{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T03:26:51Z","timestamp":1791170811669,"version":"4.1.0"},"reference-count":184,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1016\/j.jnutbio.2012.07.007","type":"journal-article","created":{"date-parts":[[2012,9,13]],"date-time":"2012-09-13T16:19:51Z","timestamp":1347553191000},"page":"1543-1551","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Mevalonate-suppressive dietary isoprenoids for bone health"],"prefix":"10.1016","volume":"23","author":[{"given":"Huanbiao","family":"Mo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoda","family":"Yeganehjoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anureet","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warren K.","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ima Nirwana","family":"Soelaiman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chwan-Li","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2012.07.007_bb0005","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1056\/NEJMra053077","article-title":"Bone quality \u2014 the material and structural basis of bone strength and fragility","volume":"354","author":"Seeman","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0010","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1126\/science.289.5484.1501","article-title":"The osteoblast: a sophisticated fibroblast under central surveillance","volume":"289","author":"Ducy","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0015","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1126\/science.289.5484.1504","article-title":"Bone resorption by osteoclasts","volume":"289","author":"Teitelbaum","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0020","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature01658","article-title":"Osteoclast differentiation and activation","volume":"423","author":"Boyle","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0025","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1359\/jbmr.1998.13.4.581","article-title":"Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras","volume":"13","author":"Luckman","year":"1998","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0030","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1073\/pnas.96.1.133","article-title":"Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro","volume":"96","author":"Fisher","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0035","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1006\/bbrc.1999.1499","article-title":"Farnesyl pyrophosphate synthase is the molecular target of nitrogen-containing bisphosphonates","volume":"264","author":"van Beek","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0040","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.bone.2005.04.021","article-title":"Phosphonocarboxylate inhibitors of Rab geranylgeranyl transferase disrupt the prenylation and membrane localization of Rab proteins in osteoclasts in vitro and in vivo","volume":"37","author":"Coxon","year":"2005","journal-title":"Bone"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0045","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1146\/annurev.bi.65.070196.001325","article-title":"Protein prenylation: molecular mechanisms and functional consequences","volume":"65","author":"Zhang","year":"1996","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0050","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.semcdb.2008.08.002","article-title":"Anti-resorptive therapies for osteoporosis","volume":"19","author":"Reid","year":"2008","journal-title":"Semin Cell Dev Biol"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0055","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/343425a0","article-title":"Regulation of the mevalonate pathway","volume":"343","author":"Goldstein","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0060","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1093\/jnci\/93.14.1062","article-title":"Blocking oncogenic Ras signaling for cancer therapy","volume":"93","author":"Adjei","year":"2001","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0065","doi-asserted-by":"crossref","first-page":"S59","DOI":"10.1097\/01.blo.0000093846.72468.66","article-title":"The mevalonate synthesis pathway as a therapeutic target in cancer","author":"Andela","year":"2003","journal-title":"Clin Orthop"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0070","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.2174\/1381612033453640","article-title":"New insights into the molecular mechanisms of action of bisphosphonates","volume":"9","author":"Rogers","year":"2003","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0075","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1126\/science.289.5484.1508","article-title":"Therapeutic approaches to bone diseases","volume":"289","author":"Rodan","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0080","doi-asserted-by":"crossref","first-page":"715","DOI":"10.2174\/1381612013397762","article-title":"Statins and bone formation","volume":"7","author":"Garrett","year":"2001","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0085","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1002\/jbmr.5650090611","article-title":"Effects of transforming growth factor \u03b2 on bone nodule formation and expression of bone morphogenetic protein 2, osteocalcin, osteopontin, alkaline phosphatase, and type I collagen mRNA in long-term cultures of fetal rat calvarial osteoblasts","volume":"9","author":"Harris","year":"1994","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0090","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1006\/bbrc.1994.1240","article-title":"Vasculotropin\/vascular endothelial growth factor induces differentiation in cultured osteoblasts","volume":"199","author":"Midy","year":"1994","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0095","doi-asserted-by":"crossref","first-page":"427S","DOI":"10.1093\/ajcn\/83.2.427S","article-title":"Nutritional modulators of bone remodeling during aging","volume":"83","author":"Mundy","year":"2006","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0100","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/71484","article-title":"Statins: lower lipids and better bones?","volume":"6","author":"Rogers","year":"2000","journal-title":"Nat Med"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0105","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/S0026-895X(25)08553-0","article-title":"Structure-activity relationships of new heterocycle-containing bisphosphonates as inhibitors of bone resorption and as inhibitors of growth of Dictyostelium discoideum amoebae","volume":"47","author":"Rogers","year":"1995","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0110","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1002\/jbmr.5650111015","article-title":"Bisphosphonates induce apoptosis in mouse macrophage-like cells in vitro by a nitric oxide-independent mechanism","volume":"11","author":"Rogers","year":"1996","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0115","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1359\/jbmr.2003.18.1.88","article-title":"The