{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T08:34:45Z","timestamp":1791102885082,"version":"4.1.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2010,2]]},"DOI":"10.1016\/j.jnutbio.2008.12.006","type":"journal-article","created":{"date-parts":[[2009,3,10]],"date-time":"2009-03-10T05:26:04Z","timestamp":1236662764000},"page":"153-161","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Regulation of cellular glutathione peroxidase by different forms and concentrations of selenium in primary cultured bovine hepatocytes"],"prefix":"10.1016","volume":"21","author":[{"given":"Xianshi","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kehe","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengwu","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuiling","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2008.12.006_bib1","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/S0167-5699(98)01294-8","article-title":"Selenium: an essential element for immune function","volume":"19","author":"McKenzie","year":"1998","journal-title":"Immunol Today"},{"key":"10.1016\/j.jnutbio.2008.12.006_bib2","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/0093-691X(94)90482-X","article-title":"Effect of prepartum injection of vitamin E and selenium on postpartum reproductive function of dairy cattle","volume":"41","author":"Ar\u00e9chiga","year":"1994","journal-title":"Theriogenology"},{"key":"10.1016\/j.jnutbio.2008.12.006_bib3","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.nut.2004.05.028","article-title":"Effect of selenium-induced oxidative stress on the cell kinetics in testis and reproductive ability of male mice","volume":"21","author":"Kaur","year":"2005","journal-title":"Nutrition"},{"key":"10.1016\/j.jnutbio.2008.12.006_bib4","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.cca.2005.05.005","article-title":"Influence of organic selenium on hsp70 response of heat-stressed and enteropathogenic Escherichia coli-challenged broiler chickens (Gallus gallus)","volume":"141","author":"Mahmoud","year":"2005","journal-title":"Comp Biochem Physiol C Toxicol Pharmacol"},{"key":"10.1016\/j.jnutbio.2008.12.006_bib5","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1007\/PL00000668","article-title":"Anticarcinogenic effects of selenium","volume":"57","author":"Schrauzer","year":"2000","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.jnutbio.2008.12.006_bib6","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1079\/BJN20031015","article-title":"Selenium and its relationship to cancer: an update","volume":"91","author":"Whanger","year":"2004","journal-title":"Br J Nutr"},{"key":"10.1016\/j.jnutbio.2008.12.006_bib7","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1093\/jn\/135.2.343","article-title":"Current evidence and research needs to support a health claim for selenium and cancer prevention","volume":"135","author":"Combs","year":"2005","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2008.12.006_bib8","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S0753-3322(03)00035-0","article-title":"The antioxidant role of selenium and seleno-compounds","volume":"57","author":"Tapiero","year":"2003","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.jnutbio.2008.12.006_bib9","doi-asserted-by":"crossref","first-page":"1457S","DOI":"10.1093\/jn\/133.5.1457S","article-title":"Selenium in the immune system","volume":"133","author":"Arthur","year":"2003","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2008.12.006_bib10","first-page":"75","article-title":"Research on the relation between selenium and Keshan disease","volume":"1","year":"1979","journal-title":"Acta Acad Med Sin"},{"key":"10.1016\/j.jnutbio.2008.12.006_bib11","first-page":"89","article-title":"Studies on low selenium belt in China and pathogeny of Keshan and Kaschin-Beck diseases","volume":"7","author":"Research Team of Environment and Endemic Diseases","year":"1986","journal-title":"Chin J Environ Sci"},{"key":"10.1016\/j.jnutbio.2008.12.006_bib12","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1126\/science.128.3331.1090.a","article-title":"Effects of selenium and vitamin E on white muscle disease","volume":"128","author":"Muth","year":"1958","journal-title":"Science"},{"key":"10.1016\/j.jnutbio.2008.12.006_bib13","doi-asserted-by":"crossref","first-page":"617","DOI":"10.3181\/00379727-95-23307","article-title":"Effect of selenium in preventing exudative diathesis in chicks","volume":"95","author":"Patterson","year":"1957","journal-title":"Proc Soc Exp Biol Med"},{"key":"10.1016\/j.jnutbio.2008.12.006_bib14","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1126\/science.179.4073.588","article-title":"Selenium biochemical role as a component of glutathione peroxidase","volume":"179","author":"Rotruck","year":"1973","journal-title":"Science"},{"key":"10.1016\/j.jnutbio.2008.12.006_bib15","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1007\/PL00000664","article-title":"The glutathione peroxidases","volume":"57","author":"Arthur","year":"2000","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.jnutbio.2008.12.006_bib16","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1006\/abbi.1993.1320","article-title":"Selenium regulation of glutathione peroxidase in human hepatoma cell line