{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T14:08:23Z","timestamp":1779890903152,"version":"3.53.1"},"reference-count":27,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2006,7]]},"DOI":"10.1016\/j.jnutbio.2005.09.002","type":"journal-article","created":{"date-parts":[[2005,10,11]],"date-time":"2005-10-11T07:23:11Z","timestamp":1129015391000},"page":"485-491","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":74,"title":["Reversal of chemical-induced liver fibrosis in Wistar rats by puerarin"],"prefix":"10.1016","volume":"17","author":[{"given":"Shuihua","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2005.09.002_bib1","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1074\/jbc.275.4.2247","article-title":"Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury","volume":"275","author":"Friedman","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2005.09.002_bib2","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1021\/np0203887","article-title":"Antihyperglycemic effect of puerarin in streptozotocin-induced diabetic rats","volume":"66","author":"Hsu","year":"2003","journal-title":"J Nat Prod"},{"key":"10.1016\/j.jnutbio.2005.09.002_bib3","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.1016\/S0024-3205(00)00885-7","article-title":"Comparison between Chinese medical herb Pueraria lobata crude extract and its main isoflavone puerarin: antioxidant properties and effects on rat liver CYP-catalysed drug metabolism","volume":"67","author":"Guerra","year":"2000","journal-title":"Life Sci"},{"key":"10.1016\/j.jnutbio.2005.09.002_bib4","first-page":"339","article-title":"Effects of puerarin against glutamate excitotoxicity on cultured mouse cerebral cortical neurons","volume":"19","author":"Dong","year":"1998","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.jnutbio.2005.09.002_bib5","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1142\/S0192415X03000722","article-title":"Hepatoprotective activity of reduohanxiao-tang (yuldahanso-tang) is related to the inhibition of beta-glucuronidase","volume":"31","author":"Bae","year":"2003","journal-title":"Am J Chin Med"},{"key":"10.1016\/j.jnutbio.2005.09.002_bib6","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1021\/jf021114s","article-title":"Evaluation of the estrogenic effects of legume extracts containing phytoestrogens","volume":"51","author":"Boue","year":"2003","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.jnutbio.2005.09.002_bib7","first-page":"339","article-title":"Effects of puerarin against glutamate excitotoxicity on cultured mouse cerebral cortical neurons","volume":"19","author":"Dong","year":"1998","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.jnutbio.2005.09.002_bib8","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1111\/j.1530-0277.1993.tb05238.x","article-title":"Biochemical studies of a new class of alcohol dehydrogenase inhibitors from Radix puerariae","volume":"17","author":"Keung","year":"1993","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.jnutbio.2005.09.002_bib9","first-page":"2165","article-title":"Inhibitory effects of flavonoids on xanthine oxidase","volume":"13","author":"Chang","year":"1993","journal-title":"Anticancer Res"},{"key":"10.1016\/j.jnutbio.2005.09.002_bib10","first-page":"180","article-title":"Effects of puerarin on cat vascular smooth muscle in vitro","volume":"15","author":"Wang","year":"1994","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.jnutbio.2005.09.002_bib11","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1089\/jop.1999.15.207","article-title":"Improvement of ocular blood flow and retinal functions with puerarin analogs","volume":"15","author":"Xuan","year":"1999","journal-title":"J Ocul Pharmacol Ther"},{"key":"10.1016\/j.jnutbio.2005.09.002_bib12","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s00726-004-0105-5","article-title":"Betaine or taurine administration prevents fibrosis and lipid peroxidation induced by rat liver by ethanol plus carbon tetrachloride intoxication","volume":"27","author":"Erman","year":"2004","journal-title":"Amino Acids"},{"key":"10.1016\/j.jnutbio.2005.09.002_bib13","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/0168-8278(95)80226-6","article-title":"Histological grading and staging of chronic hepatitis","volume":"22","author":"Ishak","year":"1995","journal-title":"J Hepatol"},{"key":"10.1016\/j.jnutbio.2005.09.002_bib14","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/0168-8278(91)90084-O","article-title":"Classification of chronic viral hepatitis: a need for reassessment","volume":"13","author":"Scheuer","year":"1991","journal-title":"J