{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T19:21:10Z","timestamp":1782933670110,"version":"3.54.5"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013770","name":"Beihua University","doi-asserted-by":"publisher","award":["2025028"],"award-info":[{"award-number":["2025028"]}],"id":[{"id":"10.13039\/501100013770","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011789","name":"Jilin Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["YDZJ202401109ZYTS"],"award-info":[{"award-number":["YDZJ202401109ZYTS"]}],"id":[{"id":"10.13039\/501100011789","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010211","name":"The Education Department of Jilin Province","doi-asserted-by":"publisher","award":["JJKH20240104KJ"],"award-info":[{"award-number":["JJKH20240104KJ"]}],"id":[{"id":"10.13039\/501100010211","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jns-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.jns.2025.123734","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:16:25Z","timestamp":1761671785000},"page":"123734","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Critical nodes in precision diagnosis and treatment of Alzheimer's disease: exploration of multidimensional biomarkers and prospects for targeted intervention"],"prefix":"10.1016","volume":"479","author":[{"given":"Yuanyuan","family":"Zuo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuying","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunwei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leiyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.jns.2025.123734_bb0005","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1016\/j.neuron.2024.01.024","article-title":"Mechanisms of sex differences in Alzheimer\u2019s disease","volume":"112","author":"Lopez-Lee","year":"2024","journal-title":"Neuron"},{"issue":"11","key":"10.1016\/j.jns.2025.123734_bb0010","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.biopsych.2023.10.008","article-title":"Depression in Alzheimer\u2019s disease: epidemiology, mechanisms, and treatment","volume":"95","author":"Huang","year":"2024","journal-title":"Biol. Psychiatry"},{"issue":"4","key":"10.1016\/j.jns.2025.123734_bb0015","first-page":"1537","article-title":"Microglia and astrocytes in Alzheimer\u2019s disease: significance and summary of recent advances","volume":"15","author":"Deng","year":"2024","journal-title":"Aging Dis."},{"issue":"8","key":"10.1016\/j.jns.2025.123734_bb0020","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1056\/NEJMoa2310168","article-title":"Biomarker changes during 20 years preceding Alzheimer\u2019s disease","volume":"390","author":"Jia","year":"2024","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.jns.2025.123734_bb0025","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3390\/ph12010041","article-title":"BACE-1 and \u03b3-secretase as therapeutic targets for Alzheimer\u2019s disease","volume":"12","author":"Maia","year":"2019","journal-title":"Pharmaceuticals"},{"issue":"4","key":"10.1016\/j.jns.2025.123734_bb0030","first-page":"P583","article-title":"BACE inhibitor LY2886721 safety and central and peripheral PK and PD in healthy subjects (HSs)","volume":"8","author":"Martenyi","year":"2012","journal-title":"Alzheimers Dement."},{"issue":"1","key":"10.1016\/j.jns.2025.123734_bb0035","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s13195-020-00614-5","article-title":"Long-term safety and tolerability of atabecestat (JNJ-54861911), an oral BACE1 inhibitor, in early Alzheimer\u2019s disease spectrum patients: a randomized, double-blind, placebo-controlled study and a two-period extension study","volume":"12","author":"Novak","year":"2020","journal-title":"Alzheimer\u2019s Res Ther"},{"issue":"3","key":"10.1016\/j.jns.2025.123734_bb0040","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1208\/s12248-022-00683-4","article-title":"An investigation of instability in dried blood spot samples for pharmacokinetic sampling in phase 3 trials of Verubecestat","volume":"24","author":"Anderson","year":"2022","journal-title":"AAPS J."