{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T17:54:40Z","timestamp":1793037280112,"version":"4.5.0"},"reference-count":119,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010814","name":"Anhui Province Department of Education","doi-asserted-by":"publisher","award":["S202310361260"],"award-info":[{"award-number":["S202310361260"]}],"id":[{"id":"10.13039\/501100010814","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006247","name":"Anhui University of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006247","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jns-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.jns.2026.125809","type":"journal-article","created":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T23:31:44Z","timestamp":1771198304000},"page":"125809","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Research progress on molecular mechanisms and therapeutic targets of blood-brain barrier dysfunction secondary to intracerebral hemorrhage"],"prefix":"10.1016","volume":"482","author":[{"given":"Zequan","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongli","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghai","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.jns.2026.125809_bb0005","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S1474-4422(21)00252-0","article-title":"Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the global burden of disease study 2019","volume":"20","author":"Feigin","year":"2021","journal-title":"Lancet Neurol."},{"issue":"8","key":"10.1016\/j.jns.2026.125809_bb0010","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1161\/CIRCRESAHA.121.319949","article-title":"Cerebral hemorrhage: pathophysiology, treatment, and future directions","volume":"130","author":"Magid-Bernstein","year":"2022","journal-title":"Circ. Res."},{"issue":"10446","key":"10.1016\/j.jns.2026.125809_bb0015","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.1016\/S0140-6736(24)00642-1","article-title":"The stroke","volume":"403","author":"Hilkens","year":"2024","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.jns.2026.125809_bb0020","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1161\/STROKEAHA.123.043033","article-title":"Code ICH: a call to action","volume":"55","author":"Li","year":"2024","journal-title":"Stroke"},{"issue":"14","key":"10.1016\/j.jns.2026.125809_bb0025","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1056\/NEJMoa2308440","article-title":"Trial of early minimally invasive removal of intracerebral hemorrhage","volume":"390","author":"Pradilla","year":"2024","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.jns.2026.125809_bb0030","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1152\/physrev.00050.2017","article-title":"Blood-brain barrier: from physiology to disease and back","volume":"99","author":"Sweeney","year":"2019","journal-title":"Physiol. Rev."},{"issue":"7323","key":"10.1016\/j.jns.2026.125809_bb0035","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nature09522","article-title":"Pericytes regulate the blood-brain barrier","volume":"468","author":"Armulik","year":"2010","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.jns.2026.125809_bb0040","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1177\/0271678X241274685","article-title":"Neuroinflammation and blood-brain barrier breakdown in acute, clinical intracerebral hemorrhage","volume":"45","author":"Jones","year":"2025","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"4","key":"10.1016\/j.jns.2026.125809_bb0045","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1177\/1747493018806167","article-title":"Glial fibrillary acidic protein for the early diagnosis of intracerebral hemorrhage: systematic review and meta-analysis of diagnostic test accuracy","volume":"14","author":"Perry","year":"2019","journal-title":"Int. J. Stroke"},{"issue":"1","key":"10.1016\/j.jns.2026.125809_bb0050","doi-asserted-by":"crossref","DOI":"10.1007\/s10143-025-03829-y","article-title":"Claudin proteins and hemorrhage severity in aneurysmal subarachnoid hemorrhage: correlation with modified fisher score but not functional outcome","volume":"48","author":"Lenzser","year":"2025","journal-title":"Neurosurg. Rev."},{"issue":"3","key":"10.1016\/j.jns.2026.125809_bb0055","doi-asserted-by":"crossref","DOI":"10.1111\/cns.14450","article-title":"Association of serum occludin levels and perihematomal edema volumes in intracranial hemorrhage patients","volume":"30","author":"Yuan","year":"2024","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.jns.2026.125809_bb0060","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.617163","article-title":"The changes of leukocytes in brain and blood after intracerebral hemorrhage","volume":"12","author":"Mei","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jns.2026.125809_bb0065","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2025.1667228","article-title":"The role of MMPs in intracerebral hemorrhage","volume":"13","author":"Guan","year":"2025","journal-title":"Front. Cell Dev. Biol."