{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T05:26:46Z","timestamp":1740547606679,"version":"3.38.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["226-2023-00153"],"award-info":[{"award-number":["226-2023-00153"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271735"],"award-info":[{"award-number":["82271735"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022963","name":"Key Research and Development Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2022C03167","2022C03111"],"award-info":[{"award-number":["2022C03167","2022C03111"]}],"id":[{"id":"10.13039\/100022963","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","jns-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.jns.2025.123415","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T23:53:57Z","timestamp":1738972437000},"page":"123415","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Echocardiographic evaluation of left ventricular function in children with spinal muscular atrophy before and after nusinersen treatment"],"prefix":"10.1016","volume":"470","author":[{"given":"Xingpeng","family":"Fu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yijie","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiqin","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yicheng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"Qian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanshan","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jns.2025.123415_bb0005","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/(SICI)1098-1004(200003)15:3<228::AID-HUMU3>3.0.CO;2-9","article-title":"An update of the mutation spectrum of the survival motor neuron gene (SMN1) in autosomal recessive spinal muscular atrophy (SMA)","volume":"15","author":"Wirth","year":"2000","journal-title":"Hum Mutat"},{"key":"10.1016\/j.jns.2025.123415_bb0010","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/joa.12083","article-title":"Spinal muscular atrophy: a motor neuron disorder or a multi-organ disease?","volume":"224","author":"Shababi","year":"2014","journal-title":"J Anat"},{"key":"10.1016\/j.jns.2025.123415_bb0015","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S1525-1578(10)60680-0","article-title":"Spinal muscular atrophy genetic testing experience at an academic medical center","volume":"4","author":"Ogino","year":"2002","journal-title":"J Mol Diagn"},{"key":"10.1016\/j.jns.2025.123415_bb0020","doi-asserted-by":"crossref","first-page":"4059","DOI":"10.1093\/hmg\/ddq329","article-title":"Cardiac defects contribute to the pathology of spinal muscular atrophy models","volume":"19","author":"Shababi","year":"2010","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jns.2025.123415_bb0025","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.nmd.2017.11.005","article-title":"Diagnosis and management of spinal muscular atrophy: Part 1: Recommendations for diagnosis, rehabilitation, orthopedic and nutritional care","volume":"28","author":"Mercuri","year":"2018","journal-title":"Neuromuscul Disord"},{"key":"10.1016\/j.jns.2025.123415_bb0030","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/s41572-022-00380-8","article-title":"Spinal muscular atrophy","volume":"8","author":"Mercuri","year":"2022","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.jns.2025.123415_bb0035","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s13023-017-0613-5","article-title":"Cardiac pathology in spinal muscular atrophy: a systematic review","volume":"12","author":"Wijngaarde","year":"2017","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.jns.2025.123415_bb0040","article-title":"The alteration of left ventricular strain in later-onset spinal muscular atrophy children","volume":"16","author":"Cui","year":"2022","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.jns.2025.123415_bb0045","doi-asserted-by":"crossref","DOI":"10.1111\/ped.15769","article-title":"Cardiac function evaluation in children with spinal muscular atrophy: A case-control study","volume":"66","author":"He","year":"2024","journal-title":"Pediatr Int"},{"key":"10.1016\/j.jns.2025.123415_bb0050","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1002\/jcph.884","article-title":"Population Pharmacokinetics of Nusinersen in the Cerebral Spinal Fluid and Plasma of Pediatric Patients With Spinal Muscular Atrophy Following Intrathecal Administrations","volume":"57","author":"Luu","year":"2017","journal-title":"J Clin Pharmacol"},{"key":"10.1016\/j.jns.2025.123415_bb0055","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s10928-021-09761-0","article-title":"A physiologically-based pharmacokinetic model to describe antisense oligonucleotide distribution after intrathecal administration","volume":"48","author":"Monine","year":"2021","journal-title":"J Pharmacokinet Pharmacodyn"},{"key":"10.1016\/j.jns.2025.123415_bb0060","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1056\/NEJMoa1702752","article-title":"Nusinersen versus Sham Control in Infantile-Onset Spinal Muscular Atrophy","volume":"377","author":"Finkel","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jns.2025.123415_bb0065","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1056\/NEJMoa1710504","article-title":"Nusinersen versus Sham Control in Later-Onset Spinal Muscular Atrophy","volume":"378","author":"Mercuri","year":"2018","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jns.2025.123415_bb0070","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1093\/eurheartj\/ehv529","article-title":"Myocardial strain imaging: how useful is it in clinical decision