{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:41:57Z","timestamp":1790714517292,"version":"4.1.0"},"reference-count":55,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2007,12]]},"DOI":"10.1016\/j.jnutbio.2007.02.002","type":"journal-article","created":{"date-parts":[[2007,5,25]],"date-time":"2007-05-25T08:54:55Z","timestamp":1180083295000},"page":"771-777","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":80,"title":["Vitamin D and aging: old concepts and new insights"],"prefix":"10.1016","volume":"18","author":[{"given":"Beate","family":"Lanske","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Shawkat","family":"Razzaque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2007.02.002_bib1","doi-asserted-by":"crossref","first-page":"F8","DOI":"10.1152\/ajprenal.00336.2004","article-title":"Vitamin D","volume":"289","author":"Dusso","year":"2005","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib2","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1006\/abbi.1999.1605","article-title":"Expression of 1,25-dihydroxyvitamin D(3) receptor in the immune system","volume":"374","author":"Veldman","year":"2000","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib3","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1006\/abbi.2000.1970","article-title":"Regulation of 25-hydroxyvitamin D3 1alpha-hydroxylase gene expression by parathyroid hormone and 1,25-dihydroxyvitamin D3","volume":"381","author":"Brenza","year":"2000","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib4","first-page":"F157","article-title":"Vitamin D","volume":"277","author":"Brown","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib5","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1023\/A:1026384421273","article-title":"Calcium and vitamin D metabolism during lactation","volume":"2","author":"Horst","year":"1997","journal-title":"J Mammary Gland Biol Neoplasia"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib6","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1210\/me.2003-0048","article-title":"Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system","volume":"17","author":"Tsujikawa","year":"2003","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib7","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1136\/bmj.326.7387.469","article-title":"Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial","volume":"326","author":"Trivedi","year":"2003","journal-title":"BMJ"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib8","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/BF00298497","article-title":"Annual injection of vitamin D and fractures of aged bones","volume":"51","author":"Heikinheimo","year":"1992","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib9","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1056\/NEJMoa055218","article-title":"Calcium plus vitamin D supplementation and the risk of fractures","volume":"354","author":"Jackson","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib10","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1365-2265.2005.02226.x","article-title":"Vitamin D and the elderly","volume":"62","author":"Mosekilde","year":"2005","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib11","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1210\/edrv.22.4.0437","article-title":"Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications","volume":"22","author":"Lips","year":"2001","journal-title":"Endocr Rev"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib12","first-page":"2967","article-title":"25-Hydroxyvitamin D(3)-1alpha-hydroxylase expression in normal and pathological parathyroid glands","volume":"87","author":"Segersten","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib13","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/0020-711X(86)90083-2","article-title":"On the ontogeny and interactions of phosphofructokinase in mouse tissues","volume":"18","author":"Reid","year":"1986","journal-title":"Int J Biochem"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib14","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/S0140-6736(89)91124-0","article-title":"Age, vitamin D, and solar ultraviolet","volume":"2","author":"Holick","year":"1989","journal-title":"Lancet"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib15","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1034\/j.1600-0781.2001.170405.x","article-title":"Subliminal ultraviolet-B irradiation for the prevention of vitamin D deficiency in the elderly: a feasibility study","volume":"17","author":"Chuck","year":"2001","journal-title":"Photodermatol Photoimmunol Photomed"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib16","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.jnutbio.2005.10.001","article-title":"Physical activity alters antioxidant status in exercising elderly subjects","volume":"17","author":"Rousseau","year":"2006","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib17","doi-asserted-by":"crossref","first-page":"400","DOI":"10.7326\/0003-4819-124-4-199602150-00003","article-title":"Vitamin D supplementation and fracture incidence in elderly persons. A randomized, placebo-controlled clinical trial","volume":"124","author":"Lips","year":"1996","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib18","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1056\/NEJM199709043371003","article-title":"Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older","volume":"337","author":"Dawson-Hughes","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib19","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/ng0897-391","article-title":"Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning","volume":"16","author":"Yoshizawa","year":"1997","journal-title":"Nat Genet"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib20","doi-asserted-by":"crossref","first-page":"9831","DOI":"10.1073\/pnas.94.18.9831","article-title":"Targeted ablation of the vitamin D receptor: an animal model of vitamin D-dependent rickets type II with alopecia","volume":"94","author":"Li","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib21","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1210\/endo.142.7.8281","article-title":"Targeted inactivation of the 25-hydroxyvitamin D(3)-1(alpha)-hydroxylase gene (CYP27B1) creates an animal model of pseudovitamin D-deficiency rickets","volume":"142","author":"Dardenne","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib22","doi-asserted-by":"crossref","first-page":"4982","DOI":"10.1210\/endo.140.11.7110","article-title":"Rescue of the skeletal phenotype of vitamin D receptor-ablated mice in the setting of normal mineral ion homeostasis: formal histomorphometric and biomechanical analyses","volume":"140","author":"Amling","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib23","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/S8756-3282(03)00023-1","article-title":"Correction of the abnormal mineral ion homeostasis with a high-calcium, high-phosphorus, high-lactose diet rescues the PDDR phenotype of mice deficient for the 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1)","volume":"32","author":"Dardenne","year":"2003","journal-title":"Bone"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib24","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.matbio.2004.09.007","article-title":"Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice","volume":"23","author":"Sitara","year":"2004","journal-title":"Matrix Biol"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib25","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/36285","article-title":"Mutation of the mouse klotho gene leads to a syndrome resembling ageing","volume":"390","author":"Kuro-o","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib26","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1056\/NEJM199204303261801","article-title":"Hypervitaminosis D associated with drinking milk","volume":"326","author":"Jacobus","year":"1992","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib27","doi-asserted-by":"crossref","first-page":"203","DOI":"10.7326\/0003-4819-127-3-199708010-00004","article-title":"Gains in bone mineral density with resolution of vitamin D