{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:19:52Z","timestamp":1791587992143,"version":"4.3.4"},"reference-count":31,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1016\/j.jnutbio.2010.10.003","type":"journal-article","created":{"date-parts":[[2011,2,19]],"date-time":"2011-02-19T04:57:16Z","timestamp":1298091436000},"page":"1172-1177","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":101,"title":["Tissue-specific distribution of aberrant DNA methylation associated with maternal low-folate status in human neural tube defects"],"prefix":"10.1016","volume":"22","author":[{"given":"Huibo","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengbo","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihua","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2010.10.003_bb0005","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/bdra.20248","article-title":"Extremely high prevalence of neural tube defects in a 4-county area in Shanxi Province, China","volume":"76","author":"Li","year":"2006","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"10.1016\/j.jnutbio.2010.10.003_bb0010","first-page":"CD001056","article-title":"Periconceptional supplementation with folate and\/or multivitamins for preventing neural tube defects","volume":"3","author":"Lumley","year":"2001","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jnutbio.2010.10.003_bb0015","doi-asserted-by":"crossref","first-page":"632","DOI":"10.7326\/0003-4819-150-9-200905050-00010","article-title":"Folic acid supplementation for the prevention of neural tube defects: an update of the evidence for the U.S. Preventive Services Task Force","volume":"150","author":"Wolff","year":"2009","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jnutbio.2010.10.003_bb0020","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/bdra.20581","article-title":"Folic acid, methylation and neural tube closure in humans","volume":"85","author":"Blom","year":"2009","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"10.1016\/j.jnutbio.2010.10.003_bb0025","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/nrn1986","article-title":"Neural tube defects and folate: case far from closed","volume":"7","author":"Blom","year":"2006","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.jnutbio.2010.10.003_bb0030","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.jnutbio.2008.01.010","article-title":"Effect of folate deficiency on placental DNA methylation in hyperhomocysteinemic rats","volume":"20","author":"Kim","year":"2009","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jnutbio.2010.10.003_bb0035","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1093\/ajcn\/72.4.998","article-title":"methylation decreases in response to moderate folate depletion in elderly women","volume":"72","author":"Rampersaud","year":"2000","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jnutbio.2010.10.003_bb0040","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1002\/bdra.20286","article-title":"Integrity of the methylation cycle is essential for mammalian neural tube closure","volume":"76","author":"Dunlevy","year":"2006","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"10.1016\/j.jnutbio.2010.10.003_bb0045","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1093\/jn\/131.10.2653","article-title":"Dietary methionine is involved in the etiology of neural tube defect-affected pregnancies in humans","volume":"131","author":"Shoob","year":"2001","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2010.10.003_bb0050","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/BF00211820","article-title":"Inhibition of cephalic neural tube closure by 5-azacytidine in neurulating rat embryos in vitro","volume":"185","author":"Matsuda","year":"1992","journal-title":"Anat Embryol (Berl)"},{"key":"10.1016\/j.jnutbio.2010.10.003_bb0055","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1101\/gad.947102","article-title":"DNA methylation patterns and epigenetic memory","volume":"16","author":"Bird","year":"2002","journal-title":"Genes Dev"},{"key":"10.1016\/j.jnutbio.2010.10.003_bb0060","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.jnutbio.2009.06.008","article-title":"DNA methylation, an epigenetic mechanism connecting folate to healthy embryonic development and aging","volume":"20","author":"Kim","year":"2009","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jnutbio.2010.10.003_bb0065","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1093\/nar\/10.8.2709","article-title":"Amount and distribution of 5-methylcytosine in human DNA from different types of tissues of cells","volume":"10","author":"Ehrlich","year":"1982","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jnutbio.2010.10.003_bb0070","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.bbrc.2008.09.044","article-title":"Quantitative analysis of human tissue-specific differences in methylation","volume":"376","author":"Igarashi","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jnutbio.2010.10.003_bb0075","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1146\/annurev.biochem.74.010904.153721","article-title":"Eukaryotic cytosine methyltransferases","volume":"74","author":"Goll","year":"2005","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.jnutbio.2010.10.003_bb0080","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/0092-8674(92)90611-F","article-title":"Targeted mutation of the DNA methyltransferase gene results in embryonic