{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:57:34Z","timestamp":1773277054613,"version":"3.50.1"},"reference-count":54,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1016\/j.jnutbio.2010.11.009","type":"journal-article","created":{"date-parts":[[2011,3,24]],"date-time":"2011-03-24T20:56:43Z","timestamp":1301000203000},"page":"1099-1104","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Novel molecular targets for prevention of obesity and osteoporosis"],"prefix":"10.1016","volume":"22","author":[{"given":"Srujana","family":"Rayalam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong-Yeh","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Anne","family":"Della-Fera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clifton A.","family":"Baile","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2010.11.009_bb0005","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1749-6632.2001.tb03593.x","article-title":"Characterization of multipotent adult progenitor cells, a subpopulation of mesenchymal stem cells","volume":"938","author":"Reyes","year":"2001","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jnutbio.2010.11.009_bb0010","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.numecd.2008.03.008","article-title":"Sibutramine: balancing weight loss benefit and possible cardiovascular risk","volume":"18","author":"de Simone","year":"2008","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"10.1016\/j.jnutbio.2010.11.009_bb0015","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1517\/13543780902953715","article-title":"Ospemifene use in postmenopausal women","volume":"18","author":"Gennari","year":"2009","journal-title":"Expert Opin Investig Drugs"},{"key":"10.1016\/j.jnutbio.2010.11.009_bb0020","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1021\/np030096l","article-title":"Natural products as sources of new drugs over the period 1981\u20132002","volume":"66","author":"Newman","year":"2003","journal-title":"J Nat Prod"},{"key":"10.1016\/j.jnutbio.2010.11.009_bb0025","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/oby.2007.90","article-title":"Enhanced effects of 1,25(OH)(2)D(3) plus genistein on adipogenesis and apoptosis in 3T3-L1 adipocytes","volume":"16","author":"Rayalam","year":"2008","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.jnutbio.2010.11.009_bb0030","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.bbrc.2007.10.051","article-title":"Enhanced effects of guggulsterone plus 1,25(OH)2D3 on 3T3-L1 adipocytes","volume":"364","author":"Rayalam","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jnutbio.2010.11.009_bb0035","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1089\/jmf.2008.0158","article-title":"Anti-obesity effects of xanthohumol plus guggulsterone in 3T3-L1 adipocytes","volume":"12","author":"Rayalam","year":"2009","journal-title":"J Med Food"},{"key":"10.1016\/j.jnutbio.2010.11.009_bb0040","doi-asserted-by":"crossref","first-page":"11205","DOI":"10.1074\/jbc.M510343200","article-title":"Complex role of the vitamin D receptor and its ligand in adipogenesis in 3T3-L1 cells","volume":"281","author":"Blumberg","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2010.11.009_bb0045","doi-asserted-by":"crossref","first-page":"E820","DOI":"10.1152\/ajpendo.90763.2008","article-title":"Involvement of the vitamin D receptor in energy metabolism: regulation of uncoupling proteins","volume":"296","author":"Wong","year":"2009","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.jnutbio.2010.11.009_bb0050","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/j.1432-1033.1994.00335.x","article-title":"Further oxidation of hydroxycalcidiol by calcidiol 24-hydroxylase. A study with the mature enzyme expressed in Escherichia coli","volume":"224","author":"Akiyoshi-Shibata","year":"1994","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.jnutbio.2010.11.009_bb0055","first-page":"2597","article-title":"Genistein and 17beta-estradiol, but not equol, regulate vitamin D synthesis in human colon and breast cancer cells","volume":"26","author":"Lechner","year":"2006","journal-title":"Anticancer Res"},{"key":"10.1016\/j.jnutbio.2010.11.009_bb0060","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1016\/S0024-3205(00)80006-5","article-title":"Effect of 1,25(OH)2D3 on expression of estrogen receptor-alpha mRNA on rat osteosarcoma cell line (ROS 17\/2.8)","volume":"66","author":"Ohsawa","year":"2000","journal-title":"Life