ability of statins to inhibit bone resorption is directly related to their inhibitory effect on HMG-CoA reductase activity","volume":"18","author":"Staal","year":"2003","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0120","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1211\/jpp.58.11.0005","article-title":"Distribution of lovastatin to bone and its effect on bone turnover in rats","volume":"58","author":"Jadhav","year":"2006","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0125","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1359\/jbmr.2000.15.4.650","article-title":"Compactin suppresses bone resorption by inhibiting the fusion of prefusion osteoclasts and disrupting the actin ring in osteoclasts","volume":"15","author":"Woo","year":"2000","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0130","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1002\/ijc.23745","article-title":"Simvastatin, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, suppresses osteoclastogenesis induced by receptor activator of nuclear factor-kappaB ligand through modulation of NF-kappaB pathway","volume":"123","author":"Ahn","year":"2008","journal-title":"Int J Cancer"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0135","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.regpep.2010.03.003","article-title":"Simvastatin inhibits osteoclast differentiation induced by bone morphogenetic protein-2 and RANKL through regulating MAPK, AKT and Src signaling","volume":"162","author":"Yamashita","year":"2010","journal-title":"Regul Pept"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0140","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.bcp.2004.08.036","article-title":"Inhibitory effects of mevastatin and a geranylgeranyl transferase I inhibitor (GGTI-2166) on mononuclear osteoclast formation induced by receptor activator of NF\u03baB ligand (RANKL) or tumor necrosis factor-\u03b1 (TNF-\u03b1)","volume":"69","author":"Woo","year":"2005","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0145","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/S0006-291X(03)01408-6","article-title":"Simvastatin induces osteoblastic differentiation and inhibits adipocytic differentiation in mouse bone marrow stromal cells","volume":"308","author":"Song","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0150","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1006\/bbrc.2000.4232","article-title":"Simvastatin promotes osteoblast differentiation and mineralization in MC3T3-E1 cells","volume":"280","author":"Maeda","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0155","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1126\/science.286.5446.1946","article-title":"Stimulation of bone formation in vitro and in rodents by statins","volume":"286","author":"Mundy","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0160","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.nutres.2010.06.011","article-title":"Red yeast rice stimulates osteoblast proliferation and increases alkaline phosphatase activity in MC3T3-E1 cells","volume":"30","author":"Cho","year":"2010","journal-title":"Nutr Res"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0165","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/jcb.20074","article-title":"Induction of osteoblast differentiation indices by statins in MC3T3-E1 cells","volume":"92","author":"Maeda","year":"2004","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0170","doi-asserted-by":"crossref","first-page":"3113","DOI":"10.1210\/en.2011-0016","article-title":"Effects of farnesyl pyrophosphate accumulation on calvarial osteoblast differentiation","volume":"152","author":"Weivoda","year":"2011","journal-title":"Endocrinology"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0175","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/j.1600-0765.2010.01329.x","article-title":"Lactone form 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) stimulate the osteoblastic differentiation of mouse periodontal ligament cells via the ERK pathway","volume":"46","author":"Kim","year":"2011","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0180","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.bbrc.2011.02.085","article-title":"alpha-Tocotrienol inhibits osteoclastic bone resorption by suppressing RANKL expression and signaling and bone resorbing activity","volume":"406","author":"Ha","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0185","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1359\/jbmr.2000.15.8.1467","article-title":"Protein geranylgeranylation is required for osteoclast formation, function, and survival: inhibition by bisphosphonates and GGTI-298","volume":"15","author":"Coxon","year":"2000","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0190","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.bbrc.2003.12.051","article-title":"Vitamin K(2) and geranylgeraniol, its side chain component, inhibited osteoclast formation in a different manner","volume":"314","author":"Hiruma","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0195","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1359\/jbmr.060111","article-title":"Effect of monoterpenes on the formation and activation of osteoclasts in vitro","volume":"21","author":"Dolder","year":"2006","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0200","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1158\/0008-5472.CAN-08-3249","article-title":"Zerumbone abolishes RANKL-induced NF-kappaB activation, inhibits osteoclastogenesis, and suppresses human breast cancer-induced bone loss in athymic nude mice","volume":"69","author":"Sung","year":"2009","journal-title":"Cancer Res"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2012.05.002","article-title":"Bisphosphonate- and statin-induced enhancement of OPG expression and inhibition of CD9, M-CSF, and RANKL expressions via inhibition of the Ras\/MEK\/ERK pathway and activation of p38MAPK in mouse bone marrow stromal cell line ST2","author":"Tsubaki","year":"2012","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0210","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1359\/jbmr.1998.13.11.1668","article-title":"Heterocycle-containing bisphosphonates cause apoptosis and inhibit bone resorption by preventing protein prenylation: evidence from structure-activity relationships in J774 macrophages","volume":"13","author":"Luckman","year":"1998","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0215","doi-asserted-by":"crossref","first-page":"34967","DOI":"10.1074\/jbc.274.49.34967","article-title":"Bisphosphonates act directly on the osteoclast to induce caspase cleavage of mst1 kinase during apoptosis. A link between inhibition of the mevalonate pathway and regulation of an apoptosis-promoting kinase","volume":"274","author":"Reszka","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0220","first-page":"696","article-title":"Simvastatin inhibits cytokine production and nuclear factor-\u03baB activation in interleukin 1\u03b2-stimulated synoviocytes from rheumatoid arthritis