{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:09:16Z","timestamp":1791180556446,"version":"4.1.0"},"reference-count":68,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2010,4]]},"DOI":"10.1016\/j.jnutbio.2009.01.007","type":"journal-article","created":{"date-parts":[[2009,5,9]],"date-time":"2009-05-09T04:25:51Z","timestamp":1241843151000},"page":"338-344","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Docosahexaenoic acid down-regulates phenobarbital-induced cytochrome P450 2B1 gene expression in rat primary hepatocytes via the sphingomyelinase\/ceramide pathway"],"prefix":"10.1016","volume":"21","author":[{"given":"Chia-Yang","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Chun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Li","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Wen","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong-Kuei","family":"Lii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haw-Wen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2009.01.007_bib1","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1042\/bj3350465","article-title":"Signal transduction of stress via ceramide","volume":"335","author":"Mathias","year":"1998","journal-title":"Biochem J"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib2","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1006\/taap.1996.8029","article-title":"Sphingolipids\u2014the enigmatic lipid class: biochemistry, physiology, and pathophysiology","volume":"142","author":"Merrill","year":"1997","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib3","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1146\/annurev.physiol.60.1.643","article-title":"Regulation of ceramide production and apoptosis","volume":"60","author":"Kolesnick","year":"1998","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib4","first-page":"263","article-title":"Resveratrol structure and ceramide-associated growth inhibition in prostate cancer cells","volume":"29","author":"Sala","year":"2003","journal-title":"Drugs Exp Clin Res"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib5","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1124\/jpet.103.062760","article-title":"Novel ceramide analogs as potential chemotherapeutic agents in breast cancer","volume":"309","author":"Struckhoff","year":"2004","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib6","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1016\/S0006-2952(03)00125-4","article-title":"Mechanisms involved in exogenous C2- and C6-ceramide-induced cancer cell toxicity","volume":"65","author":"Fillet","year":"2003","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib7","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0304-3835(03)00050-8","article-title":"Ceramide induces cell cycle arrest and upregulates p27kip in nasopharyngeal carcinoma cells","volume":"193","author":"Zhu","year":"2003","journal-title":"Cancer Lett"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib8","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1093\/jn\/124.5.615","article-title":"Dietary sphingomyelin inhibits 1,2-dimethylhydrazine-induced colon cancer in CF1 mice","volume":"124","author":"Dillehay","year":"1994","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib9","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1002\/(SICI)1097-0142(19970201)79:3<448::AID-CNCR4>3.0.CO;2-E","article-title":"Alkaline sphingomyelinase activity is decreased in human colorectal carcinoma","volume":"79","author":"Hertervig","year":"1997","journal-title":"Cancer"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib10","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0304-4157(93)90001-5","article-title":"Sphingolipid breakdown products: anti-proliferative and tumor-suppressor lipids","volume":"1154","author":"Hannun","year":"1993","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib11","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1017\/S0029665107005411","article-title":"N-3 PUFA in CVD: influence of cytokine polymorphism","volume":"66","author":"von Schacky","year":"2007","journal-title":"Proc Nutr Soc"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib12","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s11883-004-0087-5","article-title":"Omega-3 fatty acids and inflammation","volume":"6","author":"Mori","year":"2004","journal-title":"Curr Atheroscler Rep"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib13","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/07315724.2002.10719248","article-title":"Omega-3 fatty acids in inflammation and autoimmune diseases","volume":"21","author":"Simopoulos","year":"2002","journal-title":"J Am Coll Nutr"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib14","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.neurobiolaging.2005.09.005","article-title":"Prevention of Alzheimer's disease: omega-3 fatty acid and phenolic anti-oxidant interventions","volume":"26","author":"Cole","year":"2005","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib15","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s10549-005-2415-z","article-title":"Mechanisms of omega-3 fatty acid-induced growth inhibition in MDA-MB-231 human breast cancer cells","volume":"92","author":"Schley","year":"2005","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib16","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s11596-007-0518-y","article-title":"Modulatory effects of EPA and DHA on proliferation and apoptosis of pancreatic cancer cells","volume":"27","author":"Zhang","year":"2007","journal-title":"J