},{"issue":"12","key":"10.1016\/j.jns.2025.123734_bb0045","doi-asserted-by":"crossref","first-page":"3816","DOI":"10.1093\/brain\/awaa332","article-title":"BACE inhibition causes rapid, regional, and non-progressive volume reduction in Alzheimer\u2019s disease brain","volume":"143","author":"Sur","year":"2020","journal-title":"Brain"},{"issue":"11","key":"10.1016\/j.jns.2025.123734_bb0050","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1002\/alz.12164","article-title":"Dementia, Cognitive outcomes in trials of two BACE inhibitors in Alzheimer\u2019s disease","volume":"16","author":"Wessels","year":"2020","journal-title":"Alzheimers Dement."},{"issue":"20","key":"10.1016\/j.jns.2025.123734_bb0055","doi-asserted-by":"crossref","first-page":"3176","DOI":"10.1016\/j.neuron.2023.07.005","article-title":"Neuronal \u03b3-secretase regulates lipid metabolism, linking cholesterol to synaptic dysfunction in Alzheimer\u2019s disease","volume":"111","author":"Essayan-Perez","year":"2023","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.jns.2025.123734_bb0060","doi-asserted-by":"crossref","first-page":"4479","DOI":"10.1038\/s41467-024-48776-2","article-title":"Apo and A\u03b246-bound \u03b3-secretase structures provide insights into amyloid-\u03b2 processing by the APH-1B isoform","volume":"15","author":"Odor\u010di\u0107","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jns.2025.123734_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104665","article-title":"Safety, tolerability, immunogenicity, and efficacy of UB-311 in participants with mild Alzheimer\u2019s disease: a randomised, double-blind, placebo-controlled, phase 2a study","volume":"94","author":"Yu","year":"2023","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jns.2025.123734_bb0070","doi-asserted-by":"crossref","first-page":"149018","DOI":"10.1016\/j.brainres.2024.149018","article-title":"Immunotherapeutic approaches for Alzheimer\u2019s disease: Exploring active and passive vaccine progress","author":"Bhadane","year":"2024","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.jns.2025.123734_bb0075","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s13195-024-01441-8","article-title":"Updated safety results from phase 3 lecanemab study in early Alzheimer\u2019s disease","volume":"16","author":"Honig","year":"2024","journal-title":"Alzheimer\u2019s Res Ther"},{"issue":"27","key":"10.1016\/j.jns.2025.123734_bb0080","doi-asserted-by":"crossref","first-page":"eabl8809","DOI":"10.1126\/sciadv.abl8809","article-title":"Alzheimer\u2019s disease: Ablating single master site abolishes tau hyperphosphorylation","volume":"8","author":"Stefanoska","year":"2022","journal-title":"Sci. Adv."},{"issue":"12","key":"10.1016\/j.jns.2025.123734_bb0085","doi-asserted-by":"crossref","first-page":"5482","DOI":"10.1002\/alz.13090","article-title":"Amisulpride as a potential disease-modifying drug in the treatment of tauopathies","volume":"19","author":"Jahreis","year":"2023","journal-title":"Alzheimers Dement."},{"issue":"8","key":"10.1016\/j.jns.2025.123734_bb0090","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1001\/jamaneurol.2022.1375","article-title":"Safety and efficacy of Semorinemab in individuals with prodromal to mild Alzheimer disease: a randomized clinical trial","volume":"79","author":"Teng","year":"2022","journal-title":"JAMA Neurol."},{"issue":"6","key":"10.1016\/j.jns.2025.123734_bb0095","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.14283\/jpad.2024.163","article-title":"Phase 1 studies of the anti-tau monoclonal antibody JNJ-63733657 in healthy participants and participants with Alzheimer\u2019s disease","volume":"11","author":"Galpern","year":"2024","journal-title":"J. Prev Alzheimers Dis."},{"issue":"1","key":"10.1016\/j.jns.2025.123734_bb0100","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s40035-023-00383-9","article-title":"Inhibiting tau-induced elevated nSMase2 activity and ceramides is therapeutic in an Alzheimer\u2019s disease mouse model","volume":"12","author":"Tallon","year":"2023","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.jns.2025.123734_bb0105","first-page":"1","article-title":"Microglia prevent beta-amyloid plaque formation in the early stage of an Alzheimer\u2019s disease mouse model with suppression of glymphatic clearance","volume":"12","author":"Feng","year":"2020","journal-title":"Alzheimer\u2019s Res Ther"},{"key":"10.1016\/j.jns.2025.123734_bb0110","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.nbd.2018.01.006","article-title":"YOD1 attenuates neurogenic proteotoxicity through its