{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:08:28Z","timestamp":1790712508503,"version":"4.1.0"},"reference-count":13,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000304","name":"Parkinson's UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000304","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012153","name":"Cure Parkinson's NZ","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012153","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000864","name":"Michael J Fox Foundation for Parkinson's Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015659","name":"Cure Parkinson's","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015652","name":"Barts Charity","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015652","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jns-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.jns.2026.125785","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:19:30Z","timestamp":1770682770000},"page":"125785","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["A cross-sectional exploration of the relationship between Parkinson's disease and peripheral blood immune cells in an ethnically diverse East London population"],"prefix":"10.1016","volume":"484","author":[{"given":"J.","family":"Kenny","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Torricelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Zirra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Boyle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.T.","family":"Peri\u00f1\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Gallagher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Budu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.C.","family":"Dey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.J.","family":"Noyce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.jns.2026.125785_bb0005","doi-asserted-by":"crossref","first-page":"e464","DOI":"10.1016\/S2666-7568(24)00094-1","article-title":"Temporal trends in the prevalence of Parkinson\u2019s disease from 1980 to 2023: a systematic review and meta-analysis","volume":"5","author":"Zhu","year":"2024","journal-title":"Lancet Healthy Longev."},{"issue":"5","key":"10.1016\/j.jns.2026.125785_bb0010","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1093\/brain\/114.5.2283","article-title":"Ageing and parkinson\u2019s disease: substantia nigra regional selectivity","volume":"114","author":"Fearnley","year":"1991","journal-title":"Brain"},{"issue":"9","key":"10.1016\/j.jns.2026.125785_bb0015","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1038\/ng.3043","article-title":"Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson\u2019s disease","volume":"46","author":"Nalls","year":"2014","journal-title":"Nat. Genet."},{"issue":"12","key":"10.1016\/j.jns.2026.125785_bb0020","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/S1474-4422(19)30320-5","article-title":"Identification of novel risk loci, causal insights, and heritable risk for Parkinson\u2019s disease: a meta-analysis of genome-wide association studies","volume":"18","author":"Nalls","year":"2019","journal-title":"Lancet Neurol."},{"issue":"22","key":"10.1016\/j.jns.2026.125785_bb0025","doi-asserted-by":"crossref","first-page":"637","DOI":"10.21037\/atm.2019.10.105","article-title":"Abnormal subpopulations of peripheral blood lymphocytes are involved in Parkinson\u2019s disease","volume":"7","author":"Sun","year":"2019","journal-title":"Ann. Transl. Med."},{"issue":"1\u20132","key":"10.1016\/j.jns.2026.125785_bb0030","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jneuroim.2012.07.015","article-title":"Reduced T helper and B lymphocytes in Parkinson\u2019s disease","volume":"252","author":"Stevens","year":"2012","journal-title":"J. Neuroimmunol."},{"issue":"4","key":"10.1016\/j.jns.2026.125785_bb0035","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1002\/ana.26034","article-title":"Lower lymphocyte count is associated with increased risk of Parkinson\u2019s disease","volume":"89","author":"Jensen","year":"2021","journal-title":"Ann. Neurol."},{"issue":"10","key":"10.1016\/j.jns.2026.125785_bb0040","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1002\/mds.28685","article-title":"Peripheral immune profile and neutrophil-to-lymphocyte ratio in Parkinson\u2019s disease","volume":"36","author":"Mu\u00f1oz-Delgado","year":"2021","journal-title":"Mov. Disord."},{"issue":"1","key":"10.1016\/j.jns.2026.125785_bb0045","article-title":"Peripheral inflammatory immune response differs among sporadic and familial Parkinson\u2019s disease","volume":"9","author":"Mu\u00f1oz-Delgado","year":"2023","journal-title":"Npj Parkinsons Dis."},{"issue":"1","key":"10.1016\/j.jns.2026.125785_bb0050","doi-asserted-by":"crossref","DOI":"10.1038\/s41531-025-01031-x","article-title":"The East London Parkinson\u2019s disease project \u2013 a case-control study of Parkinson\u2019s disease in a diverse population","volume":"11","author":"Zirra","year":"2025","journal-title":"Npj Parkinsons Dis."},{"key":"10.1016\/j.jns.2026.125785_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.parkreldis.2023.105480","article-title":"Neutrophil-to-lymphocyte ratio and lymphocyte count reflect alterations in central neurodegeneration-associated proteins and clinical severity in Parkinson disease patients","volume":"112","author":"Grillo","year":"2023","journal-title":"Parkinsonism Relat. Disord."},{"issue":"7726","key":"10.1016\/j.jns.2026.125785_bb0060","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s41586-018-0579-z","article-title":"The UK biobank resource with deep phenotyping and genomic data","volume":"562","author":"Bycroft","year":"2018","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.jns.2026.125785_bb0065","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3233\/JPD-191763","article-title":"Ethnic variation in the manifestation of Parkinson\u2019s disease: a narrative review","volume":"10","author":"Ben-Joseph","year":"2019","journal-title":"J. Parkinsons Dis."}],"updated-by":[{"DOI":"10.1016\/j.jns.2026.126164","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000}},{"DOI":"10.1016\/j.jns.2026.126164","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,11,15]],"date-time":"2026-11-15T00:00:00Z","timestamp":1794700800000}}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X26000675?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X26000675?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:23:51Z","timestamp":1790709831000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X26000675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":13,"alternative-id":["S0022510X26000675"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2026.125785","relation":{},"ISSN":["0022-510X"],"issn-type":[{"value":"0022-510X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A cross-sectional exploration of the relationship between Parkinson's disease and peripheral blood immune cells in an ethnically diverse East London population","name":"articletitle","label":"Article Title"},{"value":"Journal of the Neurological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jns.2026.125785","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"125785"}}