{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T14:41:18Z","timestamp":1792248078546,"version":"4.4.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jns-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.jns.2026.126215","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:48:03Z","timestamp":1792079283000},"page":"126215","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Genomic, clinical, and radiological characterization of spontaneous cervical artery dissections: Findings from a single-center cohort"],"prefix":"10.1016","volume":"491","author":[{"given":"Irene","family":"Scala","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Trevisan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pier Andrea","family":"Rizzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Bisegna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Donnarumma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Concolino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Minucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Castori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Bersano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Calabresi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Leoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Frisullo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jns.2026.126215_bb0005","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1111\/ijs.12154","article-title":"Incidence and outcome of cerebrovascular events related to cervical artery dissection: the Dijon stroke registry","volume":"9","author":"Bejot","year":"2014","journal-title":"Int. J. Stroke"},{"key":"10.1016\/j.jns.2026.126215_bb0010","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1136\/jnnp.2004.040543","article-title":"Ischaemic stroke in young adults: predictors of outcome and recurrence","volume":"76","author":"Nedeltchev","year":"2005","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.jns.2026.126215_bb0015","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1212\/01.wnl.0000244486.30455.71","article-title":"Incidence and outcome of cervical artery dissection: a population-based study","volume":"67","author":"Lee","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2026.126215_bb0020","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1212\/WNL.0b013e318293e2eb","article-title":"Cervical artery dissection: trauma and other potential mechanical trigger events","volume":"80","author":"Engelter","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2026.126215_bb0025","doi-asserted-by":"crossref","first-page":"e459","DOI":"10.1161\/STROKEAHA.108.534669","article-title":"The genetics of cervical artery dissection: a systematic review","volume":"40","author":"Debette","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.jns.2026.126215_bb0030","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1161\/01.STR.27.4.622","article-title":"Recurrent spontaneous arterial dissections: risk in familial versus nonfamilial disease","volume":"27","author":"Schievink","year":"1996","journal-title":"Stroke"},{"key":"10.1016\/j.jns.2026.126215_bb0035","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1212\/WNL.0000000000001027","article-title":"Familial occurrence and heritable connective tissue disorders in cervical artery dissection","volume":"83","author":"Debette","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2026.126215_bb0040","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1136\/jnnp.2007.115634","article-title":"Morphometric analysis of collagen fibrils in skin of patients with spontaneous cervical artery dissection","volume":"79","author":"Volker","year":"2008","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.jns.2026.126215_bb0045","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1002\/ana.10268","article-title":"Exclusion mapping of the genetic predisposition for cervical artery dissections by linkage analysis","volume":"52","author":"Grond-Ginsbach","year":"2002","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.jns.2026.126215_bb0050","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1161\/01.STR.0000226624.93519.78","article-title":"Genetic analysis of familial connective tissue alterations associated with cervical artery dissections suggests locus heterogeneity","volume":"37","author":"Wiest","year":"2006","journal-title":"Stroke"},{"key":"10.1016\/j.jns.2026.126215_bb0055","doi-asserted-by":"crossref","first-page":"210","DOI":"10.2174\/156652409787581547","article-title":"The association of connective tissue disorders with cervical artery dissections","volume":"9","author":"Grond-Ginsbach","year":"2009","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.jns.2026.126215_bb0060","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1177\/2396987319861869","article-title":"Rare genetic variants in patients with cervical artery dissection","volume":"4","author":"Traenka","year":"2019","journal-title":"Eur. Stroke J."},{"key":"10.1016\/j.jns.2026.126215_bb0065","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1177\/2396987317693402","article-title":"Next generation sequencing analysis of patients with familial cervical artery dissection","volume":"2","author":"Grond-Ginsbach","year":"2017","journal-title":"Eur. Stroke J."