},{"issue":"2","key":"10.1016\/j.jns.2026.125809_bb0070","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0315333","article-title":"Potential blood biomarkers that can be used as prognosticators of spontaneous intracerebral hemorrhage: a systematic review and meta-analysis","volume":"20","author":"Sasongko","year":"2025","journal-title":"PLoS One"},{"key":"10.1016\/j.jns.2026.125809_bb0075","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2021.699736","article-title":"Profiling of blood-brain barrier disruption in mouse intracerebral hemorrhage models: collagenase injection vs. autologous arterial whole blood infusion","volume":"15","author":"Jia","year":"2021","journal-title":"Front. Cell. Neurosci."},{"issue":"3","key":"10.1016\/j.jns.2026.125809_bb0080","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1007\/s00062-023-01285-z","article-title":"Temporal evolution of perihematomal blood-brain barrier compromise and edema growth after intracerebral hemorrhage","volume":"33","author":"Yang","year":"2023","journal-title":"Clin. Neuroradiol."},{"issue":"11","key":"10.1016\/j.jns.2026.125809_bb0085","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.crad.2022.05.028","article-title":"Association between cerebral blood flow changes and blood-brain barrier compromise in spontaneous intracerebral haemorrhage","volume":"77","author":"Zhang","year":"2022","journal-title":"Clin. Radiol."},{"issue":"12","key":"10.1016\/j.jns.2026.125809_bb0090","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.2174\/1570159X18666200720173316","article-title":"Angiogenesis and blood-brain barrier permeability in vascular remodeling after stroke","volume":"18","author":"Yang","year":"2020","journal-title":"Curr. Neuropharmacol."},{"issue":"3","key":"10.1016\/j.jns.2026.125809_bb0095","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s12975-021-00897-2","article-title":"Neurovascular units and neural-glia networks in intracerebral hemorrhage: from mechanisms to translation","volume":"12","author":"Sun","year":"2021","journal-title":"Transl. Stroke Res."},{"key":"10.1016\/j.jns.2026.125809_bb0100","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.brainres.2016.12.011","article-title":"Mechanisms of modulation of brain microvascular endothelial cells function by thrombin","volume":"1657","author":"Brailoiu","year":"2017","journal-title":"Brain Res."},{"key":"10.1016\/j.jns.2026.125809_bb0105","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.jare.2024.11.008","article-title":"Endothelial NMMHC IIA dissociation from PAR1 activates the CREB3\/ ARF4 signaling in thrombin-mediated intracerebral hemorrhage","volume":"75","author":"Dai","year":"2025","journal-title":"J. Adv. Res."},{"issue":"1","key":"10.1016\/j.jns.2026.125809_bb0110","doi-asserted-by":"crossref","DOI":"10.1038\/s41420-022-00997-4","article-title":"Thrombin induces morphological and inflammatory astrocytic responses via activation of PAR1 receptor","volume":"8","author":"Chen","year":"2022","journal-title":"Cell Death Discov."},{"issue":"6","key":"10.1016\/j.jns.2026.125809_bb0115","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.4103\/1673-5374.357905","article-title":"Thrombin increases the expression of cholesterol 25-hydroxylase in rat astrocytes after spinal cord injury","volume":"18","author":"Chen","year":"2023","journal-title":"Neural Regen. Res."},{"issue":"4","key":"10.1016\/j.jns.2026.125809_bb0120","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3892\/etm.2021.10930","article-title":"Thrombin aggravates hypoxia\/reoxygenation injury of astrocytes by activating the autophagy pathway mediated by SPRED2","volume":"22","author":"Wang","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.jns.2026.125809_bb0125","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.neuroscience.2017.03.026","article-title":"Role of thrombin-PAR1-PKC\u03b8\/\u03b4 axis in brain pericytes in thrombin-induced MMP-9 production and blood-brain barrier dysfunction in vitro","volume":"350","author":"Machida","year":"2017","journal-title":"Neuroscience"},{"issue":"3","key":"10.1016\/j.jns.2026.125809_bb0130","doi-asserted-by":"crossref","DOI":"10.1161\/STROKEAHA.111.000433","article-title":"Efficacy and safety of Vorapaxar in patients with prior ischemic stroke","volume":"44","author":"Morrow","year":"2013","journal-title":"Stroke"},{"issue":"12","key":"10.1016\/j.jns.2026.125809_bb0135","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1038\/jcbfm.2010.45","article-title":"Hemoglobin-induced oxidative stress contributes to matrix metalloproteinase activation and blood-brain barrier dysfunction in vivo","volume":"30","author":"Katsu","year":"2010","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"7","key":"10.1016\/j.jns.2026.125809_bb0140","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.4103\/1673-5374.251190","article-title":"Potential therapeutic molecular targets for blood-brain barrier disruption after subarachnoid hemorrhage","volume":"14","author":"Kanamaru","year":"2019","journal-title":"Neural Regen. Res."