{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T22:56:20Z","timestamp":1793228180226,"version":"4.5.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1016\/j.jnutbio.2009.04.010","type":"journal-article","created":{"date-parts":[[2009,7,19]],"date-time":"2009-07-19T04:18:15Z","timestamp":1247977095000},"page":"726-735","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":108,"title":["Oleuropein aglycon prevents cytotoxic amyloid aggregation of human amylin"],"prefix":"10.1016","volume":"21","author":[{"given":"Stefania","family":"Rigacci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Guidotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Bucciantini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Parri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Nediani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Cerbai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Stefani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Berti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2009.04.010_bib1","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1007\/s00109-003-0464-5","article-title":"Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution","volume":"81","author":"Stefani","year":"2003","journal-title":"J Mol Med"},{"issue":"Suppl 2","key":"10.1016\/j.jnutbio.2009.04.010_bib2","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1002\/(SICI)1096-9136(199706)14:2+<S9::AID-DIA397>3.0.CO;2-D","article-title":"Amylin: history and overview","volume":"14","author":"Ludvik","year":"1997","journal-title":"Diabet Med"},{"key":"10.1016\/j.jnutbio.2009.04.010_bib3","doi-asserted-by":"crossref","first-page":"4694","DOI":"10.1021\/bi0160462","article-title":"Islet amyloid: phase partitioning and secondary nucleation are central to the mechanism of fibrillogenesis","volume":"41","author":"Padrick","year":"2002","journal-title":"Biochemistry"},{"key":"10.1016\/j.jnutbio.2009.04.010_bib4","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/BF01660981","article-title":"Immunohistology of islet amyloid polypeptide in diabetes mellitus: semi-quantitative studies in a post-mortem series","volume":"421","author":"Rocken","year":"1992","journal-title":"Virchows Arch A Pathol Anat Histopathol"},{"key":"10.1016\/j.jnutbio.2009.04.010_bib5","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.2337\/db05-1672","article-title":"\u03b2-cell deficit due to increased apoptosis in the human Islet Amyloid Polypeptide Transgenic (HIP) rat recapitulates the metabolic defects present in Type 2 Diabetes","volume":"55","author":"Matveyenko","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.jnutbio.2009.04.010_bib6","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.biocel.2005.12.009","article-title":"Role of Islet amyloid in Type 2 diabetes mellitus","volume":"38","author":"H\u00f6ppener","year":"2006","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.jnutbio.2009.04.010_bib7","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.2337\/diabetes.52.7.1701","article-title":"Replication increases beta-cell vulnerability to human islet amyloid polypeptide-induced apoptosis","volume":"52","author":"Ritzel","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.jnutbio.2009.04.010_bib8","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1146\/annurev.biochem.75.101304.123901","article-title":"Protein misfolding, functional amyloid, and human disease","volume":"75","author":"Chiti","year":"2006","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.jnutbio.2009.04.010_bib9","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1210\/er.2007-0037","article-title":"Islet amyloid in Type 2 diabetes, and the toxic oligomer hypothesis","volume":"29","author":"Haataja","year":"2008","journal-title":"Endocrin Rev"},{"key":"10.1016\/j.jnutbio.2009.04.010_bib10","doi-asserted-by":"crossref","first-page":"31374","DOI":"10.1074\/jbc.M400348200","article-title":"Pre-fibrillar amyloid protein aggregates share common features of cytotoxicity","volume":"279","author":"Bucciantini","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2009.04.010_bib11","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1080\/1071576021000049890","article-title":"Amyloid \u03b2-peptide (1-42)-induced oxidative stress and neurotoxicity: implications for neurodegeneration in Alzheimer's disease brain. A review","volume":"36","author":"Butterfield","year":"2002","journal-title":"Free Radic Res"},{"key":"10.1016\/j.jnutbio.2009.04.010_bib12","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1002\/(SICI)1097-0010(20000515)80:7<1013::AID-JSFA571>3.0.CO;2-C","article-title":"Oleuropein