{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T13:14:51Z","timestamp":1771074891484,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2007,2]]},"DOI":"10.1016\/j.jnutbio.2006.03.005","type":"journal-article","created":{"date-parts":[[2006,5,20]],"date-time":"2006-05-20T07:22:44Z","timestamp":1148109764000},"page":"97-104","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Hearts in adult offspring of copper-deficient dams exhibit decreased cytochrome c oxidase activity, increased mitochondrial hydrogen peroxide generation and enhanced formation of intracellular residual bodies"],"prefix":"10.1016","volume":"18","author":[{"given":"W. Thomas","family":"Johnson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Samuel M.","family":"Newman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2006.03.005_bib1","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1146\/annurev.bi.65.070196.003023","article-title":"Crosstalk between nuclear and mitochondrial genomes","volume":"65","author":"Poyton","year":"1996","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.jnutbio.2006.03.005_bib2","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1093\/jn\/113.10.2048","article-title":"Changes in tissue growth, concentrations of copper, iron, cytochrome oxidase and superoxide dismutase subsequent to subsequent to dietary or genetic copper deficiency in mice","volume":"113","author":"Prohaska","year":"1983","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2006.03.005_bib3","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1093\/jn\/121.3.355","article-title":"Changes in Cu, Zn-superoxide dismutase, cytochrome c oxidase, glutathione peroxidase and glutathione transferase activities in copper-deficient mice and rats","volume":"121","author":"Prohaska","year":"1991","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2006.03.005_bib4","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/S0271-5317(05)80739-0","article-title":"Platelet cytochrome c oxidase as an indicator of copper status in rats","volume":"13","author":"Johnson","year":"1993","journal-title":"Nutr Res"},{"key":"10.1016\/j.jnutbio.2006.03.005_bib5","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1093\/jn\/124.6.789","article-title":"Low levels of ATP synthase and cytochrome c oxidase subunit peptide from hearts of copper-deficient rats are not altered by the administration of dimethyl sulfoxide","volume":"124","author":"Chao","year":"1994","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2006.03.005_bib6","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/0955-2863(95)80007-Y","article-title":"Cardiac levels of fibronectin, lamin, isomyosins, and cytochrome c oxidase of weanling rats are more vulnerable to copper deficiency than those of postweanling rats","volume":"6","author":"Liao","year":"1995","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jnutbio.2006.03.005_bib7","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0300-9629(96)00365-9","article-title":"Cardiac nuclear encoded cytochrome c oxidase subunits are decreased with copper restriction but not iron restriction: gene expression, protein synthesis and heat shock protein aspects","volume":"117A","author":"Medeiros","year":"1997","journal-title":"Comp Biochem Physiol"},{"key":"10.1016\/j.jnutbio.2006.03.005_bib8","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1023\/A:1009274131473","article-title":"Decrease of cytochrome c oxidase protein in heart mitochondria of copper-deficient rats","volume":"11","author":"Rossi","year":"1998","journal-title":"Biometals"},{"key":"10.1016\/j.jnutbio.2006.03.005_bib9","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1093\/jn\/125.6.1447","article-title":"Copper deficiency alters rat peptidylglycine \u03b1-amidating monooxygenase activity","volume":"125","author":"Prohaska","year":"1995","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2006.03.005_bib10","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1172\/JCI105672","article-title":"Cytochrome oxidase repair during treatment of copper deficiency: relation to mitochondrial turnover","volume":"46","author":"Dallman","year":"1967","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jnutbio.2006.03.005_bib11","first-page":"412","article-title":"Biology of disease-free radicals and tissue injury","volume":"47","author":"Freeman","year":"1982","journal-title":"Lab Invest"},{"key":"10.1016\/j.jnutbio.2006.03.005_bib12","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1002\/ajmg.1398","article-title":"Mitochondria, oxygen free radicals, and apoptosis","volume":"106","author":"Raha","year":"2001","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.jnutbio.2006.03.005_bib13","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/0891-5849(93)90139-L","article-title":"Aging, cytochrome c oxidase activity, and hydrogen peroxide release by mitochondria","volume":"14","author":"Sohal","year":"1993","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jnutbio.2006.03.005_bib14","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1093\/jn\/134.6.1328","article-title":"Increased heme oxygenase-1 expression during copper deficiency in rats results from increased mitochondrial generation of hydrogen peroxide","volume":"134","author":"Johnson","year":"2004","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2006.03.005_bib15","series-title":"Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc","author":"Institute of Medicine","year":"2001"},{"key":"10.1016\/j.jnutbio.2006.03.005_bib16","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1093\/jn\/123.11.1939","article-title":"AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet","volume":"123","author":"Reeves","year":"1993","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2006.03.005_bib17","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1093\/jn\/117.6.1085","article-title":"Effect of copper deficiency on erythrocyte membrane proteins of rats","volume":"117","author":"Johnson","year":"1987","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2006.03.005_bib18","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1093\/clinchem\/20.12.1556","article-title":"Measurement of ceruloplasmin from