patients","volume":"25","author":"Lazzerini","year":"2007","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0225","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1002\/mnfr.200700418","article-title":"Tocotrienol-rich fraction of palm oil exhibits anti-inflammatory property by suppressing the expression of inflammatory mediators in human monocytic cells","volume":"52","author":"Wu","year":"2008","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0230","first-page":"lb178","article-title":"\u03b3-Tocotrienol inhibits IL-6 by suppression of C\/EBP\u03b2 expression and NF-\u03baB signaling in lipopolysaccharide-stimulated macrophages","volume":"25","author":"Wang","year":"2011","journal-title":"FASEB J"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0235","doi-asserted-by":"crossref","first-page":"2840","DOI":"10.1002\/art.22824","article-title":"Protein isoprenylation regulates secretion of matrix metalloproteinase 1 from rheumatoid synovial fibroblasts: effects of statins and farnesyl and geranylgeranyl transferase inhibitors","volume":"56","author":"Abeles","year":"2007","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0240","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1007\/s11745-009-3326-2","article-title":"Tocotrienols suppress proinflammatory markers and cyclooxygenase-2 expression in RAW264.7 macrophages","volume":"44","author":"Yam","year":"2009","journal-title":"Lipids"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0245","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1111\/j.1476-5381.2010.01111.x","article-title":"Protein isoprenylation regulates osteogenic differentiation of mesenchymal stem cells: effect of alendronate, and farnesyl and geranylgeranyl transferase inhibitors","volume":"162","author":"Duque","year":"2011","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0250","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/S8756-3282(03)00239-4","article-title":"Lovastatin inhibits adipogenic and stimulates osteogenic differentiation by suppressing PPARgamma2 and increasing Cbfa1\/Runx2 expression in bone marrow mesenchymal cell cultures","volume":"33","author":"Li","year":"2003","journal-title":"Bone"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0255","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1006\/bbrc.2001.5597","article-title":"Pitavastatin enhanced BMP-2 and osteocalcin expression by inhibition of Rho-associated kinase in human osteoblasts","volume":"287","author":"Ohnaka","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0260","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1210\/jcem.86.3.7366","article-title":"Clinical review 123: Anabolic therapy for osteoporosis","volume":"86","author":"Rosen","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0265","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s00198-002-1323-x","article-title":"HMG CoA reductase inhibitors and the skeleton: a comprehensive review","volume":"14","author":"Bauer","year":"2003","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0270","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1007\/s00431-002-0955-3","article-title":"Lovastatin increases longitudinal bone growth and bone morphogenetic protein-2 levels in the growth plate of Sprague\u2013Dawley rats","volume":"161","author":"Leem","year":"2002","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0275","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1186\/ar413","article-title":"The role of statins as potential targets for bone formation","volume":"4","author":"Garrett","year":"2002","journal-title":"Arthritis Res"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0280","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1006\/bbrc.2000.2697","article-title":"Compactin and simvastatin, but not pravastatin, induce bone morphogenetic protein-2 in human osteosarcoma cells","volume":"271","author":"Sugiyama","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0285","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1210\/en.2002-220682","article-title":"Statins augment vascular endothelial growth factor expression in osteoblastic cells via inhibition of protein prenylation","volume":"144","author":"Maeda","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0290","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1002\/jcb.21259","article-title":"Simvastatin and atorvastatin enhance gene expression of collagen type 1 and osteocalcin in primary human osteoblasts and MG-63 cultures","volume":"101","author":"Ruiz-Gaspa","year":"2007","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0295","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s13577-011-0028-x","article-title":"Effect of simvastatin on the osteogenetic behavior of alveolar osteoblasts and periodontal ligament cells","volume":"25","author":"Liu","year":"2012","journal-title":"Hum Cell"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0300","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1749-8546-3-4","article-title":"Chinese red yeast rice (Monascus purpureus-fermented rice) promotes bone formation","volume":"3","author":"Wong","year":"2008","journal-title":"Chin Med."},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0305","first-page":"4937","article-title":"d-\u03b4-Tocotrienol-mediated cell cycle arrest and apoptosis in human melanoma cells","volume":"30","author":"Fernandes","year":"2010","journal-title":"Anticancer Res"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0310","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1002\/ijc.20809","article-title":"Induction of cytotoxicity in human lung adenocarcinoma cells by 6-O-carboxypropyl-\u03b1-tocotrienol, a redox-silent derivative of \u03b1-tocotrienol","volume":"115","author":"Yano","year":"2005","journal-title":"Int J Cancer"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0315","doi-asserted-by":"crossref","first-page":"11230","DOI":"10.1016\/S0021-9258(18)82115-9","article-title":"Tocotrienols regulate cholesterol production in mammalian cells by post-transcriptional suppression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase","volume":"268","author":"Parker","year":"1993","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0320","doi-asserted-by":"crossref","first-page":"25054","DOI":"10.1074\/jbc.M605575200","article-title":"Insig-dependent ubiquitination and degradation of 3-hydroxy-3-methylglutaryl coenzyme a reductase stimulated by \u03b4- and \u03b3-tocotrienols","volume":"281","author":"Song","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0325","doi-asserted-by":"crossref","first-page":"10544","DOI":"10.1016\/S0021-9258(18)67419-8","article-title":"The structure of an inhibitor of cholesterol biosynthesis isolated from barley","volume":"261","author":"Qureshi","year":"1986","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0330","doi-asserted-by":"crossref","first-page":"3595","DOI":"10.1021\/jm00098a002","article-title":"Hypocholesterolemic activity of synthetic and natural tocotrienols","volume":"35","author":"Pearce","year":"1992","journal-title":"J Med Chem"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0335","doi-asserted-by":"crossref","first-page":"4793","DOI":"10.1210\/endo.141.12.7921","article-title":"In