Huazhong Univ Sci Technolog Med Sci"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib17","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1207\/s15327914nc5001_10","article-title":"Conjugated docosahexaenoic acid is a potent inducer of cell cycle arrest and apoptosis and inhibits growth of colo 201 human colon cancer cells","volume":"50","author":"Danbara","year":"2004","journal-title":"Nutr Cancer"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib18","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1042\/bj20021667","article-title":"Cell-cycle arrest in Jurkat leukaemic cells: a possible role for docosahexaenoic acid","volume":"371","author":"Siddiqui","year":"2003","journal-title":"Biochem J"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib19","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/BF02977789","article-title":"Induction of phase I, II and III drug metabolism\/transport by xenobiotics","volume":"28","author":"Xu","year":"2005","journal-title":"Arch Pharm Res"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib20","doi-asserted-by":"crossref","first-page":"12762","DOI":"10.1074\/jbc.270.21.12762","article-title":"cAMP-Associated inhibition of phenobarbital-inducible cytochrome P450 gene expression in primary rat hepatocyte cultures","volume":"270","author":"Sidhu","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib21","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.taap.2007.08.009","article-title":"DHA Down-regulates phenobarbital-induced cytochrome P450 2B1 gene expression in rat primary hepatocytes by attenuating CAR translocation","volume":"225","author":"Li","year":"2007","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib22","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1023\/A:1011177223129","article-title":"Treatment based on a combination of the CYP2B1\/cyclophosphamide system and p53 delivery enhances tumour regression in human pancreatic cancer","volume":"12","author":"Mercad\u00e9","year":"2001","journal-title":"Ann Oncol"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib23","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.amjoto.2004.06.012","article-title":"Enhancement of cyclophosphamide sensitivity in squamous cell carcinoma transfected with cytochrome P-450 2B1","volume":"26","author":"Iida","year":"2005","journal-title":"Am J Otolaryngol"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib24","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0090-9556(24)15302-0","article-title":"Development of a substrate-activity based approach to identify the major human liver P-450 catalysts of cyclophosphamide and ifosfamide activation based on cDNA-expressed activities and liver microsomal P-450 profiles","volume":"27","author":"Roy","year":"1999","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib25","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1080\/01635581.2001.9680631","article-title":"Prostaglandin E2 is involved in the increase of cytochrome P-450 2B1 expression by alpha-tocopheryl succinate in primary rat hepatocytes in the presence of phenobarbital","volume":"41","author":"Tsai","year":"2001","journal-title":"Nutr Cancer"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib26","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1006\/bbrc.1994.1596","article-title":"Molecular cloning and expression of rat prostaglandin E receptor EP2 subtype","volume":"200","author":"Sando","year":"1994","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib27","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1006\/bbrc.1993.1904","article-title":"Molecular cloning and intrarenal localization of rat prostaglandin E2 receptor EP3 subtype","volume":"194","author":"Takeuchi","year":"1993","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib28","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.bbrc.2004.12.023","article-title":"Prostaglandin E2 down-regulation of cytochrome P-450 2B1 expression induced by phenobarbital is through EP2 receptor in rat hepatocytes","volume":"327","author":"Li","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib29","doi-asserted-by":"crossref","first-page":"349","DOI":"10.2174\/138920006776873526","article-title":"Evolution and function of the NR1I nuclear hormone receptor subfamily (VDR, PXR, and CAR) with respect to metabolism of xenobiotics and endogenous compounds","volume":"7","author":"Reschly","year":"2006","journal-title":"Curr Drug Metab"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib30","doi-asserted-by":"crossref","first-page":"6318","DOI":"10.1128\/MCB.19.9.6318","article-title":"Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene","volume":"19","author":"Kawamoto","year":"1999","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib31","doi-asserted-by":"crossref","first-page":"7559","DOI":"10.1074\/jbc.M008090200","volume":"276","author":"Kim","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib32","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0091-679X(08)61797-5","article-title":"Preparation of isolated rat liver cells","volume":"13","author":"Seglen","year":"1976","journal-title":"Methods Cell Biol"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib33","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0076-6879(78)52006-5","article-title":"Isolation and use of liver cells","volume":"52","author":"Mold\u00e9us","year":"1978","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib34","doi-asserted-by":"crossref","first-page":"3103","DOI":"10.1074\/jbc.272.5.3103","article-title":"Extracellular ATP induces