Sci"},{"key":"10.1016\/j.jnutbio.2010.11.009_bb0065","doi-asserted-by":"crossref","first-page":"4252","DOI":"10.1210\/endo.139.10.6216","article-title":"Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta","volume":"139","author":"Kuiper","year":"1998","journal-title":"Endocrinology"},{"key":"10.1016\/j.jnutbio.2010.11.009_bb0070","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0300-2977(95)00008-B","article-title":"Endocrine aspects of obesity","volume":"47","author":"Drent","year":"1995","journal-title":"The Netherlands journal of medicine"},{"key":"10.1016\/j.jnutbio.2010.11.009_bb0075","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1210\/endo-125-4-1870","article-title":"Modulation by vitamin D status of the responsiveness of rat bone to gonadal steroids","volume":"125","author":"Somjen","year":"1989","journal-title":"Endocrinology"},{"key":"10.1016\/j.jnutbio.2010.11.009_bb0080","article-title":"The common role of vitamin D in osteoporosis and metabolic syndrome","author":"Larijani","year":"2008"},{"key":"10.1016\/j.jnutbio.2010.11.009_bb0085","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s00774-005-0639-y","article-title":"Randomized trial comparing low-dose hormone replacement therapy and HRT plus 1alpha-OH-vitamin D3 (alfacalcidol) for treatment of postmenopausal bone loss","volume":"24","author":"Mizunuma","year":"2006","journal-title":"J Bone Miner Metab"},{"key":"10.1016\/j.jnutbio.2010.11.009_bb0090","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1097\/00029330-200608010-00008","article-title":"Is 1, 25-dihydroxyvitamin D3 an ideal substitute for dexamethasone for inducing osteogenic differentiation of human adipose tissue-derived stromal cells in vitro?","volume":"119","author":"Zhou","year":"2006","journal-title":"Chinese medical journal"},{"key":"10.1016\/j.jnutbio.2010.11.009_bb0095","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S1097-2765(00)00050-2","article-title":"Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors","volume":"6","author":"Lu","year":"2000","journal-title":"Mol Cell"},{"key":"10.1016\/j.jnutbio.2010.11.009_bb0100","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1126\/science.284.5418.1362","article-title":"Identification of a nuclear receptor for bile acids","volume":"284","author":"Makishima","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.jnutbio.2010.11.009_bb0105","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1172\/JCI21025","article-title":"Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c","volume":"113","author":"Watanabe","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jnutbio.2010.11.009_bb0110","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1172\/JCI25604","article-title":"Farnesoid X receptor is essential for normal glucose homeostasis","volume":"116","author":"Ma","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jnutbio.2010.11.009_bb0115","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1194\/jlr.M001602","article-title":"FXR activation reverses insulin resistance and lipid abnormalities and protects against liver steatosis in Zucker (fa\/fa) obese rats","volume":"51","author":"Cipriani","year":"2010","journal-title":"J Lipid Res"},{"key":"10.1016\/j.jnutbio.2010.11.009_bb0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000149779","article-title":"Farnesoid X receptor induces GLUT4 expression through FXR response element in the GLUT4 promoter","volume":"22","author":"Shen","year":"2008","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.jnutbio.2010.11.009_bb0125","doi-asserted-by":"crossref","first-page":"10214","DOI":"10.1074\/jbc.M209323200","article-title":"Guggulsterone is a farnesoid X receptor antagonist in coactivator association assays but acts to enhance transcription of bile salt export pump","volume":"278","author":"Cui","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2010.11.009_bb0130","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1254\/jphs.08006FP","article-title":"The novel compounds that activate farnesoid X receptor: the diversity of their effects on gene expression","volume":"107","author":"Suzuki","year":"2008","journal-title":"J Pharmacol Sci"},{"key":"10.1016\/j.jnutbio.2010.11.009_bb0135","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1677\/joe.1.06105","article-title":"1,25-Dihydroxyvitamin D3 and its receptor inhibit the chenodeoxycholic acid-dependent transactivation by farnesoid X receptor","volume":"188","author":"Honjo","year":"2006","journal-title":"J