{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T06:32:23Z","timestamp":1793946743234,"version":"4.8.0"},"reference-count":14,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R03AG078946"],"award-info":[{"award-number":["R03AG078946"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000890","name":"National Multiple Sclerosis Society","doi-asserted-by":"publisher","award":["BI-2306-41591"],"award-info":[{"award-number":["BI-2306-41591"]}],"id":[{"id":"10.13039\/100000890","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jns-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.jns.2026.125904","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T03:42:08Z","timestamp":1774928528000},"page":"125904","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Clocks out of sync: Increased epigenetic aging variability in multiple sclerosis"],"prefix":"10.1016","volume":"485","author":[{"given":"Fernanda L.","family":"Schumacher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Cutter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christin E.","family":"Burd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kellie","family":"Archer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.jns.2026.125904_bb0005","doi-asserted-by":"crossref","first-page":"e1029","DOI":"10.1212\/WNL.0000000000007035","article-title":"The prevalence of MS in the United States: a population-based estimate using health claims data","volume":"92","author":"Wallin","year":"2019","journal-title":"Neurology"},{"issue":"Pt 3","key":"10.1016\/j.jns.2026.125904_bb0010","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1093\/brain\/awh714","article-title":"Age at disability milestones in multiple sclerosis","volume":"129","author":"Confavreux","year":"2006","journal-title":"Brain J. Neurol."},{"issue":"9","key":"10.1016\/j.jns.2026.125904_bb0015","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1038\/s43587-025-00958-3","article-title":"Systems age: a single blood methylation test to quantify aging heterogeneity across 11 physiological systems","volume":"5","author":"Sehgal","year":"2025","journal-title":"Nat. Aging"},{"issue":"10","key":"10.1016\/j.jns.2026.125904_bb0020","doi-asserted-by":"crossref","first-page":"3156","DOI":"10.1186\/gb-2013-14-10-r115","article-title":"DNA methylation age of human tissues and cell types","volume":"14","author":"Horvath","year":"2013","journal-title":"Genome Biol."},{"issue":"7","key":"10.1016\/j.jns.2026.125904_bb0025","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.18632\/aging.101508","article-title":"Epigenetic clock for skin and blood cells applied to Hutchinson Gilford progeria syndrome and ex vivo studies","volume":"10","author":"Horvath","year":"2018","journal-title":"Aging"},{"issue":"2","key":"10.1016\/j.jns.2026.125904_bb0030","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.molcel.2012.10.016","article-title":"Genome-wide methylation profiles reveal quantitative views of human aging rates","volume":"49","author":"Hannum","year":"2013","journal-title":"Mol. Cell"},{"issue":"4","key":"10.1016\/j.jns.2026.125904_bb0035","doi-asserted-by":"crossref","first-page":"573","DOI":"10.18632\/aging.101414","article-title":"An epigenetic biomarker of aging for lifespan and healthspan","volume":"10","author":"Levine","year":"2018","journal-title":"Aging"},{"issue":"2","key":"10.1016\/j.jns.2026.125904_bb0040","doi-asserted-by":"crossref","first-page":"303","DOI":"10.18632\/aging.101684","article-title":"DNA methylation GrimAge strongly predicts lifespan and healthspan","volume":"11","author":"Lu","year":"2019","journal-title":"Aging"},{"issue":"1","key":"10.1016\/j.jns.2026.125904_bb0045","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1038\/s42003-024-06609-4","article-title":"Development of an epigenetic clock resistant to changes in immune cell composition","volume":"7","author":"Tomusiak","year":"2024","journal-title":"Commun. Biol."},{"key":"10.1016\/j.jns.2026.125904_bb0050","doi-asserted-by":"crossref","first-page":"1734464","DOI":"10.3389\/fmolb.2025.1734464","article-title":"DNA methylation and prediction of biological age","volume":"12","author":"Chen","year":"2026","journal-title":"Front. Mol. Biosci."},{"issue":"1","key":"10.1016\/j.jns.2026.125904_bb0055","doi-asserted-by":"crossref","first-page":"S356","DOI":"10.1134\/S0006297924602843","article-title":"Epigenetic clock: DNA methylation as a marker of biological age and age-associated diseases","volume":"90","author":"Kiselev","year":"2025","journal-title":"Biochem. Mosc."},{"issue":"7","key":"10.1016\/j.jns.2026.125904_bb0060","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/s43587-022-00248-2","article-title":"A computational solution for bolstering reliability of epigenetic clocks: implications for clinical trials and longitudinal tracking","volume":"2","author":"Higgins-Chen","year":"2022","journal-title":"Nat. Aging"},{"issue":"1","key":"10.1016\/j.jns.2026.125904_bb0065","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1007\/s11357-024-01287-w","article-title":"Biological aging of different blood cell types","volume":"47","author":"Marttila","year":"2025","journal-title":"GeroScience"},{"issue":"1","key":"10.1016\/j.jns.2026.125904_bb0070","doi-asserted-by":"crossref","DOI":"10.1093\/bioadv\/vbaf005","article-title":"EstiMAge: development of a DNA methylation clock to estimate the methylation age of single cells","volume":"5","author":"Sa\u00dfmannshausen","year":"2025","journal-title":"Bioinform. Adv."}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X26001863?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X26001863?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T06:18:48Z","timestamp":1793945928000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X26001863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":14,"alternative-id":["S0022510X26001863"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2026.125904","relation":{},"ISSN":["0022-510X"],"issn-type":[{"value":"0022-510X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clocks out of sync: Increased epigenetic aging variability in multiple sclerosis","name":"articletitle","label":"Article Title"},{"value":"Journal of the Neurological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jns.2026.125904","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"125904"}}