{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:09:56Z","timestamp":1791227396777,"version":"4.1.0"},"reference-count":57,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.jnutbio.2014.05.005","type":"journal-article","created":{"date-parts":[[2014,6,5]],"date-time":"2014-06-05T15:35:28Z","timestamp":1401982528000},"page":"1035-1044","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["Vitamin A deficiency modulates iron metabolism via ineffective erythropoiesis"],"prefix":"10.1016","volume":"25","author":[{"given":"Marcela S.B.","family":"da Cunha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Egle M.A.","family":"Siqueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano S.","family":"Trindade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra F.","family":"Arruda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2014.05.005_bb0005","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1079\/BJN19960165","article-title":"Supplemental vitamin A enhances the recovery from iron deficiency in rats with chronic vitamin A deficiency","volume":"75","author":"Roodenburg","year":"1996","journal-title":"Br J Nutr"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0010","doi-asserted-by":"crossref","first-page":"3607","DOI":"10.1093\/jn\/132.12.3607","article-title":"Iron deficiency and marginal vitamin A deficiency affect growth, hematological indices and the regulation of iron metabolism genes in rats","volume":"132","author":"Strube","year":"2002","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0015","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.nut.2008.11.030","article-title":"Vitamin A deficiency increases hepcidin expression and oxidative stress in rat","volume":"25","author":"Arruda","year":"2009","journal-title":"Nutrition"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0020","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/s12011-012-9397-6","article-title":"Vitamin A modulates the expression of genes involved in iron bioavailability","volume":"149","author":"Citelli","year":"2012","journal-title":"Biol Trace Elem Res"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0025","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1053\/j.gastro.2008.09.027","article-title":"Suppressive effects of retinoids on iron-induced oxidative stress in the liver","volume":"136","author":"Tsuchiya","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0030","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.cell.2010.06.028","article-title":"Two to tango: regulation of mammalian iron metabolism","volume":"142","author":"Hentze","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0035","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1126\/science.1104742","article-title":"Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization","volume":"306","author":"Nemeth","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0040","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.cmet.2007.10.006","article-title":"Iron regulatory proteins are essential for intestinal function and control key iron absorption molecules in the duodenum","volume":"7","author":"Galy","year":"2008","journal-title":"Cell Metab"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0045","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1172\/JCI0215686","article-title":"The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation","volume":"110","author":"Nicolas","year":"2002","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0050","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1073\/pnas.0409808102","article-title":"Regulation of hepcidin transcription by interleukin-1 and interleukin-6","volume":"102","author":"Lee","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0055","doi-asserted-by":"crossref","first-page":"3204","DOI":"10.1182\/blood-2006-06-027631","article-title":"Interleukin-6 induces hepcidin expression through STAT3","volume":"108","author":"Wrighting","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0060","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1182\/blood-2006-07-033969","article-title":"STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation","volume":"109","author":"Verga Falzacappa","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0065","doi-asserted-by":"crossref","first-page":"1166S","DOI":"10.3945\/ajcn.112.034637","article-title":"Vitamin A, and retinoic acid in T cell-related immunity","volume":"96","author":"Ross","year":"2012","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0070","first-page":"CD008524","article-title":"Vitamin A supplementation for preventing morbidity and mortality in children from 6 months to 5 years of age","author":"Imdad","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0075","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1038\/sj.ejcn.1601998","article-title":"Reduced production of immunoregulatory cytokines in vitamin A- and zinc-deficient Indonesian infants","volume":"58","author":"Wieringa","year":"2004","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0080","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1089\/jir.2009.0028","article-title":"All-trans retinoic acid ameliorates trinitrobenzene sulfonic acid-induced colitis by shifting Th1 to Th2 profile","volume":"30","author":"Bai","year":"2010","journal-title":"J Interferon Cytokine Res"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0085","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.smim.2008.07.007","article-title":"Retinoic acid-dependent regulation of immune responses by dendritic cells and macrophages","volume":"21","author":"Manicassamy","year":"2009","journal-title":"Semin Immunol"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0090","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1194\/jlr.R100015-JLR200","article-title":"Gene expression regulation by retinoic acid","volume":"43","author":"Balmer","year":"2002","journal-title":"J Lipid