},{"key":"10.1016\/j.jns.2026.126215_bb0070","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1136\/jnnp.2010.231902","article-title":"Mutations in TGFBR2 gene cause spontaneous cervical artery dissection","volume":"82","author":"Pezzini","year":"2011","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.jns.2026.126215_bb0075","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1212\/01.WNL.0000159739.24607.98","article-title":"Generalized arteriopathy in patients with cervical artery dissection","volume":"64","author":"Volker","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2026.126215_bb0080","doi-asserted-by":"crossref","first-page":"e91","DOI":"10.1161\/STR.0000000000000457","article-title":"Treatment and outcomes of cervical artery dissection in adults: a scientific statement from the American heart association","volume":"55","author":"Yaghi","year":"2024","journal-title":"Stroke"},{"key":"10.1016\/j.jns.2026.126215_bb0085","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/j.1747-4949.2009.00281.x","article-title":"CADISP-genetics: an international project searching for genetic risk factors of cervical artery dissections","volume":"4","author":"Debette","year":"2009","journal-title":"Int. J. Stroke"},{"key":"10.1016\/j.jns.2026.126215_bb0090","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s00270-023-03620-w","article-title":"CIRSE standards of practice for the endovascular treatment of visceral and renal artery aneurysms and pseudoaneurysms","volume":"47","author":"Rossi","year":"2024","journal-title":"Cardiovasc. Intervent. Radiol."},{"key":"10.1016\/j.jns.2026.126215_bb0095","doi-asserted-by":"crossref","first-page":"e182","DOI":"10.1016\/j.jtcvs.2023.04.023","article-title":"2022 ACC\/AHA guideline for the diagnosis and management of aortic disease: a report of the American heart association\/American college of cardiology joint committee on clinical practice guidelines","volume":"166","author":"Writing Committee M","year":"2023","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"10.1016\/j.jns.2026.126215_bb0100","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1212\/WNL.15.5.462","article-title":"Tortuosity, coiling, and kinking of the internal carotid artery. II. Relationship of morphological variation to cerebrovascular insufficiency","volume":"15","author":"Weibel","year":"1965","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2026.126215_bb0105","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/S0140-6736(61)90004-6","article-title":"Kinking of the internal carotid artery","volume":"1","author":"Metz","year":"1961","journal-title":"Lancet"},{"key":"10.1016\/j.jns.2026.126215_bb0110","first-page":"68","article-title":"Carotid artery tortuosity, kinking, coiling: stroke risk factor, marker, or curiosity?","volume":"105","author":"Togay-Isikay","year":"2005","journal-title":"Acta Neurol. Belg."},{"key":"10.1016\/j.jns.2026.126215_bb0115","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1177\/1358863X18821816","article-title":"First international consensus on the diagnosis and management of fibromuscular dysplasia","volume":"24","author":"Gornik","year":"2019","journal-title":"Vasc. Med."},{"key":"10.1016\/j.jns.2026.126215_bb0120","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1212\/WNL.0000000000001030","article-title":"Connective tissue anomalies in patients with spontaneous cervical artery dissection","volume":"83","author":"Giossi","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2026.126215_bb0125","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1136\/jmg.2009.072785","article-title":"The revised Ghent nosology for the Marfan syndrome","volume":"47","author":"Loeys","year":"2010","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.jns.2026.126215_bb0130","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/ajmg.c.31552","article-title":"The 2017 international classification of the Ehlers-Danlos syndromes","volume":"175","author":"Malfait","year":"2017","journal-title":"Am. J. Med. Genet. C: Semin. Med. Genet."},{"key":"10.1016\/j.jns.2026.126215_bb0135","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1136\/ard.32.5.413","article-title":"Articular mobility in an African population","volume":"32","author":"Beighton","year":"1973","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jns.2026.126215_bb0140","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1111\/j.1538-7836.2010.03975.x","article-title":"ISTH\/SSC bleeding assessment tool: a standardized questionnaire and a proposal for a new bleeding score for inherited bleeding disorders","volume":"8","author":"Rodeghiero","year":"2010","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.jns.2026.126215_bb0145","doi-asserted-by":"crossref","DOI":"10.3390\/jcm11133818","article-title":"Prevalence of CAH-X syndrome in Italian patients with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency","volume":"11","author":"Paragliola","year":"2022","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.jns.2026.126215_bb0150","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American college of medical genetics and genomics and the association for molecular pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet. Med."