{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:17:33Z","timestamp":1791047853427,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2011,3]]},"DOI":"10.1016\/j.jnutbio.2010.01.010","type":"journal-article","created":{"date-parts":[[2010,6,23]],"date-time":"2010-06-23T04:34:56Z","timestamp":1277267696000},"page":"242-251","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":90,"title":["DNA methylase and demethylase activities are modulated by one-carbon metabolism in Alzheimer's disease models"],"prefix":"10.1016","volume":"22","author":[{"given":"Andrea","family":"Fuso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzina","family":"Nicolia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosaria A.","family":"Cavallaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigfrido","family":"Scarpa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2010.01.010_bb0005","first-page":"25","article-title":"Gene-environment interactions and epigenetic basis of human diseases","volume":"10","author":"Liu","year":"2008","journal-title":"Curr Issues Mol Biol"},{"key":"10.1016\/j.jnutbio.2010.01.010_bb0010","doi-asserted-by":"crossref","DOI":"10.1007\/s00018-009-0015-5","article-title":"DNA hypomethylation in the origin ad pathogenesis of human diseases","author":"Pogribny","year":"2009","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.jnutbio.2010.01.010_bb0015","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.mcn.2004.09.007","article-title":"Homocysteine\/S-adenosylmethionine cycle alterations unbalance DNA methylation status with consequent up-regulation of beta-amyloid production","volume":"28","author":"Fuso","year":"2005","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.jnutbio.2010.01.010_bb0020","first-page":"275","article-title":"\u03b3-secretase is differentially modulated by alterations of homocysteine cycle in neuroblastoma and glioblastoma cells","volume":"11","author":"Fuso","year":"2007","journal-title":"J Alz Dis"},{"key":"10.1016\/j.jnutbio.2010.01.010_bb0025","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.mcn.2007.12.018","article-title":"B-vitamin deprivation induces hyperhomocysteinemia and brain S-adenosylhomocysteine, depletes brain S-adenosylmethionine, and enhances PS1 and BACE expression and amyloid-beta deposition in mice","volume":"37","author":"Fuso","year":"2008","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.jnutbio.2010.01.010_bb0030","article-title":"Changes in Presenilin 1 gene methylation pattern in diet-induced B vitamin deficiency","author":"Fuso","year":"2009","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.jnutbio.2010.01.010_bb0035","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1086\/524110","article-title":"DNA methylation signatures within the human brain","volume":"81","author":"Ladd-Acosta","year":"2007","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jnutbio.2010.01.010_bb0040","doi-asserted-by":"crossref","first-page":"e895","DOI":"10.1371\/journal.pone.0000895","article-title":"DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons","volume":"2","author":"Siegmund","year":"2007","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jnutbio.2010.01.010_bb0045","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.1001\/jama.299.24.2877","article-title":"Intra-individual change over time in DNA methylation with familial clustering","volume":"299","author":"Bjornsson","year":"2008","journal-title":"J Am Med Ass"},{"key":"10.1016\/j.jnutbio.2010.01.010_bb0050","doi-asserted-by":"crossref","first-page":"e2698","DOI":"10.1371\/journal.pone.0002698","article-title":"Age-specific epigenetic drift in late-onset Alzheimer's disease","volume":"3","author":"Wang","year":"2008","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jnutbio.2010.01.010_bb0055","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.neurobiolaging.2007.07.020","article-title":"DNA methylation impacts on learning and memory in aging","volume":"30","author":"Liu","year":"2009","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.jnutbio.2010.01.010_bb0060","article-title":"Epigenetic changes in Alzheimer's disease: decrements in DNA methylation","author":"Mastroeni","year":"2009","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.jnutbio.2010.01.010_bb0065","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1096\/fasebj.10.4.8647346","article-title":"S-adenosylmethionine and methylation","volume":"10","author":"Chiang","year":"1996","journal-title":"FASEB J"},{"key":"10.1016\/j.jnutbio.2010.01.010_bb0070","doi-asserted-by":"crossref","first-page":"3871","DOI":"10.1046\/j.1432-1327.2001.02278.x","article-title":"Roles of homocysteine in cell metabolism: old and new function","volume":"268","author":"Medina","year":"2001","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.jnutbio.2010.01.010_bb0075","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1093\/ajcn\/80.1.114","article-title":"Homocysteine, folate, and vitamin B-12 in mild cognitive impairment, Alzheimer disease, and vascular dementia","volume":"80","author":"Quadri","year":"2004","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jnutbio.2010.01.010_bb0080","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1515\/CCLM.2004.208","article-title":"Homocysteine, vitamin