{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:44:50Z","timestamp":1780469090413,"version":"3.54.1"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS12731"],"award-info":[{"award-number":["R01NS12731"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS092207"],"award-info":[{"award-number":["R01NS092207"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS125635"],"award-info":[{"award-number":["R01NS125635"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jns-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.jns.2025.123598","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T17:28:47Z","timestamp":1751563727000},"page":"123598","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Quantitative analysis of cerebral vasculature and its clinical effect on cognitive change in Alzheimer's dementia and mild cognitive impairment"],"prefix":"10.1016","volume":"476","author":[{"given":"Taewon","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In-Uk","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seunghee","family":"Na","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel S.","family":"Hippe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gador","family":"Canton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Hatsukami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmud","family":"Mossa-Basha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niranjan","family":"Balu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jns.2025.123598_bb0005","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s12916-014-0206-2","article-title":"The overlap between vascular disease and Alzheimer\u2019s disease - lessons from pathology","volume":"12","author":"Attems","year":"2014","journal-title":"BMC Med."},{"issue":"10248","key":"10.1016\/j.jns.2025.123598_bb0010","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0140-6736(20)30367-6","article-title":"Dementia prevention, intervention, and care: 2020 report of the Lancet Commission","volume":"396","author":"Livingston","year":"2020","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.jns.2025.123598_bb0015","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1097\/WAD.0000000000000442","article-title":"Apolipoprotein E4 moderates the association between vascular risk factors and brain pathology","volume":"35","author":"Kaufman","year":"2021","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"10.1016\/j.jns.2025.123598_bb0020","author":"Workgroup"},{"key":"10.1016\/j.jns.2025.123598_bb0025","doi-asserted-by":"crossref","first-page":"927","DOI":"10.3389\/fneur.2020.00927","article-title":"Cerebral small vessel disease and Alzheimer\u2019s disease: a review","volume":"11","author":"Kim","year":"2020","journal-title":"Front. Neurol."},{"issue":"16","key":"10.1016\/j.jns.2025.123598_bb0030","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1212\/WNL.0000000000003837","article-title":"Intracranial atherosclerosis and dementia: the atherosclerosis risk in communities (ARIC) study","volume":"88","author":"Dearborn","year":"2017","journal-title":"Neurology"},{"issue":"11","key":"10.1016\/j.jns.2025.123598_bb0035","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1161\/01.ATV.0000095973.42032.44","article-title":"Circle of Willis atherosclerosis is a risk factor for sporadic Alzheimer\u2019s disease","volume":"23","author":"Roher","year":"2003","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"4","key":"10.1016\/j.jns.2025.123598_bb0040","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.jalz.2010.08.228","article-title":"Intracranial atherosclerosis as a contributing factor to Alzheimer\u2019s disease dementia","volume":"7","author":"Roher","year":"2011","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.jns.2025.123598_bb0045","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.dadm.2017.10.001","article-title":"Lower cerebral blood flow in subjects with Alzheimer's dementia, mild cognitive impairment, and subjective cognitive decline using two-dimensional phase-contrast magnetic resonance imaging","volume":"9","author":"Leijenaar","year":"2017","journal-title":"Alzheimers Dement. (Amst)"},{"key":"10.1016\/j.jns.2025.123598_bb0050","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.mri.2021.02.012","article-title":"Vessel length on SNAP MRA and TOF MRA is a potential imaging biomarker for brain blood flow","volume":"79","author":"Gould","year":"2021","journal-title":"Magn. Reson. Imaging"},{"issue":"1","key":"10.1016\/j.jns.2025.123598_bb0055","doi-asserted-by":"crossref","first-page":"7456","DOI":"10.1038\/s41598-022-11418-y","article-title":"Associations of intracranial artery length and branch number on non-contrast enhanced MRA with cognitive impairment in individuals with carotid atherosclerosis","volume":"12","author":"Chen","year":"2022","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.jns.2025.123598_bb0060","doi-asserted-by":"crossref","first-page":"3229","DOI":"10.1002\/mrm.26961","article-title":"Development of a quantitative intracranial vascular features extraction tool on 3D MRA using semiautomated open-curve active contour vessel tracing","volume":"79","author":"Chen","year":"2018","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.jns.2025.123598_bb0065","article-title":"Quantitative assessment of the intracranial vasculature of infants and adults using iCafe (intracranial artery feature extraction)","volume":"12","author":"Chen","year":"2021","journal-title":"Front. Neurol."