its oxidase activity in serum by use of o-dianisidine dihydrochloride","volume":"20","author":"Schosinsky","year":"1974","journal-title":"Clin Chem"},{"key":"10.1016\/j.jnutbio.2006.03.005_bib19","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/0955-2863(92)90088-Z","article-title":"Mitochondrial respiration in heart, liver, and kidney of copper-deficient rats","volume":"3","author":"Bode","year":"1992","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jnutbio.2006.03.005_bib20","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1471-4159.1974.tb06920.x","article-title":"Copper deficiency in the developing rat brain: a possible model for Menkes' steely-hair disease","volume":"23","author":"Prohaska","year":"1974","journal-title":"J Neurochem"},{"key":"10.1016\/j.jnutbio.2006.03.005_bib21","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0022-1759(96)00244-X","article-title":"A highly sensitive fluorescent microassay of H2O2 release from activated human leukocytes using a dihydroxyphenoxazine derivative","volume":"202","author":"Mohanty","year":"1997","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.jnutbio.2006.03.005_bib22","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1006\/abio.1997.2391","article-title":"A stable nonfluorescent derivative of reorufin for the fluorometric determination of trace hydrogen peroxide: applications in detecting the activity of phagocyte NADPH oxidase and other oxidases","volume":"253","author":"Zhou","year":"1997","journal-title":"Anal Biochem"},{"key":"10.1016\/j.jnutbio.2006.03.005_bib23","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1083\/jcb.25.2.407","article-title":"A simplified lead citrate stain for use in electron microscopy","volume":"25","author":"Venable","year":"1965","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jnutbio.2006.03.005_bib24","series-title":"Morphology","author":"Aherne","year":"1982"},{"key":"10.1016\/j.jnutbio.2006.03.005_bib25","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1016\/S0021-9258(18)62305-1","article-title":"The turnover of mitochondria in a variety of tissues of young adult and aged rats","volume":"246","author":"Menzies","year":"1971","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2006.03.005_bib26","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/S0968-0004(00)01674-1","article-title":"Mitochondria, oxygen free radicals, and ageing","volume":"25","author":"Raha","year":"2000","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.jnutbio.2006.03.005_bib27","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1080\/15216540152845957","article-title":"The mitochondrial generation of reactive oxygen species: mechanisms and implications in human pathology","volume":"52","author":"Lenaz","year":"2001","journal-title":"IUBMB Life"},{"key":"10.1016\/j.jnutbio.2006.03.005_bib28","doi-asserted-by":"crossref","first-page":"4149","DOI":"10.1073\/pnas.96.7.4149","article-title":"NADH-quinine oxidoreductase: PSST subunit couples electron transfer from iron\u2013sulfur cluster N2 to quinone","volume":"96","author":"Schuler","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jnutbio.2006.03.005_bib29","doi-asserted-by":"crossref","first-page":"262","DOI":"10.3181\/00379727-203-43599","article-title":"A unified perspective on copper deficiency and cardiomyopathy","volume":"203","author":"Medeiros","year":"1993","journal-title":"Proc Soc Exp Biol Med"},{"key":"10.1016\/j.jnutbio.2006.03.005_bib30","doi-asserted-by":"crossref","first-page":"299","DOI":"10.3181\/00379727-215-44141","article-title":"Newer findings on a unified perspective on copper restriction and cardiomyopathy","volume":"215","author":"Mederios","year":"1997","journal-title":"Proc Soc Exp Biol Med"},{"key":"10.1016\/j.jnutbio.2006.03.005_bib31","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3181\/00379727-210-43923","article-title":"Marginal copper-restricted diets produce altered cardiac ultrastructure in the rat","volume":"210","author":"Wildman","year":"1995","journal-title":"Proc Soc Exp Biol Med"},{"key":"10.1016\/j.jnutbio.2006.03.005_bib32","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.nutres.2005.07.005","article-title":"Marginal copper intakes over a protracted period in genetically and nongenetically susceptible heart disease rats disturb electrocardiograms and enhance lipid deposition","volume":"25","author":"Medeiros","year":"2005","journal-title":"Nutr Res"},{"key":"10.1016\/j.jnutbio.2006.03.005_bib33","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0167-4943(01)00218-7","article-title":"Quantifying dense bodies and lipofuscin during aging: a morphologist's perspective","volume":"34","author":"Schmucker","year":"2002","journal-title":"Arch Gerontol Geriatr"},{"key":"10.1016\/j.jnutbio.2006.03.005_bib34","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/0891-5849(96)00175-X","article-title":"Biochemical basis of lipofuscin, ceroid, and age pigment-like fluorophores","volume":"21","author":"Yin","year":"1996","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jnutbio.2006.03.005_bib35","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S1568-1637(03)00028-X","article-title":"Aging, lipofuscin formation, and free radical-mediated inhibition of cellular proteolytic systems","volume":"2","author":"Szweda","year":"2003","journal-title":"Ageing Res Rev"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286306000751?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286306000751?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T14:57:23Z","timestamp":1760626643000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286306000751"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["S0955286306000751"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2006.03.005","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2007,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hearts in adult offspring of copper-deficient dams exhibit decreased cytochrome c oxidase activity, increased mitochondrial hydrogen peroxide generation and enhanced formation of intracellular residual bodies","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2006.03.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}