Endocrinol"},{"key":"10.1016\/j.jnutbio.2010.11.009_bb0140","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1152\/physrev.00010.2008","article-title":"Role of bile acids and bile acid receptors in metabolic regulation","volume":"89","author":"Lefebvre","year":"2009","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jnutbio.2010.11.009_bb0145","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1089\/thy.2007.0255","article-title":"Bile acids and the membrane bile acid receptor TGR5 \u2014 connecting nutrition and metabolism","volume":"18","author":"Thomas","year":"2008","journal-title":"Thyroid"},{"key":"10.1016\/j.jnutbio.2010.11.009_bb0150","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/nature04330","article-title":"Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation","volume":"439","author":"Watanabe","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.jnutbio.2010.11.009_bb0155","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.bbrc.2007.06.130","article-title":"Anti-hyperglycemic activity of a TGR5 agonist isolated from Olea europaea","volume":"362","author":"Sato","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jnutbio.2010.11.009_bb0160","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1124\/pr.57.2.5","article-title":"International Union of Pharmacology. XLVI. G protein-coupled receptor list","volume":"57","author":"Foord","year":"2005","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.jnutbio.2010.11.009_bb0165","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.drudis.2009.02.005","article-title":"TGR5: an emerging bile acid G-protein-coupled receptor target for the potential treatment of metabolic disorders","volume":"14","author":"Tiwari","year":"2009","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.jnutbio.2010.11.009_bb0170","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1210\/en.2004-1043","article-title":"Type 2 iodothyronine selenodeiodinase is expressed throughout the mouse skeleton and in the MC3T3-E1 mouse osteoblastic cell line during differentiation","volume":"146","author":"Gouveia","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.jnutbio.2010.11.009_bb0175","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.1210\/me.2005-0224","article-title":"Contrasting skeletal phenotypes in mice with an identical mutation targeted to thyroid hormone receptor alpha1 or beta","volume":"19","author":"O'Shea","year":"2005","journal-title":"Mol Endocrinol (Baltimore, Md)"},{"key":"10.1016\/j.jnutbio.2010.11.009_bb0180","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1055\/s-2007-969626","article-title":"Thyroid stimulating action of Z-guggulsterone obtained from Commiphora mukul","volume":"50","author":"Tripathi","year":"1984","journal-title":"Planta Med"},{"key":"10.1016\/j.jnutbio.2010.11.009_bb0185","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1002\/mnfr.200500053","article-title":"Xanthohumol stimulates iodide uptake in rat thyroid-derived FRTL-5 cells","volume":"49","author":"Radovic","year":"2005","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.jnutbio.2010.11.009_bb0190","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1006\/bbrc.2002.6561","article-title":"A novel interaction between thyroid hormones and 1,25(OH)(2)D(3) in osteoclast formation","volume":"291","author":"Miura","year":"2002","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jnutbio.2010.11.009_bb0195","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1146\/annurev.nutr.23.011702.073102","article-title":"GUGULIPID: a natural cholesterol-lowering agent","volume":"23","author":"Urizar","year":"2003","journal-title":"Annu Rev Nutr"},{"key":"10.1016\/j.jnutbio.2010.11.009_bb0200","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1146\/annurev.pharmtox.40.1.519","article-title":"The PAS superfamily: sensors of environmental and developmental signals","volume":"40","author":"Gu","year":"2000","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.jnutbio.2010.11.009_bb0205","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1146\/annurev.cellbio.12.1.55","article-title":"Ah receptor signaling pathways","volume":"12","author":"Schmidt","year":"1996","journal-title":"Annu Rev Cell Dev Biol"},{"key":"10.1016\/j.jnutbio.2010.11.009_bb0210","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1046\/j.1365-2443.1997.1490345.x","article-title":"Loss of teratogenic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking the Ah (dioxin) receptor","volume":"2","author":"Mimura","year":"1997","journal-title":"Genes