{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T00:26:57Z","timestamp":1786753617129,"version":"build-2736575974"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","jns-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.jns.2024.123340","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T14:51:40Z","timestamp":1733755900000},"page":"123340","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Brain health: Pathway to primary prevention of neurodegenerative disorders of environmental origin"],"prefix":"10.1016","volume":"468","author":[{"given":"Peter S.","family":"Spencer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shala-Ghaderi","family":"Berntsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Buguet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Butterfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald B.","family":"Calne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Calne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Gim\u00e9nez-Rold\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Hugon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahiba","family":"Kahlon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glen E.","family":"Kisby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmeline","family":"Lagrange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Marie E.","family":"Landtblom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert C.","family":"Ludolph","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter B.","family":"Nunn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie S.","family":"Palmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Reis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo C.","family":"Rom\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jussi O.T.","family":"Sipil\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott S.","family":"Spencer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel Valdes","family":"Angues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Paul","family":"Vernoux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Momoko","family":"Yabushita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jns.2024.123340_bb0005","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/S1474-4422(24)00270-9","article-title":"World Brain Day 2024: a focus on brain health and prevention","volume":"23","author":"Grisold","year":"2024","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jns.2024.123340_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.jns.2024.123095","article-title":"World Brain Day 2024: promoting brain health and prevention","volume":"463","author":"Wijeratne","year":"2024","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.jns.2024.123340_bb0015","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12408","article-title":"Projected increase in amyotrophic lateral sclerosis from 2015 to 2040","volume":"7","author":"Arthur","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jns.2024.123340_bb0020","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1159\/000493386","article-title":"Amyotrophic lateral sclerosis descriptive epidemiology: the origin of geographic difference","volume":"52","author":"Logroscino","year":"2019","journal-title":"Neuroepidemiology"},{"issue":"s1","key":"10.1016\/j.jns.2024.123340_bb0025","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.3233\/JPD-181474","article-title":"The emerging evidence of the Parkinson pandemic","volume":"8","author":"Dorsey","year":"2018","journal-title":"J. Parkinsons Dis."},{"key":"10.1016\/j.jns.2024.123340_bb0030","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2021.776847","article-title":"Global trends in the incidence, prevalence, and years lived with disability of Parkinson\u2019s disease in 204 countries\/territories from 1990 to 2019","volume":"9","author":"Ou","year":"2021","journal-title":"Front. Public Health"},{"key":"10.1016\/j.jns.2024.123340_bb0035","doi-asserted-by":"crossref","DOI":"10.7189\/jogh.13.04160","article-title":"Global, regional, and national burden of neurological disorders in 204 countries and territories worldwide","volume":"13","author":"Huang","year":"2023","journal-title":"J. Glob. Health"},{"key":"10.1016\/j.jns.2024.123340_bb0040","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.937486","article-title":"Global, regional, and national burden of Alzheimer's disease and other dementias, 1990-2019","volume":"14","author":"Li","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.jns.2024.123340_bb0045","first-page":"1549","article-title":"Disappearance