vivo effects of bisphosphonates on the osteoclast mevalonate pathway","volume":"141","author":"Fisher","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0340","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/S0021-9258(17)42396-9","article-title":"Mevalonic acid-dependent degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in vivo and in vitro","volume":"269","author":"Correll","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0345","doi-asserted-by":"crossref","first-page":"17390","DOI":"10.1016\/S0021-9258(17)32450-X","article-title":"Identification of farnesol as the non-sterol derivative of mevalonic acid required for the accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase","volume":"269","author":"Correll","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0350","doi-asserted-by":"crossref","first-page":"52479","DOI":"10.1074\/jbc.M310053200","article-title":"Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol","volume":"278","author":"Sever","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0355","doi-asserted-by":"crossref","first-page":"5736","DOI":"10.1074\/jbc.M206564200","article-title":"Regulation of isoprenoid\/cholesterol biosynthesis in cells from mevalonate kinase-deficient patients","volume":"278","author":"Houten","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0360","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1006\/bbrc.1996.1265","article-title":"Farnesol and geranylgeraniol induce actin cytoskeleton disorganization and apoptosis in A549 lung adenocarcinoma cells","volume":"225","author":"Miquel","year":"1996","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0365","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1258\/ebm.2011.010379","article-title":"Mevalonate depletion mediates the suppressive impact of geranylgeraniol on murine B16 melanoma cells","volume":"236","author":"Katuru","year":"2011","journal-title":"Exp Biol Med (Maywood)"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0370","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1016\/0006-2952(80)90183-5","article-title":"Inhibition of hepatic cholesterol synthesis and S-3-hydroxy-3-methylglutaryl-CoA reductase by mono and bicyclic monoterpenes administered in vivo","volume":"29","author":"Clegg","year":"1980","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0375","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1016\/S0021-9258(18)34920-2","article-title":"The mechanism of cyclic monoterpene inhibition of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase in vivo in the rat","volume":"257","author":"Clegg","year":"1982","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0380","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1093\/jn\/133.1.38","article-title":"Plant-derived monoterpenes suppress hamster kidney cell 3-hydroxy-3-methylglutaryl coenzyme a reductase synthesis at the post-transcriptional level","volume":"133","author":"Peffley","year":"2003","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0385","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1006\/bbrc.1999.1849","article-title":"Mechanism of aminobisphosphonate action: characterization of alendronate inhibition of the isoprenoid pathway","volume":"266","author":"Keller","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0390","first-page":"53","article-title":"Regulation of osteoclast differentiation by statins","volume":"3","author":"Grasser","year":"2003","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0395","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1006\/bbrc.1996.6014","article-title":"Metabolism of farnesol: phosphorylation of farnesol by rat liver microsomal and peroxisomal fractions","volume":"230","author":"Westfall","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0400","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1006\/abbi.1998.0611","article-title":"Phosphorylation of farnesol in rat liver microsomes: properties of farnesol kinase and farnesyl phosphate kinase","volume":"353","author":"Bentinger","year":"1998","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0405","doi-asserted-by":"crossref","unstructured":"Krause C, de Gorter DJJ, Karperien M, ten Dijke P. Signal transduction cascades controlling osteoblast differentiation. Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism: American Society for Bone and Mineral Research; 2008. p. 10\u20136.","DOI":"10.1002\/9780470623992.ch2"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0410","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1111\/j.1440-1681.2005.04264.x","article-title":"Tocotrienol offers better protection than tocopherol from free radical-induced damage of rat bone","volume":"32","author":"Ahmad","year":"2005","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0415","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s00223-008-9190-x","article-title":"Beneficial effects of tocotrienol and tocopherol on bone histomorphometric parameters in Sprague\u2013Dawley male rats after nicotine cessation","volume":"84","author":"Hermizi","year":"2009","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0420","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1254\/jjp.80.67","article-title":"Inhibitory effect of vitamin K2 (menatetrenone) on bone resorption in ovariectomized rats: a histomorphometric and dual energy X-ray absorptiometric study","volume":"80","author":"Akiyama","year":"1999","journal-title":"Jpn J Pharmacol"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0425","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/S8756-3282(03)00027-9","article-title":"Common herbs, essential oils, and monoterpenes potently modulate bone metabolism","volume":"32","author":"Muhlbauer","year":"2003","journal-title":"Bone"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0430","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.tripleo.2008.07.013","article-title":"Local application of statin promotes bone repair through the suppression of osteoclasts and the enhancement of osteoblasts at bone-healing sites in rats","volume":"107","author":"Ayukawa","year":"2009","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0435","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1365-2842.2009.02011.x","article-title":"Simvastatin enhances bone formation around titanium implants in rat tibiae","volume":"37","author":"Ayukawa","year":"2010","journal-title":"J Oral Rehabil"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0440","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s00774-009-0122-2","article-title":"Vitamin E exhibits bone anabolic actions in normal male rats","volume":"28","author":"Shuid","year":"2010","journal-title":"J Bone Miner Metab"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0445","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1359\/jbmr.080603","article-title":"Transdermal lovastatin enhances fracture repair in rats","volume":"23","author":"Gutierrez","year":"2008","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0450","first-page":"589","article-title":"Lipid clearing agents in steroid-induced