},{"key":"10.1016\/j.jns.2026.126215_bb0155","doi-asserted-by":"crossref","first-page":"3912","DOI":"10.1093\/eurheartj\/ehae178","article-title":"2024 ESC guidelines for the management of elevated blood pressure and hypertension","volume":"45","author":"McEvoy","year":"2024","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.jns.2026.126215_bb0160","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.2337\/dc26-S002","article-title":"2. Diagnosis and classification of diabetes: standards of care in diabetes-2026","volume":"49","author":"American Diabetes Association Professional Practice Committee for D","year":"2026","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jns.2026.126215_bb0165","doi-asserted-by":"crossref","first-page":"4359","DOI":"10.1093\/eurheartj\/ehaf190","article-title":"2025 focused update of the 2019 ESC\/EAS guidelines for the management of dyslipidaemias","volume":"46","author":"Mach","year":"2025","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.jns.2026.126215_bb0170","series-title":"Italiani meno sedentari. Stabili eccesso di peso, alcol a rischio, abitudine al fumo","author":"ISTAT","year":"2024"},{"key":"10.1016\/j.jns.2026.126215_bb0175","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1111\/cge.13683","article-title":"COL1-related overlap disorder: a novel connective tissue disorder incorporating the osteogenesis imperfecta\/Ehlers-Danlos syndrome overlap","volume":"97","author":"Morlino","year":"2020","journal-title":"Clin. Genet."},{"key":"10.1016\/j.jns.2026.126215_bb0180","first-page":"588","article-title":"Genotypic and phenotypic characterization of Chinese patients with osteogenesis imperfecta","volume":"40","author":"Li","year":"2019","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.jns.2026.126215_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.gim.2025.101454","article-title":"ACMG SF v3.3 list for reporting of secondary findings in clinical exome and genome sequencing: a policy statement of the American college of medical genetics and genomics (ACMG)","volume":"27","author":"Lee","year":"2025","journal-title":"Genet. Med."},{"key":"10.1016\/j.jns.2026.126215_bb0190","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/ana.410440224","article-title":"Ultrastructural connective tissue abnormalities in patients with spontaneous cervicocerebral artery dissections","volume":"44","author":"Brandt","year":"1998","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.jns.2026.126215_bb0195","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1212\/WNL.57.1.24","article-title":"Pathogenesis of cervical artery dissections: association with connective tissue abnormalities","volume":"57","author":"Brandt","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2026.126215_bb0200","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s00401-004-0839-x","article-title":"Different types of connective tissue alterations associated with cervical artery dissections","volume":"107","author":"Hausser","year":"2004","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.jns.2026.126215_bb0205","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1007\/s00415-008-0585-4","article-title":"Aberrations of dermal connective tissue in patients with cervical artery dissection (sCAD)","volume":"255","author":"Uhlig","year":"2008","journal-title":"J. Neurol."},{"key":"10.1016\/j.jns.2026.126215_bb0210","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1212\/WNL.0b013e318217e71c","article-title":"The outer arterial wall layers are primarily affected in spontaneous cervical artery dissection","volume":"76","author":"Volker","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2026.126215_bb0215","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/1750-1172-8-78","article-title":"Helical mutations in type I collagen that affect the processing of the amino-propeptide result in an osteogenesis imperfecta\/Ehlers-Danlos syndrome overlap syndrome","volume":"8","author":"Malfait","year":"2013","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.jns.2026.126215_bb0220","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.ajhg.2010.10.006","article-title":"Mutations in myosin light chain kinase cause familial aortic dissections","volume":"87","author":"Wang","year":"2010","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.jns.2026.126215_bb0225","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/s41436-018-0038-0","article-title":"MYLK pathogenic variants aortic disease presentation, pregnancy risk, and characterization of pathogenic missense variants","volume":"21","author":"Wallace","year":"2019","journal-title":"Genet. Med."},{"key":"10.1016\/j.jns.2026.126215_bb0230","doi-asserted-by":"crossref","first-page":"e334","DOI":"10.1161\/CIR.0000000000001106","article-title":"2022 ACC\/AHA guideline for the diagnosis and management of aortic disease: a report of the American heart association\/American college of cardiology joint committee on clinical practice guidelines","volume":"146","author":"Isselbacher","year":"2022","journal-title":"Circulation"}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X26004971?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X26004971?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T13:55:03Z","timestamp":1792245303000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X26004971"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":46,"alternative-id":["S0022510X26004971"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2026.126215","relation":{},"ISSN":["0022-510X"],"issn-type":[{"value":"0022-510X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genomic, clinical, and radiological characterization of spontaneous cervical artery dissections: Findings from a single-center cohort","name":"articletitle","label":"Article Title"},{"value":"Journal of the Neurological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jns.2026.126215","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"126215"}}