Hepatol"},{"key":"10.1016\/j.jnutbio.2005.09.002_bib15","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1172\/JCI1018","article-title":"Mechanisms of spontaneous resolution of rat liver fibrosis: hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors","volume":"102","author":"Iredale","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jnutbio.2005.09.002_bib16","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1136\/gut.48.4.548","article-title":"Apoptosis of hepatic stellate cells: involvement in resolution of biliary fibrosis and regulation by soluble growth factors","volume":"48","author":"Issa","year":"2001","journal-title":"Gut"},{"key":"10.1016\/j.jnutbio.2005.09.002_bib17","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1096\/fj.02-0494fje","article-title":"Mutation in collagen-I that confers resistance to the action of collagenase results in failure of recovery from CCl4-induced liver fibrosis, persistence of activated hepatic stellate cells, and diminished hepatocyte regeneration","volume":"17","author":"Issa","year":"2003","journal-title":"FASEB J"},{"key":"10.1016\/j.jnutbio.2005.09.002_bib18","first-page":"4904","article-title":"Chemoprevention of 4-nitroquinoline 1-oxide-induced rat oral carcinogenesis by the dietary flavonoids chalcone, 2-hydroxychalcone and quercetin","volume":"56","author":"Makita","year":"1996","journal-title":"Cancer Res"},{"key":"10.1016\/j.jnutbio.2005.09.002_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0163-7258(03)00042-1","article-title":"Natural products for cancer prevention: a global perspective","volume":"99","author":"Reddy","year":"2003","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.jnutbio.2005.09.002_bib20","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S1089-3261(05)70154-9","article-title":"Pathogenesis of hepatocellular carcinoma","volume":"5","author":"Macdonald","year":"2001","journal-title":"Clin Liver Dis"},{"key":"10.1016\/j.jnutbio.2005.09.002_bib21","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1111\/j.1530-0277.1999.tb04209.x","article-title":"Prevention and treatment of liver fibrosis based on pathogenesis","volume":"23","author":"Lieber","year":"1999","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.jnutbio.2005.09.002_bib22","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.3109\/00365529609036901","article-title":"Animal models of liver fibrosis","volume":"31","author":"Wu","year":"1996","journal-title":"Scand J Gastroentero"},{"key":"10.1016\/j.jnutbio.2005.09.002_bib23","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1007\/BF01964970","article-title":"Hepatoprotection by malotilate against carbon tetrachloride-alcohol-induced liver fibrosis","volume":"18","author":"Siegers","year":"1986","journal-title":"Agents Actions"},{"key":"10.1016\/j.jnutbio.2005.09.002_bib24","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/bdd.2510120403","article-title":"Drugs and the liver","volume":"12","author":"Sallie","year":"1991","journal-title":"Biopharm Drug Dispos"},{"key":"10.1016\/j.jnutbio.2005.09.002_bib25","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/S0955-2863(03)00053-6","article-title":"Activity of Cassia auriculata leaf extract in rats with alcoholic liver injury","volume":"14","author":"Senthil Kumar","year":"2003","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jnutbio.2005.09.002_bib26","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1083\/jcb.138.6.1219","article-title":"Maintenance of calcium homeostasis in the endoplasmic reticulum by bcl-2","volume":"138","author":"He","year":"1997","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jnutbio.2005.09.002_bib27","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1161\/01.CIR.96.5.1580","article-title":"The bcl-2 gene product prevents programmed cell death of ventricular myocytes","volume":"96","author":"Kirshenbaum","year":"1997","journal-title":"Circulation"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286305002391?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286305002391?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T14:56:25Z","timestamp":1760626585000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286305002391"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7]]},"references-count":27,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["S0955286305002391"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2005.09.002","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2006,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reversal of chemical-induced liver fibrosis in Wistar rats by puerarin","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2005.09.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}