analysis of 6,500 whole genome sequences in amyotrophic lateral sclerosis, NPJ Genom. Med. 7 (2022) 8. doi:https:\/\/doi.org\/10.1038\/s41525-021-00267-9.","DOI":"10.1038\/s41525-021-00267-9"},{"key":"10.1016\/j.jns.2024.122885_bb0190","article-title":"Analysis of ERBB4 variants in amyotrophic lateral sclerosis within a Chinese cohort","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Neurol."},{"key":"10.1016\/j.jns.2024.122885_bb0195","doi-asserted-by":"crossref","first-page":"38421","DOI":"10.1074\/jbc.M302111200","article-title":"Ectodomain cleavage of ErbB-4: characterization of the cleavage site and m80 fragment","volume":"278","author":"Cheng","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jns.2024.122885_bb0200","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1083\/jcb.200403155","article-title":"The ERBB4\/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone","volume":"167","author":"Williams","year":"2004","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.jns.2024.122885_bb0205","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1165\/rcmb.2010-0179OC","article-title":"Neuregulin receptor ErbB4 functions as a transcriptional cofactor for the expression of surfactant protein B in the fetal lung","volume":"45","author":"Zscheppang","year":"2011","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.jns.2024.122885_bb0210","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/aja.1001940306","article-title":"Neuroblastoma x spinal cord (NSC) hybrid cell lines resemble developing motor neurons","volume":"194","author":"Cashman","year":"1992","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.jns.2024.122885_bb0215","doi-asserted-by":"crossref","DOI":"10.2144\/02335pf01","article-title":"Creating randomized amino acid libraries with the QuikChange Multi Site-Directed Mutagenesis Kit","volume":"33","author":"Hogrefe","year":"2002","journal-title":"Biotechniques"},{"key":"10.1016\/j.jns.2024.122885_bb0220","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S0014-4827(02)00100-3","article-title":"ErbB-4: mechanism of action and biology","volume":"284","author":"Carpenter","year":"2003","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.jns.2024.122885_bb0225","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1126\/science.1065412","article-title":"Gamma -secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase","volume":"294","author":"Ni","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.jns.2024.122885_bb0230","doi-asserted-by":"crossref","first-page":"6318","DOI":"10.1074\/jbc.M110371200","article-title":"Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4","volume":"277","author":"Lee","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jns.2024.122885_bb0235","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1750-1326-8-28","article-title":"Genetics of amyotrophic lateral sclerosis: an update","volume":"8","author":"Chen","year":"2013","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.jns.2024.122885_bb0240","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0012924","article-title":"Molecular cloning and characterization of the human ErbB4 gene: identification of novel splice isoforms in the developing and adult brain","volume":"5","author":"Tan","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.jns.2024.122885_bb0245","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.4161\/cc.10.16.17194","article-title":"Function of ERBB4 is determined by alternative splicing","volume":"10","author":"Veikkolainen","year":"2011","journal-title":"Cell Cycle"},{"key":"10.1016\/j.jns.2024.122885_bb0250","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1177\/002215540405201006","article-title":"ErbB transmembrane tyrosine kinase receptors are expressed by sensory and motor neurons projecting into sciatic nerve","volume":"52","author":"Pearson","year":"2004","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.jns.2024.122885_bb0255","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s40478-016-0286-7","article-title":"Neuregulin 1 confers neuroprotection in SOD1-linked amyotrophic lateral sclerosis mice via restoration of C-boutons of spinal motor neurons","volume":"4","author":"Lasiene","year":"2016","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.jns.2024.122885_bb0260","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/nrn2392","article-title":"Neuregulin 1 in neural development, synaptic plasticity and schizophrenia","volume":"9","author":"Mei","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.jns.2024.122885_bb0265","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0896-6273(00)81176-9","article-title":"Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses","volume":"26","author":"Huang","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.jns.2024.122885_bb0270","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.neuron.2007.04.009","article-title":"Neuregulin-1 enhances depolarization-induced GABA release","volume":"54","author":"Woo","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.jns.2024.122885_bb0275","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/s41398-021-01485-6","article-title":"ErbB4 promotes inhibitory synapse formation by cell adhesion, independent of its kinase activity","volume":"11","author":"Luo","year":"2021","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.jns.2024.122885_bb0280","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.pnpbp.2009.03.021","article-title":"Expression of ErbB4 in substantia nigra dopamine neurons of monkeys and humans","volume":"33","author":"Zheng","year":"2009","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.jns.2024.122885_bb0285","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.neulet.2012.10.050","article-title":"Neuregulin-1 receptor tyrosine kinase ErbB4 is upregulated in midbrain dopaminergic neurons in Parkinson disease","volume":"531","author":"Depboylu","year":"2012","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.jns.2024.122885_bb0290","doi-asserted-by":"crossref","first-page":"116","DOI":"10.5115\/acb.2011.44.2.116","article-title":"Expression of ErbB4 in the neurons of Alzheimer's disease brain and APP\/PS1 mice, a model of Alzheimer's disease","volume":"44","author":"Woo","year":"2011","journal-title":"Anat. Cell. Biol."},{"key":"10.1016\/j.jns.2024.122885_bb0295","doi-asserted-by":"crossref","first-page":"3497","DOI":"10.1002\/cne.25207","article-title":"ErbB4 mediates amyloid beta-induced neurotoxicity through JNK\/tau pathway activation: implications for Alzheimer\u2019s disease","volume":"529","author":"Zhang","year":"2021","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.jns.2024.122885_bb0300","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.15252\/embj.201694221","article-title":"TDP-43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons","volume":"35","author":"Schwenk","year":"2016","journal-title":"EMBO J."}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X24000200?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X24000200?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T05:03:43Z","timestamp":1777439023000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X24000200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":60,"alternative-id":["S0022510X24000200"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2024.122885","relation":{},"ISSN":["0022-510X"],"issn-type":[{"value":"0022-510X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification and characterization of novel ERBB4 variant associated with sporadic amyotrophic lateral sclerosis (ALS)","name":"articletitle","label":"Article Title"},{"value":"Journal of the Neurological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jns.2024.122885","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"122885"}}