B12 and folate in vascular dementia and in Alzheimer disease","volume":"42","author":"Malaguarnera","year":"2004","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.jnutbio.2010.01.010_bb0085","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.amjmed.2004.08.019","article-title":"Homocysteine versus the vitamins folate, B6, and B12 as predictors of cognitive function and decline in older high-functioning adults: MacArthur studies of successful aging","volume":"118","author":"Kado","year":"2005","journal-title":"Am J Med"},{"key":"10.1016\/j.jnutbio.2010.01.010_bb0090","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1007\/s00018-004-4201-1","article-title":"Biochemistry and biology of mammalian DNA methyltransferases","volume":"61","author":"Hermann","year":"2004","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.jnutbio.2010.01.010_bb0095","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.brainres.2008.07.074","article-title":"Diet and the epigenetic (re)programming of phenotypic differences in behavior","volume":"1237","author":"McGowan","year":"2008","journal-title":"Brain Res"},{"key":"10.1016\/j.jnutbio.2010.01.010_bb0100","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1006\/jmbi.2001.4709","article-title":"The activity of the murine DNA methyltransferase Dnmt1 is controlled by interaction of the catalytic domain with the N-terminal part of the enzyme leading to an allosteric activation of the enzyme after binding to methylated DNA","volume":"309","author":"Fatemi","year":"2001","journal-title":"J Mol Biol"},{"key":"10.1016\/j.jnutbio.2010.01.010_bb0105","doi-asserted-by":"crossref","first-page":"8211","DOI":"10.1128\/MCB.19.12.8211","article-title":"In vivo activity of murine de novo methyltransferases, Dnmt3a and Dnmt3b","volume":"19","author":"Hsieh","year":"1999","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jnutbio.2010.01.010_bb0110","doi-asserted-by":"crossref","first-page":"5237","DOI":"10.1073\/pnas.97.10.5237","article-title":"Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a","volume":"97","author":"Ramsahoye","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jnutbio.2010.01.010_bb0115","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1006\/jmbi.2001.4710","article-title":"Enzymatic properties of recombinant Dnmt3a DNA methyltransferase from mouse: the enzyme modifies DNA in a non-processive manner and also methylates non-CpG sites","volume":"309","author":"Gowher","year":"2001","journal-title":"J Mol Biol"},{"key":"10.1016\/j.jnutbio.2010.01.010_bb0120","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1093\/jb\/mvg095","article-title":"Distinct enzymatic properties of recombinant mouse DNA methyltransferases Dnmt3a and Dnmt3b","volume":"133","author":"Suetake","year":"2003","journal-title":"J Biochem"},{"key":"10.1016\/j.jnutbio.2010.01.010_bb0125","doi-asserted-by":"crossref","first-page":"5135","DOI":"10.1073\/pnas.100107597","article-title":"5-methylcytosine-DNA glycosylase activity is present in a cloned G\/T mismatch DNA glycosylase associated with the chicken embryo DNA demethylation complex","volume":"97","author":"Zhu","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jnutbio.2010.01.010_bb0130","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nature05515","article-title":"Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation","volume":"445","author":"Barreto","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.jnutbio.2010.01.010_bb0135","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.gene.2008.05.009","article-title":"DNA demethylation induced by the methyl-CpG-binding domain protein MBD3","volume":"420","author":"Brown","year":"2008","journal-title":"Gene"},{"key":"10.1016\/j.jnutbio.2010.01.010_bb0140","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nature06544","article-title":"Cyclical DNA methylation of a transcriptionally active promoter","volume":"452","author":"M\u00e9tivier","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.jnutbio.2010.01.010_bb0145","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/17533","article-title":"A mammalian protein with specific demethylase activity for mCpG DNA","volume":"397","author":"Bhattacharya","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.jnutbio.2010.01.010_bb0150","doi-asserted-by":"crossref","first-page":"8363","DOI":"10.1074\/jbc.274.13.8363","article-title":"DNA demethylase is a processive enzyme","volume":"274","author":"Cervoni","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2010.01.010_bb0155","doi-asserted-by":"crossref","first-page":"20812","DOI":"10.1074\/jbc.M211813200","article-title":"The methyl donor S-adenosylmethionine inhibits active demethylation of DNA: a candidate novel mechanism for the pharmacological effects of S-adenosylmethionine","volume":"278","author":"Detich","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2010.01.010_bb0160","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nature06640","article-title":"Transient cyclical methylation of promoter