making?","volume":"37","author":"Smiseth","year":"2016","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jns.2025.123415_bb0075","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.jcmg.2017.11.017","article-title":"Assessment of Left Ventricular Function by Echocardiography: The Case for Routinely Adding Global Longitudinal Strain to Ejection Fraction","volume":"11","author":"Potter","year":"2018","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.jns.2025.123415_bb0080","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1093\/ehjci\/jex140","article-title":"Echocardiographic reference ranges for normal left ventricular 2D strain: results from the EACVI NORRE study","volume":"18","author":"Sugimoto","year":"2017","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.jns.2025.123415_bb0085","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.acvd.2016.11.003","article-title":"Left ventricular dyssynchrony and 2D and 3D global longitudinal strain for differentiating physiological and pathological left ventricular hypertrophy","volume":"110","author":"Ternacle","year":"2017","journal-title":"Arch Cardiovasc Dis"},{"key":"10.1016\/j.jns.2025.123415_bb0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.echo.2014.10.003","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"28","author":"Lang","year":"2015","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.jns.2025.123415_bb0095","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.echo.2008.02.006","article-title":"Regression equations for calculation of z scores of cardiac structures in a large cohort of healthy infants, children, and adolescents: an echocardiographic study","volume":"21","author":"Pettersen","year":"2008","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.jns.2025.123415_bb0100","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1002\/jcu.23252","article-title":"Percentile curves of normal echocardiographic measurements values for left heart structures in 1570 Han Chinese preterm and term infants","volume":"50","author":"Wang","year":"2022","journal-title":"J Clin Ultrasound"},{"key":"10.1016\/j.jns.2025.123415_bb0105","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1136\/heartjnl-2012-302353","article-title":"Relative apical sparing of longitudinal strain using two-dimensional speckle-tracking echocardiography is both sensitive and specific for the diagnosis of cardiac amyloidosis","volume":"98","author":"Phelan","year":"2012","journal-title":"Heart"},{"key":"10.1016\/j.jns.2025.123415_bb0110","doi-asserted-by":"crossref","first-page":"oeac10","DOI":"10.1093\/ehjopen\/oeac010","article-title":"Coronary-specific quantification of myocardial deformation by strain echocardiography may disclose the culprit vessel in patients with non-ST-segment elevation acute coronary syndrome","volume":"2","author":"Guaricci","year":"2022","journal-title":"Eur Heart J Open"},{"key":"10.1016\/j.jns.2025.123415_bb0115","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1136\/heartjnl-2014-307391","article-title":"Subclinical LV dysfunction and 10-year outcomes in type 2 diabetes mellitus","volume":"101","author":"Holland","year":"2015","journal-title":"Heart"},{"key":"10.1016\/j.jns.2025.123415_bb0120","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1001\/jamacardio.2019.2952","article-title":"Assessment of Prognostic Value of Left Ventricular Global Longitudinal Strain for Early Prediction of Chemotherapy-Induced Cardiotoxicity: A Systematic Review and Meta-analysis","volume":"4","author":"Oikonomou","year":"2019","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jns.2025.123415_bb0125","first-page":"15","article-title":"Global Longitudinal Strain in Cardio-Oncology: A Review","author":"Slawinski","year":"2023","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jns.2025.123415_bb0130","doi-asserted-by":"crossref","DOI":"10.1007\/s00392-024-02548-6","article-title":"Subclinical left ventricular dysfunction in rheumatoid arthritis: findings from the prospective Porto-RA cohort","author":"Alexandre","year":"2024","journal-title":"Clin Res Cardiol"},{"key":"10.1016\/j.jns.2025.123415_bb0135","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0213680","article-title":"Systemic nature of spinal muscular atrophy revealed by studying insurance claims","volume":"14","author":"Lipnick","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.jns.2025.123415_bb0140","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1093\/eurheartj\/ehaa522","article-title":"Myocardial involvement in Kugelberg-Welander disease","volume":"41","author":"Sokolska","year":"2020","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jns.2025.123415_bb0145","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1097\/PHM.0b013e31804b1d66","article-title":"Medical considerations of long-term survival of Werdnig-Hoffmann disease","volume":"86","author":"Bach","year":"2007","journal-title":"Am J Phys Med Rehabil"},{"key":"10.1016\/j.jns.2025.123415_bb0150","doi-asserted-by":"crossref","first-page":"3906","DOI":"10.1093\/hmg\/ddq330","article-title":"Arrhythmia and cardiac defects are a feature of spinal muscular atrophy model mice","volume":"19","author":"Heier","year":"2010","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jns.2025.123415_bb0155","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/ejhg.2012.222","article-title":"Severe SMA mice show organ impairment that cannot be rescued by therapy with the HDACi JNJ-26481585","volume":"21","author":"Schreml","year":"2013","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.jns.2025.123415_bb0160","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.1093\/hmg\/ddad121","article-title":"AAV9-mediated SMN gene therapy