{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T10:54:26Z","timestamp":1781520866453,"version":"3.54.1"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["V113B-018"],"award-info":[{"award-number":["V113B-018"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jns-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.jns.2025.123467","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T13:19:06Z","timestamp":1742217546000},"page":"123467","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Peripapillary vessel wall changes correlate with disease severity in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)"],"prefix":"10.1016","volume":"472","author":[{"given":"Sheng-Chu","family":"Chi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin-Ho","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Chu","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An-Guor","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Chung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Chen","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.jns.2025.123467_bb0005","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S1474-4422(09)70127-9","article-title":"Cadasil","volume":"8","author":"Chabriat","year":"2009","journal-title":"Lancet Neurol."},{"issue":"6602","key":"10.1016\/j.jns.2025.123467_bb0010","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/383707a0","article-title":"Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia","volume":"383","author":"Joutel","year":"1996","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.jns.2025.123467_bb0015","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12916-017-0778-8","article-title":"Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) as a model of small vessel disease: update on clinical, diagnostic, and management aspects","volume":"15","author":"Di Donato","year":"2017","journal-title":"BMC Med."},{"issue":"10","key":"10.1016\/j.jns.2025.123467_bb0020","first-page":"2481","article-title":"The spatial distribution of MR imaging abnormalities in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy and their relationship to age and clinical features","volume":"26","author":"Singhal","year":"2005","journal-title":"AJNR Am. J. Neuroradiol."},{"issue":"5","key":"10.1016\/j.jns.2025.123467_bb0025","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1212\/WNL.56.5.628","article-title":"MRI hyperintensities of the temporal lobe and external capsule in patients with CADASIL","volume":"56","author":"O\u2019Sullivan","year":"2001","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.jns.2025.123467_bb0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.17305\/bjbms.2015.247","article-title":"Imaging characteristics of cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL)","volume":"15","author":"Stojanov","year":"2015","journal-title":"Bosn. J. Basic Med. Sci."},{"issue":"10","key":"10.1016\/j.jns.2025.123467_bb0035","first-page":"1307","article-title":"Renal involvement in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL): report of a case with a six-year follow-up","volume":"27","author":"Ragno","year":"2012","journal-title":"Histol. Histopathol."},{"issue":"3","key":"10.1016\/j.jns.2025.123467_bb0040","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.624","article-title":"CADASIL: ultrastructural insights into the morphology of granular osmiophilic material","volume":"7","author":"Lorenzi","year":"2017","journal-title":"Brain Behav."},{"issue":"13","key":"10.1016\/j.jns.2025.123467_bb0045","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.016233","article-title":"Cerebral microbleed burdens in specific brain regions are associated with disease severity of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy","volume":"9","author":"Chung","year":"2020","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.jns.2025.123467_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.jns.2024.123109","article-title":"Nailfold capillary measurements correlated to NOTCH3 R544C mutation in preclinical CADASIL patients","volume":"462","author":"Liang","year":"2024","journal-title":"J. Neurol. Sci."},{"issue":"8","key":"10.1016\/j.jns.2025.123467_bb0055","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0136501","article-title":"Characterization of CADASIL among the Han Chinese in Taiwan: distinct genotypic and phenotypic profiles","volume":"10","author":"Liao","year":"2015","journal-title":"PLoS ONE"},{"issue":"8","key":"10.1016\/j.jns.2025.123467_bb0060","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1016\/j.ophtha.2006.03.030","article-title":"Ophthalmologic findings in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: a cross-sectional study","volume":"113","author":"Roine","year":"2006","journal-title":"Ophthalmology"},{"issue":"11","key":"10.1016\/j.jns.2025.123467_bb0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0112311","article-title":"Multimodal retinal vessel analysis in CADASIL patients","volume":"9","author":"Alten","year":"2014","journal-title":"PLoS ONE"},{"issue":"9","key":"10.1016\/j.jns.2025.123467_bb0070","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.4103\/0366-6999.204935","article-title":"Study of enhanced depth imaging optical coherence tomography in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy","volume":"130","author":"Fang","year":"2017","journal-title":"Chin. Med. J."