{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T15:08:11Z","timestamp":1774278491678,"version":"3.50.1"},"reference-count":6,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jns-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jns.2026.125758","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T16:17:57Z","timestamp":1768925877000},"page":"125758","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Authors' reply to comment letter on ZILU25 study"],"prefix":"10.1016","volume":"481","author":[{"given":"Vincenzo","family":"Di Stefano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Vinciguerra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelangelo","family":"Maestri Tassoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Frangiamore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.jns.2026.125758_bb0005","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S1474-4422(23)00080-7","article-title":"Safety and efficacy of zilucoplan in patients with generalised myasthenia gravis (RAISE): a randomised, double-blind, placebo-controlled, phase 3 study","volume":"22","author":"Howard","year":"2023","journal-title":"Lancet Neurol. [Internet]"},{"key":"10.1016\/j.jns.2026.125758_bb0010","article-title":"Long-term safety and efficacy of zilucoplan in patients with generalized myasthenia gravis: interim analysis of the RAISE-XT open-label extension study","volume":"17","author":"Howard","year":"2024","journal-title":"Ther. Adv. Neurol. Disord. [Internet]"},{"issue":"5","key":"10.1016\/j.jns.2026.125758_bb0015","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1001\/jamaneurol.2019.5125","article-title":"Clinical effects of the self-administered subcutaneous complement inhibitor Zilucoplan in patients with moderate to severe generalized myasthenia gravis: results of a phase 2 randomized, double-blind, placebo-controlled, multicenter clinical trial","volume":"77","author":"Howard","year":"2020","journal-title":"JAMA Neurol. [Internet]"},{"key":"10.1016\/j.jns.2026.125758_bb0020","series-title":"The Lancet Neurology","first-page":"1023","article-title":"Myasthenia gravis: Subgroup classification and therapeutic strategies","volume":"vol. 14","author":"Gilhus","year":"2015"},{"key":"10.1016\/j.jns.2026.125758_bb0025","doi-asserted-by":"crossref","first-page":"125671","DOI":"10.1016\/j.jns.2025.125671","article-title":"Early real-life experience on Zilucoplan for generalized myasthenia gravis: ZILU25 multicenter observational study","volume":"479","author":"Di Stefano","year":"2025","journal-title":"J. Neurol. Sci. [Internet]"},{"key":"10.1016\/j.jns.2026.125758_bb0030","doi-asserted-by":"crossref","first-page":"125741","DOI":"10.1016\/j.jns.2026.125741","article-title":"Comments on ZILU25: real-world efficacy of Zilucoplan in generalized myasthenia gravis","volume":"481","author":"Zheng","year":"2026","journal-title":"J. Neurol. Sci. [Internet]"}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X26000390?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X26000390?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T14:21:51Z","timestamp":1774275711000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X26000390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":6,"alternative-id":["S0022510X26000390"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2026.125758","relation":{},"ISSN":["0022-510X"],"issn-type":[{"value":"0022-510X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Authors' reply to comment letter on ZILU25 study","name":"articletitle","label":"Article Title"},{"value":"Journal of the Neurological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jns.2026.125758","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.jns.2026.125759","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"125758"}}