rescues cardiac desmin but not lamin A\/C and elastin dysregulation in Smn2B\/- spinal muscular atrophy mice","volume":"32","author":"Brown","year":"2023","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jns.2025.123415_bb0165","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1093\/cvr\/cvx183","article-title":"Cardiac troponins: from myocardial infarction to chronic disease","volume":"113","author":"Park","year":"2017","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jns.2025.123415_bb0170","doi-asserted-by":"crossref","first-page":"e618","DOI":"10.1161\/CIR.0000000000000617","article-title":"Fourth Universal Definition of Myocardial Infarction (2018)","volume":"138","author":"Thygesen","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.jns.2025.123415_bb0175","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/mus.27088","article-title":"Cardiac findings in pediatric patients with spinal muscular atrophy types 2 and 3","volume":"63","author":"Djordjevic","year":"2021","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.jns.2025.123415_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.jns.2023.122816","article-title":"Troponin T in spinal and bulbar muscular atrophy (SBMA)","volume":"456","author":"Musso","year":"2024","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.jns.2025.123415_bb0185","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1016\/j.amjcard.2019.01.044","article-title":"Normal Values for Left Ventricular Strain and Synchrony in Children Based on Speckle Tracking Echocardiography","volume":"123","author":"Adar","year":"2019","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jns.2025.123415_bb0190","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1017\/S1047951118002378","article-title":"Reference values for two-dimensional myocardial strain echocardiography of the left ventricle in healthy children","volume":"29","author":"Koopman","year":"2019","journal-title":"Cardiol Young"},{"key":"10.1016\/j.jns.2025.123415_bb0195","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/S0140-6736(04)17018-9","article-title":"Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study","volume":"364","author":"Yusuf","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.jns.2025.123415_bb0200","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1093\/hmg\/6.8.1205","article-title":"The survival motor neuron protein in spinal muscular atrophy","volume":"6","author":"Coovert","year":"1997","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jns.2025.123415_bb0205","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.molmed.2012.11.002","article-title":"Spinal muscular atrophy: going beyond the motor neuron","volume":"19","author":"Hamilton","year":"2013","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.jns.2025.123415_bb0210","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.1093\/hmg\/ddy195","article-title":"Temporal and tissue-specific variability of SMN protein levels in mouse models of spinal muscular atrophy","volume":"27","author":"Groen","year":"2018","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jns.2025.123415_bb0215","doi-asserted-by":"crossref","first-page":"3895","DOI":"10.1093\/hmg\/ddq300","article-title":"Early heart failure in the SMNDelta7 model of spinal muscular atrophy and correction by postnatal scAAV9-SMN delivery","volume":"19","author":"Bevan","year":"2010","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jns.2025.123415_bb0220","doi-asserted-by":"crossref","first-page":"E5863","DOI":"10.1073\/pnas.1509758112","article-title":"Systemic, postsymptomatic antisense oligonucleotide rescues motor unit maturation delay in a new mouse model for type II\/III spinal muscular atrophy","volume":"112","author":"Bogdanik","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jns.2025.123415_bb0225","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1111\/joa.12793","article-title":"Developmental and degenerative cardiac defects in the Taiwanese mouse model of severe spinal muscular atrophy","volume":"232","author":"Maxwell","year":"2018","journal-title":"J Anat"},{"key":"10.1016\/j.jns.2025.123415_bb0230","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1101\/gad.1941310","article-title":"Antisense correction of SMN2 splicing in the CNS rescues necrosis in a type III SMA mouse model","volume":"24","author":"Hua","year":"2010","journal-title":"Genes Dev"},{"key":"10.1016\/j.jns.2025.123415_bb0235","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1212\/WNL.0000000000002445","article-title":"Results from a phase 1 study of nusinersen (ISIS-SMN(Rx)) in children with spinal muscular atrophy","volume":"86","author":"Chiriboga","year":"2016","journal-title":"Neurology"}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X25000322?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X25000322?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T14:04:00Z","timestamp":1740492240000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X25000322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":47,"alternative-id":["S0022510X25000322"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2025.123415","relation":{},"ISSN":["0022-510X"],"issn-type":[{"type":"print","value":"0022-510X"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Echocardiographic evaluation of left ventricular function in children with spinal muscular atrophy before and after nusinersen treatment","name":"articletitle","label":"Article Title"},{"value":"Journal of the Neurological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jns.2025.123415","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"123415"}}