{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T03:42:42Z","timestamp":1752550962597,"version":"3.41.0"},"reference-count":13,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:00:00Z","timestamp":1747094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jns-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.jns.2025.123533","type":"journal-article","created":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T14:59:00Z","timestamp":1746889140000},"page":"123533","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Safety assessment of switching from fingolimod to siponimod: An Italian multicenter prospective study"],"prefix":"10.1016","volume":"474","author":[{"given":"Gianmarco","family":"Abbadessa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Schiavetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Bollo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Cellerino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppina","family":"Miele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aurora","family":"Zangh\u00ec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Cavalla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessio","family":"Signori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Bulgari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Trotta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Scarano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Fantozzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doriana","family":"Landi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krzysztof","family":"Smolik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina Torri","family":"Clerici","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"De Luca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiana","family":"Marinelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Buttari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marinella","family":"Clerico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gina","family":"Ferrazzano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Chiara","family":"Buscarinu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Livia","family":"Pasquali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaria","family":"Tomasso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Vercellino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Maida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Floriana","family":"Bile","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Lavorgna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuele","family":"D\u2019Amico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matilde","family":"Inglese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Pia","family":"Sormani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Iaffaldano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Bonavita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"Pt 3","key":"10.1016\/j.jns.2025.123533_bb0005","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1093\/brain\/awm329","article-title":"Disability and T2 MRI lesions: a 20-year follow-up of patients with relapse onset of multiple sclerosis","volume":"131","author":"Fisniku","year":"2008","journal-title":"Brain"},{"issue":"1","key":"10.1016\/j.jns.2025.123533_bb0010","doi-asserted-by":"crossref","DOI":"10.1002\/hsr2.474","article-title":"Transition to secondary progressive multiple sclerosis: the consequences for patients and healthcare systems, a healthcare professional survey","volume":"5","author":"Caseby","year":"2022","journal-title":"Health Sci Rep."},{"key":"10.1016\/j.jns.2025.123533_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2021.103174","article-title":"Results from SPECTRUM: a survey of healthcare professionals to understand current diagnosis and management practices for secondary progressive multiple sclerosis in the United Kingdom","volume":"55","author":"Duddy","year":"2021","journal-title":"Mult. Scler. Relat. Disord."},{"issue":"1","key":"10.1016\/j.jns.2025.123533_bb0020","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1080\/13696998.2022.2078103","article-title":"Stick or twist? Cost-effectiveness of siponimod compared with continuing existing disease-modifying therapies in the treatment of active secondary progressive multiple sclerosis in the UK","volume":"25","author":"Montgomery","year":"2022","journal-title":"J. Med. Econ."},{"issue":"3","key":"10.1016\/j.jns.2025.123533_bb0025","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0264123","article-title":"Cost-effectiveness and budget impact analysis of siponimod in the treatment of secondary progressive multiple sclerosis in Italy","volume":"17","author":"Cortesi","year":"2022","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.jns.2025.123533_bb0030","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s40273-021-01023-8","article-title":"Cost effectiveness and budget impact of Siponimod compared to interferon Beta-1a in the treatment of adult patients with secondary progressive multiple sclerosis with active disease in Switzerland","volume":"39","author":"Schur","year":"2021","journal-title":"Pharmacoeconomics"},{"issue":"20","key":"10.1016\/j.jns.2025.123533_bb0035","doi-asserted-by":"crossref","first-page":"6033","DOI":"10.3390\/jcm11206033","article-title":"Disease reactivation in secondary progressive multiple sclerosis patients switching from Fingolimod to Siponimod: a case series","volume":"11","author":"Abbadessa","year":"2022","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.jns.2025.123533_bb0040","doi-asserted-by":"crossref","first-page":"100346","DOI":"10.1016\/j.ensci.2021.100346","article-title":"Disease reactivation in a patient with secondary progressive multiple sclerosis after switching treatment from fingolimod to siponimod","volume":"23","author":"Senzaki","year":"2021","journal-title":"eNeurologicalSci"},{"issue":"4837\u20134838","key":"10.1016\/j.jns.2025.123533_bb0045","first-page":"20210814","article-title":"Severe lymphopenia switching from Fingolimod to Siponimod","volume":"42","author":"Sparaco","year":"2021","journal-title":"Neurol. Sci."},{"year":"2015","series-title":"Guideline on clinical investigation of medicinal products for the treatment of Multiple Sclerosis","author":"European Medicines Agency Science Medicines Health","key":"10.1016\/j.jns.2025.123533_bb0050"},{"issue":"8","key":"10.1016\/j.jns.2025.123533_bb0060","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1111\/ene.15406","article-title":"Confirmed disability progression as a marker of permanent disability in multiple sclerosis","volume":"29","author":"Sharmin","year":"2022","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.jns.2025.123533_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2023.104766","article-title":"Effects of baseline age and disease duration on the efficacy and safety of siponimod in patients with active SPMS: post hoc analyses from the EXPAND study","volume":"75","author":"Hua","year":"2023","journal-title":"Mult. Scler. Relat. Disord."},{"issue":"4","key":"10.1016\/j.jns.2025.123533_bb0070","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1002\/acn3.52017","article-title":"Sphingosine 1-phosphate receptor modulators in multiple sclerosis treatment: a practical review","volume":"11","author":"Coyle","year":"2024","journal-title":"Ann. Clin. Transl. Neurol."}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X25001509?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X25001509?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T14:35:15Z","timestamp":1751207715000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X25001509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":13,"alternative-id":["S0022510X25001509"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2025.123533","relation":{},"ISSN":["0022-510X"],"issn-type":[{"type":"print","value":"0022-510X"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Safety assessment of switching from fingolimod to siponimod: An Italian multicenter prospective study","name":"articletitle","label":"Article Title"},{"value":"Journal of the Neurological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jns.2025.123533","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"123533"}}