anchorage-independent expression of cyclin A and rescues the transformed phenotype of a ras-resistant mutant cell line","volume":"272","author":"Yang","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib35","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib36","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1248\/bpb.27.903","article-title":"Gene activations of CYP2B1 and CYP3A1 by dihydropyridine calcium channel antagonists in the rat liver: the structure\u2013activity relationship","volume":"27","author":"Konno","year":"2004","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib37","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/S0006-2952(99)00189-6","article-title":"Lack of modulation by phenobarbital of cyclic AMP levels or protein kinase A activity in rat primary hepatocytes","volume":"58","author":"Beck","year":"1999","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib38","doi-asserted-by":"crossref","first-page":"C839","DOI":"10.1152\/ajpcell.00197.2007","article-title":"Cadmium-induced ceramide formation triggers calpain-dependent apoptosis in cultured kidney proximal tubule cells","volume":"293","author":"Lee","year":"2007","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib39","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib40","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1139\/y59-099","article-title":"A rapid method of total lipid extraction and purification","volume":"37","author":"Bligh","year":"1959","journal-title":"Can J Biochem Physiol"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib41","doi-asserted-by":"crossref","first-page":"5572","DOI":"10.1210\/jc.2003-030776","article-title":"Sphingosine-1-phosphate in inhibition of male germ cell apoptosis in the human testis","volume":"88","author":"Suomalainen","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib42","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1002\/ijc.21238","article-title":"Omega-3 polyunsaturated fatty acids attenuate breast cancer growth through activation of a neutral sphingomyelinase-mediated pathway","volume":"117","author":"Wu","year":"2005","journal-title":"Int J Cancer"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib43","doi-asserted-by":"crossref","first-page":"29971","DOI":"10.1074\/jbc.M805402200","article-title":"Identification of Mg2+-dependent neutral sphingomyelinase 1 as a mediator of heat stress-induced ceramide generation and apoptosis","volume":"283","author":"Yabu","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib44","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1158\/1078-0432.CCR-07-1811","article-title":"Vitamin E succinate induces ceramide-mediated apoptosis in head and neck squamous cell carcinoma in vitro and in vivo","volume":"14","author":"Gu","year":"2008","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib45","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1046\/j.1365-2567.1997.d01-2227.x","article-title":"Activation of neutral sphingomyelinase in human neutrophils by polyunsaturated fatty acids","volume":"91","author":"Robinson","year":"1997","journal-title":"Immunology"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib46","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1007\/s10495-007-0119-z","article-title":"Apoptosis induced by capsaicin in prostate PC-3 cells involves ceramide accumulation, neutral sphingomyelinase, and JNK activation","volume":"12","author":"S\u00e1nchez","year":"2007","journal-title":"Apoptosis"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib47","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1006\/scdb.1997.0153","article-title":"Sphingomyelinases in cell regulation","volume":"8","author":"Liu","year":"1997","journal-title":"Semin Cell Dev Biol"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib48","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.jnutbio.2005.12.003","article-title":"n-6 and n-3 polyunsaturated fatty acids down-regulate cytochrome P-450 2B1 gene expression induced by phenobarbital in primary rat hepatocytes","volume":"17","author":"Li","year":"2006","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib49","first-page":"1331","article-title":"Sensitization of human breast cancer cells to cyclophosphamide and ifosfamide by transfer of a liver cytochrome P450 gene","volume":"56","author":"Chen","year":"1996","journal-title":"Cancer Res"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib50","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.200800112","article-title":"Docosahexaenoic acid downregulates phenobarbital-induced cytochrome P450 2B1 gene expression in rat primary hepatocytes via the c-Jun NH2-terminal kinase mitogen-activated protein kinase pathway","author":"Lu","year":"2009","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib51","doi-asserted-by":"crossref","first-page":"25233","DOI":"10.1074\/jbc.270.42.25233","article-title":"Regulation of cytochrome P450 2C11 (CYP2C11) gene expression by interleukin-1, sphingomyelin hydrolysis, and ceramides in rat hepatocytes","volume":"270","author":"Chen","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib52","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S0006-291X(02)02541-X","article-title":"Modulation of CYP3A4 expression by ceramide in human colon carcinoma HT-29 cells","volume":"298","author":"Chun","year":"2002","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib53","doi-asserted-by":"crossref","first-page":"14550","DOI":"10.1074\/jbc.273.23.14550","article-title":"Sphingomyelin synthase, a potential regulator of intracellular