{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T16:55:48Z","timestamp":1771260948132,"version":"3.50.1"},"reference-count":61,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1016\/j.jnutbio.2012.07.002","type":"journal-article","created":{"date-parts":[[2012,9,13]],"date-time":"2012-09-13T16:20:02Z","timestamp":1347553202000},"page":"343-352","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Plant stanols induce intestinal tumor formation by up-regulating Wnt and EGFR signaling in ApcMin mice"],"prefix":"10.1016","volume":"24","author":[{"given":"Maija","family":"Marttinen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Essi","family":"P\u00e4iv\u00e4rinta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Storvik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Huikko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heli","family":"Luoma-Halkola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vieno","family":"Piironen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Maria","family":"Pajari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marja","family":"Mutanen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2012.07.002_bb0005","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1080\/01635589209514203","article-title":"The role of dietary phytosterols in colon carcinogenesis","volume":"18","author":"Rao","year":"1992","journal-title":"Nutr Cancer"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0010","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1080\/01635589209514178","article-title":"Dietary cholesterol enhances preneoplastic aberrant crypt formation and alters cell proliferation in the murine colon treated with azoxymethane","volume":"17","author":"Kendall","year":"1992","journal-title":"Nutr Cancer"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0015","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0304-3835(92)90268-Z","article-title":"Dietary cholesterol enhances the induction and development of colonic preneoplastic lesions in C57BL\/6J and BALB\/cJ mice treated with azoxymethane","volume":"63","author":"Rao","year":"1992","journal-title":"Cancer Lett"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0020","first-page":"403","article-title":"Protective effect of plant sterols against chemically induced colon tumors in rats","volume":"40","author":"Raicht","year":"1980","journal-title":"Cancer Res"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0025","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/BF00410305","article-title":"The kinetics of the protective effect of beta-sitosterol against MNU-induced colonic neoplasia","volume":"103","author":"Deschner","year":"1982","journal-title":"J Cancer Res Clin Oncol"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0030","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/0278-6915(92)90195-Q","article-title":"Dose-dependent effects of dietary phytosterol on epithelial cell proliferation of the murine colon","volume":"30","author":"Janezic","year":"1992","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0035","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1097\/00008469-200106000-00006","article-title":"Phytosterols have an unfavourable effect on bacterial activity and no evident protective effect on colon carcinogenesis","volume":"10","author":"Quilliot","year":"2001","journal-title":"Eur J Cancer Prev"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0040","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1038\/sj.bjc.6690476","article-title":"Correlation of neomycin, faecal neutral and acid sterols with colon carcinogenesis in rats","volume":"80","author":"Panda","year":"1999","journal-title":"Br J Cancer"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0045","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1002\/1097-0142(19870901)60:5<994::AID-CNCR2820600513>3.0.CO;2-R","article-title":"Relationship between fecal neutral steroid concentrations and malignancy in colon cells","volume":"60","author":"Peuchant","year":"1987","journal-title":"Cancer"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0050","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1093\/ajcn\/74.1.141","article-title":"Plant sterol intakes and colorectal cancer risk in the Netherlands Cohort Study on Diet and Cancer","volume":"74","author":"Norm\u00e9n","year":"2001","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0055","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/359235a0","article-title":"APC mutations occur early during colorectal tumorigenesis","volume":"359","author":"Powell","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0060","doi-asserted-by":"crossref","first-page":"15095","DOI":"10.1073\/pnas.222118199","article-title":"Multistage carcinogenesis and the incidence of colorectal cancer","volume":"99","author":"Luebeck","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0065","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1126\/science.1350108","article-title":"Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene","volume":"256","author":"Su","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0070","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1146\/annurev.cellbio.20.012103.094541","article-title":"The adenomatous polyposis coli protein: the Achilles heel of the gut epithelium","volume":"20","author":"N\u00e4thke","year":"2004","journal-title":"Annu Rev Cell Dev Biol"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0075","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1126\/science.281.5382.1509","article-title":"Identification of c-MYC as a target of the APC pathway","volume":"281","author":"He","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0080","doi-asserted-by":"crossref","first-page":"5522","DOI":"10.1073\/pnas.96.10.5522","article-title":"The cyclin D1 gene is a target of the beta-catenin\/LEF-1 pathway","volume":"96","author":"Shtutman","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0085","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0092-8674(02)01014-0","article-title":"The beta-catenin\/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells","volume":"111","author":"van de Wetering","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0090","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0092-8674(00)00122-7","article-title":"Linking colorectal cancer to Wnt signaling","volume":"103","author":"Bienz","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0095","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1677\/erc.0.0080011","article-title":"The epidermal growth factor receptor family as a central element for cellular signal transduction and diversification","volume":"8","author":"Prenzel","year":"2001","journal-title":"Endocr