},{"issue":"3","key":"10.1016\/j.jns.2026.125809_bb0145","doi-asserted-by":"crossref","DOI":"10.1111\/cns.14681","article-title":"Intracerebral hemorrhage-induced brain injury in mice: the role of peroxiredoxin 2-toll-like receptor 4 inflammatory axis","volume":"30","author":"Du","year":"2024","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.jns.2026.125809_bb0150","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.trsl.2022.08.011","article-title":"The NLRP3 inflammasome fires up heme-induced inflammation in hemolytic conditions","volume":"252","author":"Salgar","year":"2023","journal-title":"Transl. Res."},{"key":"10.1016\/j.jns.2026.125809_bb0155","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1146\/annurev-nutr-062320-112625","article-title":"Molecular mechanisms of iron and heme metabolism","volume":"42","author":"Dutt","year":"2022","journal-title":"Annu. Rev. Nutr."},{"issue":"1","key":"10.1016\/j.jns.2026.125809_bb0160","doi-asserted-by":"crossref","first-page":"9","DOI":"10.31083\/j.jin2201009","article-title":"Neuroinflammation in bilirubin neurotoxicity","volume":"22","author":"Zhang","year":"2023","journal-title":"J. Integr. Neurosci."},{"issue":"4","key":"10.1016\/j.jns.2026.125809_bb0165","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.pneurobio.2010.08.001","article-title":"Preclinical and clinical research on inflammation after intracerebral hemorrhage","volume":"92","author":"Wang","year":"2010","journal-title":"Prog. Neurobiol."},{"issue":"3","key":"10.1016\/j.jns.2026.125809_bb0170","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1007\/s12035-016-9785-6","article-title":"Microglial polarization and inflammatory mediators after intracerebral hemorrhage","volume":"54","author":"Zhang","year":"2017","journal-title":"Mol. Neurobiol."},{"issue":"7","key":"10.1016\/j.jns.2026.125809_bb0175","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/nrneurol.2017.69","article-title":"Modulators of microglial activation and polarization after intracerebral haemorrhage","volume":"13","author":"Lan","year":"2017","journal-title":"Nat. Rev. Neurol."},{"issue":"1","key":"10.1016\/j.jns.2026.125809_bb0180","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s11033-024-09859-x","article-title":"GM130-silencing may aggravate blood-brain barrier damage and affect microglia polarization by down-regulating PD-L1 expression after experimental intracerebral hemorrhage","volume":"51","author":"Chen","year":"2024","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.jns.2026.125809_bb0185","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.678744","article-title":"Immune cells in the BBB disruption after acute ischemic stroke: targets for immune therapy?","volume":"12","author":"Qiu","year":"2021","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.jns.2026.125809_bb0190","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s12975-018-0614-2","article-title":"Interleukin 6-mediated endothelial barrier disturbances can be attenuated by blockade of the IL6 receptor expressed in brain microvascular endothelial cells","volume":"9","author":"Blecharz-Lang","year":"2018","journal-title":"Transl. Stroke Res."},{"key":"10.1016\/j.jns.2026.125809_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106678","article-title":"Microglia-released leukotriene B4 promotes neutrophil infiltration and microglial activation following intracerebral hemorrhage","volume":"85","author":"Hijioka","year":"2020","journal-title":"Int. Immunopharmacol."},{"issue":"4","key":"10.1016\/j.jns.2026.125809_bb0200","doi-asserted-by":"crossref","first-page":"4093","DOI":"10.1007\/s12035-024-04534-5","article-title":"miRNA506 activates Sphk1 binding with Sirt1 to inhibit brain injury after intracerebral hemorrhage via PI3K\/AKT signaling pathway","volume":"62","author":"Liang","year":"2025","journal-title":"Mol. Neurobiol."},{"issue":"12","key":"10.1016\/j.jns.2026.125809_bb0205","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-024-07310-4","article-title":"Sphk1\/S1P pathway promotes blood-brain barrier breakdown after intracerebral hemorrhage through inducing Nlrp3-mediated endothelial cell pyroptosis","volume":"15","author":"Feng","year":"2024","journal-title":"Cell Death Dis."},{"issue":"5","key":"10.1016\/j.jns.2026.125809_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e26909","article-title":"Modulation of GPER1 alleviates early brain injury via inhibition of A1 reactive astrocytes activation after intracerebral hemorrhage in mice","volume":"10","author":"Mao","year":"2024","journal-title":"Heliyon"},{"issue":"7638","key":"10.1016\/j.jns.2026.125809_bb0215","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature21029","article-title":"Neurotoxic reactive astrocytes are induced by activated microglia","volume":"541","author":"Liddelow","year":"2017","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.jns.2026.125809_bb0220","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-022-02428-8","article-title":"Homer1 promotes the conversion of A1 astrocytes to A2 astrocytes and improves the recovery of transgenic mice after intracerebral hemorrhage","volume":"19","author":"Fei","year":"2022","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jns.2026.125809_bb0225","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2024.1327472","article-title":"Astrocytes in intracerebral hemorrhage: impact and therapeutic objectives","volume":"17","author":"Dong","year":"2024","journal-title":"Front. Mol. Neurosci."