Res"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0095","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.jnutbio.2005.08.006","article-title":"Global effects of vitamin A deficiency on gene expression in rat liver: evidence for hypoandrogenism","volume":"17","author":"McClintick","year":"2006","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0100","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/jcp.22417","article-title":"Retinoids regulate stem cell differentiation","volume":"226","author":"Gudas","year":"2011","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0105","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1093\/jn\/123.11.1939","article-title":"AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet","volume":"123","author":"Reeves","year":"1993","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0110","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/S0022-2275(20)30178-4","article-title":"Simplified methodology to determine breast milk retinol concentrations","volume":"43","author":"Tanumihardjo","year":"2002","journal-title":"J Lipid Res"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0115","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1159\/000315528","article-title":"Effect of vitamin A deficiency on iron bioavailability","volume":"57","author":"Mehdad","year":"2010","journal-title":"Ann Nutr Metab"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0120","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0048-9697(95)04218-P","article-title":"The analysis of lead, cadmium, zinc, copper and nickel content in human bones from the upper Silesian industrial district","volume":"159","author":"Baranowska","year":"1995","journal-title":"Sci Total Environ"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0125","series-title":"T\u00e9cnicas b\u00e1sicas em Biologia Molecular","author":"Azevedo","year":"2010"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0130","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0135","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1097\/01.sla.0000256891.45790.4d","article-title":"Heme oxygenase-1 induction by the clinically used anesthetic isoflurane protects rat livers from ischemia\/reperfusion injury","volume":"245","author":"Schmidt","year":"2007","journal-title":"Ann Surg"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0140","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/biof.1056","article-title":"Retinoids: potent regulators of metabolism","volume":"39","author":"Brun","year":"2013","journal-title":"BioFactors"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0145","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.jnutbio.2006.10.006","article-title":"Vitamin A, regulation of gene expression: molecular mechanism of a prototype gene","volume":"18","author":"McGrane","year":"2007","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0150","doi-asserted-by":"crossref","first-page":"696","DOI":"10.3945\/jn.108.102988","article-title":"Vitamin A deficiency in rats induces anatomic and metabolic changes comparable with those of neurodegenerative disorders","volume":"139","author":"Ghenimi","year":"2009","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0155","doi-asserted-by":"crossref","first-page":"792","DOI":"10.3945\/jn.109.119388","article-title":"Vitamin A deficiency increases protein catabolism and induces urea cycle enzymes in rats","volume":"140","author":"Esteban-Pretel","year":"2010","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0160","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1093\/jn\/109.8.1419","article-title":"Growth, appetite, sequence of pathological signs and survival following the induction of rapid, synchronous vitamin A deficiency in the rat","volume":"109","author":"Anzano","year":"1979","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0165","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1007\/s12011-008-8271-z","article-title":"The effect of iron and zinc dietary restriction of pregnant rats on physical growth of litters","volume":"128","author":"Shahbazi","year":"2009","journal-title":"Biol Trace Elem Res"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0170","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/2045-3701-2-11","article-title":"Retinoic acid synthesis and functions in early embryonic development","volume":"2","author":"Kam","year":"2012","journal-title":"Cell Biosci"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0175","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1258\/002367771781006492","article-title":"The production of experimental vitamin A deficiency in rats and mice","volume":"5","author":"Moore","year":"1971","journal-title":"Lab Anim"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0180","doi-asserted-by":"crossref","first-page":"S129","DOI":"10.1067\/mjd.2001.113714","article-title":"Cellular metabolism and actions of 13-cis-retinoic acid","volume":"45","author":"Blaner","year":"2001","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0185","first-page":"10","article-title":"Analysis, occurrence, and function of 9-cis-retinoic acid","volume":"2012","author":"Kane","year":"1821","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0190","doi-asserted-by":"crossref","first-page":"291S","DOI":"10.1093\/jn\/133.1.291S","article-title":"Retinoid production and catabolism: role of diet in regulating retinol esterification and retinoic acid oxidation","volume":"133","author":"Ross","year":"2003","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0195","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1136\/gut.2010.214312","article-title":"Iron sensing and signalling","volume":"61","author":"Evstatiev","year":"2012","journal-title":"Gut"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0200","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1172\/JCI42011","article-title":"Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice","volume":"120","author":"De