and related compounds","volume":"80","author":"Soler-Rivas","year":"2000","journal-title":"J Sci Food Agric"},{"key":"10.1016\/j.jnutbio.2009.04.010_bib13","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/med.1028","article-title":"Antioxidant and other biological activities of phenols from olives and olive oil","volume":"22","author":"Visioli","year":"2002","journal-title":"Med Res Rev"},{"key":"10.1016\/j.jnutbio.2009.04.010_bib14","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0024-3205(97)01150-8","article-title":"Oleuropein, the bitter principles of olives, enhances nitric oxide production by mouse macrophages","volume":"62","author":"Visioli","year":"1998","journal-title":"Life Sci"},{"key":"10.1016\/j.jnutbio.2009.04.010_bib15","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1161\/01.ATV.0000062884.69432.A0","article-title":"Olive oil and red wine antioxidant polyphenols inhibit endothelial activation: antiatherogenic properties of mediterranean diet phytochemicals","volume":"23","author":"Carluccio","year":"2003","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jnutbio.2009.04.010_bib16","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S1470-2045(00)00015-2","article-title":"Olive oil consumption and health: the possible role of antioxidants","volume":"1","author":"Owen","year":"2000","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.jnutbio.2009.04.010_bib17","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.yjmcc.2006.11.016","article-title":"Acute doxorubicin cardiotoxicity is successfully treated with the phytochemical oleuropein through suppression of oxidative and nitrosative stress","volume":"42","author":"Andreadou","year":"2007","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.jnutbio.2009.04.010_bib18","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1093\/jn\/136.8.2213","article-title":"The olive constituent oleuropein exhibits anti-ischemic, antioxidative, and hypolipidemic effects in anesthetized rabbits","volume":"136","author":"Andreadou","year":"2006","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2009.04.010_bib19","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.jasms.2005.11.016","article-title":"Noncovalent interaction between amyloid-\u03b2-peptide (1-40) and oleuropein studied by electrospray ionization mass spectrometry","volume":"17","author":"Bazoti","year":"2006","journal-title":"J Am Soc Mass Spectrom"},{"key":"10.1016\/j.jnutbio.2009.04.010_bib20","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.jasms.2008.03.011","article-title":"Localization of the noncovalent binding site between amyloid-\u03b2-peptide and oleuropein using electrospray ionization FT-ICR mass spectrometry","volume":"19","author":"Bazoti","year":"2008","journal-title":"J Am Soc Mass Spectrom"},{"key":"10.1016\/j.jnutbio.2009.04.010_bib21","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1152\/ajpendo.00082.2006","article-title":"Inhibition of human IAPP fibril formation does not prevent \u03b2-cell death: evidence for distinct actions of oligomers and fibrils of human IAPP","volume":"291","author":"Meier","year":"2006","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.jnutbio.2009.04.010_bib22","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1073\/pnas.0507471103","article-title":"Design of a mimic of nonamyloidogenic and bioactive human islet amyloid polypeptide (IAPP) as nanomolar affinity inhibitor of IAPP cytotoxic fibrillogenesis","volume":"103","author":"Yan","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jnutbio.2009.04.010_bib23","doi-asserted-by":"crossref","first-page":"9159","DOI":"10.1073\/pnas.96.16.9159","article-title":"Enzymatic activation of oleuropein: a protein crosslinker used as chemical defence by privet tree","volume":"96","author":"Konno","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jnutbio.2009.04.010_bib24","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/416507a","article-title":"Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases","volume":"416","author":"Bucciantini","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.jnutbio.2009.04.010_bib25","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1006\/jmbi.1999.2646","article-title":"Conformational transitions of islet amyloid polypeptide (IAPP) in amyloid formation in vitro","volume":"287","author":"Kayed","year":"1999","journal-title":"J Mol Biol"},{"key":"10.1016\/j.jnutbio.2009.04.010_bib26","doi-asserted-by":"crossref","first-page":"14454","DOI":"10.1021\/bi048582a","article-title":"Inhibition of islet amyloid polypeptide fibril formation: a potential role for heteroaromatic