},{"issue":"3","key":"10.1016\/j.jns.2026.125809_bb0230","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1177\/0271678X231214838","article-title":"CCL5 mediated astrocyte-T cell interaction disrupts blood-brain barrier in mice after hemorrhagic stroke","volume":"44","author":"Zhou","year":"2024","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"1","key":"10.1016\/j.jns.2026.125809_bb0235","doi-asserted-by":"crossref","DOI":"10.1186\/s12967-023-04044-3","article-title":"CCL5\/CCR5-mediated peripheral inflammation exacerbates blood-brain barrier disruption after intracerebral hemorrhage in mice","volume":"21","author":"Lin","year":"2023","journal-title":"J. Transl. Med."},{"issue":"4","key":"10.1016\/j.jns.2026.125809_bb0240","doi-asserted-by":"crossref","first-page":"2692","DOI":"10.1007\/s13311-021-01126-2","article-title":"Upregulation of AQP4 improves blood-brain barrier integrity and perihematomal edema following intracerebral hemorrhage","volume":"18","author":"Jeon","year":"2021","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.jns.2026.125809_bb0245","article-title":"AQP2 promotes astrocyte activation by modulating the TLR4\/NF\u03baB-p65 pathway following intracerebral hemorrhage","volume":"13","author":"Deng","year":"2022","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.jns.2026.125809_bb0250","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202305339","article-title":"Astrocyte-derived extracellular vesicular miR-143-3p dampens autophagic degradation of endothelial adhesion molecules and promotes neutrophil transendothelial migration after acute brain injury","volume":"11","author":"Wu","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jns.2026.125809_bb0255","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.neulet.2014.06.052","article-title":"Tumor necrosis factor-\u03b1-stimulated brain pericytes possess a unique cytokine and chemokine release profile and enhance microglial activation","volume":"578","author":"Matsumoto","year":"2014","journal-title":"Neurosci. Lett."},{"issue":"2","key":"10.1016\/j.jns.2026.125809_bb0260","doi-asserted-by":"crossref","DOI":"10.3390\/biom15020164","article-title":"Intracerebral hemorrhage-associated iron release leads to pericyte-dependent cerebral capillary function disruption","volume":"15","author":"Balk","year":"2025","journal-title":"Biomolecules"},{"issue":"1","key":"10.1016\/j.jns.2026.125809_bb0265","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-025-03518-z","article-title":"Comprehensive insight on immune landscape in intracerebral hemorrhage patients with single-cell RNA sequencing: from blood to hematoma","volume":"22","author":"Du","year":"2025","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jns.2026.125809_bb0270","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2022.1091498","article-title":"The roles of chemokines following intracerebral hemorrhage in animal models and humans","volume":"15","author":"Wang","year":"2023","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.jns.2026.125809_bb0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2023.114451","article-title":"Recruitment of regulatory T cells with rCCL17 promotes M2 microglia\/macrophage polarization through TGF\u03b2\/TGF\u03b2R\/Smad2\/3 pathway in a mouse model of intracerebral hemorrhage","volume":"367","author":"Deng","year":"2023","journal-title":"Exp. Neurol."},{"issue":"8","key":"10.1016\/j.jns.2026.125809_bb0280","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1161\/STROKEAHA.124.046394","article-title":"Toll-like receptors mediate opposing dendritic cell effects on Treg\/Th17 balance in mice with intracerebral hemorrhage","volume":"55","author":"Zhu","year":"2024","journal-title":"Stroke"},{"issue":"12","key":"10.1016\/j.jns.2026.125809_bb0285","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20200213","article-title":"Brain transforms natural killer cells that exacerbate brain edema after intracerebral hemorrhage","volume":"217","author":"Li","year":"2020","journal-title":"J. Exp. Med."},{"issue":"23","key":"10.1016\/j.jns.2026.125809_bb0290","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abq0712","article-title":"CD4+T cells aggravate hemorrhagic brain injury","volume":"9","author":"Shi","year":"2023","journal-title":"Sci. Adv."},{"issue":"12","key":"10.1016\/j.jns.2026.125809_bb0295","doi-asserted-by":"crossref","first-page":"10097","DOI":"10.1007\/s12035-024-04209-1","article-title":"An amino acids and dipeptide injection inhibits the TNF-\u03b1\/HMGB1 inflammatory signaling pathway to reduce pyroptosis and M1 microglial polarization in POCD mice: the gut to the brain","volume":"61","author":"Ji","year":"2024","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.jns.2026.125809_bb0300","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.bbi.2021.02.001","article-title":"Microglia-derived interleukin-10 accelerates post-intracerebral hemorrhage hematoma clearance by regulating CD36","volume":"94","author":"Li","year":"2021","journal-title":"Brain Behav. Immun."