osteoporosis","volume":"94","author":"Wang","year":"1995","journal-title":"J Formos Med Assoc"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0455","doi-asserted-by":"crossref","first-page":"309","DOI":"10.4103\/0253-7613.16855","article-title":"\u03b3-tocotrienol is required for normal vitamin D metabolism in female rats","volume":"37","author":"Norazlina","year":"2005","journal-title":"Indian J Pharmacol"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0460","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1046\/j.1440-6047.2002.00290.x","article-title":"Tocotrienols are needed for normal bone calcification in growing female rats","volume":"11","author":"Norazlina","year":"2002","journal-title":"Asia Pac J Clin Nutr"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0465","doi-asserted-by":"crossref","first-page":"3205","DOI":"10.1001\/jama.283.24.3205","article-title":"HMG-CoA reductase inhibitors and the risk of fractures","volume":"283","author":"Meier","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0470","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1016\/S0140-6736(00)02400-4","article-title":"Inhibitors of hydroxymethylglutaryl-coenzyme A reductase and risk of fracture among older women","volume":"355","author":"Chan","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0475","doi-asserted-by":"crossref","first-page":"3211","DOI":"10.1001\/jama.283.24.3211","article-title":"HMG-CoA reductase inhibitors and the risk of hip fractures in elderly patients","volume":"283","author":"Wang","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0480","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1007\/s00198-003-1568-z","article-title":"Hip fracture risk in statin users \u2014 a population-based Danish case\u2013control study","volume":"15","author":"Rejnmark","year":"2004","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0485","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1359\/JBMR.040607","article-title":"HMG-CoA reductase inhibitors and the risk of vertebral fracture","volume":"19","author":"Schoofs","year":"2004","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0490","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1111\/j.1464-5491.2004.01292.x","article-title":"HMG-CoA reductase inhibitors prevent bone loss in patients with Type 2 diabetes mellitus","volume":"21","author":"Nakashima","year":"2004","journal-title":"Diabet Med"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0495","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1016\/S0140-6736(00)02408-9","article-title":"Oral statins and increased bone-mineral density in postmenopausal women","volume":"355","author":"Edwards","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0500","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1517\/13543784.17.10.1435","article-title":"Statins: under investigation for increasing bone mineral density and augmenting fracture healing","volume":"17","author":"Tang","year":"2008","journal-title":"Expert Opin Investig Drugs"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0505","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1046\/j.1532-5415.2003.515248.x","article-title":"Atorvastatin, 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, reduces bone resorption in the elderly","volume":"51","author":"Kuzuya","year":"2003","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0510","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1385\/JCD:5:2:151","article-title":"Effect of HMG-CoA reductase inhibitors (statins) on bone mineral density","volume":"5","author":"Funkhouser","year":"2002","journal-title":"J Clin Densitom"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0515","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1007\/s00198-004-1793-0","article-title":"Hydroxymethylglutaryl-coenzyme A reductase inhibitors and osteoporosis: a meta-analysis","volume":"16","author":"Hatzigeorgiou","year":"2005","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0520","first-page":"1137","article-title":"HMG-CoA reductase inhibitors increase BMD in type 2 diabetes mellitus patients","volume":"85","author":"Chung","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0525","doi-asserted-by":"crossref","first-page":"97","DOI":"10.7326\/0003-4819-139-2-200307150-00009","article-title":"Statin use, clinical fracture, and bone density in postmenopausal women: results from the Women's Health Initiative Observational Study","volume":"139","author":"LaCroix","year":"2003","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0530","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1001\/jama.285.14.1850","article-title":"Use of statins and risk of fractures","volume":"285","author":"van Staa","year":"2001","journal-title":"JAMA"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0535","first-page":"1921","article-title":"Statin drugs and the risk of fracture. 4S Study Group.","volume":"284","author":"Pedersen","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0540","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.metabol.2004.01.010","article-title":"Simvastatin increases bone mineral density in hypercholesterolemic postmenopausal women","volume":"53","author":"Lupattelli","year":"2004","journal-title":"Metabolism"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0545","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S8756-3282(03)00034-6","article-title":"Effect of simvastatin treatment on bone mineral density and bone turnover in hypercholesterolemic postmenopausal women: a 1-year longitudinal study","volume":"32","author":"Montagnani","year":"2003","journal-title":"Bone"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0550","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1001\/archinte.164.2.146","article-title":"Use of statins and fracture: results of 4 prospective studies and cumulative meta-analysis of observational studies and controlled trials","volume":"164","author":"Bauer","year":"2004","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0555","doi-asserted-by":"crossref","first-page":"4556","DOI":"10.1210\/jcem.86.9.8001","article-title":"Simvastatin increases serum osteocalcin concentration in patients treated for hypercholesterolaemia","volume":"86","author":"Chan","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0560","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s001980200070","article-title":"Relation of statin use and bone loss: a prospective population-based cohort study in early postmenopausal women","volume":"13","author":"Sirola","year":"2002","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0565","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1001\/archinte.162.5.537","article-title":"Statin use, bone mineral density, and fracture risk: Geelong Osteoporosis Study","volume":"162","author":"Pasco","year":"2002","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0570","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/s007740050034","article-title":"Effects of menatetrenone on the bone and calcium metabolism in osteoporosis: a double-blind placebo-controlled study","volume":"16","author":"Orimo","year":"1998","journal-title":"J