{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T11:39:40Z","timestamp":1774697980243,"version":"3.50.1"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jns-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.jns.2026.125786","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:28:11Z","timestamp":1770078491000},"page":"125786","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Correlation between blood biomarkers and patient-reported outcomes (PROs) of depression and mental health scores in individuals with multiple sclerosis (iwMS)"],"prefix":"10.1016","volume":"482","author":[{"given":"Moogeh","family":"Baharnoori","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bonnie","family":"Glanz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariann","family":"Polgar-Turcsanyi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shrishti","family":"Saxena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard","family":"Weiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Healy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanuja","family":"Chitnis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jns.2026.125786_bb0005","doi-asserted-by":"crossref","first-page":"e1029","DOI":"10.1212\/WNL.0000000000007035","article-title":"The prevalence of MS in the United States: a population-based estimate using health claims data","volume":"92","author":"Wallin","year":"2019","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2026.125786_bb0010","doi-asserted-by":"crossref","first-page":"e1810","DOI":"10.1212\/WNL.0000000000200150","article-title":"The economic burden of multiple sclerosis in the United States: estimate of direct and indirect costs","volume":"98","author":"Bebo","year":"2022","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2026.125786_bb0015","doi-asserted-by":"crossref","first-page":"1120541","DOI":"10.3389\/fnins.2023.1120541","article-title":"The prevalence and risk factors of anxiety in multiple sclerosis: a systematic review and meta-analysis","volume":"17","author":"Zhang","year":"2023","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.jns.2026.125786_bb0020","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1212\/01.WNL.0000095964.34294.B4","article-title":"Major depression in multiple sclerosis: a population-based perspective","volume":"61","author":"Patten","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2026.125786_bb0025","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.jns.2016.11.067","article-title":"Prevalence of depression and anxiety in multiple sclerosis: a systematic review and meta-analysis","volume":"372","author":"Boeschoten","year":"2017","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.jns.2026.125786_bb0030","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1177\/1352458508099477","article-title":"The burden of mental comorbidity in multiple sclerosis: frequent, underdiagnosed, and undertreated","volume":"15","author":"Marrie","year":"2009","journal-title":"Mult. Scler."},{"key":"10.1016\/j.jns.2026.125786_bb0035","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s10865-010-9247-y","article-title":"Treatment adherence in multiple sclerosis: association with emotional status, personality, and cognition","volume":"33","author":"Bruce","year":"2010","journal-title":"J. Behav. Med."},{"key":"10.1016\/j.jns.2026.125786_bb0040","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.jval.2012.07.010","article-title":"Work productivity in relapsing multiple sclerosis: associations with disability, depression, fatigue, anxiety, cognition, and health-related quality of life","volume":"15","author":"Glanz","year":"2012","journal-title":"Value Health"},{"key":"10.1016\/j.jns.2026.125786_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2023.104695","article-title":"Early neurofilament light and glial fibrillary acidic protein levels improve predictive models of multiple sclerosis outcomes","volume":"74","author":"Bose","year":"2023","journal-title":"Mult. Scler. Relat. Disord."},{"key":"10.1016\/j.jns.2026.125786_bb0050","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1002\/acn3.52187","article-title":"Serum glial fibrillary acidic protein predicts disease progression in multiple sclerosis","volume":"11","author":"Madill","year":"2024","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"10.1016\/j.jns.2026.125786_bb0055","doi-asserted-by":"crossref","first-page":"e1007","DOI":"10.1212\/WNL.0000000000007032","article-title":"Blood neurofilament light chain as a biomarker of MS disease activity and treatment response","volume":"92","author":"Kuhle","year":"2019","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2026.125786_bb0060","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/BF02260859","article-title":"A health-related quality of life measure for multiple sclerosis","volume":"4","author":"Vickrey","year":"1995","journal-title":"Qual. Life Res."},{"key":"10.1016\/j.jns.2026.125786_bb0065","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.jad.2024.09.063","article-title":"Association between serum neurofilament light chains and depression: a cross-sectional study based on NHANES 2013-2014 database","volume":"368","author":"Zhang","year":"2025","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jns.2026.125786_bb0070","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.jad.2024.08.130","article-title":"Relationship between serum neurofilament light chain protein and depression: a nationwide survey and Mendelian randomization study","volume":"366","author":"Liu","year":"2024","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jns.2026.125786_bb0075","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1186\/s12888-024-05964-0","article-title":"Serum neurofilament light chain levels are associated with depression among US adults: a cross-sectional analysis among US adults, 2013-2014","volume":"24","author":"Song","year":"2024","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.jns.2026.125786_bb0080","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.jad.2024.07.146","article-title":"Serum neurofilament light chain, markers of systemic inflammation and clinically relevant depressive symptoms in US adults","volume":"363","author":"Guo","year":"2024","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jns.2026.125786_bb0085","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1093\/ijnp\/pyab068","article-title":"Neurofilament light chain is a novel biomarker for major depression and related executive dysfunction","volume":"25","author":"Chen","year":"2022","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.jns.2026.125786_bb0090","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1176\/appi.ajp.161.4.598","article-title":"Lower hippocampal volume in patients suffering from depression: a meta-analysis","volume":"161","author":"Campbell","year":"2004","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jns.2026.125786_bb0095","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1017\/S0033291799001567","article-title":"Quantitative MRI of the hippocampus and amygdala in severe depression","volume":"30","author":"Mervaala","year":"2000","journal-title":"Psychol. Med."