},{"issue":"1","key":"10.1016\/j.jns.2025.123467_bb0075","doi-asserted-by":"crossref","first-page":"8148","DOI":"10.1038\/s41598-018-26475-5","article-title":"OCT-angiography reveals reduced vessel density in the deep retinal plexus of CADASIL patients","volume":"8","author":"Nelis","year":"2018","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.jns.2025.123467_bb0080","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0268572","article-title":"Reduced macular vessel density and inner retinal thickness correlate with the severity of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)","volume":"17","author":"Lin","year":"2022","journal-title":"PLoS ONE"},{"issue":"11","key":"10.1016\/j.jns.2025.123467_bb0085","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1038\/s41433-022-02328-4","article-title":"Ophthalmic characteristics and retinal vasculature changes in Williams syndrome, and its association with systemic diseases","volume":"37","author":"Yeh","year":"2023","journal-title":"Eye (Lond)"},{"issue":"5 Supplement","key":"10.1016\/j.jns.2025.123467_bb0090","first-page":"741","article-title":"Early treatment diabetic retinopathy study design and baseline patient characteristics: ETDRS report number 7","volume":"98","year":"1991","journal-title":"Ophthalmology"},{"issue":"1","key":"10.1016\/j.jns.2025.123467_bb0095","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0022-510X(93)90041-V","article-title":"A semiquantative rating scale for the assessment of signal hyperintensities on magnetic resonance imaging","volume":"114","author":"Scheltens","year":"1993","journal-title":"J. Neurol. Sci."},{"issue":"8","key":"10.1016\/j.jns.2025.123467_bb0100","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1212\/WNL.59.8.1134","article-title":"Diagnostic strategies in CADASIL","volume":"59","author":"Markus","year":"2002","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.jns.2025.123467_bb0105","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J. Psychiatr. Res."},{"issue":"2","key":"10.1016\/j.jns.2025.123467_bb0110","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1177\/1073191115602552","article-title":"The trail making test","volume":"24","author":"Llin\u00e0s-Regl\u00e0","year":"2017","journal-title":"Assessment"},{"issue":"5","key":"10.1016\/j.jns.2025.123467_bb0115","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1161\/STROKEAHA.111.000721","article-title":"Advanced intimal hyperplasia without luminal narrowing of leptomeningeal arteries in CADASIL","volume":"44","author":"Dong","year":"2013","journal-title":"Stroke"},{"key":"10.1016\/j.jns.2025.123467_bb0120","article-title":"The pericyte: a critical cell in the pathogenesis of CADASIL","volume":"2","author":"Ruchoux","year":"2021","journal-title":"Cereb. Circ. Cogn. Behav."},{"issue":"12","key":"10.1016\/j.jns.2025.123467_bb0125","doi-asserted-by":"crossref","first-page":"2812","DOI":"10.1161\/STROKEAHA.110.586883","article-title":"Lenticulostriate arterial lumina are normal in cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy: a high-field in vivo MRI study","volume":"41","author":"Liem","year":"2010","journal-title":"Stroke"},{"issue":"4","key":"10.1016\/j.jns.2025.123467_bb0130","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1111\/j.1750-3639.2004.tb00078.x","article-title":"Fibrosis and stenosis of the long penetrating cerebral arteries: the cause of the white matter pathology in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy","volume":"14","author":"Miao","year":"2004","journal-title":"Brain Pathol."},{"issue":"1","key":"10.1016\/j.jns.2025.123467_bb0135","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1097\/WNO.0b013e318267fd5f","article-title":"Retinal nerve fiber layer thickness in patients with Alzheimer disease","volume":"33","author":"Kirbas","year":"2013","journal-title":"J. Neuroophthalmol."},{"issue":"6","key":"10.1016\/j.jns.2025.123467_bb0140","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1111\/j.1468-1331.2007.01795.x","article-title":"Reduction of optic nerve fiber layer thickness in CADASIL","volume":"14","author":"Parisi","year":"2007","journal-title":"Eur. J. Neurol."},{"issue":"1","key":"10.1016\/j.jns.2025.123467_bb0145","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1159\/000321339","article-title":"Retinal nerve fiber layer thinning in CADASIL: an optical coherence tomography and MRI study","volume":"31","author":"Rufa","year":"2011","journal-title":"Cerebrovasc. Dis."}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X2500084X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X2500084X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T22:51:38Z","timestamp":1762210298000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X2500084X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":29,"alternative-id":["S0022510X2500084X"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2025.123467","relation":{},"ISSN":["0022-510X"],"issn-type":[{"value":"0022-510X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Peripapillary vessel wall changes correlate with disease severity in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)","name":"articletitle","label":"Article Title"},{"value":"Journal of the Neurological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jns.2025.123467","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"123467"}}