{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T17:44:20Z","timestamp":1777657460648,"version":"3.51.4"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100018936","name":"Qingdao Postdoctoral Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018936","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jns-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.jns.2026.125845","type":"journal-article","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T17:44:56Z","timestamp":1772473496000},"page":"125845","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Association of OBPIIa genetic variants with prodromal Parkinsonian phenotypes and dopaminergic biomarkers in the PPMI cohort"],"prefix":"10.1016","volume":"484","author":[{"given":"Chunyan","family":"Jiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Kong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuting","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiqing","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaixin","family":"Dou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binghui","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaqing","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anmu","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jns.2026.125845_bb0005","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0140-6736(14)61393-3","article-title":"Parkinson\u2019s disease","volume":"386","author":"Kalia","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.jns.2026.125845_bb0010","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.parkreldis.2008.12.005","article-title":"Prevalence of smell loss in Parkinson\u2019s disease\u2013a multicenter study","volume":"15","author":"Haehner","year":"2009","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.jns.2026.125845_bb0015","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nrneurol.2012.80","article-title":"Olfactory dysfunction in Parkinson disease","volume":"8","author":"Doty","year":"2012","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.jns.2026.125845_bb0020","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/ana.20160","article-title":"Idiopathic hyposmia as a preclinical sign of Parkinson\u2019s disease","volume":"56","author":"Ponsen","year":"2004","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.jns.2026.125845_bb0025","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","article-title":"Staging of brain pathology related to sporadic Parkinson\u2019s disease","volume":"24","author":"Braak","year":"2003","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.jns.2026.125845_bb0030","first-page":"1","article-title":"Olfactory dysfunction: common in later life and early warning of neurodegenerative disease","volume":"110","author":"H\u00fcttenbrink","year":"2013","journal-title":"Dtsch. Arztebl. Int."},{"key":"10.1016\/j.jns.2026.125845_bb0035","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S1474-4422(06)70373-8","article-title":"Non-motor symptoms of Parkinson\u2019s disease: diagnosis and management","volume":"5","author":"Chaudhuri","year":"2006","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jns.2026.125845_bb0040","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.nbd.2016.12.013","article-title":"The olfactory bulb as the entry site for prion-like propagation in neurodegenerative diseases","volume":"109","author":"Rey","year":"2018","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.jns.2026.125845_bb0045","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/S1474-4422(17)30123-0","article-title":"Olfactory dysfunction in neurodegenerative diseases: is there a common pathological substrate?","volume":"16","author":"Doty","year":"2017","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jns.2026.125845_bb0050","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1038\/nature06162","article-title":"Genetic variation in a human odorant receptor alters odour perception","volume":"449","author":"Keller","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.jns.2026.125845_bb0055","doi-asserted-by":"crossref","first-page":"7241","DOI":"10.1021\/bi015916c","article-title":"Evidence of an odorant-binding protein in the human olfactory mucus: location, structural characterization, and odorant-binding properties","volume":"41","author":"Briand","year":"2002","journal-title":"Biochemistry"},{"key":"10.1016\/j.jns.2026.125845_bb0060","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.bbr.2017.05.015","article-title":"Variant in a common odorant-binding protein gene is associated with bitter sensitivity in people","volume":"329","author":"Tomassini Barbarossa","year":"2017","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.jns.2026.125845_bb0065","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/j.1749-6632.1998.tb10584.x","article-title":"Odorant-binding proteins: structural aspects","volume":"855","author":"Pelosi","year":"1998","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.jns.2026.125845_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.126872","article-title":"Mammalian odorant-binding proteins are prone to form amorphous aggregates and amyloid fibrils","volume":"253","author":"Stepanenko","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jns.2026.125845_bb0075","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/s41420-025-02671-x","article-title":"An unexpected insight into the cause of olfactory dysfunction: fibrillogenesis of odorant-binding proteins","volume":"11","author":"Stepanenko","year":"2025","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.jns.2026.125845_bb0080","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1093\/hmg\/9.2.289","article-title":"A novel human odorant-binding protein gene family resulting from genomic duplicons at 9q34: differential