{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T16:45:47Z","timestamp":1775666747420,"version":"3.50.1"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012329","name":"European Association of National Metrology Institutes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jns-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.jns.2025.123669","type":"journal-article","created":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T15:11:26Z","timestamp":1755961886000},"page":"123669","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["The expanding clinical utility of blood neurofilament light chain (bNfL): a multi-disciplinary diagnostic tool"],"prefix":"10.1016","volume":"478","author":[{"given":"Peter","family":"K\u00f6rtvelyessy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burak","family":"Arslan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonah","family":"Nietiet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Leithner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra","family":"H\u00fchnchen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"B\u00f6hmerle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Endres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph J.","family":"Ploner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heiner","family":"Audebert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrin","family":"Hahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"L\u00fcschow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa-Valerie","family":"Biztan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Spethmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriaan J.","family":"Graw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadine","family":"Unterwalder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Meisel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas J.","family":"Ashton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaj","family":"Blennow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"G\u00f6schel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jns.2025.123669_bb0005","doi-asserted-by":"crossref","first-page":"3400","DOI":"10.1038\/s41467-021-23620-z","article-title":"A multicentre validation study of the diagnostic value of plasma neurofilament light","volume":"12","author":"Ashton","year":"2021","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.jns.2025.123669_bb0010","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1093\/brain\/awy154","article-title":"Serum neurofilament as a predictor of disease worsening and brain and spinal cord atrophy in multiple sclerosis","volume":"141","author":"Barro","year":"2018","journal-title":"Brain J. Neurol."},{"issue":"8","key":"10.1016\/j.jns.2025.123669_bb0015","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1038\/s41380-024-02524-6","article-title":"Introducing neurofilament light chain measure in psychiatry: current evidence, opportunities, and pitfalls","volume":"29","author":"Bavato","year":"2024","journal-title":"Mol. Psychiatry"},{"issue":"7","key":"10.1016\/j.jns.2025.123669_bb0020","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1515\/cclm-2023-1311","article-title":"Neurofilament light protein as a biomarker for spinal muscular atrophy: a review and reference ranges","volume":"62","author":"Bayoumy","year":"2024","journal-title":"Clin. Chem. Lab. Med."},{"issue":"3","key":"10.1016\/j.jns.2025.123669_bb0025","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/S1474-4422(22)00009-6","article-title":"Serum neurofilament light chain for individual prognostication of disease activity in people with multiple sclerosis: a retrospective modelling and validation study","volume":"21","author":"Benkert","year":"2022","journal-title":"Lancet Neurol."},{"issue":"1","key":"10.1016\/j.jns.2025.123669_bb0030","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1186\/s13054-023-04497-4","article-title":"Neurofilament light chains to assess sepsis-associated encephalopathy: are we on the track toward clinical implementation?","volume":"27","author":"Bircak-Kuchtova","year":"2023","journal-title":"Crit. Care"},{"issue":"9","key":"10.1016\/j.jns.2025.123669_bb0035","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1001\/jamaneurol.2019.1534","article-title":"Diagnostic value of cerebrospinal fluid neurofilament light protein in neurology: a systematic review and meta-analysis","volume":"76","author":"Bridel","year":"2019","journal-title":"JAMA Neurol."