{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T22:47:59Z","timestamp":1783118879633,"version":"3.54.6"},"reference-count":44,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1016\/j.jnutbio.2009.12.003","type":"journal-article","created":{"date-parts":[[2010,4,14]],"date-time":"2010-04-14T04:35:42Z","timestamp":1271219742000},"page":"95-100","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"title":["Dietary lycopene supplementation suppresses Th2 responses and lung eosinophilia in a mouse model of allergic asthma"],"prefix":"10.1016","volume":"22","author":[{"given":"Leia C.","family":"Hazlewood","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa G.","family":"Wood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip M.","family":"Hansbro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul S.","family":"Foster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2009.12.003_bb0005","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/j.jaci.2007.03.048","article-title":"Eosinophil trafficking in allergy and asthma","volume":"119","author":"Rosenberg","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jnutbio.2009.12.003_bb0010","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1111\/j.1365-2222.2008.02958.x","article-title":"Eosinophils: biological properties and role in health and disease","volume":"38","author":"Hogan","year":"2008","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jnutbio.2009.12.003_bb0015","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1067\/mai.2002.126780","article-title":"Oxidative stress in allergic respiratory diseases","volume":"110","author":"Bowler","year":"2002","journal-title":"J Allergy Clin Immunol"},{"issue":"Suppl 2","key":"10.1016\/j.jnutbio.2009.12.003_bb0020","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1136\/thorax.55.suppl_2.S51","article-title":"Oxidant stress in asthma","volume":"55","author":"Dworski","year":"2000","journal-title":"Thorax"},{"key":"10.1016\/j.jnutbio.2009.12.003_bb0025","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1006\/pupt.2001.0319","article-title":"Reactive oxygen species as mediators in asthma","volume":"14","author":"Henricks","year":"2001","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1016\/j.jnutbio.2009.12.003_bb0030","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1183\/09031936.03.00017003a","article-title":"Biomarkers of lipid peroxidation, airway inflammation and asthma","volume":"21","author":"Wood","year":"2003","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jnutbio.2009.12.003_bb0035","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1136\/thorax.2002.002477","article-title":"Oxidants and asthma","volume":"59","author":"Caramori","year":"2004","journal-title":"Thorax"},{"key":"10.1016\/j.jnutbio.2009.12.003_bb0040","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1203\/01.PDR.0000049510.15555.30","article-title":"The antioxidant milieu at asthmatic respiratory tract surfaces","volume":"53","author":"Cross","year":"2003","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jnutbio.2009.12.003_bb0045","first-page":"183","article-title":"Protective effect of lycopene in cardiovascular disease","volume":"12","author":"Riccioni","year":"2008","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10.1016\/j.jnutbio.2009.12.003_bb0050","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1080\/02770900701421880","article-title":"Plasma lycopene and antioxidant vitamins in asthma: the PLAVA study","volume":"44","author":"Riccioni","year":"2007","journal-title":"J Asthma"},{"key":"10.1016\/j.jnutbio.2009.12.003_bb0055","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1164\/ajrccm.151.5.7735592","article-title":"A prospective study of diet and adult-onset asthma","volume":"151","author":"Troisi","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jnutbio.2009.12.003_bb0060","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1080\/07315724.2005.10719490","article-title":"Airway and circulating levels of carotenoids in asthma and healthy controls","volume":"24","author":"Wood","year":"2005","journal-title":"J Am Coll Nutr"},{"key":"10.1016\/j.jnutbio.2009.12.003_bb0065","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1034\/j.1398-9995.2000.00748.x","article-title":"Reduction of exercise-induced asthma oxidative stress by lycopene, a natural antioxidant","volume":"55","author":"Neuman","year":"2000","journal-title":"Allergy"},{"key":"10.1016\/j.jnutbio.2009.12.003_bb0070","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1080\/10715760701767307","article-title":"Lycopene-rich treatments modify noneosinophilic airway inflammation in asthma: proof of concept","volume":"42","author":"Wood","year":"2008","journal-title":"Free Radic Res"},{"key":"10.1016\/j.jnutbio.2009.12.003_bb0075","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.jaci.2004.12.1139","article-title":"Diet as a