{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T15:11:52Z","timestamp":1774278712890,"version":"3.50.1"},"reference-count":17,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS113828"],"award-info":[{"award-number":["R01NS113828"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jns-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jns.2026.125739","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T07:38:45Z","timestamp":1767685125000},"page":"125739","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["The impact of adding optical coherence tomography in MS diagnostic criteria on the classification of tumefactive demyelination"],"prefix":"10.1016","volume":"481","author":[{"given":"Fiorella S.","family":"Guido","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John J.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul A.","family":"Decker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahboubeh","family":"Fereidan-Esfahani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin D.","family":"Chodnicki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deena A.","family":"Tajfirouz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eoin P.","family":"Flanagan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orhun H.","family":"Kantarci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. Mark","family":"Keegan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean J.","family":"Pittock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan-Mendelt","family":"Tillema","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia F.","family":"Lucchinetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanette E.","family":"Eckel-Passow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. Oliver","family":"Tobin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jns.2026.125739_bb0005","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1111\/ene.15182","article-title":"Population-based incidence and clinico-radiological characteristics of tumefactive demyelination in Olmsted County, Minnesota, United States","volume":"29","author":"Fereidan-Esfahani","year":"2022","journal-title":"Eur. J. Neurol."},{"issue":"Pt 7","key":"10.1016\/j.jns.2026.125739_bb0010","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1093\/brain\/awn098","article-title":"Clinical and radiographic spectrum of pathologically confirmed tumefactive multiple sclerosis","volume":"131","author":"Lucchinetti","year":"2008","journal-title":"Brain"},{"issue":"9","key":"10.1016\/j.jns.2026.125739_bb0015","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1002\/acn3.51844","article-title":"Defining the natural history of tumefactive demyelination: a retrospective cohort of 257 patients","volume":"10","author":"Fereidan-Esfahani","year":"2023","journal-title":"Ann. Clin. Transl. Neurol."},{"issue":"8","key":"10.1016\/j.jns.2026.125739_bb0020","doi-asserted-by":"crossref","first-page":"e189","DOI":"10.1515\/cclm-2023-1416","article-title":"Cerebrospinal fluid kappa free light chains in patients with tumefactive demyelination","volume":"62","author":"Banks","year":"2024","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.jns.2026.125739_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2023.105408","article-title":"Clinical and radiological characteristics and outcomes of patients with recurrent or relapsing tumefactive demyelination","volume":"82","author":"Pervin","year":"2024","journal-title":"Mult. Scler. Relat. Disord."},{"issue":"1","key":"10.1016\/j.jns.2026.125739_bb0030","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S1474-4422(13)70259-X","article-title":"Optic neuritis","volume":"13","author":"Toosy","year":"2014","journal-title":"Lancet Neurol."},{"issue":"12","key":"10.1016\/j.jns.2026.125739_bb0035","doi-asserted-by":"crossref","first-page":"e1130","DOI":"10.1212\/WNL.0000000000006207","article-title":"Inclusion of optic nerve involvement in dissemination in space criteria for multiple sclerosis","volume":"91","author":"Brownlee","year":"2018","journal-title":"Neurology"},{"issue":"4","key":"10.1016\/j.jns.2026.125739_bb0040","doi-asserted-by":"crossref","first-page":"e482","DOI":"10.1212\/WNL.0000000000011339","article-title":"Optic nerve topography in multiple sclerosis diagnosis: the utility of visual evoked potentials","volume":"96","author":"Vidal-Jordana","year":"2021","journal-title":"Neurology"},{"issue":"6","key":"10.1016\/j.jns.2026.125739_bb0045","doi-asserted-by":"crossref","first-page":"e527","DOI":"10.1212\/WNL.0000000000006873","article-title":"Optical coherence tomography is highly sensitive in detecting prior optic neuritis","volume":"92","author":"Xu","year":"2019","journal-title":"Neurology"},{"issue":"6","key":"10.1016\/j.jns.2026.125739_bb0050","doi-asserted-by":"crossref","first-page":"e733","DOI":"10.1212\/WNL.0000000000009832","article-title":"Optical coherence tomography for detection of asymptomatic optic nerve lesions in clinically isolated syndrome","volume":"95","author":"Outteryck","year":"2020","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.jns.2026.125739_bb0055","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1093\/brain\/awaa458","article-title":"Subclinical anterior optic pathway involvement in early multiple sclerosis and clinically isolated syndromes","volume":"144","author":"Pisa","year":"2021","journal-title":"Brain"},{"issue":"1","key":"10.1016\/j.jns.2026.125739_bb0060","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000207805","article-title":"Adding the optic nerve in multiple sclerosis diagnostic criteria: a longitudinal, prospective, multicenter study","volume":"102","author":"Vidal-Jordana","year":"2024","journal-title":"Neurology"},{"issue":"4","key":"10.1016\/j.jns.2026.125739_bb0065","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1136\/jnnp-2014-308189","article-title":"Bidirectional trans-synaptic axonal degeneration in the visual pathway in multiple sclerosis","volume":"86","author":"Balk","year":"2015","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"Pt 3","key":"10.1016\/j.jns.2026.125739_bb0070","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1093\/brain\/awv396","article-title":"Longitudinal evidence for anterograde trans-synaptic degeneration after optic neuritis","volume":"139","author":"Tur","year":"2016","journal-title":"Brain"},{"issue":"7","key":"10.1016\/j.jns.2026.125739_bb0075","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1177\/1352458516679035","article-title":"Retrograde trans-synaptic visual pathway degeneration in multiple sclerosis: a case series","volume":"23","author":"Al-Louzi","year":"2017","journal-title":"Mult. Scler."},{"issue":"5","key":"10.1016\/j.jns.2026.125739_bb0080","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1002\/ana.25462","article-title":"Optimal intereye difference thresholds by optical coherence tomography in multiple sclerosis: an international study","volume":"85","author":"Nolan-Kenney","year":"2019","journal-title":"Ann. Neurol."},{"issue":"13","key":"10.1016\/j.jns.2026.125739_bb0085","doi-asserted-by":"crossref","first-page":"e1418","DOI":"10.1212\/WNL.0000000000206820","article-title":"Tumefactive demyelination in MOG Ab-associated disease, multiple sclerosis, and AQP-4-IgG-positive neuromyelitis optica spectrum disorder","volume":"100","author":"Cacciaguerra","year":"2023","journal-title":"Neurology"}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X26000201?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X26000201?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T14:23:45Z","timestamp":1774275825000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X26000201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":17,"alternative-id":["S0022510X26000201"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2026.125739","relation":{},"ISSN":["0022-510X"],"issn-type":[{"value":"0022-510X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The impact of adding optical coherence tomography in MS diagnostic criteria on the classification of tumefactive demyelination","name":"articletitle","label":"Article Title"},{"value":"Journal of the Neurological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jns.2026.125739","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"125739"}}