interactions","volume":"43","author":"Porat","year":"2004","journal-title":"Biochemistry"},{"key":"10.1016\/j.jnutbio.2009.04.010_bib27","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1096\/fj.04-3086fje","article-title":"Patterns of cell death triggered in two different cell lines by HypF-N pre-fibrillar aggregates","volume":"19","author":"Bucciantini","year":"2005","journal-title":"FASEB J"},{"key":"10.1016\/j.jnutbio.2009.04.010_bib28","doi-asserted-by":"crossref","first-page":"6033","DOI":"10.1073\/pnas.0708354105","article-title":"Membrane damage by human islet amyloid polypeptide through fibril growth at the membrane","volume":"105","author":"Engel","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jnutbio.2009.04.010_bib29","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/S0076-6879(99)09020-5","article-title":"Quantification of beta-sheet amyloid fibril structures with Thioflavine T","volume":"309","author":"LeVine","year":"1999","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.jnutbio.2009.04.010_bib30","doi-asserted-by":"crossref","DOI":"10.1155\/2008\/421287","article-title":"Recent insight in Islet amyloid polypeptide-induced membrane disruption and its role in \u03b2-cell death in Type 2 diabetes mellitus","author":"Khemt\u00e9mourian","year":"2008","journal-title":"Exp Diabetes Res"},{"key":"10.1016\/j.jnutbio.2009.04.010_bib31","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/j.jmb.2006.12.007","article-title":"Early kinetics of amyloid fibril formation reveals conformational reorganisation of initial aggregates","volume":"366","author":"Cerd\u00e0-Costa","year":"2007","journal-title":"J Mol Biol"},{"key":"10.1016\/j.jnutbio.2009.04.010_bib32","doi-asserted-by":"crossref","first-page":"3635","DOI":"10.1529\/biophysj.107.122283","article-title":"The (1-63) region of the p53 transactivation domain aggregates in vitro into cytotoxic amyloid assemblies","volume":"94","author":"Rigacci","year":"2008","journal-title":"Biophys J"},{"key":"10.1016\/j.jnutbio.2009.04.010_bib33","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1747-0285.2005.00318.x","article-title":"Inhibition of amyloid fibril formation by polyphenols: structural similarity and aromatic interactions as a common inhibition mechanism","volume":"67","author":"Porat","year":"2006","journal-title":"Chem Biol Drug Des"},{"key":"10.1016\/j.jnutbio.2009.04.010_bib34","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1006\/bbrc.1998.8735","article-title":"Free radical-scavenging properties of olive oil polyphenols","volume":"247","author":"Visioli","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jnutbio.2009.04.010_bib35","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/cbic.200800762","article-title":"Inhibiting islet amyloid polypeptide fibril formation by the red wine compound resveratrol","volume":"10","author":"Mishra","year":"2009","journal-title":"Chembiochem"},{"key":"10.1016\/j.jnutbio.2009.04.010_bib36","doi-asserted-by":"crossref","first-page":"15901","DOI":"10.1021\/bi048812l","article-title":"Role of aromatic interactions in amyloid formation by peptides derived from human amylin","volume":"43","author":"Tracz","year":"2004","journal-title":"Biochemistry"},{"key":"10.1016\/j.jnutbio.2009.04.010_bib37","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1093\/jn\/132.3.409","article-title":"Olive oil phenols are adsorbed in humans","volume":"132","author":"Vissers","year":"2002","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2009.04.010_bib38","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1080\/10715760500373000","article-title":"The fate of olive oil polyphenols in the gastrointestinal tract: implications of gastric and colonic microflora-dependent biotransformation","volume":"40","author":"Corona","year":"2006","journal-title":"Free Radic Res"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286309001004?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286309001004?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T15:01:47Z","timestamp":1760626907000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286309001004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8]]},"references-count":38,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["S0955286309001004"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2009.04.010","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2010,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oleuropein aglycon prevents cytotoxic amyloid aggregation of human amylin","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2009.04.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}