levels of ceramide and diacylglycerol during SV40 transformation. Does sphingomyelin synthase account for the putative phosphatidylcholine-specific phospholipase C?","volume":"273","author":"Luberto","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib54","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1161\/01.ATV.0000112036.72200.ac","article-title":"Apolipoprotein C-I induces apoptosis in human aortic smooth muscle cells via recruiting neutral sphingomyelinase","volume":"24","author":"Kolmakova","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib55","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1038\/sj.cdd.4401095","article-title":"Cyclic GMP-dependent inhibition of acid sphingomyelinase by nitric oxide: an early step in protection against apoptosis","volume":"9","author":"Barsacchi","year":"2002","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib56","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1096\/fasebj.12.11.999","article-title":"Positive feedback control of neutral sphingomyelinase activity by ceramide","volume":"12","author":"Jaffr\u00e9zou","year":"1998","journal-title":"FASEB J"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib57","doi-asserted-by":"crossref","first-page":"5480","DOI":"10.1073\/pnas.070062397","article-title":"Nitric oxide inhibits tumor necrosis factor-alpha-induced apoptosis by reducing the generation of ceramide","volume":"97","author":"De Nadai","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib58","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1126\/science.274.5294.1855","article-title":"Functions of ceramide in coordinating cellular responses to stress","volume":"274","author":"Hannun","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib59","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0009-3084(99)00082-1","article-title":"Ceramide and sphingomyelinases in the regulation of stress responses","volume":"102","author":"Sawai","year":"1999","journal-title":"Chem Phys Lipids"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib60","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0962-8924(99)01694-3","article-title":"Ceramide in the eukaryotic stress response","volume":"10","author":"Hannun","year":"2000","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib61","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1124\/mol.64.2.502","article-title":"Prevalence of necrosis in C2-ceramide-induced cytotoxicity in NB16 neuroblastoma cells","volume":"64","author":"Ramos","year":"2003","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib62","doi-asserted-by":"crossref","first-page":"3590","DOI":"10.1210\/endo.142.8.8293","article-title":"Saturated FFAs, palmitic acid and stearic acid, induce apoptosis in human granulosa cells","volume":"142","author":"Mu","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib63","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.2337\/diabetes.54.6.1838","article-title":"Palmitate-induced apoptosis in cultured bovine retinal pericytes: roles of NAD(P)H oxidase, oxidant stress, and ceramide","volume":"54","author":"Cacicedo","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib64","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jcf.2006.01.004","article-title":"Fatty acids in blood and intestine following docosahexaenoic acid supplementation in adults with cystic fibrosis","volume":"5","author":"Jumpsen","year":"2006","journal-title":"J Cystic Fibrosis"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib65","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0014-5793(97)01620-7","article-title":"Differential effects of ceramides upon adenylyl cyclase subtypes","volume":"422","author":"B\u00f6sel","year":"1998","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib66","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1096\/fj.05-5518fje","article-title":"Effects of sphingosine-1-phosphate and ceramide-1-phosphate on rat intestinal smooth muscle cells: implications for postoperative ileus","volume":"20","author":"Dragusin","year":"2006","journal-title":"FASEB J"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib67","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1042\/bj3360611","article-title":"Activation of phospholipase A2 in human neutrophils by polyunsaturated fatty acids and its role in stimulation of superoxide production","volume":"336","author":"Robinson","year":"1998","journal-title":"Biochem J"},{"key":"10.1016\/j.jnutbio.2009.01.007_bib68","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1172\/JCI13210","article-title":"Arachidonic acid as a bioactive molecule","volume":"107","author":"Brash","year":"2001","journal-title":"J Clin Invest"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286309000163?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286309000163?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T15:03:07Z","timestamp":1760626987000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286309000163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4]]},"references-count":68,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["S0955286309000163"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2009.01.007","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2010,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Docosahexaenoic acid down-regulates phenobarbital-induced cytochrome P450 2B1 gene expression in rat primary hepatocytes via the sphingomyelinase\/ceramide pathway","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2009.01.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}