Hep3B","volume":"304","author":"Baker","year":"1993","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.jnutbio.2008.12.006_bib17","doi-asserted-by":"crossref","first-page":"2932","DOI":"10.1128\/MCB.18.5.2932","article-title":"Selenium deficiency reduces the abundance of mRNA for Se-dependent glutathione peroxidase 1 by a UGA-dependent mechanism likely to be nonsense codon-mediated decay of cytoplasmic mRNA","volume":"18","author":"Moriarty","year":"1998","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jnutbio.2008.12.006_bib18","first-page":"131","article-title":"Selenium toxicity in domestic animals","author":"Mihajlovi\u0107","year":"1992","journal-title":"Glas Srp Akad Nauka (Med)"},{"key":"10.1016\/j.jnutbio.2008.12.006_bib19","doi-asserted-by":"crossref","first-page":"942","DOI":"10.2527\/2001.794942x","article-title":"Comparative effects of high dietary levels of organic and inorganic selenium on selenium toxicity of growing\u2013finishing pigs","volume":"79","author":"Kim","year":"2001","journal-title":"J Anim Sci"},{"key":"10.1016\/j.jnutbio.2008.12.006_bib20","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1177\/104063870601800108","article-title":"Comparative toxicosis of sodium selenite and selenomethionine in lambs","volume":"18","author":"Tiwary","year":"2006","journal-title":"J Vet Diagn Invest"},{"key":"10.1016\/j.jnutbio.2008.12.006_bib21","first-page":"20S","article-title":"Bioavailability of selenium","volume":"51","author":"Fairweather-Tait","year":"1997","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.jnutbio.2008.12.006_bib22","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1079\/BJN20041251","article-title":"The use of high-selenium yeast to raise selenium status: how does it measure up","volume":"92","author":"Rayman","year":"2004","journal-title":"Br J Nutr"},{"key":"10.1016\/j.jnutbio.2008.12.006_bib23","first-page":"346","article-title":"Selenium regulation of selenium-dependent glutathione peroxidases in animals and transfected CHO cells","volume":"10","author":"Sunde","year":"1997","journal-title":"Biomed Environ Sci"},{"key":"10.1016\/j.jnutbio.2008.12.006_bib24","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1042\/bj3570851","article-title":"Selenium regulation of transcript abundance and translational efficiency of glutathione peroxidase-1 and -4 in rat liver","volume":"357","author":"Weiss Sachdev","year":"2001","journal-title":"Biochem J"},{"key":"10.1016\/j.jnutbio.2008.12.006_bib25","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/sj.ejcn.1601800","article-title":"Assessment of requirements for selenium and adequacy of selenium status: a review","volume":"58","author":"Thomson","year":"2004","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.jnutbio.2008.12.006_bib26","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1093\/jn\/128.1.130","article-title":"Dietary selenium supplementation is required to support full expression of three selenium-dependent glutathione peroxidases in various tissues of weanling pigs","volume":"128","author":"Lei","year":"1998","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2008.12.006_bib27","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1093\/jn\/135.9.2144","article-title":"Dietary selenium requirements based on glutathione peroxidase-1 activity and mRNA levels and other Se-dependent parameters are not increased by pregnancy and lactation in rats","volume":"135","author":"Sunde","year":"2005","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2008.12.006_bib28","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0091-679X(08)61797-5","article-title":"Preparation of isolated rat liver cells","volume":"13","author":"Seglen","year":"1976","journal-title":"Methods Cell Biol"},{"key":"10.1016\/j.jnutbio.2008.12.006_bib29","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.2527\/1993.7182218x","article-title":"Preparation of extended in vitro cultures of bovine hepatocytes that are hormonally responsive","volume":"71","author":"Donkin","year":"1993","journal-title":"J Anim Sci"},{"key":"10.1016\/j.jnutbio.2008.12.006_bib30","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S1385-299X(97)00047-0","article-title":"Detoxification of exogenous hydrogen peroxide and organic hydroperoxides by cultured astroglial cells assessed by microtiter plate assay","volume":"2","author":"Dringen","year":"1998","journal-title":"Brain Res Protoc"},{"key":"10.1016\/j.jnutbio.2008.12.006_bib31","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.1038\/nprot.2006.378","article-title":"Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method","volume":"1","author":"Rahman","year":"2006","journal-title":"Nat Protoc"},{"key":"10.1016\/j.jnutbio.2008.12.006_bib32","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1093\/jn\/125.6.1438","article-title":"Glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase are differentially regulated in rats by dietary selenium","volume":"125","author":"Lei","year":"1995","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2008.12.006_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jnutbio.2007.02.005","article-title":"Selenium as an anticancer nutrient: roles in cell proliferation and tumor cell invasion","volume":"19","author":"Zeng","year":"2008","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jnutbio.2008.12.006_bib34","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/BF00144126","article-title":"Uptake