lethality","volume":"69","author":"Li","year":"1992","journal-title":"Cell"},{"key":"10.1016\/j.jnutbio.2010.10.003_bb0085","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1159\/000015590","article-title":"DNA hypomethylation and unusual chromosome instability in cell lines from ICF syndrome patients","volume":"89","author":"Tuck-Muller","year":"2000","journal-title":"Cytogenet Cell Genet"},{"key":"10.1016\/j.jnutbio.2010.10.003_bb0090","first-page":"741","article-title":"Imprinting mutations suggested by abnormal DNA methylation patterns in familial Angelman and Prader-Willi syndromes","volume":"54","author":"Reis","year":"1994","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jnutbio.2010.10.003_bb0095","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.devbrainres.2005.06.002","article-title":"Inhibition of transmethylation disturbs neurulation in chick embryos","volume":"158","author":"Afman","year":"2005","journal-title":"Brain Res Dev Brain Res"},{"key":"10.1016\/j.jnutbio.2010.10.003_bb0100","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1002\/bdra.20397","article-title":"etal. High prevalence of NTD in Shanxi Province: a combined epidemiological approach","volume":"79","author":"Gu","year":"2007","journal-title":"Birth Defects Res A: Clin Mol Teratol"},{"key":"10.1016\/j.jnutbio.2010.10.003_bb0105","first-page":"1","article-title":"DNA methylation protocols. Overview","volume":"200","author":"Mills","year":"2002","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.jnutbio.2010.10.003_bb0110","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1093\/ajcn\/72.3.751","article-title":"Assessment of vitamin B-12, folate, and vitamin B-6 status and relation to sulfur amino acid metabolism in neonates","volume":"72","author":"Minet","year":"2000","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jnutbio.2010.10.003_bb0115","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/0005-2787(73)90264-5","article-title":"The content of 5-methylcytosine in animal DNA: the species and tissue specificity","volume":"299","author":"Vanyushin","year":"1973","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jnutbio.2010.10.003_bb0120","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1093\/carcin\/bgi037","article-title":"Cell and stage of transformation-specific effects of folate deficiency on methionine cycle intermediates and DNA methylation in an in vitro model","volume":"26","author":"Stempak","year":"2005","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.jnutbio.2010.10.003_bb0125","doi-asserted-by":"crossref","first-page":"2413S","DOI":"10.1093\/jn\/132.8.2413S","article-title":"Folate status: effects on pathways of colorectal carcinogenesis","volume":"132","author":"Choi","year":"2002","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2010.10.003_bb0130","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1074\/jbc.275.3.1952","article-title":"Control of organ-specific demethylation by an element of the T-cell receptor-alpha locus control region","volume":"275","author":"Santoso","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2010.10.003_bb0135","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0092-8674(00)81656-6","article-title":"DNA methyltransferase Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development","volume":"99","author":"Okano","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.jnutbio.2010.10.003_bb0140","first-page":"255","article-title":"et al. Pathological analysis of neural tube defects among 70 perinatal autopsies","volume":"19","author":"Zou","year":"2006","journal-title":"Chin J Perinat Med"},{"key":"10.1016\/j.jnutbio.2010.10.003_bb0145","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1006\/abbi.1997.0246","article-title":"Betaine-homocysteine methyltransferase expression in porcine and human tissues and chromosomal localization of the human gene","volume":"345","author":"Sunden","year":"1997","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.jnutbio.2010.10.003_bb0150","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1093\/ajcn\/61.5.1083","article-title":"etal. Moderate folate deficiency does not cause global hypomethylation of hepatic and colonic DNA or c-myc\u2013specific hypomethylation of colonic","volume":"61","author":"Kim","year":"1995","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jnutbio.2010.10.003_bb0155","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S1567-133X(03)00121-2","article-title":"Analysis of DNA (cytosine 5) methyltransferase mRNA sequence and expression in bovine preimplantation embryos, fetal and adult tissues","volume":"3","author":"Golding","year":"2003","journal-title":"Gene Expr Patterns"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286310002561?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286310002561?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T15:05:10Z","timestamp":1760627110000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286310002561"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":31,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["S0955286310002561"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2010.10.003","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2011,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tissue-specific distribution of aberrant DNA methylation associated with maternal low-folate status in human neural tube defects","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2010.10.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}