deubiquitinating activity","volume":"112","author":"Tanji","year":"2018","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.jns.2025.123734_bb0115","article-title":"YOD1 regulates microglial homeostasis by deubiquitinating MYH9 to promote the pathogenesis of Alzheimer\u2019s disease","author":"Sun","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"issue":"1","key":"10.1016\/j.jns.2025.123734_bb0120","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1186\/s12974-022-02548-1","article-title":"MicroRNA-22-3p ameliorates Alzheimer\u2019s disease by targeting SOX9 through the NF-\u03baB signaling pathway in the hippocampus","volume":"19","author":"Xia","year":"2022","journal-title":"J. Neuroinflammation"},{"issue":"6","key":"10.1016\/j.jns.2025.123734_bb0125","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1016\/j.jaci.2023.07.010","article-title":"The role of Janus kinase signaling in the pathology of atopic dermatitis","volume":"152","author":"Guttman-Yassky","year":"2023","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.jns.2025.123734_bb0130","article-title":"A neurodegenerative cellular stress response linked to dark microglia and toxic lipid secretion","author":"Flury","year":"2024","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.jns.2025.123734_bb0135","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3233\/JAD-220556","article-title":"Supplementation With carotenoids, omega-3 fatty acids, and vitamin e has a positive effect on the symptoms and progression of Alzheimer\u2019s disease","volume":"90","author":"Nolan","year":"2022","journal-title":"J Alzheimer\u2019s Dis"},{"issue":"16","key":"10.1016\/j.jns.2025.123734_bb0140","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241612733","article-title":"N-acetylcysteine amide against a\u03b2-induced Alzheimer\u2019s-like pathology in rats","volume":"24","author":"Alkandari","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.jns.2025.123734_bb0145","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1093\/brain\/awad432","article-title":"New cyclophilin D inhibitor rescues mitochondrial and cognitive function in Alzheimer\u2019s disease","volume":"147","author":"Samanta","year":"2024","journal-title":"Brain"},{"issue":"10","key":"10.1016\/j.jns.2025.123734_bb0150","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/s41419-024-07062-1","article-title":"NAD+-boosting agent nicotinamide mononucleotide potently improves mitochondria stress response in Alzheimer\u2019s disease via ATF4-dependent mitochondrial UPR","volume":"15","author":"Xiong","year":"2024","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.jns.2025.123734_bb0155","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3233\/JAD-231249","article-title":"Effect and mechanism of rapamycin on cognitive deficits in animal models of Alzheimer\u2019s disease: a systematic review and Meta-analysis of preclinical studies","volume":"99","author":"Cai","year":"2024","journal-title":"J Alzheimer\u2019s Dis"},{"key":"10.1016\/j.jns.2025.123734_bb0160","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.2147\/CIA.S429440","article-title":"Rapamycin responds to Alzheimer\u2019s disease: a potential translational therapy","volume":"18","author":"Hou","year":"2023","journal-title":"Clin. Interv. Aging"},{"key":"10.1016\/j.jns.2025.123734_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117012","article-title":"Study on the neuroprotective effect of Zhimu-Huangbo extract on mitochondrial dysfunction in HT22 cells induced by D-galactose by promoting mitochondrial autophagy","volume":"318","author":"Xue","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jns.2025.123734_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.102112","article-title":"The proteinopenia hypothesis: loss of a\u03b2(42) and the onset of Alzheimer\u2019s disease","volume":"92","author":"Espay","year":"2023","journal-title":"Ageing Res. Rev."},{"issue":"4","key":"10.1016\/j.jns.2025.123734_bb0175","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1002\/alz.12724","article-title":"Plasma A\u03b242\/40 ratio, p-tau181, GFAP, and NfL across the Alzheimer\u2019s disease continuum: a cross-sectional and longitudinal study in the AIBL cohort","volume":"19","author":"Chatterjee","year":"2023","journal-title":"Alzheimers Dement."