{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T03:47:11Z","timestamp":1768708031514,"version":"3.49.0"},"reference-count":64,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1016\/j.jnutbio.2014.10.014","type":"journal-article","created":{"date-parts":[[2014,12,3]],"date-time":"2014-12-03T05:20:43Z","timestamp":1417584043000},"page":"241-249","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Oral exposure to the anti-pyridoxine compound 1-amino d-proline further perturbs homocysteine metabolism through the transsulfuration pathway in moderately vitamin B6 deficient rats"],"prefix":"10.1016","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8996-1558","authenticated-orcid":false,"given":"Shyamchand","family":"Mayengbam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Raposo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Aliani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James D.","family":"House","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2014.10.014_bb0005","doi-asserted-by":"crossref","first-page":"614S","DOI":"10.1093\/ajcn\/71.2.614s","article-title":"B vitamins, homocysteine, and neurocognitive function in the elderly","volume":"71","author":"Selhub","year":"2000","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0010","series-title":"Homocysteine: Related Vitamins and Neuropsychiatric Disorders","first-page":"21","article-title":"Homocysteine metabolism","author":"Christina","year":"2007"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0015","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0065-2571(98)00008-9","article-title":"Regulation of homocysteine metabolism","volume":"39","author":"House","year":"1999","journal-title":"Adv Enzym Regul"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0020","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1002\/hep.23382","article-title":"Epigenetic regulation of hepatic endoplasmic reticulum stress pathways in the ethanol-fed cystathionine beta synthase-deficient mouse","volume":"51","author":"Esfandiari","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0025","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1152\/physrev.00047.2011","article-title":"S-adenosylmethionine in liver health, injury, and cancer","volume":"92","author":"Lu","year":"2012","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0030","doi-asserted-by":"crossref","first-page":"10072","DOI":"10.1073\/pnas.112336399","article-title":"Folate deficiency disturbs hepatic methionine metabolism and promotes liver injury in the ethanol-fed micropig","volume":"99","author":"Halsted","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0035","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1146\/annurev.nutr.24.012003.132418","article-title":"Sulfur amino acid metabolism: pathways for production and removal of homocysteine and cysteine","volume":"24","author":"Stipanuk","year":"2004","journal-title":"Annu Rev Nutr"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0040","doi-asserted-by":"crossref","first-page":"4636","DOI":"10.1002\/chem.200700002","article-title":"Theoretical study of the reaction of vitamin B6 with 1O2","volume":"13","author":"Matxain","year":"2007","journal-title":"Chem Eur J"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0045","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/nure.12014","article-title":"Mechanistic perspective on the relationship between pyridoxal 5\u2032-phosphate and inflammation","volume":"71","author":"Paul","year":"2013","journal-title":"Nutr Rev"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0050","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1016\/j.jnutbio.2013.08.005","article-title":"Dietary vitamin B6 intake modulates colonic inflammation in the IL10\u2212\/\u2212 model of inflammatory bowel disease","volume":"24","author":"Selhub","year":"2013","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0055","first-page":"7","article-title":"Vitamin B6 status, deficiency and its consequences \u2014 an overview","volume":"22","author":"Spinneker","year":"2007","journal-title":"Nutr Hosp"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0060","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1002\/mnfr.201100694","article-title":"Nutritional B vitamin deficiency disrupts lipid metabolism causing accumulation of proatherogenic lipoproteins in the aorta adventitia of ApoE null mice","volume":"56","author":"McNeil","year":"2012","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0065","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3177\/jnsv.28.77","article-title":"Stimulation of cholesterol metabolism in pyridoxine-deficient rats","volume":"28","author":"Iwami","year":"1982","journal-title":"J Nutr Sci Vitaminol (Tokyo)"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0070","doi-asserted-by":"crossref","first-page":"291","DOI":"10.3177\/jnsv.22.291","article-title":"Factors affecting liver lipid content in pyridoxing-deficient rats. I. Dietary protein levels","volume":"22","author":"Suzuki","year":"1976","journal-title":"J Nutr Sci Vitaminol (Tokyo)"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0075","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1136\/gut.18.1.23","article-title":"Vitamin B6 deficiency in chronic liver disease \u2014 evidence for increased degradation of pyridoxal-5\u2032-phosphate","volume":"18","author":"Labadarios","year":"1977","journal-title":"Gut"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0080","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1600-0773.1994.tb01364.x","article-title":"The effect of vitamin B6 deficiency on acetylhydrazine hepatic necrosis","volume":"74","author":"Ganley","year":"1994","journal-title":"Pharmacol Toxicol"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0085","doi-asserted-by":"crossref","first-page":"293","DOI":"10.3109\/01480549109002191","article-title":"Effect of subacute administration of isoniazid and pyridoxine on lipids in plasma, liver and adipose tissues in the rabbit","volume":"14","author":"Karthikeyan","year":"1991","journal-title":"Drug Chem Toxicol"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0090","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1021\/jf60191a037","article-title":"Vitamin B6 antagonists of natural origin","volume":"22\u20131","author":"Klosterman","year":"1974","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0095","series-title":"Flaxseed in Human Nutrition","first-page":"92","article-title":"Analysis and bioavailability of lignans in Flaxseed","author":"Thompson","year":"2003"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0100","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1021\/jf404786v","article-title":"Identification, characterization, and quantification of an anti-pyridoxine factor from flaxseed using ultrahigh-performance liquid chromatography-mass spectrometry","volume":"62","author":"Mayengbam","year":"2014","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0105","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1021\/bi00853a028","article-title":"Isolation, characterization, and synthesis of linatine. A vitamin B6 antagonist from flaxseed (Linum usitatissimum)","volume":"6","author":"Klosterman","year":"1967","journal-title":"Biochemistry (N