},{"issue":"14","key":"10.1016\/j.jns.2025.123669_bb0040","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241411624","article-title":"Neurofilament-light, a promising biomarker: analytical, metrological and clinical challenges","volume":"24","author":"Coppens","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.jns.2025.123669_bb0045","doi-asserted-by":"crossref","DOI":"10.1002\/alz.70343","article-title":"Clinical use and reporting of neurofilament quantification in neurological disorders: a global overview","volume":"21","author":"Delaby","year":"2025","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.jns.2025.123669_bb0050","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2022.795317","article-title":"Plasma neurofilament light chain levels are elevated in children and young adults with Wolfram syndrome","volume":"16","author":"Eisenstein","year":"2022","journal-title":"Front. Neurosci."},{"issue":"10","key":"10.1016\/j.jns.2025.123669_bb0055","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1111\/cns.13894","article-title":"Repeated neurofilament light chain measurements did not capture Riluzole therapeutic effect in amyotrophic lateral sclerosis patients","volume":"28","author":"Esselin","year":"2022","journal-title":"CNS Neurosci. Ther."},{"issue":"7","key":"10.1016\/j.jns.2025.123669_bb0060","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1016\/j.clinph.2021.03.016","article-title":"Critical illness polyneuropathy, myopathy and neuronal biomarkers in COVID-19 patients: a prospective study","volume":"132","author":"Frithiof","year":"2021","journal-title":"Clin. Neurophysiol."},{"issue":"8","key":"10.1016\/j.jns.2025.123669_bb0065","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1136\/jnnp-2018-320106","article-title":"Neurofilament light chain as a biomarker in neurological disorders","volume":"90","author":"Gaetani","year":"2019","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"3","key":"10.1016\/j.jns.2025.123669_bb0070","article-title":"Harmonization and standardization of biofluid-based biomarker measurements for AT(N) classification in Alzheimer\u2019s disease","volume":"15","author":"Giangrande","year":"2023","journal-title":"Alzheimers Dement."},{"issue":"1","key":"10.1016\/j.jns.2025.123669_bb0075","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.1111\/epi.17132","article-title":"Serum neurofilament light as biomarker of seizure-related neuronal injury in status epilepticus","volume":"63","author":"Giovannini","year":"2022","journal-title":"Epilepsia"},{"issue":"1","key":"10.1016\/j.jns.2025.123669_bb0080","doi-asserted-by":"crossref","first-page":"2386233","DOI":"10.1080\/20450907.2024.2386233","article-title":"Neurofilament light chain in serum of cancer patients with acute neurological complications","volume":"13","author":"Gottiparthy","year":"2024","journal-title":"CNS Oncol."},{"issue":"3","key":"10.1016\/j.jns.2025.123669_bb0085","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1111\/bjh.19036","article-title":"Neurofilament light chain: a potential biomarker for cerebrovascular disease in children with sickle cell anaemia","volume":"203","author":"Green","year":"2023","journal-title":"Br. J. Haematol."},{"issue":"6","key":"10.1016\/j.jns.2025.123669_bb0090","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.154395","article-title":"Neurofilament proteins as a potential biomarker in chemotherapy-induced polyneuropathy","volume":"7","author":"Huehnchen","year":"2022","journal-title":"JCI Insight"},{"issue":"5","key":"10.1016\/j.jns.2025.123669_bb0095","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41582-024-00955-x","article-title":"Neurofilaments as biomarkers in neurological disorders\u2014towards clinical application","volume":"20","author":"Khalil","year":"2024","journal-title":"Nat. Rev. Neurol."},{"issue":"5","key":"10.1016\/j.jns.2025.123669_bb0100","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41582-024-00955-x","article-title":"Neurofilaments as biomarkers in neurological disorders\u2014towards clinical application","volume":"20","author":"Khalil","year":"2024","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.jns.2025.123669_bb0105","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2018.00504","article-title":"CSF biomarkers of neurodegeneration in progressive non-fluent aphasia and other forms of frontotemporal dementia: clues for pathomechanisms?","volume":"9","author":"K\u00f6rtvelyessy","year":"2018","journal-title":"Front. Neurol."},{"issue":"1","key":"10.1016\/j.jns.2025.123669_bb0110","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/s41398-025-03241-6","article-title":"Neurofilament light chain levels in neuronal surface antibody-associated autoimmune encephalitis: a systematic review and meta-analysis","volume":"15","author":"Lai","year":"2025","journal-title":"Transl. Psychiatry"},{"issue":"13","key":"10.1016\/j.jns.2025.123669_bb0115","doi-asserted-by":"crossref","first-page":"e1479","DOI":"10.1212\/WNL.0000000000007179","article-title":"Serum NFL discriminates Parkinson disease from atypical parkinsonisms","volume":"92","author":"Marques","year":"2019","journal-title":"Neurology"},{"issue":"9","key":"10.1016\/j.jns.2025.123669_bb0120","doi-asserted-by":"crossref","DOI":"10.1111\/ene.16379","article-title":"Serum neurofilament light chain in distinct phenotypes of amyotrophic lateral sclerosis: a longitudinal, multicenter study","volume":"31","author":"Meyer","year":"2024","journal-title":"Eur. J. Neurol."