Relat Cancer"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0100","first-page":"932932","article-title":"EGFR signaling in colorectal carcinoma","author":"Krasinskas","year":"2011","journal-title":"Patholog Res Int"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0105","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1002\/jcb.22505","article-title":"Compartmentalization of EGFR in cellular membranes: role of membrane rafts","volume":"109","author":"Balbis","year":"2010","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0110","first-page":"182","article-title":"Dissecting lipid raft facilitated cell signaling pathways in cancer","volume":"1785","author":"Patra","year":"2008","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0115","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.bbamcr.2005.05.005","article-title":"Growth factor receptors, lipid rafts and caveolae: an evolving story","volume":"1746","author":"Pike","year":"2005","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0120","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.phymed.2007.01.003","article-title":"beta-Sitosterol activates Fas signaling in human breast cancer cells","volume":"14","author":"Awad","year":"2007","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0125","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1093\/jn\/130.5.1166","article-title":"Vegetable oils high in phytosterols make erythrocytes less deformable and shorten the life span of stroke-prone spontaneously hypertensive rats","volume":"130","author":"Ratnayake","year":"2000","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0130","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0009-3084(99)00067-5","article-title":"Optimisation of plant sterols incorporation in human keratinocyte plasma membrane and modulation of membrane fluidity","volume":"101","author":"Mora","year":"1999","journal-title":"Chem Phys Lipids"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0135","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/0092-8674(93)90484-8","article-title":"Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse","volume":"75","author":"Dietrich","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0140","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1007\/s00217-005-0031-0","article-title":"Oxidative stability of phytosterols in some food applications","volume":"222","author":"Soupas","year":"2005","journal-title":"Eur Food Res Technol"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0145","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.jnutbio.2005.01.013","article-title":"Promotion of adenoma growth by dietary insulin is associated with increase in cyclin D1 and decrease in adhesion proteins in Min\/+ mice mucosa","volume":"16","author":"Misikangas","year":"2005","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0150","doi-asserted-by":"crossref","first-page":"11221","DOI":"10.1074\/jbc.M611871200","article-title":"Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity","volume":"282","author":"Fang","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0155","doi-asserted-by":"crossref","first-page":"20997","DOI":"10.1074\/jbc.271.35.20997","article-title":"The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1","volume":"271","author":"Galisteo","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0160","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0092-8674(00)80213-5","article-title":"The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor","volume":"89","author":"Brown","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0165","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0092-8674(00)81333-1","article-title":"Lessons from hereditary colorectal cancer","volume":"87","author":"Kinzler","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0170","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1158\/0008-5472.CAN-05-3343","article-title":"Epidermal growth factor receptor signaling is required for microadenoma formation in the mouse azoxymethane model of colonic carcinogenesis","volume":"67","author":"Fichera","year":"2007","journal-title":"Cancer Res"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0175","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1073\/pnas.032678499","article-title":"Importance of epidermal growth factor receptor signaling in establishment of adenomas and maintenance of carcinomas during intestinal tumorigenesis","volume":"99","author":"Roberts","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0180","doi-asserted-by":"crossref","first-page":"9380","DOI":"10.1158\/0008-5472.CAN-07-0710","article-title":"Targeting cyclooxygenase-2 and the epidermal growth factor receptor for the prevention and treatment of intestinal cancer","volume":"67","author":"Buchanan","year":"2007","journal-title":"Cancer Res"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0185","doi-asserted-by":"crossref","first-page":"43261","DOI":"10.1074\/jbc.M404276200","article-title":"Apc deficiency is associated with increased Egfr activity in the intestinal enterocytes and adenomas of C57BL\/6J-Min\/+ mice","volume":"279","author":"Moran","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0190","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1186\/1476-4598-9-236","article-title":"Convergence between Wnt-\u03b2-catenin and EGFR signaling in cancer","volume":"9","author":"Hu","year":"2010","journal-title":"Mol Cancer"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0195","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S1535-6108(03)00304-0","article-title":"Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion","volume":"4","author":"Lu","year":"2003","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0200","doi-asserted-by":"crossref","first-page":"11045","DOI":"10.1158\/0008-5472.CAN-07-0986","article-title":"16-kDa prolactin inhibits endothelial cell migration by down-regulating the Ras-Tiam1-Rac1-Pak1 signaling pathway","volume":"67","author":"Lee","year":"2007","journal-title":"Cancer Res"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0205","doi-asserted-by":"crossref","first-page":"3362","DOI":"10.1038\/onc.2010.95","article-title":"Rac1 is crucial for Ras-dependent skin tumor formation by controlling Pak1-Mek-Erk hyperactivation and hyperproliferation in vivo","volume":"29","author":"Wang","year":"2010","journal-title":"Oncogene"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0210","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1038\/onc.2011.294","article-title":"A Rac1\/PAK1 cascade controls \u03b2-catenin activation in colon cancer