},{"issue":"11","key":"10.1016\/j.jns.2025.123734_bb0180","first-page":"1375","article-title":"Head-to-head comparison of 8 plasma amyloid-\u03b2 42\/40 assays in Alzheimer disease","volume":"78","author":"Janelidze","year":"2021","journal-title":"JAMA"},{"key":"10.1016\/j.jns.2025.123734_bb0185","doi-asserted-by":"crossref","DOI":"10.1002\/alz.094604","article-title":"Development, Validation, and Clinical Utility of the Janssen plasma p-tau 217+ tau Simoa assay","volume":"20","author":"Triana-Baltzer","year":"2024","journal-title":"Alzheimers Dement."},{"issue":"11","key":"10.1016\/j.jns.2025.123734_bb0190","doi-asserted-by":"crossref","first-page":"8074","DOI":"10.1002\/alz.14315","article-title":"Head-to-head comparison of leading blood tests for Alzheimer\u2019s disease pathology","volume":"20","author":"Schindler","year":"2024","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.jns.2025.123734_bb0195","doi-asserted-by":"crossref","first-page":"1320653","DOI":"10.3389\/fneur.2024.1320653","article-title":"Evaluation of serum neurofilament light chain and glial fibrillary acidic protein in the diagnosis of Alzheimer\u2019s disease","volume":"15","author":"Fang","year":"2024","journal-title":"Front. Neurol."},{"issue":"1","key":"10.1016\/j.jns.2025.123734_bb0200","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1186\/s12916-024-03418-8","article-title":"Peripheral GFAP and NfL as early biomarkers for dementia: longitudinal insights from the UK biobank","volume":"22","author":"Wang","year":"2024","journal-title":"BMC Med."},{"issue":"2","key":"10.1016\/j.jns.2025.123734_bb0205","doi-asserted-by":"crossref","first-page":"619","DOI":"10.3233\/JAD-200711","article-title":"Therapeutic potential of TNF-\u03b1 inhibition for Alzheimer\u2019s disease prevention","volume":"78","author":"Torres-Acosta","year":"2020","journal-title":"J Alzheimer\u2019s Dis"},{"key":"10.1016\/j.jns.2025.123734_bb0210","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.bbi.2023.06.027","article-title":"Associations of neuroinflammatory IL-6 and IL-8 with brain atrophy, memory decline, and core AD biomarkers - in cognitively unimpaired older adults","volume":"113","author":"Capogna","year":"2023","journal-title":"Brain Behav. Immun."},{"issue":"9","key":"10.1016\/j.jns.2025.123734_bb0215","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1007\/s00259-023-06209-0","article-title":"Longitudinal head-to-head comparison of (11)C-PiB and (18)F-florbetapir PET in a phase 2\/3 clinical trial of anti-amyloid-\u03b2 monoclonal antibodies in dominantly inherited Alzheimer\u2019s disease","volume":"50","author":"Chen","year":"2023","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"issue":"1","key":"10.1016\/j.jns.2025.123734_bb0220","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.2850","article-title":"Amyloid-\u03b2 PET in Alzheimer\u2019s disease: a systematic review and Bayesian meta-analysis","volume":"13","author":"Ruan","year":"2023","journal-title":"Brain Behav."},{"issue":"1","key":"10.1016\/j.jns.2025.123734_bb0225","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/s41398-022-01850-z","article-title":"Increased retention of tau PET ligand [(18)F]-AV1451 in Alzheimer\u2019s disease psychosis","volume":"12","author":"Gomar","year":"2022","journal-title":"Transl. Psychiatry"},{"issue":"1","key":"10.1016\/j.jns.2025.123734_bb0230","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s13195-023-01160-6","article-title":"Early tau detection in flortaucipir images: validation in autopsy-confirmed data and implications for disease progression","volume":"15","author":"Kotari","year":"2023","journal-title":"Alzheimer\u2019s Res Ther"},{"issue":"11","key":"10.1016\/j.jns.2025.123734_bb0235","doi-asserted-by":"crossref","first-page":"7465","DOI":"10.1002\/alz.14147","article-title":"Inflammatory protein associations with brain MRI measures: Framingham Offspring Cohort","volume":"20","author":"Chen","year":"2024","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.jns.2025.123734_bb0240","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.neubiorev.2020.11.007","article-title":"White matter hyperintensities and risks of cognitive impairment and dementia: a systematic review and meta-analysis of 36 prospective studies","volume":"120","author":"Hu","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.jns.2025.123734_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2022.101614","article-title":"Artificial intelligence in brain MRI analysis of Alzheimer\u2019s disease over the past 12 years: A systematic review","volume":"77","author":"Frizzell","year":"2022","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.jns.2025.123734_bb0250","article-title":"Task-and resting-state fMRI studies in multiple sclerosis: from regions to systems and time-varying analysis","volume":"35","author":"Rocca","year":"2022","journal-title":"Curr. Status and Future Perspect."