DNA","volume":"452","author":"Kangaspeska","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.jnutbio.2010.01.010_bb0165","doi-asserted-by":"crossref","first-page":"15763","DOI":"10.1074\/jbc.M511767200","article-title":"Evidence that DNA (cytosine-5) methyltransferase regulates synaptic plasticity in the hippocampus","volume":"281","author":"Levenson","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2010.01.010_bb0170","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1038\/nn.2436","article-title":"Dynamic DNA methylation programs persistent adverse effects of early-life stress","volume":"12","author":"Murgatroyd","year":"2009","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.jnutbio.2010.01.010_bb0175","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1146\/annurev-pharmtox-061008-103102","article-title":"Epigenetics, DNA methylation, and chromatin modifying drugs","volume":"49","author":"Szyf","year":"2009","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.jnutbio.2010.01.010_bb0180","first-page":"1259","article-title":"Expression analysis of estrogen receptor alpha coregulators in breast carcinoma: evidence that NCOR1 expression is predictive of the response to tamoxifen","volume":"9","author":"Girault","year":"2003","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jnutbio.2010.01.010_bb0185","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1006\/bbrc.1999.1613","article-title":"Reduced mRNA expression of the DNA demethylase, MBD2, in human colorectal and stomach cancers","volume":"264","author":"Kanai","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jnutbio.2010.01.010_bb0190","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.ydbio.2003.12.031","article-title":"Windows for sex-specific methylation marked by DNA methyltransferase expression profiles in mouse germ cells","volume":"268","author":"La Salle","year":"2004","journal-title":"Dev Biol"},{"key":"10.1016\/j.jnutbio.2010.01.010_bb0195","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.gene.2005.02.015","article-title":"The expression of de novo DNA methylase DNMT3b, of the methyl-CpG binding protein MBD2 and of 5-MCDG glycosylase shows two waves of induction during CaCO-2 cell differentiation","volume":"351","author":"Di Giaimo","year":"2005","journal-title":"Gene"},{"key":"10.1016\/j.jnutbio.2010.01.010_bb0200","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/mc.10033","article-title":"DNA methyltransferase and demethylase in human prostate cancer","volume":"33","author":"Patra","year":"2002","journal-title":"Mol Carcinog"},{"key":"10.1016\/j.jnutbio.2010.01.010_bb0205","first-page":"155","article-title":"Measuring DNA demethylase activity in vitro","volume":"200","author":"Szyf","year":"2002","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.jnutbio.2010.01.010_bb0210","doi-asserted-by":"crossref","first-page":"3648","DOI":"10.1182\/blood-2007-06-096701","article-title":"Homocysteine inhibits endothelial cell growth via DNA hypomethylation of the cyclin A gene","volume":"110","author":"Jamaluddin","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.jnutbio.2010.01.010_bb0215","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1093\/jn\/136.6.1522","article-title":"A folate- and methyl-deficient diet alters the expression of DNA methyltransferases and methyl CpG binding proteins involved in epigenetic gene silencing in livers of F344 rats","volume":"136","author":"Ghoshal","year":"2006","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2010.01.010_bb0220","doi-asserted-by":"crossref","first-page":"4452","DOI":"10.1093\/nar\/29.21.4452","article-title":"5-methylcytosine DNA glycosylase participates in the genome-wide loss of DNA methylation occurring during mouse myoblast differentiation","volume":"29","author":"Jost","year":"2001","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jnutbio.2010.01.010_bb0225","doi-asserted-by":"crossref","first-page":"e1000013","DOI":"10.1371\/journal.pgen.1000013","article-title":"GADD45A does not promote DNA demethylation","volume":"4","author":"Jin","year":"2008","journal-title":"Plos Genet"},{"key":"10.1016\/j.jnutbio.2010.01.010_bb0230","doi-asserted-by":"crossref","first-page":"98","DOI":"10.4161\/epi.4.2.7858","article-title":"Conserved DNA methylation in Gadd45a(\u2212\/\u2212) mice","volume":"4","author":"Engel","year":"2009","journal-title":"Epigenetics"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286310000598?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286310000598?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T15:04:19Z","timestamp":1760627059000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286310000598"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3]]},"references-count":46,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["S0955286310000598"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2010.01.010","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2011,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DNA methylase and demethylase activities are modulated by one-carbon metabolism in Alzheimer's disease models","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2010.01.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}