{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:43:35Z","timestamp":1791283415625,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2009,4]]},"DOI":"10.1016\/j.jnutbio.2008.04.004","type":"journal-article","created":{"date-parts":[[2008,7,8]],"date-time":"2008-07-08T06:42:34Z","timestamp":1215499354000},"page":"312-320","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Time course gene expression in the one-carbon metabolism network using HepG2 cell line grown in folate-deficient medium"],"prefix":"10.1016","volume":"20","author":[{"given":"Abalo","family":"Chango","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afif Abdel","family":"Nour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Souad","family":"Bousserouel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"Eveillard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline M.","family":"Anton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"Gu\u00e9ant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.jnutbio.2008.04.004_bib1","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1093\/carcin\/bgm149","article-title":"Folate receptor and human reduced folate carrier expression in HepG2 cell line exposed to fumonisin B1 and folate deficiency","volume":"28","author":"Abdel Nour","year":"2007","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.jnutbio.2008.04.004_bib2","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/0002-9378(92)91337-A","article-title":"Oral folic acid supplementation for cervical dysplasia: a clinical intervention trial","volume":"166","author":"Butterworth","year":"1992","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.jnutbio.2008.04.004_bib3","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.ygyno.2004.09.031","article-title":"Polymorphism in folate- and methionine-metabolizing enzyme and aberrant CpG island hypermethylation in uterine cervical cancer","volume":"96","author":"Kang","year":"2005","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.jnutbio.2008.04.004_bib4","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1159\/000076460","article-title":"Polymorphisms in the MTHFR gene are associated with breast cancer","volume":"24","author":"Ergul","year":"2003","journal-title":"Tumour Biol"},{"key":"10.1016\/j.jnutbio.2008.04.004_bib5","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1093\/jnci\/djk006","article-title":"Folate and risk of breast cancer: a meta-analysis","volume":"99","author":"Larsson","year":"2007","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.jnutbio.2008.04.004_bib6","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1002\/ijc.10138","article-title":"Dietary intake of folic acid and colorectal cancer risk in a cohort of women","volume":"97","author":"Terry","year":"2002","journal-title":"Int J Cancer"},{"key":"10.1016\/j.jnutbio.2008.04.004_bib7","doi-asserted-by":"crossref","first-page":"2413S","DOI":"10.1093\/jn\/132.8.2413S","article-title":"Folate status: effects on pathways of colorectal carcinogenesis","volume":"132","author":"Choi","year":"2002","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2008.04.004_bib8","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1079\/PNS2004","article-title":"Folate, DNA stability and colorectal neoplasia","volume":"63","author":"Duthie","year":"2004","journal-title":"Proc Nutr Soc"},{"key":"10.1016\/j.jnutbio.2008.04.004_bib9","doi-asserted-by":"crossref","first-page":"2350S","DOI":"10.1093\/jn\/132.8.2350S","article-title":"Epidemiologic studies of folate and colorectal neoplasia: a review","volume":"132","author":"Giovannucci","year":"2002","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2008.04.004_bib10","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1016\/S0016-5085(03)00279-8","article-title":"Folate status, genomic DNA hypomethylation, and risk of colorectal adenoma and cancer: a case control study","volume":"124","author":"Pufulete","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jnutbio.2008.04.004_bib11","first-page":"13","article-title":"Biochemical pharmacology of pemetrexed","volume":"18","author":"Calvert","year":"2004","journal-title":"Oncology (Huntingt)"},{"key":"10.1016\/j.jnutbio.2008.04.004_bib12","doi-asserted-by":"crossref","first-page":"5020","DOI":"10.1016\/j.bmc.2006.03.001","article-title":"Targeting the alpha-folate receptor with cyclopenta[g]quinazoline-based inhibitors of thymidylate synthase","volume":"14","author":"Henderson","year":"2006","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.jnutbio.2008.04.004_bib13","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0006-291X(03)01173-2","article-title":"Kinetic properties of human thymidylate synthase, an anticancer drug target","volume":"307","author":"Sergeeva","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jnutbio.2008.04.004_bib14","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0169-409X(02)00042-X","article-title":"Folate-mediated delivery of macromolecular anticancer therapeutic agents","volume":"54","author":"Lu","year":"2002","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.jnutbio.2008.04.004_bib15","first-page":"2131","article-title":"Folate receptor targeted delivery of liposomal daunorubicin into tumor cells","volume":"22","author":"Ni","year":"2002","journal-title":"Anticancer Res"},{"key":"10.1016\/j.jnutbio.2008.04.004_bib16","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0741-8329(02)00225-2","article-title":"Folate deficiency, methionine metabolism, and alcoholic liver disease","volume":"27","author":"Halsted","year":"2002","journal-title":"Alcohol"},{"key":"10.1016\/j.jnutbio.2008.04.004_bib17","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1016\/S0016-5085(03)00276-2","article-title":"Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice","volume":"124","author":"Ji","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jnutbio.2008.04.004_bib18","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1042\/bj20021523","article-title":"Phosphatidylethanolamine N-methyltransferase (PEMT) knockout mice have hepatic steatosis and abnormal hepatic choline metabolite concentrations despite ingesting a recommended dietary intake of choline","volume":"370","author":"Zhu","year":"2003","journal-title":"Biochem J"},{"key":"10.1016\/j.jnutbio.2008.04.004_bib19","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1016\/j.bcp.2005.09.021","article-title":"Role of elevated S-adenosylhomocysteine in rat hepatocyte apoptosis: protection by