of ALS from Guam: implications for exogenous causes","volume":"35","author":"Chen","year":"1995","journal-title":"Rinsho Shinkeigaku"},{"key":"10.1016\/j.jns.2024.123340_bb0050","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.neuro.2016.03.017","article-title":"Seeking environmental causes of neurodegenerative disease and envisioning primary prevention","volume":"56","author":"Spencer","year":"2016","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.jns.2024.123340_bb0055","series-title":"Adv. Neurol.","first-page":"69","article-title":"Geographic isolates: their role in neuroepidemiology","volume":"Vol. 19","author":"Kurland","year":"1978"},{"key":"10.1016\/j.jns.2024.123340_bb0060","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1001\/jamaneurol.2013.1817","article-title":"C9orf72 hexanucleotide repeat expansion and Guam amyotrophic lateral sclerosis-parkinsonism-dementia complex","volume":"70","author":"Dombroski","year":"2013","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.jns.2024.123340_bb0065","article-title":"Increased threat of island endemic tree\u2019s extirpation via invasion-induced decline of intrinsic resistance to recurring tropical cyclones","volume":"6","author":"Marler","year":"2013","journal-title":"Commun. Integrat. Biol."},{"key":"10.1016\/j.jns.2024.123340_bb0070","doi-asserted-by":"crossref","unstructured":"P.S. Spencer, V.S. Palmer, G.F. Kisby GE. Western Pacific ALS-PDC: evidence implicating cycad genotoxins. J. Neurol. Sci. 2020;15:419:117185. doi:https:\/\/doi.org\/10.1016\/j.jns.2020.117185.","DOI":"10.1016\/j.jns.2020.117185"},{"key":"10.1016\/j.jns.2024.123340_bb0075","first-page":"659","article-title":"Amyotrophic lateral sclerosis and diabetes on Guam: changing patterns of chronic disease in an island community","volume":"34","author":"Haddock","year":"2003","journal-title":"Southeast Asian J. Trop. Med. Public Health"},{"key":"10.1016\/j.jns.2024.123340_bb0080","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1080\/0964704X.2021.1885946","article-title":"Lytico-bodig in Guam: historical links between diet and illness during and after Spanish colonization","volume":"30","author":"Gim\u00e9nez-Rold\u00e1n","year":"2021","journal-title":"J. Hist. Neurosci."},{"key":"10.1016\/j.jns.2024.123340_bb0085","series-title":"Toxicity of Cycads Implications for Neurodegenerative Diseases and Cancer. Transcripts of Four Cycad Conferences. New York","first-page":"5","article-title":"Transcript of proceedings of conference on the identification of toxic elements of cycads (plant family: Cycadaceae), National Institutes of Health, Bethesda, MD, February 28, 1962","author":"Whiting","year":"1988"},{"key":"10.1016\/j.jns.2024.123340_bb0090","doi-asserted-by":"crossref","unstructured":"D. Reed, D. Labarthe, K.M Chen, R. Stallones. A cohort study of amyotrophic lateral sclerosis and parkinsonism-dementia on Guam and Rota. Am. J. Epidemiol. 1987;125:92\u2013100. doi:https:\/\/doi.org\/10.1093\/oxfordjournals.aje.a114515.","DOI":"10.1093\/oxfordjournals.aje.a114515"},{"key":"10.1016\/j.jns.2024.123340_bb0095","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1212\/01.wnl.0000262027.31623.b2","article-title":"Cycad exposure and risk of dementia, MCI, and PDC in the Chamorro population of Guam","volume":"68","author":"Borenstein","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2024.123340_bb0100","series-title":"Handbook of Clinical Neurology, vol. 22, System Disorders and Atrophy, Part 2. Amsterdam, the Netherlands","first-page":"353","article-title":"ALS and parkinsonism-dementia in the Kii peninsula","author":"Shiraki","year":"1975"},{"key":"10.1016\/j.jns.2024.123340_bb0105","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1002\/mds.26264","article-title":"A unique retinal epitheliopathy is associated with amyotrophic lateral sclerosis\/parkinsonism-dementia complex of Guam","volume":"30","author":"Steele","year":"2015","journal-title":"Mov. Disord."