risk factor for atopy and asthma","volume":"115","author":"Devereux","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jnutbio.2009.12.003_bb0080","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1164\/rccm.200405-611PP","article-title":"Diet and asthma","volume":"170","author":"McKeever","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jnutbio.2009.12.003_bb0085","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1165\/rcmb.2006-0135OC","article-title":"Airway hyperreactivity in exacerbation of chronic asthma is independent of eosinophilic inflammation","volume":"35","author":"Siegle","year":"2006","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jnutbio.2009.12.003_bb0090","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s11745-004-1261-z","article-title":"Incorporation of n-3 fatty acids into plasma and liver lipids of rats: importance of background dietary fat","volume":"39","author":"MacDonald-Wicks","year":"2004","journal-title":"Lipids"},{"key":"10.1016\/j.jnutbio.2009.12.003_bb0095","doi-asserted-by":"crossref","unstructured":"Steinke JW. Anti-interleukin-4 therapy. Immunol Allergy Clin North Am 2004;24:599-614, vi.","DOI":"10.1016\/j.iac.2004.06.008"},{"key":"10.1016\/j.jnutbio.2009.12.003_bb0100","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1126\/science.282.5397.2261","article-title":"Requirement for IL-13 independently of IL-4 in experimental asthma","volume":"282","author":"Grunig","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.jnutbio.2009.12.003_bb0105","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1126\/science.282.5397.2258","article-title":"Interleukin-13: central mediator of allergic asthma","volume":"282","author":"Wills-Karp","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.jnutbio.2009.12.003_bb0110","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.bbrc.2008.07.032","article-title":"Lycopene suppresses ovalbumin-induced airway inflammation in a murine model of asthma","volume":"374","author":"Lee","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jnutbio.2009.12.003_bb0115","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1183\/09031936.99.13102299","article-title":"Antioxidant intake and adult-onset wheeze: a case-control study. Aberdeen WHEASE Study Group","volume":"13","author":"Bodner","year":"1999","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jnutbio.2009.12.003_bb0120","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1136\/thorax.55.9.775","article-title":"Diet and childhood asthma in a society in transition: a study in urban and rural Saudi Arabia","volume":"55","author":"Hijazi","year":"2000","journal-title":"Thorax"},{"key":"10.1016\/j.jnutbio.2009.12.003_bb0125","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1164\/rccm.2112074","article-title":"Antioxidant supplementation and lung functions among children with asthma exposed to high levels of air pollutants","volume":"166","author":"Romieu","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jnutbio.2009.12.003_bb0130","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1365-2249.2004.02606.x","article-title":"Antioxidant supplementation and nasal inflammatory responses among young asthmatics exposed to high levels of ozone","volume":"138","author":"Sienra-Monge","year":"2004","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jnutbio.2009.12.003_bb0135","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1164\/rccm.200301-055OC","article-title":"Relationship of serum antioxidants to asthma prevalence in youth","volume":"169","author":"Rubin","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jnutbio.2009.12.003_bb0140","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1016\/S0140-6736(00)03132-9","article-title":"Dietary vitamin E, IgE concentrations, and atopy","volume":"356","author":"Fogarty","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.jnutbio.2009.12.003_bb0145","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1006\/clin.1994.1108","article-title":"Long-term dietary vitamin E retards development of retrovirus-induced disregulation in cytokine production","volume":"72","author":"Wang","year":"1994","journal-title":"Clin Immunol Immunopathol"},{"key":"10.1016\/j.jnutbio.2009.12.003_bb0150","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1016\/j.lfs.2004.09.037","article-title":"Inhibitory effect of vitamin E on proinflammatory cytokines- and endotoxin-induced nitric oxide release in alveolar macrophages","volume":"76","author":"Khanduja","year":"2005","journal-title":"Life Sci"},{"key":"10.1016\/j.jnutbio.2009.12.003_bb0155","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/sj.ejcn.1601187","article-title":"Low-dose supplementation with lycopene or beta-carotene does not enhance cell-mediated immunity in healthy free-living elderly humans","volume":"55","author":"Corridan","year":"2001","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.jnutbio.2009.12.003_bb0160","first-page":"19","article-title":"The