},{"issue":"6","key":"10.1016\/j.jns.2025.123669_bb0125","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1111\/ene.15773","article-title":"Performance of serum neurofilament light chain in a wide spectrum of clinical courses of amyotrophic lateral sclerosis-a cross-sectional multicenter study","volume":"30","author":"Meyer","year":"2023","journal-title":"Eur. J. Neurol."},{"issue":"1","key":"10.1016\/j.jns.2025.123669_bb0130","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1001\/jamaneurol.2018.3223","article-title":"Serum neurofilament light chain for prognosis of outcome after cardiac arrest","volume":"76","author":"Moseby-Knappe","year":"2019","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.jns.2025.123669_bb0135","series-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2024"},{"issue":"6","key":"10.1016\/j.jns.2025.123669_bb0140","doi-asserted-by":"crossref","first-page":"e518","DOI":"10.1212\/WNL.0000000000004932","article-title":"Plasma neurofilament light chain concentration in the inherited peripheral neuropathies","volume":"90","author":"Sandelius","year":"2018","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2025.123669_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2024.105729","article-title":"Longitudinal change of serum NfL as disease activity biomarker candidate in MOGAD: a descriptive cohort study","volume":"88","author":"Schindler","year":"2024","journal-title":"Mult. Scler. Relat. Disord."},{"issue":"3","key":"10.1016\/j.jns.2025.123669_bb0150","doi-asserted-by":"crossref","first-page":"e412","DOI":"10.1212\/WNL.0000000000011090","article-title":"Neurofilament light chain as a biomarker of hereditary transthyretin-mediated amyloidosis","volume":"96","author":"Ticau","year":"2021","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2025.123669_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2024.105072","article-title":"Dynamics and prognostic value of serum neurofilament light chain in Guillain-Barr\u00e9 syndrome","volume":"102","author":"van Tilburg","year":"2024","journal-title":"eBioMedicine"},{"issue":"1","key":"10.1016\/j.jns.2025.123669_bb0160","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1159\/000533473","article-title":"Neuro-specific and immuno-inflammatory biomarkers in umbilical cord blood in neonatal hypoxic-ischemic encephalopathy","volume":"121","author":"Toorell","year":"2024","journal-title":"Neonatology"},{"issue":"1","key":"10.1016\/j.jns.2025.123669_bb0165","doi-asserted-by":"crossref","DOI":"10.1136\/bmjmed-2024-000958","article-title":"Blood level of neurofilament light chain as a biomarker for neurological disorders","volume":"4","author":"Turner","year":"2025","journal-title":"BMJ Med."},{"key":"10.1016\/j.jns.2025.123669_bb0170","author":"Wickham"},{"key":"10.1016\/j.jns.2025.123669_bb0175","series-title":"dplyr: A grammar of data manipulation. (Version R package version 1.1. 2) [Computer software]","author":"Wickham","year":"2023"},{"issue":"20","key":"10.1016\/j.jns.2025.123669_bb0180","doi-asserted-by":"crossref","first-page":"e1985","DOI":"10.1212\/WNL.0000000000200257","article-title":"Levels of neurofilament light at the preataxic and ataxic stages of spinocerebellar Ataxia type 1","volume":"98","author":"Wilke","year":"2022","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.jns.2025.123669_bb0185","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s13195-021-00815-6","article-title":"Diagnostic and prognostic value of plasma neurofilament light and total-tau in sporadic Creutzfeldt-Jakob disease","volume":"13","author":"Zerr","year":"2021","journal-title":"Alzheimer\u2019s Res Ther"}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X25002898?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X25002898?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T05:02:04Z","timestamp":1764046924000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X25002898"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":37,"alternative-id":["S0022510X25002898"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2025.123669","relation":{},"ISSN":["0022-510X"],"issn-type":[{"value":"0022-510X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The expanding clinical utility of blood neurofilament light chain (bNfL): a multi-disciplinary diagnostic tool","name":"articletitle","label":"Article Title"},{"value":"Journal of the Neurological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jns.2025.123669","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"123669"}}