expression in the oral and genital spheres","volume":"9","author":"Lacazette","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.jns.2026.125845_bb0085","doi-asserted-by":"crossref","first-page":"199","DOI":"10.3109\/10409239409086801","article-title":"Odorant-binding proteins","volume":"29","author":"Pelosi","year":"1994","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"10.1016\/j.jns.2026.125845_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2022.113860","article-title":"A polymorphism in the human gene encoding OBPIIa affects the perceived intensity of smelled odors","volume":"427","author":"Sollai","year":"2022","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.jns.2026.125845_bb0095","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1093\/chemse\/bjz020","article-title":"Odor identification performance in idiopathic Parkinson\u2019s disease is associated with gender and the genetic variability of the olfactory binding protein","volume":"44","author":"Melis","year":"2019","journal-title":"Chem. Senses"},{"key":"10.1016\/j.jns.2026.125845_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2019.112030","article-title":"Association between the rs2590498 polymorphism of odorant binding protein (OBPIIa) gene and olfactory performance in healthy subjects","volume":"372","author":"Sollai","year":"2019","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.jns.2026.125845_bb0105","doi-asserted-by":"crossref","DOI":"10.1002\/pro.70451","article-title":"Beyond Olfaction: New Insights into Human Odorant Binding Proteins","volume":"35","author":"Chen","year":"2026","journal-title":"Protein Sci"},{"key":"10.1016\/j.jns.2026.125845_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116947","article-title":"Emerging insights into lipocalin-2: unraveling its role in Parkinson\u2019s disease","volume":"177","author":"Qiu","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jns.2026.125845_bb0115","doi-asserted-by":"crossref","first-page":"2480","DOI":"10.1158\/2767-9764.CRC-24-0243","article-title":"NCI\u2019S proteomic data commons: a cloud-based proteomics repository empowering comprehensive cancer analysis through cross-referencing with genomic and imaging data","volume":"4","author":"Thangudu","year":"2024","journal-title":"Cancer Res. Commun."},{"key":"10.1016\/j.jns.2026.125845_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcpro.2023.100640","article-title":"PaxDb 5.0: curated protein quantification data suggests adaptive proteome changes in yeasts","volume":"22","author":"Huang","year":"2023","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.jns.2026.125845_bb0125","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1002\/mds.22340","article-title":"Movement disorder society-sponsored revision of the unified Parkinson\u2019s disease rating scale (MDS-UPDRS): scale presentation and clinimetric testing results","volume":"23","author":"Goetz","year":"2008","journal-title":"Mov. Disord."},{"key":"10.1016\/j.jns.2026.125845_bb0130","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0257372","article-title":"Biomarkers of neurodegeneration and glial activation validated in Alzheimer\u2019s disease assessed in longitudinal cerebrospinal fluid samples of Parkinson\u2019s disease","volume":"16","author":"Bartl","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.jns.2026.125845_bb0135","first-page":"1277","article-title":"Association of cerebrospinal fluid \u03b2-amyloid 1-42, T-tau, P-tau181, and \u03b1-synuclein levels with clinical features of drug-naive patients with early Parkinson disease","volume":"70","author":"Kang","year":"2013","journal-title":"JAMA Neurol."},{"issue":"Suppl. 7","key":"10.1016\/j.jns.2026.125845_bb0140","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1002\/mds.10571","article-title":"Dopamine transporter: basic aspects and neuroimaging","volume":"18","author":"Piccini","year":"2003","journal-title":"Mov. Disord."},{"key":"10.1016\/j.jns.2026.125845_bb0145","doi-asserted-by":"crossref","DOI":"10.1111\/cns.70522","article-title":"Uncovering the associations of LILRB4 genotypes with Parkinson\u2019s disease: from clinical traits to potential pathologies","volume":"31","author":"Zhou","year":"2025","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.jns.2026.125845_bb0150","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.pneurobio.2011.09.005","article-title":"The Parkinson progression marker initiative (PPMI)","volume":"95","author":"Parkinson Progression Marker Initiative","year":"2011","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.jns.2026.125845_bb0155","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13293-025-00692-w","article-title":"Sex and gender differences in the molecular etiology of Parkinson\u2019s disease: considerations for study design and data analysis","volume":"16","author":"Schaffner","year":"2025","journal-title":"Biol. Sex Differ."},{"key":"10.1016\/j.jns.2026.125845_bb0160","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.parkreldis.2008.10.001","article-title":"Correlation between changes in CSF dopamine turnover and development of dyskinesia in Parkinson\u2019s disease","volume":"15","author":"Lunardi","year":"2009","journal-title":"Parkinsonism Relat. Disord."},{"issue":"Suppl. 1","key":"10.1016\/j.jns.2026.125845_bb0165","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1016\/S1353-8020(11)70017-7","article-title":"Recent advances in CSF biomarkers for Parkinson\u2019s disease","volume":"18","author":"LeWitt","year":"2012","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.jns.2026.125845_bb0170","doi-asserted-by":"crossref","first-page":"703","DOI":"10.3390\/nu13020703","article-title":"Olfactory function in patients with inflammatory bowel disease (IBD) is associated with their body mass index and polymorphism in the odor binding-protein (OBPIIa) gene","volume":"13","author":"Sollai","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.jns.2026.125845_bb0175","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/B978-0-12-407766-9.00015-8","article-title":"Lipocalin 13 regulation of glucose and lipid metabolism in obesity","volume":"91","author":"Zhou","year":"2013","journal-title":"Vitam. Horm."