of selenite, selenomethionine and selenate by brush border membrane vesicles isolated from rat small intestine","volume":"7","author":"Vendeland","year":"1994","journal-title":"Biometals"},{"key":"10.1016\/j.jnutbio.2008.12.006_bib35","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0300-483X(91)90224-O","article-title":"Effect of in vitro treatment of rat hepatocytes with selenium, and\/or cadmium on cell viability, glucose output, and cellular glutathione","volume":"69","author":"Bell","year":"1991","journal-title":"Toxicology"},{"key":"10.1016\/j.jnutbio.2008.12.006_bib36","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0300-483X(95)03080-Y","article-title":"Toxicity, metabolism and absorption of selenite by isolated rat hepatocytes","volume":"100","author":"Park","year":"1995","journal-title":"Toxicology"},{"key":"10.1016\/j.jnutbio.2008.12.006_bib37","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0300-483X(90)90037-H","article-title":"Comparative embryotoxicity of selenite and selenate: uptake in murine embryonal and fetal tissues and effects on blastocysts and embryonic cells in vitro","volume":"63","author":"Danielsson","year":"1990","journal-title":"Toxicology"},{"key":"10.1016\/j.jnutbio.2008.12.006_bib38","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1254\/jphs.FP0060204","article-title":"Inhibition by selenium compounds of catecholamine secretion due to inhibition of Ca2+ influx in cultured bovine adrenal chromaffin cells","volume":"101","author":"Uezono","year":"2006","journal-title":"J Pharmacol Sci"},{"key":"10.1016\/j.jnutbio.2008.12.006_bib39","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0946-672X(03)80024-X","article-title":"Effect of increasing selenite concentrations, vitamin E supplementation and different fetal calf serum content on GPx1 activity in primary cultured rabbit hepatocytes","volume":"17","author":"M\u00fcller","year":"2003","journal-title":"J Trace Elem Med Biol"},{"key":"10.1016\/j.jnutbio.2008.12.006_bib40","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1093\/clinchem\/33.8.1448","article-title":"Improved procedure for determining glutathione in plasma as an index of myocardial oxidative stress","volume":"33","author":"Curello","year":"1987","journal-title":"Clin Chem"},{"key":"10.1016\/j.jnutbio.2008.12.006_bib41","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1093\/jn\/117.1.99","article-title":"Effect of selenium depletion and repletion on plasma glutathione and glutathione-dependent enzymes in the rat","volume":"117","author":"Hill","year":"1987","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2008.12.006_bib42","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.lungcan.2006.09.007","article-title":"Effects of selenium supplementation on expression of glutathione peroxidase isoforms in cultured human lung adenocarcinoma cell lines","volume":"55","author":"Romanowska","year":"2007","journal-title":"Lung Cancer"},{"key":"10.1016\/j.jnutbio.2008.12.006_bib43","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1634\/stemcells.2005-0117","article-title":"Selenium supplementation restores the antioxidative capacity and prevents cell damage in bone marrow stromal cells in vitro","volume":"24","author":"Ebert","year":"2006","journal-title":"Stem Cells"},{"key":"10.1016\/j.jnutbio.2008.12.006_bib44","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1042\/bj3060581","article-title":"Differential regulation of glutathione peroxidase by selenomethionine and hyperoxia in endothelial cells","volume":"306","author":"Jornot","year":"1995","journal-title":"Biochem J"},{"key":"10.1016\/j.jnutbio.2008.12.006_bib45","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.fct.2005.10.002","article-title":"Aqueous extracts of selenium-fertilized broccoli increase selenoprotein activity and inhibit DNA single-strand breaks, but decrease the activity of quinone reductase in Hepa 1c1c7 cells","volume":"44","author":"Keck","year":"2006","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.jnutbio.2008.12.006_bib46","first-page":"4407","article-title":"Selenite and selenate inhibit human lymphocyte growth via different mechanisms","volume":"56","author":"Spyrou","year":"1996","journal-title":"Cancer Res"},{"key":"10.1016\/j.jnutbio.2008.12.006_bib47","doi-asserted-by":"crossref","first-page":"3401","DOI":"10.1016\/0006-2952(88)90688-0","article-title":"Studies of the role of DNA fragmentation in selenium toxicity","volume":"37","author":"Garberg","year":"1988","journal-title":"Biochem Pharmacol"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286308002660?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286308002660?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T15:01:13Z","timestamp":1760626873000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286308002660"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["S0955286308002660"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2008.12.006","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2010,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Regulation of cellular glutathione peroxidase by different forms and concentrations of selenium in primary cultured bovine hepatocytes","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2008.12.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}