intoxication","volume":"127","author":"Adams","year":"1997","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib28","doi-asserted-by":"crossref","first-page":"5372","DOI":"10.1073\/pnas.95.9.5372","article-title":"Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities","volume":"95","author":"Beck","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib29","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1172\/JCI200419081","article-title":"Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism","volume":"113","author":"Shimada","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib30","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.molmed.2006.05.002","article-title":"Hypervitaminosis D and premature aging: lessons learned from Fgf23 and Klotho mutant mice","volume":"12","author":"Razzaque","year":"2006","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib31","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1096\/fj.05-5432fje","article-title":"Premature ageing-like phenotype in fibroblast growth factor 23 null mice is a vitamin-D mediated process","volume":"20","author":"Razzaque","year":"2006","journal-title":"FASEB J"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib32","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.2353\/ajpath.2006.060329","article-title":"Genetic ablation of vitamin D activation pathway reverses biochemical and skeletal anomalies in Fgf-23-null animals","volume":"169","author":"Sitara","year":"2006","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib33","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1093\/ndt\/gfh991","article-title":"FGF-23, vitamin D and calcification: the unholy triad","volume":"20","author":"Razzaque","year":"2005","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib34","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1097\/01.mnh.0000172716.41853.1e","article-title":"Recent findings in phosphate homeostasis","volume":"14","author":"Prie","year":"2005","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib35","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1097\/01.mnh.0000232885.81142.83","article-title":"Klotho as a regulator of fibroblast growth factor signaling and phosphate\/calcium metabolism","volume":"15","author":"Kuro-o","year":"2006","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib36","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S1471-4914(01)01921-9","article-title":"Disease model: human aging","volume":"7","author":"Kuro-o","year":"2001","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib37","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S1568-1637(02)00027-2","article-title":"Klotho: a fundamental regulator of aging","volume":"1","author":"Nabeshima","year":"2002","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib38","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1097\/01.mnh.0000172717.49476.80","article-title":"Role of fibroblast growth factor 23 in health and in chronic kidney disease","volume":"14","author":"Fukagawa","year":"2005","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib39","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.jnutbio.2006.07.002","article-title":"Effect of fish oil on bone mineral density in aging C57BL\/6 female mice","volume":"18","author":"Bhattacharya","year":"2007","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib40","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.arr.2005.10.001","article-title":"Aging of mesenchymal stem cells","volume":"5","author":"Sethe","year":"2006","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib41","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.arr.2005.06.009","article-title":"Expression profiling in the aging brain: a perspective","volume":"4","author":"Galvin","year":"2005","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib42","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.arr.2006.03.002","article-title":"Mitochondrial DNA mutations, energy metabolism and apoptosis in aging muscle","volume":"5","author":"Dirks","year":"2006","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib43","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.arr.2005.10.002","article-title":"Design and analysis in genetic studies of human ageing and longevity","volume":"5","author":"Tan","year":"2006","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib44","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.arr.2006.04.001","article-title":"Oxidative phosphorylation and aging","volume":"5","author":"Lesnefsky","year":"2006","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib45","doi-asserted-by":"crossref","first-page":"5690","DOI":"10.1210\/en.2006-0302","article-title":"Life-long suppression of growth hormone-insulin-like growth factor I activity in genetically altered rats could prevent age-related renal damage","volume":"147","author":"Zha","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib46","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1093\/hmg\/ddi034","article-title":"An FGF23 missense mutation causes familial tumoral calcinosis with hyperphosphatemia","volume":"14","author":"Benet-Pages","year":"2005","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib47","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1359\/jbmr.061105","article-title":"Hyperostosis \u2014 hyperphosphatemia syndrome: a congenital disorder of O-glycosylation associated with augmented processing of fibroblast growth factor 23","volume":"22","author":"Frishberg","year":"2007","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib48","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/81664","article-title":"Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23","volume":"26","year":"2000","journal-title":"Nat Genet"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib49","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1161\/01.RES.0000157171.04054.30","article-title":"Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity","volume":"96","author":"Arking","year":"2005","journal-title":"Circ Res"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1053\/ajkd.2003.50007","article-title":"Prevalence of chronic kidney disease and decreased kidney function in the adult US population: Third National Health and Nutrition Examination Survey","volume":"41","author":"Coresh","year":"2003","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib51","first-page":"379","article-title":"Uremic tumoral calcinosis in patients receiving long-term hemodialysis therapy","volume":"26","author":"Cofan","year":"1999","journal-title":"J Rheumatol"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib52","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/ki.1990.293","article-title":"Soft tissue calcification in pediatric patients with end-stage renal disease","volume":"38","author":"Milliner","year":"1990","journal-title":"Kidney Int"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib53","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1440-1797.2003.00237.x","article-title":"Intracranial calcification and tumoural calcinosis during vitamin D therapy","volume":"9","author":"Seyahi","year":"2004","journal-title":"Nephrology (Carlton)"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib54","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1056\/NEJM200107053450115","article-title":"Vitamin D intoxication associated with an over-the-counter supplement","volume":"345","author":"Koutkia","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jnutbio.2007.02.002_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2007.02.002","article-title":"Premature aging in klotho mutant mice: cause or consequence?","author":"Lanske","year":"2007","journal-title":"Ageing Res Rev"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286307000605?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286307000605?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T14:57:44Z","timestamp":1760626664000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286307000605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":55,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["S0955286307000605"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2007.02.002","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2007,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vitamin D and aging: old concepts and new insights","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2007.02.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}