},{"issue":"6","key":"10.1016\/j.jns.2025.123734_bb0255","doi-asserted-by":"crossref","DOI":"10.1111\/acel.14137","article-title":"Multi-proteomic analyses of 5xFAD mice reveal new molecular signatures of early-stage Alzheimer\u2019s disease","volume":"23","author":"Lee","year":"2024","journal-title":"Aging Cell"},{"key":"10.1016\/j.jns.2025.123734_bb0260","article-title":"Extracellular vesicles as a drug delivery system: A systematic review of preclinical studies","volume":"175","author":"de Castilla","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"1","key":"10.1016\/j.jns.2025.123734_bb0265","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1186\/s13195-022-01133-1","article-title":"Proteomic profiling of circulating plasma exosomes reveals novel biomarkers of Alzheimer\u2019s disease","volume":"14","author":"Cai","year":"2022","journal-title":"Alzheimer\u2019s Res Ther"},{"issue":"23","key":"10.1016\/j.jns.2025.123734_bb0270","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1056\/NEJMoa2308583","article-title":"APOE3 Christchurch heterozygosity and autosomal dominant Alzheimer\u2019s disease","volume":"390","author":"Quiroz","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jns.2025.123734_bb0275","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s13024-022-00574-4","article-title":"ApoE in Alzheimer\u2019s disease: pathophysiology and therapeutic strategies","volume":"17, (1)","author":"Raulin","year":"2022","journal-title":"Mol. Neurodegener."},{"issue":"1","key":"10.1016\/j.jns.2025.123734_bb0280","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1186\/s12916-023-02930-7","article-title":"Aberrant palmitoylation caused by a ZDHHC21 mutation contributes to pathophysiology of Alzheimer\u2019s disease","volume":"21","author":"Li","year":"2023","journal-title":"BMC Med."},{"issue":"6","key":"10.1016\/j.jns.2025.123734_bb0285","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1002\/alz.12468","article-title":"Integrative metabolomics-genomics approach reveals key metabolic pathways and regulators of Alzheimer\u2019s disease","volume":"18","author":"Horgusluoglu","year":"2022","journal-title":"Alzheimers Dement."},{"issue":"8006","key":"10.1016\/j.jns.2025.123734_bb0290","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/s41586-024-07185-7","article-title":"APOE4\/4 is linked to damaging lipid droplets in Alzheimer\u2019s disease microglia","volume":"628","author":"Haney","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.jns.2025.123734_bb0295","first-page":"1","article-title":"Metabolic phenotyping reveals a reduction in the bioavailability of serotonin and kynurenine pathway metabolites in both the urine and serum of individuals living with Alzheimer\u2019s disease","volume":"13","author":"Whiley","year":"2021","journal-title":"Alzheimer\u2019s Res Ther"}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X25003545?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X25003545?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T10:04:45Z","timestamp":1773309885000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X25003545"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":59,"alternative-id":["S0022510X25003545"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2025.123734","relation":{},"ISSN":["0022-510X"],"issn-type":[{"value":"0022-510X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Critical nodes in precision diagnosis and treatment of Alzheimer's disease: exploration of multidimensional biomarkers and prospects for targeted intervention","name":"articletitle","label":"Article Title"},{"value":"Journal of the Neurological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jns.2025.123734","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"123734"}}