},{"issue":"1","key":"10.1016\/j.jns.2026.125809_bb0305","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-021-02101-6","article-title":"Ceria nanoparticles ameliorate white matter injury after intracerebral hemorrhage: microglia-astrocyte involvement in remyelination","volume":"18","author":"Zheng","year":"2021","journal-title":"J. Neuroinflammation"},{"issue":"8","key":"10.1016\/j.jns.2026.125809_bb0310","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.jpha.2023.02.007","article-title":"Temporal dynamics of microglia-astrocyte interaction in neuroprotective glial scar formation after intracerebral hemorrhage","volume":"13","author":"Zheng","year":"2023","journal-title":"J. Pharm. Anal."},{"issue":"8","key":"10.1016\/j.jns.2026.125809_bb0315","article-title":"P2X7 receptor activation aggravates NADPH oxidase 2-induced oxidative stress after intracerebral hemorrhage","volume":"16","author":"Deng","year":"2021","journal-title":"Neural Regen. Res."},{"issue":"23","key":"10.1016\/j.jns.2026.125809_bb0320","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252313180","article-title":"Secondary brain injury after parenchymal cerebral hemorrhage in humans: the role of NOX2-mediated oxidative stress and endothelin-1","volume":"25","author":"De Michele","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.jns.2026.125809_bb0325","first-page":"1734","article-title":"Knockdown of NADPH oxidase 4 reduces mitochondrial oxidative stress and neuronal pyroptosis following intracerebral hemorrhage","volume":"18","author":"Ding","year":"2023","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.jns.2026.125809_bb0330","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.112749","article-title":"Targeting the multifaceted roles of mitochondria in intracerebral hemorrhage and therapeutic prospects","volume":"148","author":"Li","year":"2022","journal-title":"Biomed. Pharmacother."},{"issue":"3","key":"10.1016\/j.jns.2026.125809_bb0335","doi-asserted-by":"crossref","first-page":"283","DOI":"10.4196\/kjpp.24.182","article-title":"Shikonin attenuates blood-brain barrier injury and oxidative stress in rats with subarachnoid hemorrhage by activating Sirt1\/ Nrf2\/HO-1 signaling","volume":"29","author":"Li","year":"2025","journal-title":"Korean J. Physiol. Pharmacol."},{"key":"10.1016\/j.jns.2026.125809_bb0340","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2024.114703","article-title":"Mitochondrial ferritin upregulation reduced oxidative stress and blood-brain-barrier disruption by maintaining cellular iron homeostasis in a neonatal rat model of germinal matrix hemorrhage","volume":"374","author":"Yuan","year":"2024","journal-title":"Exp. Neurol."},{"issue":"4","key":"10.1016\/j.jns.2026.125809_bb0345","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/cns.70385","article-title":"Cannabinoid receptors reduced early brain damage by regulating NOX-2 and the NLRP3 inflammasome in an animal model of intracerebral hemorrhage","volume":"31","author":"Mart\u00ednez-Torres","year":"2025","journal-title":"CNS Neurosci. Ther."},{"issue":"16","key":"10.1016\/j.jns.2026.125809_bb0350","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1089\/ars.2021.0215","article-title":"Kynurenine\/aryl hydrocarbon receptor modulates mitochondria-mediated oxidative stress and neuronal apoptosis in experimental intracerebral hemorrhage","volume":"37","author":"Ren","year":"2022","journal-title":"Antioxid. Redox Signal."},{"issue":"20","key":"10.1016\/j.jns.2026.125809_bb0355","first-page":"11184","article-title":"Inhibiting microRNA-200a-3p attenuates pyroptosis via targeting the SIRT1\/NF-\u03baB\/NLRP3 pathway in H2O2-induced HAEC","volume":"15","author":"Liu","year":"2023","journal-title":"Aging-Us"},{"key":"10.1016\/j.jns.2026.125809_bb0360","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102256","article-title":"Reduction of lactoferrin aggravates neuronal ferroptosis after intracerebral hemorrhagic stroke in hyperglycemic mice","volume":"50","author":"Xiao","year":"2022","journal-title":"Redox Biol."},{"issue":"4","key":"10.1016\/j.jns.2026.125809_bb0365","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1161\/STROKEAHA.116.015609","article-title":"Neuronal death after hemorrhagic stroke in vitro and in vivo shares features of ferroptosis and necroptosis","volume":"48","author":"Zille","year":"2017","journal-title":"Stroke"},{"issue":"10","key":"10.1016\/j.jns.2026.125809_bb0370","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1523\/JNEUROSCI.0923-20.2021","article-title":"Hemin-induced death models hemorrhagic stroke and is a variant of classical neuronal ferroptosis","volume":"42","author":"Zille","year":"2022","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.jns.2026.125809_bb0375","doi-asserted-by":"crossref","DOI":"10.1007\/s12031-025-02310-1","article-title":"TNFSF9 silence impedes cerebral ischemia-reperfusion injury via modulating SLC3A2 expression in brain microvascular endothelial cells","volume":"75","author":"Liang","year":"2025","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.jns.2026.125809_bb0380","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103342","article-title":"Lipocalin-2 aggravates blood-brain barrier dysfunction after intravenous thrombolysis by promoting endothelial cell ferroptosis via regulating the HMGB1\/Nrf2\/HO-1 pathway","volume":"76","author":"Liu","year":"2024","journal-title":"Redox Biol."