Domenico","year":"2010","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0205","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0014-5793(94)00673-3","article-title":"Retinoic acid up-regulates erythropoietin production in hepatoma cells and in vitamin A-depleted rats","volume":"349","author":"Okano","year":"1994","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0210","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1101\/gad.871601","article-title":"A developmental transition in definitive erythropoiesis: erythropoietin expression is sequentially regulated by retinoic acid receptors and HNF4","volume":"15","author":"Makita","year":"2001","journal-title":"Genes Dev"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0215","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1080\/15216540410001703956","article-title":"New insights into the regulation of erythroid cells","volume":"56","author":"Ingley","year":"2004","journal-title":"IUBMB Life"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0220","first-page":"163","article-title":"The effect of erythropoietin on normal and neoplastic cells","volume":"6","author":"Elliott","year":"2012","journal-title":"Biologics"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0225","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.beha.2004.09.001","article-title":"Modification of iron regulation by the inflammatory response","volume":"18","author":"Weiss","year":"2005","journal-title":"Best Pract Res Clin Haematol"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0230","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.3324\/haematol.2011.053397","article-title":"Late stage erythroid precursor production is impaired in mice with chronic inflammation","volume":"97","author":"Prince","year":"2012","journal-title":"Haematologica"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0235","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1089\/jir.1998.18.555","article-title":"Proinflammatory cytokines lowering erythropoietin production","volume":"18","author":"Jelkmann","year":"1998","journal-title":"J Interferon Cytokine Res"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0240","doi-asserted-by":"crossref","first-page":"3261","DOI":"10.1182\/blood.V98.12.3261","article-title":"Ineffective erythropoiesis in Stat5a(\u2212\/\u2212)5b(\u2212\/\u2212) mice due to decreased survival of early erythroblasts","volume":"98","author":"Socolovsky","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0245","doi-asserted-by":"crossref","first-page":"5027","DOI":"10.1182\/blood-2006-09-048868","article-title":"Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin","volume":"109","author":"Gardenghi","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0250","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.3945\/jn.111.144105","article-title":"Hypoxia inducible factor-2 alpha is translationally repressed in response to dietary iron deficiency in Sprague\u2013Dawley rats","volume":"141","author":"Davis","year":"2011","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0255","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.blre.2012.12.003","article-title":"Regulation of erythropoiesis by hypoxia-inducible factors","volume":"27","author":"Haase","year":"2013","journal-title":"Blood Rev"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0260","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.hoc.2010.08.003","article-title":"Anemia, ineffective erythropoiesis, and hepcidin: interacting factors in abnormal iron metabolism leading to iron overload in beta-thalassemia","volume":"24","author":"Gardenghi","year":"2010","journal-title":"Hematol Oncol Clin North Am"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0265","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/nm1629","article-title":"High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin","volume":"13","author":"Tanno","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0270","first-page":"184","article-title":"Growth differentiation factor 15 in erythroid health and disease","volume":"17","author":"Tanno","year":"2010","journal-title":"Curr Opin Hematol"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0275","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.3324\/haematol.2009.020123","article-title":"Heme controls ferroportin1 (FPN1) transcription involving Bach1, Nrf2 and a MARE\/ARE sequence motif at position \u22127007 of the FPN1 promoter","volume":"95","author":"Marro","year":"2010","journal-title":"Haematologica"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0280","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1124\/pr.107.07104","article-title":"Pharmacological and clinical aspects of heme oxygenase","volume":"60","author":"Abraham","year":"2008","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.jnutbio.2014.05.005_bb0285","doi-asserted-by":"crossref","first-page":"6054","DOI":"10.1182\/blood-2010-03-272138","article-title":"Dysfunction of the heme recycling system in heme oxygenase 1-deficient mice: effects on macrophage viability and tissue iron distribution","volume":"116","author":"Kovtunovych","year":"2010","journal-title":"Blood"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286314001156?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286314001156?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T15:14:58Z","timestamp":1760627698000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286314001156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":57,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S0955286314001156"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2014.05.005","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vitamin A deficiency modulates iron metabolism via ineffective erythropoiesis","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2014.05.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}