Bone Miner Metab"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0575","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/S0002-9343(01)00679-9","article-title":"Effects of 1-year treatment with fluvastatin or pravastatin on bone","volume":"110","author":"Watanabe","year":"2001","journal-title":"Am J Med"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0580","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s00198-004-1598-1","article-title":"Age-dependent effects of atorvastatin on biochemical bone turnover markers: a randomized controlled trial in postmenopausal women","volume":"15","author":"Berthold","year":"2004","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0585","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1211\/jpp.58.1.0002","article-title":"Statins and osteoporosis: new role for old drugs","volume":"58","author":"Jadhav","year":"2006","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0590","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0140-6736(00)04042-3","article-title":"Effect of pravastatin on frequency of fracture in the LIPID study: secondary analysis of a randomised controlled trial. Long-term Intervention with Pravastatin in Ischaemic Disease","volume":"357","author":"Reid","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0595","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1001\/archinte.1996.00440170097011","article-title":"Safety and tolerability of cholesterol lowering with simvastatin during 5 years in the Scandinavian Simvastatin Survival Study","volume":"156","author":"Pedersen","year":"1996","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0600","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1359\/jbmr.040209","article-title":"Effects of simvastatin on bone turnover and BMD: a 1-year randomized controlled trial in postmenopausal osteopenic women","volume":"19","author":"Rejnmark","year":"2004","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0605","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.1001\/jama.283.24.3255","article-title":"Do statins prevent both cardiovascular disease and fracture?","volume":"283","author":"Cummings","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0610","doi-asserted-by":"crossref","first-page":"6222s","DOI":"10.1158\/1078-0432.CCR-06-0843","article-title":"Molecular mechanisms of action of bisphosphonates: current status","volume":"12","author":"Roelofs","year":"2006","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0615","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1006\/abbi.1999.1502","article-title":"Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase","volume":"373","author":"Bergstrom","year":"2000","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0620","doi-asserted-by":"crossref","first-page":"73S","DOI":"10.1016\/S8756-3282(99)00070-8","article-title":"Molecular mechanisms of action of bisphosphonates","volume":"24","author":"Rogers","year":"1999","journal-title":"Bone"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0625","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1124\/mol.56.1.131","article-title":"Farnesol and geranylgeraniol prevent activation of caspases by aminobisphosphonates: biochemical evidence for two distinct pharmacological classes of bisphosphonate drugs","volume":"56","author":"Benford","year":"1999","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0630","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.coph.2006.03.005","article-title":"Recent advances in understanding the mechanism of action of bisphosphonates","volume":"6","author":"Coxon","year":"2006","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0635","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0014-2999(94)90539-8","article-title":"Effect of vitamin K2 (menatetrenone) on osteoclast-like cell formation in mouse bone marrow cultures","volume":"263","author":"Akiyama","year":"1994","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0640","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/8756-3282(94)00027-W","article-title":"The inhibitory effect of vitamin K2 (menatetrenone) on bone resorption may be related to its side chain","volume":"16","author":"Hara","year":"1995","journal-title":"Bone"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0645","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s00223-002-2061-y","article-title":"Menatetrenone (vitamin K2) acts directly on circulating human osteoclast precursors","volume":"73","author":"Taira","year":"2003","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0650","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/BF02537822","article-title":"Some new aspects of isoprenoid biosynthesis in plants\u2013a review","volume":"30","author":"Bach","year":"1995","journal-title":"Lipids"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0655","first-page":"294","article-title":"Isoprenoid-mediated inhibition of mevalonate synthesis: potential application to cancer","volume":"221","author":"Elson","year":"1999","journal-title":"Proc Soc Exp Biol Med"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0660","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1177\/153537020422900701","article-title":"Studies of the isoprenoid-mediated inhibition of mevalonate synthesis applied to cancer chemotherapy and chemoprevention","volume":"229","author":"Mo","year":"2004","journal-title":"Exp Biol Med (Maywood)"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0665","series-title":"Handbook of nutraceuticals and functional foods CRC series in modern nutrition","first-page":"31","article-title":"Isoprenoids, health and disease","author":"Crowell","year":"2001"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0670","series-title":"Nutritional oncology","first-page":"629","article-title":"Isoprenoids and novel inhibitors of mevalonate pathway activities","author":"Mo","year":"2006"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0675","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1021\/jf00084a023","article-title":"Inhibition of hepatic mevalonate biosynthesis by the monoterpene, d-limonene","volume":"36","author":"Qureshi","year":"1988","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0680","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0304-3835(01)00723-6","article-title":"Volatile isoprenoid constituents of fruits, vegetables and herbs cumulatively suppress the proliferation of murine B16 melanoma and human HL-60 leukemia cells","volume":"175","author":"Tatman","year":"2002","journal-title":"Cancer Lett"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0685","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/S0006-2952(99)00162-8","article-title":"Inhibitory effect of genistein on osteoclast-like cell formation in mouse marrow cultures","volume":"58","author":"Gao","year":"1999","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0690","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1002\/jcb.22935","article-title":"Phytoestrogens directly inhibit TNF-alpha-induced bone resorption in RAW264.7 cells by suppressing c-fos-induced NFATc1 