},{"issue":"10","key":"10.1016\/j.jns.2026.125809_bb0385","doi-asserted-by":"crossref","first-page":"3842","DOI":"10.7150\/ijbs.96262","article-title":"Single-cell and spatial transcriptomics reveals ferroptosis as the most enriched programmed cell death process in hemorrhage stroke-induced oligodendrocyte-mediated white matter injury","volume":"20","author":"Gu","year":"2024","journal-title":"Int. J. Biol. Sci."},{"issue":"10","key":"10.1016\/j.jns.2026.125809_bb0390","doi-asserted-by":"crossref","first-page":"7549","DOI":"10.1007\/s12035-024-04000-2","article-title":"Mechanism of HDAC1 regulating iron overload-induced neuronal oxidative damage after cerebral hemorrhage","volume":"61","author":"Han","year":"2024","journal-title":"Mol. Neurobiol."},{"issue":"7","key":"10.1016\/j.jns.2026.125809_bb0395","doi-asserted-by":"crossref","DOI":"10.3390\/antiox11071257","article-title":"Overexpression of mitochondrial ferritin enhances blood-brain barrier integrity following ischemic stroke in mice by maintaining iron homeostasis in endothelial cells","volume":"11","author":"Wang","year":"2022","journal-title":"Antioxidants"},{"issue":"2","key":"10.1016\/j.jns.2026.125809_bb0400","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1007\/s13311-020-00839-0","article-title":"Matrix metalloproteinases in acute intracerebral hemorrhage","volume":"17","author":"Lattanzi","year":"2020","journal-title":"Neurotherapeutics"},{"issue":"10","key":"10.1016\/j.jns.2026.125809_bb0405","doi-asserted-by":"crossref","first-page":"7639","DOI":"10.1007\/s12035-024-04028-4","article-title":"Edaravone maintains AQP4 polarity via OS\/MMP9\/\u03b2-DG pathway in an experimental intracerebral hemorrhage mouse model","volume":"61","author":"Wang","year":"2024","journal-title":"Mol. Neurobiol."},{"issue":"8","key":"10.1016\/j.jns.2026.125809_bb0410","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1158\/0008-5472.CAN-23-0151","article-title":"MMP9 clears the way for metastatic cell penetration across the blood-brain barrier","volume":"83","author":"McCarty","year":"2023","journal-title":"Cancer Res."},{"key":"10.1016\/j.jns.2026.125809_bb0415","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2022.1117999","article-title":"The hallmark and crosstalk of immune cells after intracerebral hemorrhage: immunotherapy perspectives","volume":"16","author":"Zhang","year":"2023","journal-title":"Front. Neurosci."},{"issue":"1\u20133","key":"10.1016\/j.jns.2026.125809_bb0420","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1089\/ars.2021.0072","article-title":"Targeting oxidative stress and inflammatory response for blood-brain barrier protection in intracerebral hemorrhage","volume":"37","author":"Chen","year":"2022","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.jns.2026.125809_bb0425","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1155\/2021\/8815441","article-title":"Mechanisms of oxidative stress and therapeutic targets following intracerebral hemorrhage","volume":"2021","author":"Yao","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.jns.2026.125809_bb0430","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/3215391","article-title":"Oxidative stress in intracerebral hemorrhage: sources, mechanisms, and therapeutic targets","volume":"2016","author":"Hu","year":"2016","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.jns.2026.125809_bb0435","article-title":"Oxidative stress following intracerebral hemorrhage: from molecular mechanisms to therapeutic targets","volume":"13","author":"Zhang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jns.2026.125809_bb0440","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.111869","article-title":"The NLRP3 inhibitor, OLT1177 attenuates brain injury in experimental intracerebral hemorrhage","volume":"131","author":"Fang","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jns.2026.125809_bb0445","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.122277","article-title":"Improving outcomes in intracerebral hemorrhage through microglia\/macrophage-targeted IL-10 delivery with phosphatidylserine liposomes","volume":"301","author":"Han","year":"2023","journal-title":"Biomaterials"},{"key":"10.1016\/j.jns.2026.125809_bb0450","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2025.110576","article-title":"Hydroxysafflor yellow A attenuates the blood-brain barrier dysfunction and neuroinflammation through anti-inflammatory microglial polarization after intracerebral hemorrhage","volume":"278","author":"Zheng","year":"2025","journal-title":"Neuropharmacology"},{"issue":"9","key":"10.1016\/j.jns.2026.125809_bb0455","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1161\/STROKEAHA.123.043005","article-title":"Fractalkine enhances hematoma resolution and improves neurological function via CX3CR1\/AMPK\/PPAR? pathway after GMH (publication with expression of concern. See vol. 56, 2025)","volume":"54","author":"Chen","year":"2023","journal-title":"Stroke"},{"issue":"12","key":"10.1016\/j.jns.2026.125809_bb0460","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.3275","article-title":"Inhibitory effect and mechanism of Rosiglitazone on M1 type polarization of central microglia in intracerebral hemorrhage mice based on JNK\/STAT3 signaling pathway","volume":"13","author":"Chao","year":"2023","journal-title":"Brain Behav."