betaine","volume":"70","author":"Kharbanda","year":"2005","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.jnutbio.2008.04.004_bib20","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0022-3476(74)80721-3","article-title":"Homocystinuria due to cystathionine synthase deficiency: enzymatic and ultrastructural studies","volume":"84","author":"Gaull","year":"1974","journal-title":"J Pediatr"},{"key":"10.1016\/j.jnutbio.2008.04.004_bib21","doi-asserted-by":"crossref","first-page":"e36","DOI":"10.1093\/nar\/30.9.e36","article-title":"Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR","volume":"30","author":"Pfaffl","year":"2002","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jnutbio.2008.04.004_bib22","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.jnutbio.2008.04.004_bib23","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1093\/carcin\/23.7.1103","article-title":"The impact of chromatin in human cancer: linking DNA methylation to gene silencing","volume":"23","author":"Ballestar","year":"2002","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.jnutbio.2008.04.004_bib24","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1002\/0470862637.ch17","article-title":"Reversal of gene silencing as a therapeutic target for cancer \u2014 roles for DNA methylation and its interdigitation with chromatin","volume":"259","author":"Baylin","year":"2004","journal-title":"Novartis Found Symp"},{"key":"10.1016\/j.jnutbio.2008.04.004_bib25","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1126\/science.1065173","article-title":"Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor","volume":"295","author":"Di Croce","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.jnutbio.2008.04.004_bib26","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1128\/MCB.25.6.2147-2157.2005","article-title":"Transcription factor interactions and chromatin modifications associated with p53-mediated, developmental repression of the alpha-fetoprotein gene","volume":"25","author":"Nguyen","year":"2005","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jnutbio.2008.04.004_bib27","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1093\/nar\/28.17.3233","article-title":"Transcriptional repression of BRCA1 by aberrant cytosine methylation, histone hypoacetylation and chromatin condensation of the BRCA1 promoter","volume":"28","author":"Rice","year":"2000","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jnutbio.2008.04.004_bib28","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/sj.ejhg.5201727","article-title":"Implication of abnormal epigenetic patterns for human diseases","volume":"15","author":"Santos-Reboucas","year":"2007","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.jnutbio.2008.04.004_bib29","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/j.ejca.2005.02.020","article-title":"CpG island methylation and expression of tumour-associated genes in lung carcinoma","volume":"41","author":"Dammann","year":"2005","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.jnutbio.2008.04.004_bib30","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1093\/jb\/mvi048","article-title":"The essential role of histone H3 Lys9 di-methylation and MeCP2 binding in MGMT silencing with poor DNA methylation of the promoter CpG island","volume":"137","author":"Zhao","year":"2005","journal-title":"J Biochem (Tokyo)"},{"key":"10.1016\/j.jnutbio.2008.04.004_bib31","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1073\/pnas.95.6.3059","article-title":"Cloning and mapping of a cDNA for methionine synthase reductase, a flavoprotein defective in patients with homocystinuria","volume":"95","author":"Leclerc","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jnutbio.2008.04.004_bib32","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.ymgme.2007.02.001","article-title":"Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase","volume":"91","author":"Elmore","year":"2007","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.jnutbio.2008.04.004_bib33","doi-asserted-by":"crossref","first-page":"9476","DOI":"10.1073\/pnas.0603694103","article-title":"Human methionine synthase reductase is a molecular chaperone for human methionine synthase","volume":"103","author":"Yamada","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jnutbio.2008.04.004_bib34","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1093\/jn\/124.11.2197","article-title":"Severe folate deficiency causes secondary depletion of choline and phosphocholine in rat liver","volume":"124","author":"Kim","year":"1994","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2008.04.004_bib35","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1002\/dvdy.20288","article-title":"DNA Methyltransferase expression in the mouse germ line during periods of de novo methylation","volume":"232","author":"Lees-Murdock","year":"2005","journal-title":"Dev Dyn"},{"key":"10.1016\/j.jnutbio.2008.04.004_bib36","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.4161\/cbt.4.10.2073","article-title":"DNA Methyltransferase-3a interacts with p53 and represses p53-mediated gene expression","volume":"4","author":"Wang","year":"2005","journal-title":"Cancer Biol Ther"},{"key":"10.1016\/j.jnutbio.2008.04.004_bib37","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/416552a","article-title":"DNMT1 and DNMT3b cooperate to silence genes in human cancer cells","volume":"416","author":"Rhee","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.jnutbio.2008.04.004_bib38","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1016\/S0399-8320(06)73554-0","article-title":"Epigenetic changes and liver carcinogenesis","volume":"30","author":"Peyrin-Biroulet","year":"2006","journal-title":"Gastroenterol Clin Biol"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286308000879?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286308000879?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T15:00:26Z","timestamp":1760626826000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286308000879"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["S0955286308000879"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2008.04.004","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2009,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Time course gene expression in the one-carbon metabolism network using HepG2 cell line grown in folate-deficient medium","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2008.04.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}