},{"key":"10.1016\/j.jns.2026.125845_bb0180","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1128\/MCB.00459-10","article-title":"Lipocalin-13 regulates glucose metabolism by both insulin-dependent and insulin-independent mechanisms","volume":"31","author":"Cho","year":"2011","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.jns.2026.125845_bb0185","doi-asserted-by":"crossref","first-page":"5608","DOI":"10.1523\/JNEUROSCI.4261-15.2016","article-title":"Pathogenic upregulation of glial lipocalin-2 in the Parkinsonian dopaminergic system","volume":"36","author":"Kim","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jns.2026.125845_bb0190","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nature03104","article-title":"Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron","volume":"432","author":"Flo","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.jns.2026.125845_bb0195","doi-asserted-by":"crossref","DOI":"10.3390\/cells11091535","article-title":"Lipocalin 2 deficiency alters prostaglandin biosynthesis and mTOR signaling regulation of thermogenesis and lipid metabolism in adipocytes","volume":"11","author":"Deis","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.jns.2026.125845_bb0200","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1080\/15548627.2023.2180202","article-title":"Reduced secretion of LCN2 (lipocalin 2) from reactive astrocytes through autophagic and proteasomal regulation alleviates inflammatory stress and neuronal damage","volume":"19","author":"Jung","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.jns.2026.125845_bb0205","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1093\/brain\/awz030","article-title":"Risk and predictors of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: a multicentre study","volume":"142","author":"Postuma","year":"2019","journal-title":"Brain"},{"key":"10.1016\/j.jns.2026.125845_bb0210","doi-asserted-by":"crossref","first-page":"395","DOI":"10.3389\/fneur.2020.00395","article-title":"Clinical and imaging markers of prodromal Parkinson\u2019s disease","volume":"11","author":"Hustad","year":"2020","journal-title":"Front. Neurol."},{"key":"10.1016\/j.jns.2026.125845_bb0215","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.semcdb.2019.07.010","article-title":"Axonal transport defects and neurodegeneration: molecular mechanisms and therapeutic implications","volume":"99","author":"Guo","year":"2020","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.jns.2026.125845_bb0220","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.brainres.2011.07.052","article-title":"Abnormal tau, mitochondrial dysfunction, impaired axonal transport of mitochondria, and synaptic deprivation in Alzheimer\u2019s disease","volume":"1415","author":"Reddy","year":"2011","journal-title":"Brain Res."},{"key":"10.1016\/j.jns.2026.125845_bb0225","doi-asserted-by":"crossref","first-page":"314","DOI":"10.3724\/abbs.2023008","article-title":"Identification, characterization and expression analysis of rLcn13, an epididymal lipocalin in rats","volume":"55","author":"Yao","year":"2023","journal-title":"Acta Biochim. Biophys. Sin. Shanghai"},{"key":"10.1016\/j.jns.2026.125845_bb0230","doi-asserted-by":"crossref","DOI":"10.1210\/jendso\/bvae015","article-title":"Modifications of the GH axis reveal unique sexually dimorphic liver signatures for Lcn13, Asns, Hamp2, Hao2, and Pgc1a","volume":"8","author":"Brie","year":"2024","journal-title":"J. Endocr. Soc."},{"key":"10.1016\/j.jns.2026.125845_bb0235","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.202000898","article-title":"Lipocalin 13 enhances insulin secretion but is dispensable for systemic metabolic control","volume":"4","author":"B\u00fchler","year":"2021","journal-title":"Life Sci. Alliance"},{"key":"10.1016\/j.jns.2026.125845_bb0240","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1159\/000126507","article-title":"Sex and estrous cycle variations of rat striatal dopamine uptake sites","volume":"58","author":"Morissette","year":"1993","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.jns.2026.125845_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2023.105479","article-title":"Neuroactive steroids and Parkinson\u2019s disease: review of human and animal studies","volume":"156","author":"Bourque","year":"2024","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.jns.2026.125845_bb0250","article-title":"Multiple hypothesis testing and Bonferroni\u2019s correction","volume":"349","author":"Sedgwick","year":"2014","journal-title":"BMJ"}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X26001279?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X26001279?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:08:59Z","timestamp":1777446539000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X26001279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":50,"alternative-id":["S0022510X26001279"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2026.125845","relation":{},"ISSN":["0022-510X"],"issn-type":[{"value":"0022-510X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of OBPIIa genetic variants with prodromal Parkinsonian phenotypes and dopaminergic biomarkers in the PPMI cohort","name":"articletitle","label":"Article Title"},{"value":"Journal of the Neurological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jns.2026.125845","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"125845"}}