},{"key":"10.1016\/j.jns.2025.123598_bb0070","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.mri.2022.12.011","article-title":"Alterations in cerebral distal vascular features and effect on cognition in a high cardiovascular risk population: a prospective longitudinal study","volume":"98","author":"Zhang","year":"2023","journal-title":"Magn. Reson. Imaging"},{"issue":"3","key":"10.1016\/j.jns.2025.123598_bb0075","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","article-title":"The diagnosis of dementia due to Alzheimer\u2019s disease: recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease","volume":"7","author":"McKhann","year":"2011","journal-title":"Alzheimers Dement."},{"issue":"3","key":"10.1016\/j.jns.2025.123598_bb0080","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.jalz.2011.03.008","article-title":"The diagnosis of mild cognitive impairment due to Alzheimer\u2019s disease: recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease","volume":"7","author":"Albert","year":"2011","journal-title":"Alzheimers Dement."},{"issue":"2","key":"10.1016\/j.jns.2025.123598_bb0085","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1212\/WNL.43.2.250","article-title":"Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop","volume":"43","author":"Rom\u00e1n","year":"1993","journal-title":"Neurology"},{"issue":"9","key":"10.1016\/j.jns.2025.123598_bb0090","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1161\/STR.0b013e3182299496","article-title":"Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association\/american stroke association","volume":"42","author":"Gorelick","year":"2011","journal-title":"Stroke"},{"issue":"2","key":"10.1016\/j.jns.2025.123598_bb0095","first-page":"300","article-title":"A validity study on the korean mini-mental state examination (K-MMSE) in dementia patients","volume":"15","year":"1997","journal-title":"J. Korean Neurol. Assoc."},{"issue":"2","key":"10.1016\/j.jns.2025.123598_bb0100","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1177\/0891988708316855","article-title":"Brief screening for mild cognitive impairment in elderly outpatient clinic: validation of the Korean version of the Montreal cognitive assessment","volume":"21","author":"Lee","year":"2008","journal-title":"J. Geriatr. Psychiatry Neurol."},{"issue":"6","key":"10.1016\/j.jns.2025.123598_bb0105","first-page":"612","article-title":"The validity of the Korean version of global deterioration scale","volume":"20","year":"2002","journal-title":"J. Korean Neurol. Assoc."},{"issue":"1","key":"10.1016\/j.jns.2025.123598_bb0110","first-page":"8","article-title":"The reliability and validity of the Korean instrumental activities of daily living (K-IADL)","volume":"20","year":"2002","journal-title":"J. Korean Neurol. Assoc."},{"issue":"3","key":"10.1016\/j.jns.2025.123598_bb0115","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.jpsychores.2004.01.004","article-title":"Development of the Korean version of the geriatric depression scale and its short form among elderly psychiatric patients","volume":"57","author":"Bae","year":"2004","journal-title":"J. Psychosom. Res."},{"issue":"1","key":"10.1016\/j.jns.2025.123598_bb0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.12779\/dnd.2023.22.1.1","article-title":"The Seoul neuropsychological screening battery (SNSB) for comprehensive neuropsychological assessment","volume":"22","author":"Ryu","year":"2023","journal-title":"Dement. Neurocogn. Disord."},{"issue":"2","key":"10.1016\/j.jns.2025.123598_bb0125","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.neuroimage.2012.01.021","article-title":"FreeSurfer","volume":"62","author":"Fischl","year":"2012","journal-title":"NeuroImage"},{"issue":"4","key":"10.1016\/j.jns.2025.123598_bb0130","doi-asserted-by":"crossref","first-page":"3774","DOI":"10.1016\/j.neuroimage.2011.11.032","article-title":"An automated tool for detection of FLAIR-hyperintense white-matter lesions in multiple sclerosis","volume":"59","author":"Schmidt","year":"2012","journal-title":"Neuroimage"},{"key":"10.1016\/j.jns.2025.123598_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101450","article-title":"Cerebral blood flow in mild cognitive impairment and Alzheimer\u2019s disease: a systematic review and meta-analysis","volume":"71","author":"Zhang","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.jns.2025.123598_bb0140","doi-asserted-by":"crossref","DOI":"10.1002\/jmri.28736","article-title":"Visualizing cerebral small vessel degeneration during aging and diseases using magnetic resonance imaging","author":"Huang","year":"2023","journal-title":"J. Magn. Reson. Imaging"},{"issue":"6","key":"10.1016\/j.jns.2025.123598_bb0145","doi-asserted-by":"crossref","DOI":"10.1111\/bpa.13061","article-title":"Pathological changes within the cerebral vasculature in Alzheimer\u2019s disease: new perspectives","volume":"32","author":"Fisher","year":"2022","journal-title":"Brain Pathol."},{"issue":"17","key":"10.1016\/j.jns.2025.123598_bb0150","doi-asserted-by":"crossref","first-page":"17224","DOI":"10.18632\/aging.103672","article-title":"Dynamic changes in vascular size and density in transgenic mice with Alzheimer's disease","volume":"12","author":"Xu","year":"2020","journal-title":"Aging (Albany NY)"},{"issue":"2","key":"10.1016\/j.jns.2025.123598_bb0155","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1093\/jnen\/nly125","article-title":"Age-related changes of the neurovascular unit in the cerebral cortex of Alzheimer disease mouse models: a neuroanatomical and molecular study","volume":"78","author":"Giuliani","year":"2019","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"4","key":"10.1016\/j.jns.2025.123598_bb0160","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/BF00690372","article-title":"Morphometric comparison of hippocampal microvasculature in ageing and demented people: diameters and densities","volume":"53","author":"Bell","year":"1981","journal-title":"Acta Neuropathol."