cells","volume":"31","author":"Zhu","year":"2012","journal-title":"Oncogene"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0215","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1242\/jcs.115.6.1331","article-title":"Cholesterol is important in control of EGF receptor kinase activity but EGF receptors are not concentrated in caveolae","volume":"115","author":"Ringerike","year":"2002","journal-title":"J Cell Sci"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0220","doi-asserted-by":"crossref","first-page":"10315","DOI":"10.1021\/bi025943i","article-title":"Cholesterol levels modulate EGF receptor-mediated signaling by altering receptor function and trafficking","volume":"41","author":"Pike","year":"2002","journal-title":"Biochemistry"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0225","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1038\/sj.jid.5700168","article-title":"Ligand-independent activation of the EGFR by lipid raft disruption","volume":"126","author":"Lambert","year":"2006","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0230","doi-asserted-by":"crossref","first-page":"49631","DOI":"10.1074\/jbc.M208327200","article-title":"Cholesterol depletion from the plasma membrane triggers ligand-independent activation of the epidermal growth factor receptor","volume":"277","author":"Chen","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0235","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1126\/science.1107710","article-title":"OSBP is a cholesterol-regulated scaffolding protein in control of ERK 1\/2 activation","volume":"307","author":"Wang","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0240","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0022-2275(20)31679-5","article-title":"Mechanisms for cholesterol homeostasis in rat jejunal mucosa: effects of cholesterol, sitosterol, and lovastatin","volume":"42","author":"Nguyen","year":"2001","journal-title":"J Lipid Res"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0245","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/CEJ.0b013e3282b721fe","article-title":"Statins and cancer: a meta-analysis of case\u2013control studies","volume":"17","author":"Taylor","year":"2008","journal-title":"Eur J Cancer Prev"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0250","doi-asserted-by":"crossref","first-page":"7370","DOI":"10.1158\/0008-5472.CAN-05-4619","article-title":"Chemoprevention of familial adenomatous polyposis by low doses of atorvastatin and celecoxib given individually and in combination to APCMin mice","volume":"66","author":"Swamy","year":"2006","journal-title":"Cancer Res"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0255","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1158\/1940-6207.CAPR-10-0028","article-title":"Inhibition of intestinal polyp formation by pitavastatin, a HMG-CoA reductase inhibitor","volume":"4","author":"Teraoka","year":"2011","journal-title":"Cancer Prev Res (Phila)"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0260","first-page":"163","article-title":"Multi-target approaches in colon cancer chemoprevention based on systems biology of tumor cell-signaling","volume":"2","author":"Guruswamy","year":"2008","journal-title":"Gene Regul Syst Biol"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0265","doi-asserted-by":"crossref","first-page":"4426s","DOI":"10.1158\/1078-0432.CCR-06-0089","article-title":"Strategies to enhance epidermal growth factor inhibition: targeting the mevalonate pathway","volume":"12","author":"Dimitroulakos","year":"2006","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0270","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1159\/000082918","article-title":"Higher farnesyl diphosphate synthase activity in human colorectal cancer inhibition of cellular apoptosis","volume":"67","author":"Notarnicola","year":"2004","journal-title":"Oncology"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0275","doi-asserted-by":"crossref","first-page":"25892","DOI":"10.1074\/jbc.274.36.25892","article-title":"Fish oil feeding decreases mature sterol regulatory element-binding protein 1 (SREBP-1) by down-regulation of SREBP-1c mRNA in mouse liver. A possible mechanism for down-regulation of lipogenic enzyme mRNAs","volume":"274","author":"Kim","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0280","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0022-2275(20)32329-4","article-title":"Gene expression of sterol regulatory element-binding proteins in hamster small intestine","volume":"42","author":"Field","year":"2001","journal-title":"J Lipid Res"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0285","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.3945\/jn.109.120311","article-title":"Hepatic nuclear sterol regulatory binding element protein 2 abundance is decreased and that of ABCG5 increased in male hamsters fed plant sterols","volume":"140","author":"Harding","year":"2010","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0290","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1038\/sj.cdd.4401910","article-title":"The P53 pathway: what questions remain to be explored?","volume":"13","author":"Levine","year":"2006","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0295","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/sj.ejcn.1601912","article-title":"Potential intake of phytosterols\/-stanols: results of a simulation study","volume":"58","author":"De Jong","year":"2004","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0300","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1079\/BJN20041364","article-title":"Simulation of prospective phytosterol intake in Germany by novel functional foods","volume":"93","author":"Kuhlmann","year":"2005","journal-title":"Br J Nutr"},{"key":"10.1016\/j.jnutbio.2012.07.002_bb0305","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/S0025-6196(11)63144-3","article-title":"Efficacy and safety of plant stanols and sterols in the management of blood cholesterol levels","volume":"78","author":"Katan","year":"2003","journal-title":"Mayo Clin Proc"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286312001957?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286312001957?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T15:10:26Z","timestamp":1760627426000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286312001957"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":61,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["S0955286312001957"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2012.07.002","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Plant stanols induce intestinal tumor formation by up-regulating Wnt and EGFR signaling in ApcMin mice","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2012.07.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}