},{"key":"10.1016\/j.jns.2026.125809_bb0465","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2022.111772","article-title":"GM130 protects against blood-brain barrier disruption and brain injury after intracerebral hemorrhage by regulating autophagy formation","volume":"163","author":"Deng","year":"2022","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.jns.2026.125809_bb0470","article-title":"FGL2 deficiency alleviates maternal inflammation-induced blood-brain barrier damage by blocking PI3K\/NF-\u03baB mediated endothelial oxidative stress","volume":"14","author":"Huang","year":"2023","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.jns.2026.125809_bb0475","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1038\/s12276-025-01454-9","article-title":"Acetylation of \u03b1-tubulin restores endothelial cell injury and blood-brain barrier disruption after intracerebral hemorrhage in mice","volume":"57","author":"Lei","year":"2025","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.jns.2026.125809_bb0480","article-title":"TAK1 inhibition mitigates intracerebral hemorrhage-induced brain injury through reduction of oxidative stress and neuronal pyroptosis via the NRF2 signaling pathway","volume":"15","author":"Zhao","year":"2024","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.jns.2026.125809_bb0485","doi-asserted-by":"crossref","DOI":"10.1111\/cns.14646","article-title":"Attenuation of neuronal ferroptosis in intracerebral hemorrhage by inhibiting HDAC1\/2: microglial heterogenization via the Nrf2\/HO1 pathway","volume":"30","author":"Jiang","year":"2024","journal-title":"CNS Neurosci. Ther."},{"issue":"11","key":"10.1016\/j.jns.2026.125809_bb0490","doi-asserted-by":"crossref","first-page":"3228","DOI":"10.1111\/cns.14255","article-title":"Endothelial TREM-1 receptor regulates the blood-brain barrier integrity after intracerebral hemorrhage in mice via SYK\/\u03b2-catenin signaling","volume":"29","author":"Xie","year":"2023","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.jns.2026.125809_bb0495","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2021.136297","article-title":"Neuroprotection of minocycline by inhibition of extracellular matrix metalloproteinase inducer expression following intracerebral hemorrhage in mice","volume":"764","author":"Liu","year":"2021","journal-title":"Neurosci. Lett."},{"issue":"2","key":"10.1016\/j.jns.2026.125809_bb0500","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1161\/STROKEAHA.123.043555","article-title":"Magnesium and hematoma expansion in intracerebral hemorrhage: a FAST-MAG randomized trial analysis","volume":"55","author":"Liotta","year":"2024","journal-title":"Stroke"},{"issue":"18","key":"10.1016\/j.jns.2026.125809_bb0505","doi-asserted-by":"crossref","DOI":"10.1002\/advs.201901166","article-title":"Magnesium regulates endothelial barrier functions through TRPM7, MagT1, and S1P1","volume":"6","author":"Zhu","year":"2019","journal-title":"Adv. Sci."},{"issue":"5","key":"10.1016\/j.jns.2026.125809_bb0510","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1177\/17474930211044635","article-title":"Intensive blood pressure lowering with nicardipine and outcomes after intracerebral hemorrhage: an individual participant data systematic review","volume":"17","author":"Toyoda","year":"2022","journal-title":"Int. J. Stroke"},{"issue":"3","key":"10.1016\/j.jns.2026.125809_bb0515","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0091167","article-title":"Anti-neuroinflammatory effects of the calcium channel blocker nicardipine on microglial cells: implications for neuroprotection","volume":"9","author":"Huang","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jns.2026.125809_bb0520","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.clineuro.2025.108723","article-title":"Statins reduce the recurrence of spontaneous intracerebral hemorrhage: a systematic review and meta-analysis","volume":"249","author":"Cui","year":"2025","journal-title":"Clin. Neurol. Neurosurg."},{"issue":"1","key":"10.1016\/j.jns.2026.125809_bb0525","doi-asserted-by":"crossref","DOI":"10.1007\/s10571-025-01566-w","article-title":"Atorvastatin protects against the macrophage\/microglia-related neuroinflammation via inhibiting lipocalin-2 in mouse experimental intracerebral hemorrhage model","volume":"45","author":"Wang","year":"2025","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.jns.2026.125809_bb0530","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2022.977941","article-title":"Dexmedetomidine post-conditioning protects blood-brain barrier integrity by modulating microglia\/macrophage polarization via inhibiting NF-\u03baB signaling pathway in intracerebral hemorrhage","volume":"15","author":"Guo","year":"2022","journal-title":"Front. Mol. Neurosci."