effect of supplemental beta-carotene on immunologic indices in patients with AIDS: a pilot study","volume":"68","author":"Fryburg","year":"1995","journal-title":"Yale J Biol Med"},{"key":"10.1016\/j.jnutbio.2009.12.003_bb0165","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1093\/ajcn\/60.4.597","article-title":"Effect of long term administration of beta-carotene on lymphocyte subsets in humans","volume":"60","author":"Murata","year":"1994","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jnutbio.2009.12.003_bb0170","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1002\/1097-0142(19910315)67:6<1556::AID-CNCR2820670616>3.0.CO;2-O","article-title":"The effects of 13-cis-retinoic acid and beta-carotene on cellular immunity in humans","volume":"67","author":"Prabhala","year":"1991","journal-title":"Cancer"},{"key":"10.1016\/j.jnutbio.2009.12.003_bb0175","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1093\/ajcn\/66.4.917","article-title":"Short- and long-term beta-carotene supplementation do not influence T cell-mediated immunity in healthy elderly persons","volume":"66","author":"Santos","year":"1997","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jnutbio.2009.12.003_bb0180","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1093\/ajcn\/53.1.90","article-title":"Effect of beta-carotene on lymphocyte subpopulations in elderly humans: evidence for a dose response relationship","volume":"53","author":"Watson","year":"1991","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jnutbio.2009.12.003_bb0185","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1097\/00002030-199610090-00006","article-title":"Beta-carotene in HIV infection: an extended evaluation","volume":"10","author":"Coodley","year":"1996","journal-title":"Aids"},{"key":"10.1016\/j.jnutbio.2009.12.003_bb0190","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1093\/ajcn\/68.1.164","article-title":"Beta-carotene-induced enhancement of natural killer cell activity in elderly men: an investigation of the role of cytokines","volume":"68","author":"Santos","year":"1998","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jnutbio.2009.12.003_bb0195","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1093\/ajcn\/64.5.772","article-title":"Natural killer cell activity in elderly men is enhanced by beta-carotene supplementation","volume":"64","author":"Santos","year":"1996","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jnutbio.2009.12.003_bb0200","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1080\/01635589009514094","article-title":"Effects of beta-carotene repletion on beta-carotene absorption, lipid peroxidation, and neutrophil superoxide formation in young men","volume":"14","author":"Mobarhan","year":"1990","journal-title":"Nutr Cancer"},{"key":"10.1016\/j.jnutbio.2009.12.003_bb0205","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/emm.2005.42","article-title":"beta-Carotene inhibits inflammatory gene expression in lipopolysaccharide-stimulated macrophages by suppressing redox-based NF-kappaB activation","volume":"37","author":"Bai","year":"2005","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.jnutbio.2009.12.003_bb0210","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1024\/0300-9831.71.6.347","article-title":"Lycopene supplementation attenuates the inflammatory status of colitis in a rat model","volume":"71","author":"Reifen","year":"2001","journal-title":"Int J Vitam Nutr Res"},{"key":"10.1016\/j.jnutbio.2009.12.003_bb0215","first-page":"77","article-title":"Effect of lycopene on immunity in rats with acute lung injury","volume":"39","author":"Li","year":"2007","journal-title":"Beijing Da Xue Xue Bao"},{"key":"10.1016\/j.jnutbio.2009.12.003_bb0220","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1365-2567.2004.01945.x","article-title":"Lycopene suppresses the lipopolysaccharide-induced phenotypic and functional maturation of murine dendritic cells through inhibition of mitogen-activated protein kinases and nuclear factor-kappaB","volume":"113","author":"Kim","year":"2004","journal-title":"Immunology"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286310000124?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286310000124?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T15:04:15Z","timestamp":1760627055000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286310000124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["S0955286310000124"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2009.12.003","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2011,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dietary lycopene supplementation suppresses Th2 responses and lung eosinophilia in a mouse model of allergic asthma","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2009.12.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}