},{"issue":"5","key":"10.1016\/j.jns.2025.123598_bb0165","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s00702-009-0226-9","article-title":"Evidence of angiogenic vessels in Alzheimer\u2019s disease","volume":"116","author":"Desai","year":"2009","journal-title":"J. Neural Transm. (Vienna)"},{"issue":"3","key":"10.1016\/j.jns.2025.123598_bb0170","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1111\/nan.12085","article-title":"Morphometry of the hippocampal microvasculature in post-stroke and age-related dementias","volume":"40","author":"Burke","year":"2014","journal-title":"Neuropathol. Appl. Neurobiol."},{"issue":"6","key":"10.1016\/j.jns.2025.123598_bb0175","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1111\/bpa.12897","article-title":"Denser brain capillary network with preserved pericytes in Alzheimer\u2019s disease","volume":"30","author":"Fernandez-Klett","year":"2020","journal-title":"Brain Pathol."},{"issue":"6","key":"10.1016\/j.jns.2025.123598_bb0180","doi-asserted-by":"crossref","first-page":"E1289","DOI":"10.1073\/pnas.1710329115","article-title":"Tau induces blood vessel abnormalities and angiogenesis-related gene expression in P301L transgenic mice and human Alzheimer's disease","volume":"115","author":"Bennett","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"Pt 12","key":"10.1016\/j.jns.2025.123598_bb0185","doi-asserted-by":"crossref","first-page":"3749","DOI":"10.1093\/brain\/aws271","article-title":"Cerebrovascular atherosclerosis correlates with Alzheimer pathology in neurodegenerative dementias","volume":"135","author":"Yarchoan","year":"2012","journal-title":"Brain"},{"issue":"1","key":"10.1016\/j.jns.2025.123598_bb0190","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00401-006-0136-y","article-title":"Circle of Willis atherosclerosis: association with Alzheimer\u2019s disease, neuritic plaques and neurofibrillary tangles","volume":"113","author":"Beach","year":"2007","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.jns.2025.123598_bb0195","doi-asserted-by":"crossref","first-page":"11934","DOI":"10.1038\/ncomms11934","article-title":"Early role of vascular dysregulation on late-onset Alzheimer\u2019s disease based on multifactorial data-driven analysis","volume":"7","author":"Iturria-Medina","year":"2016","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.jns.2025.123598_bb0200","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.neuron.2017.07.030","article-title":"The neurovascular unit coming of age: a journey through neurovascular coupling in health and disease","volume":"96","author":"Iadecola","year":"2017","journal-title":"Neuron"},{"issue":"4","key":"10.1016\/j.jns.2025.123598_bb0205","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1017\/S1041610218001370","article-title":"Is the Montreal Cognitive Assessment (MoCA) screening superior to the Mini-Mental State Examination (MMSE) in the detection of mild cognitive impairment (MCI) and Alzheimer\u2019s disease (AD) in the elderly?","volume":"31","author":"Pinto","year":"2019","journal-title":"Int. Psychogeriatr."},{"issue":"6","key":"10.1016\/j.jns.2025.123598_bb0210","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.jalz.2014.07.155","article-title":"APOE \u03b54 and risk for Alzheimer\u2019s disease: do regionally distributed white matter hyperintensities play a role?","volume":"10","author":"Brickman","year":"2014","journal-title":"Alzheimers Dement."},{"issue":"10","key":"10.1016\/j.jns.2025.123598_bb0215","doi-asserted-by":"crossref","first-page":"e2125166","DOI":"10.1001\/jamanetworkopen.2021.25166","article-title":"Association of regional White Matter hyperintensities with longitudinal Alzheimer-like pattern of neurodegeneration in older adults","volume":"4","author":"Rizvi","year":"2021","journal-title":"JAMA Netw. Open"},{"issue":"12","key":"10.1016\/j.jns.2025.123598_bb0220","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1212\/01.wnl.0000249119.95747.1f","article-title":"Extent and distribution of white matter hyperintensities in normal aging, MCI, and AD","volume":"67","author":"Yoshita","year":"2006","journal-title":"Neurology"},{"issue":"6","key":"10.1016\/j.jns.2025.123598_bb0225","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1002\/ana.24647","article-title":"White matter hyperintensities are a core feature of Alzheimer\u2019s disease: evidence from the dominantly inherited Alzheimer network","volume":"79","author":"Lee","year":"2016","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.jns.2025.123598_bb0230","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.71186","article-title":"Imaging of the pial arterial vasculature of the human brain in vivo using high-resolution 7T time-of-flight angiography","volume":"11","author":"Bollmann","year":"2022","journal-title":"Elife"}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X25002151?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X25002151?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T07:53:46Z","timestamp":1756281226000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X25002151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":46,"alternative-id":["S0022510X25002151"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2025.123598","relation":{},"ISSN":["0022-510X"],"issn-type":[{"value":"0022-510X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quantitative analysis of cerebral vasculature and its clinical effect on cognitive change in Alzheimer's dementia and mild cognitive impairment","name":"articletitle","label":"Article Title"},{"value":"Journal of the Neurological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jns.2025.123598","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"123598"}}