},{"key":"10.1016\/j.jns.2024.123340_bb0110","doi-asserted-by":"crossref","first-page":"97","DOI":"10.2147\/EB.S260823","article-title":"Etiology of retinal and cerebellar pathology in Western Pacific amyotrophic lateral sclerosis and parkinsonism-dementia complex","volume":"12","author":"Spencer","year":"2020","journal-title":"Eye Brain"},{"key":"10.1016\/j.jns.2024.123340_bb0115","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1002\/ana.410080612","article-title":"Amyotrophic lateral sclerosis among Chamorro migrants from Guam","volume":"8","author":"Garruto","year":"1980","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.jns.2024.123340_bb0120","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1212\/WNL.58.1.90","article-title":"Clinical features and changing patterns of neurodegenerative disorders on Guam, 1997-2000","volume":"58","author":"Galasko","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2024.123340_bb0125","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1212\/WNL.36.1.7","article-title":"Amyotrophic lateral sclerosis and parkinsonism-dementia on Guam: a 30-year evaluation of clinical and neuropathologic trends","volume":"36","author":"Rodgers-Johnson","year":"1986","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2024.123340_bb0130","series-title":"AD\/PD 2025. Int. Conf. Alz. Park. Dis. Related Disorders, Vienna, Austria","article-title":"Municipality-specific incidence of amyotrophic lateral sclerosis and Parkinson\u2019s disease 2010\u20132018","author":"Sipil\u00e4","year":"2025"},{"key":"10.1016\/j.jns.2024.123340_bb0135","doi-asserted-by":"crossref","first-page":"7221","DOI":"10.3390\/ijms25137221","article-title":"Introducing the role of genotoxicity in neurodegenerative diseases and neuropsychiatric disorders","volume":"25","author":"Kisby","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jns.2024.123340_bb0140","first-page":"355","article-title":"Tumor induction in germfree rats with methylazoxymethanol (MAM) and synthetic MAM acetate","volume":"39","author":"Laqueur","year":"1967","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.jns.2024.123340_bb0145","doi-asserted-by":"crossref","first-page":"7906","DOI":"10.3390\/ijms25147906","article-title":"Tau beyond tangles: DNA damage response and cytoskeletal protein crosstalk on neurodegeneration","volume":"25","author":"Asada-Utsugi","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jns.2024.123340_bb0150","doi-asserted-by":"crossref","first-page":"8676","DOI":"10.1038\/s41467-024-52886-2","article-title":"Transcript errors generate amyloid-like proteins in human cells","volume":"15","author":"Chung","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jns.2024.123340_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102413","article-title":"Regulation of DNA damage response by RNA\/DNA-binding proteins: implications for neurological disorders and aging","volume":"100","author":"Kodavati","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.jns.2024.123340_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.dnarep.2024.103678","article-title":"Genomic stress and impaired DNA repair in Alzheimer disease","volume":"139","author":"Neven","year":"2024","journal-title":"DNA Repair (Amst)"},{"key":"10.1016\/j.jns.2024.123340_bb0165","article-title":"DNA damage and chromatin rearrangement work together to promote neurodegeneration","author":"Sharma","year":"2024","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.jns.2024.123340_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.dnarep.2024.103699","article-title":"Broken strands, broken minds: exploring the nexus of DNA damage and neurodegeneration","volume":"140","author":"Stavgiannoudaki","year":"2024","journal-title":"DNA Repair (Amst)"},{"key":"10.1016\/j.jns.2024.123340_bb0175","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s40478-024-01725-y","article-title":"The cycad genotoxin methylazoxymethanol, linked to Guam ALS\/PDC, induces transcriptional mutagenesis","volume":"12","author":"Verheijen","year":"2024","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.jns.2024.123340_bb0180","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1038\/s41593-024-01627-1","article-title":"Assessing the contribution of the chemical exposome to neurodegenerative disease","volume":"27","author":"Lefevre-Arbogast","year":"2024","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jns.2024.123340_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.jns.2021.117558","article-title":"An amyotrophic lateral sclerosis hot spot in the French Alps associated with genotoxic fungi","volume":"427","author":"Lagrange","year":"2021","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.jns.2024.123340_bb0190","article-title":"Corrected speciation and gyromitrin content of false morels linked to ALS patients with mostly slow-acetylator phenotypes","volume":"35","author":"Lagrange","year":"2024","journal-title":"eNeurol. Sci."