},{"key":"10.1016\/j.jns.2026.125786_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.pscychresns.2024.111885","article-title":"Atlas-based structural analysis of prefrontal cortex atrophy in major depressive disorder: correlations with severity and episode frequency","volume":"344","author":"Kokce","year":"2024","journal-title":"Psychiatry Res. Neuroimaging"},{"key":"10.1016\/j.jns.2026.125786_bb0105","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0006-3223(01)01336-1","article-title":"Reduced volume of orbitofrontal cortex in major depression","volume":"51","author":"Bremner","year":"2002","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jns.2026.125786_bb0110","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.pscychresns.2013.05.004","article-title":"Reduced thalamic volumes in major depressive disorder","volume":"213","author":"Nugent","year":"2013","journal-title":"Psychiatry Res. Neuroimaging"},{"key":"10.1016\/j.jns.2026.125786_bb0115","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1177\/13524585221148144","article-title":"Deep gray matter substructure volumes and depressive symptoms in a large multiple sclerosis cohort","volume":"29","author":"Hu","year":"2023","journal-title":"Mult. Scler. J."},{"key":"10.1016\/j.jns.2026.125786_bb0120","doi-asserted-by":"crossref","first-page":"178","DOI":"10.7224\/1537-2073.2020-015","article-title":"Relationship between interpersonal depressive symptoms and reduced amygdala volume in people with multiple sclerosis","volume":"23","author":"Haines","year":"2021","journal-title":"Int. J. MS Care"},{"key":"10.1016\/j.jns.2026.125786_bb0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/8056370","article-title":"Dendritic spines in depression: what we learned from animal models","volume":"2016","author":"Qiao","year":"2016","journal-title":"Neural Plast."},{"key":"10.1016\/j.jns.2026.125786_bb0130","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1177\/1073858403252773","article-title":"Depression: what we can learn from postmortem studies","volume":"9","author":"Rajkowska","year":"2003","journal-title":"Neuroscientist"},{"key":"10.1016\/j.jns.2026.125786_bb0135","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.jad.2011.08.003","article-title":"Interleukin (IL)-6, tumour necrosis factor alpha (TNF-\u03b1) and soluble interleukin-2 receptors (sIL-2R) are elevated in patients with major depressive disorder: a meta-analysis and meta-regression","volume":"139","author":"Liu","year":"2012","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jns.2026.125786_bb0140","article-title":"Inflammatory proteins related to depression in multiple sclerosis: a systematic review and meta-analysis","volume":"43","author":"Kiropoulos","year":"2025","journal-title":"Brain Behav. Immun. Health"},{"key":"10.1016\/j.jns.2026.125786_bb0145","doi-asserted-by":"crossref","first-page":"5191","DOI":"10.1007\/s12035-015-9443-4","article-title":"Immune-inflammatory and oxidative and Nitrosative stress biomarkers of depression symptoms in subjects with multiple sclerosis: increased peripheral inflammation but less acute neuroinflammation","volume":"53","author":"Kallaur","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.jns.2026.125786_bb0150","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1177\/10998004211050082","article-title":"Depression and inflammatory markers in veterans with multiple sclerosis","volume":"24","author":"Newland","year":"2022","journal-title":"Biol. Res. Nurs."},{"key":"10.1016\/j.jns.2026.125786_bb0155","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1001\/archneur.58.7.1081","article-title":"Treatment of depression is associated with suppression of nonspecific and antigen-specific T(H)1 responses in multiple sclerosis","volume":"58","author":"Mohr","year":"2001","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.jns.2026.125786_bb0160","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.677879","article-title":"Antidepressants on multiple sclerosis: a review of in vitro and in vivo models","volume":"12","author":"Stamoula","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jns.2026.125786_bb0165","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jpsychires.2021.09.012","article-title":"Glial fibrillary acidic protein as blood biomarker for differential diagnosis and severity of major depressive disorder","volume":"144","author":"Steinacker","year":"2021","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.jns.2026.125786_bb0170","doi-asserted-by":"crossref","DOI":"10.1093\/gerona\/glad129","article-title":"Depressive symptoms, glial fibrillary acid protein concentrations, and cognitive decline in a cohort study","volume":"79","author":"Desai","year":"2024","journal-title":"J. Gerontol.: Ser. A"},{"key":"10.1016\/j.jns.2026.125786_bb0175","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2022.1039379","article-title":"Anti-inflammatory properties of commonly used psychiatric drugs","volume":"16","author":"Patel","year":"2023","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.jns.2026.125786_bb0180","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1212\/WNL.0000000000010346","article-title":"Serum neurofilament light as a biomarker in progressive multiple sclerosis","volume":"95","author":"Kapoor","year":"2020","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2026.125786_bb0185","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1007\/s40120-023-00535-z","article-title":"Neurofilament light chain in adult and pediatric multiple sclerosis: a promising biomarker to better characterize disease activity and personalize MS treatment","volume":"12","author":"Ghezzi","year":"2023","journal-title":"Neurol. Ther."}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X26000687?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X26000687?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T13:32:12Z","timestamp":1771680732000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X26000687"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":37,"alternative-id":["S0022510X26000687"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2026.125786","relation":{},"ISSN":["0022-510X"],"issn-type":[{"value":"0022-510X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Correlation between blood biomarkers and patient-reported outcomes (PROs) of depression and mental health scores in individuals with multiple sclerosis (iwMS)","name":"articletitle","label":"Article Title"},{"value":"Journal of the Neurological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jns.2026.125786","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"125786"}}