},{"issue":"1","key":"10.1016\/j.jns.2026.125809_bb0535","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1097\/ALN.0000000000004986","article-title":"Effects of an early intensive blood pressure-lowering strategy using remifentanil and dexmedetomidine in patients with spontaneous intracerebral hemorrhage: a multicenter, prospective, superiority, randomized controlled trial","volume":"141","author":"Dong","year":"2024","journal-title":"Anesthesiology"},{"issue":"4","key":"10.1016\/j.jns.2026.125809_bb0540","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1161\/STROKEAHA.121.035421","article-title":"Effect of deferoxamine on outcome according to baseline hematoma volume: a post hoc analysis of the i-DEF trial","volume":"53","author":"Wei","year":"2022","journal-title":"Stroke"},{"key":"10.1016\/j.jns.2026.125809_bb0545","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2022.835494","article-title":"Minimally invasive surgery for ICH evacuation combined with deferoxamine treatment increased perihematomal claudin-5 and ZO-1 expression levels and decreased BBB permeability in rabbits","volume":"13","author":"Ren","year":"2022","journal-title":"Front. Neurol."},{"issue":"24","key":"10.1016\/j.jns.2026.125809_bb0550","doi-asserted-by":"crossref","DOI":"10.3390\/nu14245251","article-title":"Interplay between gut microbiota and NLRP3 inflammasome in intracerebral hemorrhage","volume":"14","author":"Zhang","year":"2022","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.jns.2026.125809_bb0555","doi-asserted-by":"crossref","first-page":"62","DOI":"10.4103\/NRR.NRR-D-24-00917","article-title":"NLRP3 inflammasome and gut microbiota-brain axis: a new perspective on white matter injury after intracerebral hemorrhage","volume":"21","author":"Cai","year":"2026","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.jns.2026.125809_bb0560","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2022.831977","article-title":"Research progress on the role of microglia membrane proteins or receptors in neuroinflammation and degeneration","volume":"16","author":"Zhao","year":"2022","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.jns.2026.125809_bb0565","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.neuroscience.2023.11.015","article-title":"The crosstalk between immune cells after intracerebral hemorrhage","volume":"537","author":"Zhang","year":"2024","journal-title":"Neuroscience"},{"issue":"3","key":"10.1016\/j.jns.2026.125809_bb0570","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1177\/23969873231185208","article-title":"Phase II randomised, placebo-controlled, clinical trial of interleukin-1 receptor antagonist in intracerebral haemorrhage: blocking the cytokine IL-1 in ICH (BLOC-ICH)","volume":"8","author":"Parry-Jones","year":"2023","journal-title":"Eur. Stroke J."},{"issue":"7","key":"10.1016\/j.jns.2026.125809_bb0575","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.116001","article-title":"TNF-\u03b1-NF-\u03baB activation through pathological \u03b1-synuclein disrupts the BBB and exacerbates axonopathy","volume":"44","author":"Jeon","year":"2025","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.jns.2026.125809_bb0580","first-page":"10","article-title":"Ultra-early computed tomography markers of haematoma expansion: potential trial targets?","volume":"11","author":"Mutimer","year":"2025","journal-title":"Eur. Stroke J."},{"issue":"19","key":"10.1016\/j.jns.2026.125809_bb0585","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1056\/NEJMoa2313040","article-title":"Andexanet for factor Xa inhibitor-associated acute intracerebral hemorrhage","volume":"390","author":"Connolly","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jns.2026.125809_bb0590","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.617163","article-title":"The changes of leukocytes in brain and blood after intracerebral hemorrhage","volume":"12","author":"Mei","year":"2021","journal-title":"Front. Immunol."},{"issue":"17","key":"10.1016\/j.jns.2026.125809_bb0595","doi-asserted-by":"crossref","DOI":"10.3390\/cells11172755","article-title":"Leptin promotes angiogenesis via pericyte STAT3 pathway upon intracerebral hemorrhage","volume":"11","author":"Cui","year":"2022","journal-title":"Cells"}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X26000912?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X26000912?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:29:44Z","timestamp":1777422584000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X26000912"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":119,"alternative-id":["S0022510X26000912"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2026.125809","relation":{},"ISSN":["0022-510X"],"issn-type":[{"value":"0022-510X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Research progress on molecular mechanisms and therapeutic targets of blood-brain barrier dysfunction secondary to intracerebral hemorrhage","name":"articletitle","label":"Article Title"},{"value":"Journal of the Neurological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jns.2026.125809","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"125809"}}