},{"key":"10.1016\/j.jns.2024.123340_bb0195","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/00275514.2022.2146473","article-title":"Not all bad: Gyromitrin has a limited distribution in the false morels as determined by a new ultra high-performance liquid chromatography method","volume":"115","author":"Dirks","year":"2023","journal-title":"Mycologia"},{"key":"10.1016\/j.jns.2024.123340_bb0200","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1016\/0006-2952(93)90451-2","article-title":"Carbon-centered free radical formation during the metabolism of hydrazine derivatives by neutrophils","volume":"45","author":"Gamberini","year":"1993","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jns.2024.123340_bb0205","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s13002-019-0318-z","article-title":"Mushroom hunting and consumption in twenty-first century post-industrial Sweden","volume":"15","author":"Svanberg","year":"2019","journal-title":"J. Ethnobiol. Ethnomed."},{"key":"10.1016\/j.jns.2024.123340_bb0210","first-page":"40","article-title":"Uses of mushrooms by Finns and Karelians","volume":"57","author":"H\u00e4rk\u00f6nen","year":"1998","journal-title":"Int. J. Circumpolar Health"},{"key":"10.1016\/j.jns.2024.123340_bb0215","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1212\/WNL.42.7.1336","article-title":"Content of the neurotoxins cycasin (methylazoxymethanol beta-D-glucoside) and BMAA (beta-N-methylamino-L-alanine) in cycad flour prepared by Guam Chamorros","volume":"42","author":"Kisby","year":"1992","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2024.123340_bb0220","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1136\/jnnp.61.2.131","article-title":"Neuroepidemiology of amyotrophic lateral sclerosis: clues to aetiology and pathogenesis","volume":"61","author":"Rom\u00e1n","year":"1996","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.jns.2024.123340_bb0225","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1212\/WNL.43.6.1150","article-title":"Environmental antecedents of young-onset Parkinson\u2019s disease","volume":"43","author":"Butterfield","year":"1993","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2024.123340_bb0230","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/S0140-6736(86)90469-1","article-title":"Alzheimer's disease, Parkinson's disease, and motoneurone disease: abiotrophic interaction between ageing and environment?","volume":"2","author":"Calne","year":"1986","journal-title":"Lancet"},{"key":"10.1016\/j.jns.2024.123340_bb0235","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1017\/S0317167100026664","article-title":"Familial Parkinson's disease: possible role of environmental factors","volume":"14","author":"Calne","year":"1987","journal-title":"Can. J. Neurol. Sci."},{"key":"10.1016\/j.jns.2024.123340_bb0240","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0021-9673(00)92601-3","article-title":"Determination of paraquat in sunflower seeds by reversed-phase high-performance liquid chromatography","volume":"177","author":"Paschal","year":"1979","journal-title":"J. Chromatogr."},{"key":"10.1016\/j.jns.2024.123340_bb0245","doi-asserted-by":"crossref","DOI":"10.1093\/ije\/dyae004","article-title":"Agricultural paraquat dichloride use and Parkinson's disease in California's Central Valley","volume":"53","author":"Paul","year":"2024","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.jns.2024.123340_bb0250","doi-asserted-by":"crossref","first-page":"2942","DOI":"10.55905\/rdelosv16.n47-027","article-title":"Paraquat action in reproductive phases of sunflower on agronomic behavior and seed quality","volume":"16","author":"Farias","year":"2023","journal-title":"Rev. Delos."},{"key":"10.1016\/j.jns.2024.123340_bb0255","doi-asserted-by":"crossref","DOI":"10.3390\/foods12234328","article-title":"Fungal and toxin contaminants in cereal grains and flours: systematic review and meta-analysis","volume":"12","author":"Deligeorgakis","year":"2023","journal-title":"Foods"},{"key":"10.1016\/j.jns.2024.123340_bb0260","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.4315\/0362-028X-58.10.1133","article-title":"Alternaria mycotoxins in sunflower seeds: incidence and distribution of the toxins in oil and meal","volume":"58","author":"Chulze","year":"1995","journal-title":"J. Food Prot."