expression","volume":"112","author":"Karieb","year":"2011","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0695","first-page":"352","article-title":"Differential effects of genistein, estradiol and raloxifene on rat osteoclasts in vitro","volume":"57","author":"Sliwinski","year":"2005","journal-title":"Pharmacol Rep"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0700","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1271\/bbb.68.1051","article-title":"Isoflavones found in Korean soybean paste as 3-hydroxy-3-methylglutaryl Coenzyme A reductase inhibitors","volume":"68","author":"Sung","year":"2004","journal-title":"Biosci Biotechnol Biochem"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0705","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1271\/bbb.68.428","article-title":"Isoflavones inhibit 3-hydroxy-3-methylglutaryl coenzyme A reductase in vitro","volume":"68","author":"Sung","year":"2004","journal-title":"Biosci Biotechnol Biochem"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0710","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1093\/ajcn\/83.6.1254","article-title":"Fruit and vegetables: the unexpected natural answer to the question of osteoporosis prevention?","volume":"83","author":"Lanham-New","year":"2006","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0715","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/43824","article-title":"Effect of vegetables on bone metabolism","volume":"401","author":"Muhlbauer","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0720","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1093\/ajcn\/83.6.1420","article-title":"Fruit and vegetable intakes and bone mineral status: a cross sectional study in 5 age and sex cohorts","volume":"83","author":"Prynne","year":"2006","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0725","doi-asserted-by":"crossref","first-page":"539S","DOI":"10.1093\/ajcn\/70.3.539s","article-title":"Plant-based diets and bone health: nutritional implications","volume":"70","author":"Anderson","year":"1999","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0730","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1093\/ajcn\/71.1.142","article-title":"Dietary influences on bone mass and bone metabolism: further evidence of a positive link between fruit and vegetable consumption and bone health?","volume":"71","author":"New","year":"2000","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0735","doi-asserted-by":"crossref","first-page":"e124","DOI":"10.1097\/MPA.0b013e3181a20f9c","article-title":"d-\u03b4-Tocotrienol-mediated suppression of the proliferation of human PANC-1, MIA PaCa2 and BxPC-3 pancreatic carcinoma cells","volume":"38","author":"Hussein","year":"2009","journal-title":"Pancreas"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0740","series-title":"Tocotrienols: vitamin E beyond tocopherols","first-page":"185","article-title":"Role of the mevalonate pathway in tocotrienol-mediated tumor suppression","author":"Mo","year":"2008"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0745","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.mam.2007.03.001","article-title":"Tocotrienols in health and disease: the other half of the natural vitamin E family","volume":"28","author":"Sen","year":"2007","journal-title":"Mol Aspects Med"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0750","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1016\/j.foodres.2011.02.025","article-title":"Composition and antioxidative activities of supercritical CO2-extracted oils from seeds and soft parts of northern berries","volume":"44","author":"Yang","year":"2011","journal-title":"Food Res Int"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0755","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.foodchem.2008.05.017","article-title":"Berry seed press residues and their valuable ingredients with special regard to black currant seed press residues","volume":"111","author":"Helbig","year":"2008","journal-title":"Food Chem"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0760","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.jfca.2005.08.001","article-title":"Tocopherol and tocotrienol contents of raw and processed fruits and vegetables in the United States diet","volume":"19","author":"Chun","year":"2006","journal-title":"J Food Comp Analy"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0765","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1016\/j.foodchem.2008.11.018","article-title":"Antioxidant and antiproliferative properties of a tocotrienol-rich fraction from grape seeds","volume":"114","author":"Choi","year":"2009","journal-title":"Food Chem"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0770","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1080\/87559120701224956","article-title":"Biologically active components and nutraceuticals in peanuts and related products: review","volume":"23","author":"Isanga","year":"2007","journal-title":"Food Rev Int"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0775","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1021\/jf052329f","article-title":"Tocopherol and tocotrienol content of hazelnut cultivars grown in Portugal","volume":"54","author":"Amaral","year":"2006","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0780","series-title":"Tocotrienols: vitamin E beyond tocopherols","first-page":"43","article-title":"Tocotrienols in plants: sources and importance","author":"Harinantenaina","year":"2008"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0785","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1021\/jf0623844","article-title":"Tocopherol and tocotrienol levels of foods consumed in Hawaii","volume":"55","author":"Franke","year":"2007","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0790","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/jsfa.2740610223","article-title":"Tocopherol and tocotrienol compositions of raw table olive fruit","volume":"61","author":"Hassapidou","year":"1993","journal-title":"J Sci Food Agric"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0795","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.canlet.2008.03.063","article-title":"Multitargeted therapy of cancer by tocotrienols","volume":"269","author":"Nesaretnam","year":"2008","journal-title":"Cancer Lett"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0800","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1007\/s11746-998-0323-1","article-title":"Identification and estimation of tocotrienols in the annatto lipid fraction by gas chromatography\u2013mass spectrometry","volume":"75","author":"Frega","year":"1998","journal-title":"J Am Oil Chem Soc"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0805","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1007\/BF02534592","article-title":"Effects of different fractions of the barley kernel on the hepatic lipid metabolism of chickens","volume":"17","author":"Burger","year":"1982","journal-title":"Lipids"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0810","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0021-9150(84)90145-X","article-title":"Suppression of cholesterol biosynthesis by constituents