Cells"},{"key":"10.1016\/j.jnutbio.2010.11.009_bb0215","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1289\/ehp.6322","article-title":"Flavonoids as aryl hydrocarbon receptor agonists\/antagonists: effects of structure and cell context","volume":"111","author":"Zhang","year":"2003","journal-title":"Environ Health Perspect"},{"issue":"Pt 22","key":"10.1016\/j.jnutbio.2010.11.009_bb0220","doi-asserted-by":"crossref","first-page":"3311","DOI":"10.1242\/jcs.111.22.3311","article-title":"Aryl-hydrocarbon receptor is an inhibitory regulator of lipid synthesis and of commitment to adipogenesis","volume":"111","author":"Alexander","year":"1998","journal-title":"J Cell Sci"},{"key":"10.1016\/j.jnutbio.2010.11.009_bb0225","doi-asserted-by":"crossref","first-page":"3575","DOI":"10.1210\/en.2002-220003","article-title":"3-Methylcholanthrene, which binds to the arylhydrocarbon receptor, inhibits proliferation and differentiation of osteoblasts in vitro and ossification in vivo","volume":"143","author":"Naruse","year":"2002","journal-title":"Endocrinology"},{"key":"10.1016\/j.jnutbio.2010.11.009_bb0230","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.bcp.2006.01.007","article-title":"Regulating the regulator: factors that control levels and activity of the aryl hydrocarbon receptor","volume":"72","author":"Harper","year":"2006","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.jnutbio.2010.11.009_bb0235","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/nature01606","article-title":"Modulation of oestrogen receptor signalling by association with the activated dioxin receptor","volume":"423","author":"Ohtake","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.jnutbio.2010.11.009_bb0240","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1677\/joe.0.1670183","article-title":"Inhibition of dioxin effects on bone formation in vitro by a newly described aryl hydrocarbon receptor antagonist, resveratrol","volume":"167","author":"Singh","year":"2000","journal-title":"J Endocrinol"},{"key":"10.1016\/j.jnutbio.2010.11.009_bb0245","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/S0959-440X(00)00147-0","article-title":"The rotary mechanism of ATP synthase","volume":"10","author":"Stock","year":"2000","journal-title":"Curr Opin Struct Biol"},{"key":"10.1016\/j.jnutbio.2010.11.009_bb0250","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/emm.2004.60","article-title":"Extracellular ATP is generated by ATP synthase complex in adipocyte lipid rafts","volume":"36","author":"Kim","year":"2004","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.jnutbio.2010.11.009_bb0255","first-page":"931","article-title":"Possible role of cell surface H+-ATP synthase in the extracellular ATP synthesis and proliferation of human umbilical vein endothelial cells","volume":"1","author":"Arakaki","year":"2003","journal-title":"Mol Cancer Res"},{"key":"10.1016\/j.jnutbio.2010.11.009_bb0260","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1038\/sj.bjp.0703397","article-title":"Inhibition of mitochondrial proton F0F1-ATPase\/ATP synthase by polyphenolic phytochemicals","volume":"130","author":"Zheng","year":"2000","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jnutbio.2010.11.009_bb0265","doi-asserted-by":"crossref","first-page":"3405","DOI":"10.1016\/j.febslet.2007.06.041","article-title":"Cell-surface H+-ATP synthase as a potential molecular target for anti-obesity drugs","volume":"581","author":"Arakaki","year":"2007","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jnutbio.2010.11.009_bb0270","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1002\/ptr.2503","article-title":"Resveratrol induces apoptosis and inhibits adipogenesis in 3T3-L1 adipocytes","volume":"22","author":"Rayalam","year":"2008","journal-title":"Phytother Res"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286311000064?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286311000064?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T15:04:28Z","timestamp":1760627068000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286311000064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":54,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["S0955286311000064"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2010.11.009","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2011,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel molecular targets for prevention of obesity and osteoporosis","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2010.11.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}