},{"key":"10.1016\/j.jns.2024.123340_bb0265","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1007\/s00204-024-03743-0","article-title":"The characteristics, occurrence, and toxicological effects of alternariol: a mycotoxin","volume":"98","author":"Saleh","year":"2024","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.jns.2024.123340_bb0270","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.fct.2015.11.022","article-title":"Alternariol induce toxicity via cell death and mitochondrial damage on Caco-2 cells","volume":"88","author":"Fern\u00e1ndez-Blanco","year":"2016","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jns.2024.123340_bb0275","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s13024-023-00676-7","article-title":"Mitochondrial dysfunction in Parkinson\u2019s disease - a key disease hallmark with therapeutic potential","volume":"18","author":"Henrich","year":"2023","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.jns.2024.123340_bb0280","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/S1474-4422(18)30072-3","article-title":"MPTP-induced parkinsonism: an historical case series","volume":"17","author":"Nonnekes","year":"2018","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jns.2024.123340_bb0285","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a009308","article-title":"Modeling Parkinson\u2019s disease in primates: the MPTP model","volume":"2","author":"Porras","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.jns.2024.123340_bb0290","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2023.1005096","article-title":"Early-onset, conjugal, twin-discordant, and clusters of sporadic ALS: pathway to discovery of etiology via lifetime exposome research","volume":"17","author":"Spencer","year":"2023","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.jns.2024.123340_bb0295","first-page":"37","article-title":"Preliminary study of possible risk factors for amyotrophic lateral sclerosis in Gulf War & Gulf-era Veterans","volume":"12","author":"Palmer","year":"2002","journal-title":"Oregon Health Sci. Univ. Center Res. Occup. Environ. Toxicol."},{"key":"10.1016\/j.jns.2024.123340_bb0300","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1097\/ACM.0000000000000363","article-title":"Interprofessional global health education in a cosmopolitan community of North America: the iCHEE experience","volume":"89","author":"Palmer","year":"2014","journal-title":"Acad. Med."},{"key":"10.1016\/j.jns.2024.123340_bb0305","doi-asserted-by":"crossref","DOI":"10.1016\/j.jns.2024.123117","article-title":"Developing education in environmental health and medicine focusing on neurology: initiatives in Sweden (the UPRISE model), France, and Turkey","volume":"463","author":"Berntsson","year":"2024","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.jns.2024.123340_bb0310","doi-asserted-by":"crossref","DOI":"10.1016\/j.jns.2024.123252","article-title":"Bridging transdisciplinary in medical education: a pathway to achieve SDG 3 in Global Health","volume":"466","author":"Hasanah","year":"2024","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.jns.2024.123340_bb0315","doi-asserted-by":"crossref","first-page":"S119","DOI":"10.1002\/mds.20552","article-title":"On the decline and etiology of high-incidence motor system disease in West Papua (Southwest New Guinea)","volume":"20","author":"Spencer","year":"2005","journal-title":"Mov. Disord."},{"key":"10.1016\/j.jns.2024.123340_bb0320","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2013-004353","article-title":"Amyotrophic lateral sclerosis and parkinsonism in Papua, Indonesia: 2001-2012 survey results","volume":"4","author":"Okumiya","year":"2014","journal-title":"BMJ Open"},{"key":"10.1016\/j.jns.2024.123340_bb0325","author":"EPA"},{"key":"10.1016\/j.jns.2024.123340_bb0330","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.3390\/ijerph9082875","volume":"9","author":"Leukemia","year":"2012","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.jns.2024.123340_bb0335","author":"National Cancer Institute"}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X24004763?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X24004763?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T01:58:44Z","timestamp":1736474324000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X24004763"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":67,"alternative-id":["S0022510X24004763"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2024.123340","relation":{},"ISSN":["0022-510X"],"issn-type":[{"value":"0022-510X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Brain health: Pathway to primary prevention of neurodegenerative disorders of environmental origin","name":"articletitle","label":"Article Title"},{"value":"Journal of the Neurological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jns.2024.123340","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"123340"}}