of barley kernel","volume":"51","author":"Burger","year":"1984","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0815","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1093\/jn\/126.2.389","article-title":"Dietary \u03b1-tocopherol attenuates the impact of \u03b3-tocotrienol on hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in chickens","volume":"126","author":"Qureshi","year":"1996","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0820","first-page":"993","article-title":"Stimulation of avian cholesterol metabolism by \u03b1-tocopherol","volume":"40","author":"Qureshi","year":"1989","journal-title":"Nutr Rep Int"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0825","first-page":"533","article-title":"Low dose of tocotrienols protects osteoblasts against oxidative stress","volume":"162","author":"Nizar","year":"2011","journal-title":"Clin Ter"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0830","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1089\/109662004322984699","article-title":"Effects of tocopherols and tocotrienols on body composition and bone calcium content in adrenalectomized rats replaced with dexamethasone","volume":"7","author":"Ima-Nirwana","year":"2004","journal-title":"J Med Food"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0835","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s00774-010-0159-2","article-title":"Beneficial effects of vitamin E isomer supplementation on static and dynamic bone histomorphometry parameters in normal male rats","volume":"28","author":"Mehat","year":"2010","journal-title":"J Bone Miner Metab"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0840","doi-asserted-by":"crossref","first-page":"166","DOI":"10.3923\/jpt.2011.166.173","article-title":"Subacute and subchronic toxicity studies of palm vitamin E in mice","volume":"6","author":"Ima-Nirwana","year":"2011","journal-title":"J Pharmacol Toxicol"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0845","doi-asserted-by":"crossref","first-page":"300","DOI":"10.2174\/1573401310703040300","article-title":"Vitamin E does not support bone quality in orchidectomized rats","volume":"3","author":"Deyhim","year":"2007","journal-title":"Curr Nutr Food Sci"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0850","first-page":"195","article-title":"Effects of vitamin E supplementation on bone metabolism in nicotine-treated rats","volume":"48","author":"Norazlina","year":"2007","journal-title":"Singapore Med J"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0855","first-page":"393","article-title":"Recycled palm oil is better than soy oil in maintaining bone properties in a menopausal syndrome model of ovariectomized rat","volume":"16","author":"Shuid","year":"2007","journal-title":"Asia Pac J Clin Nutr"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0860","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/nm.2659","article-title":"Vitamin E decreases bone mass by stimulating osteoclast fusion","volume":"18","author":"Fujita","year":"2012","journal-title":"Nat Med"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0865","doi-asserted-by":"crossref","first-page":"8558","DOI":"10.1158\/0008-5472.CAN-04-4072","article-title":"Perillyl alcohol inhibits a calcium-dependent constitutive nuclear factor-kappaB pathway","volume":"65","author":"Berchtold","year":"2005","journal-title":"Cancer Res"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0870","doi-asserted-by":"crossref","first-page":"822.23","DOI":"10.1096\/fasebj.26.1_supplement.822.23","article-title":"Delta-Tocotrienol enhances cisplatin-induced inhibition of growth and invasion of Non-Small Cell Lung Cancer Cells","volume":"26","author":"Ji","year":"2012","journal-title":"FASEB J"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0875","article-title":"Delta-tocotrienol delays the progression of pancreatic intraepithelial neoplasia (PanIN) lesions in a conditional KrasG12D mouse model","volume":"53","author":"Husain","year":"2012","journal-title":"Am Assoc Cancer Res"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0880","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1074\/jbc.M610028200","article-title":"\u03b3-Tocotrienol inhibits nuclear factor-\u03baB signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene products and potentiation of apoptosis","volume":"282","author":"Ahn","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0885","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1007\/s11745-007-3102-0","article-title":"Synergistic antiproliferative effects of \u03b3-tocotrienol and statin treatment on mammary tumor cells","volume":"42","author":"Wali","year":"2007","journal-title":"Lipids"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0890","first-page":"523","article-title":"Tocotrienols potentiate lovastatin-mediated growth suppression in vitro and in vivo","volume":"232","author":"McAnally","year":"2007","journal-title":"Exp Biol Med (Maywood)"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0895","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1093\/jn\/129.4.804","article-title":"Apoptosis and cell-cycle arrest in human and murine tumor cells are initiated by isoprenoids","volume":"129","author":"Mo","year":"1999","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0900","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1093\/jn\/127.5.668","article-title":"Isoprenoids suppress the growth of murine B16 melanomas in vitro and in vivo","volume":"127","author":"He","year":"1997","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0905","series-title":"Nutritional Oncology","first-page":"379","article-title":"Targeting the action of isoprenoids and related phytochemicals to tumors","author":"Mo","year":"1999"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0910","series-title":"Tocotrienols: vitamin E beyond tocopherols","first-page":"237","article-title":"Tocotrienols and the regulation of cholesterol biosynthesis","author":"Cao","year":"2008"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0915","series-title":"Tocotrienols: vitamin E beyond tocopherols","first-page":"285","article-title":"Vitamin E isomers, tocotrienols, in cardioprotection","author":"Das","year":"2008"},{"key":"10.1016\/j.jnutbio.2012.07.007_bb0920","series-title":"Tocotrienols: vitamin E beyond tocopherols","first-page":"361","article-title":"Tocotrienols as natural neuroprotective vitamins","author":"Sen","year":"2008"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286312002008?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286312002008?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T15:07:38Z","timestamp":1760627258000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286312002008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":184,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["S0955286312002008"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2012.07.007","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mevalonate-suppressive dietary isoprenoids for bone health","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2012.07.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}