Y)"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0110","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/0304-4165(76)90047-7","article-title":"Antivitamin B6 effect of 1 aminoproline on rats","volume":"428","author":"Sasaoka","year":"1976","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0115","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/0003-9861(81)90099-0","article-title":"Effect of 1-aminoproline on methionine metabolism in rats","volume":"206","author":"Kimoto","year":"1981","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0120","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1093\/jn\/120.suppl_11.1503","article-title":"Vitamin B-6: a status report","volume":"120","author":"Leklem","year":"1990","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0125","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1093\/ajcn\/87.5.1446","article-title":"Plasma pyridoxal 5\u2032-phosphate in the US population: The National Health and Nutrition Examination Survey, 2003\u20132004","volume":"87","author":"Morris","year":"2008","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0130","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S1570-0232(03)00320-9","article-title":"Optimisation and validation of a sensitive high-performance liquid chromatography assay for routine measurement of pyridoxal 5-phosphate in human plasma and red cells using pre-column semicarbazide derivatisation","volume":"792","author":"Talwar","year":"2003","journal-title":"J Chromatogr B Anal Technol Biomed Life Sci"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0135","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1017\/S1751731109004078","article-title":"Impairments in pyridoxine-dependent sulphur amino acid metabolism are highly sensitive to the degree of vitamin B6 deficiency and repletion in the pig","volume":"3","author":"Zhang","year":"2009","journal-title":"Animal"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0140","doi-asserted-by":"crossref","first-page":"452","DOI":"10.3945\/jn.108.099184","article-title":"Moderate dietary vitamin B-6 restriction raises plasma glycine and cystathionine concentrations while minimally affecting the rates of glycine turnover and glycine cleavage in healthy men and women","volume":"139","author":"Lamers","year":"2009","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0145","doi-asserted-by":"crossref","first-page":"E272","DOI":"10.1152\/ajpendo.00351.2003","article-title":"Tracer-derived total and folate-dependent homocysteine remethylation and synthesis rates in humans indicate that serine is the main one-carbon donor","volume":"286","author":"Davis","year":"2004","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0150","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1093\/jn\/109.12.2126","article-title":"Effect of excess dietary methionine on the catabolism of cysteine in rats","volume":"109","author":"Stipanuk","year":"1979","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0155","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1042\/bj2980415","article-title":"Folate-deficiency-induced homocysteinaemia in rats: disruption of S-adenosylmethionine\u2019s co-ordinate regulation of homocysteine metabolism","volume":"298","author":"Miller","year":"1994","journal-title":"Biochem J"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0160","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1111\/j.1572-0241.1999.01377.x","article-title":"Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions","volume":"94","author":"Brunt","year":"1999","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0165","doi-asserted-by":"crossref","first-page":"442","DOI":"10.3390\/molecules15010442","article-title":"Vitamin B6: a molecule for human health?","volume":"15","author":"Hellmann","year":"2010","journal-title":"Molecules"},{"issue":"Suppl. 3","key":"10.1016\/j.jnutbio.2014.10.014_bb0170","first-page":"63","article-title":"Nutritional status: blood vitamins A, E, B6, B12, folic acid and carotene. Euronut SENECA investigators","volume":"45","author":"Haller","year":"1991","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0175","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1017\/S0007114511000407","article-title":"Vitamin B6: a challenging link between nutrition and inflammation in CVD","volume":"106","author":"Lotto","year":"2011","journal-title":"Br J Nutr"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0180","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1001\/jama.2010.263","article-title":"Vitamin B6 and risk of colorectal cancer: a meta-analysis of prospective studies","volume":"303","author":"Larsson","year":"2010","journal-title":"JAMA"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0185","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1177\/0148607187011004398","article-title":"The effect of vitamin B6 deficiency on food intake, growth, and renal function in chronically azotemic rats","volume":"11","author":"Wolfson","year":"1987","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0190","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1093\/jn\/130.5.1115","article-title":"Vitamin B-6 deficiency in rats reduces hepatic serine hydroxymethyltransferase and cystathionine \u03b2-synthase activities and rates of in vivo protein turnover, homocysteine remethylation and transsulfuration","volume":"130","author":"Martinez","year":"2000","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0195","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/jn\/111.2.391","article-title":"Effects of vitamin B-6 deficiency and 4\u2032-deoxypyridoxine on pyridoxal phosphate concentrations, pyridoxine kinase and other aspects of metabolism in the rat","volume":"111","author":"Coburn","year":"1981","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0200","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.3945\/jn.113.180588","article-title":"Metabolite profile analysis reveals functional effects of 28-day vitamin B-6 restriction on one-carbon metabolism and tryptophan catabolic pathways in healthy men and women","volume":"143","author":"da Silva","year":"2013","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0205","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1017\/S0029665108007076","article-title":"Homocysteine, B-vitamins and CVD","volume":"67","author":"McNulty","year":"2008","journal-title":"Proc Nutr Soc"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0210","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/s11239-011-0550-4","article-title":"Hyper-homocysteinemia: a novel risk factor or a powerful marker for cardiovascular diseases? Pathogenetic and therapeutical uncertainties","volume":"32","author":"Cacciapuoti","year":"2011","journal-title":"J Thromb Thrombolysis"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0215","doi-asserted-by":"crossref","first-page":"25283","DOI":"10.1016\/S0021-9258(18)47244-4","article-title":"Transsulfuration depends on heme in addition to pyridoxal 5\u2032-phosphate. Cystathionine beta-synthase is a heme protein","volume":"269","author":"Kery","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0220","doi-asserted-by":"crossref","first-page":"22457","DOI":"10.1074\/jbc.M109.010868","article-title":"Relative contributions of cystathionine beta-synthase and gamma-cystathionase to H2S biogenesis via alternative trans-sulfuration reactions","volume":"284","author":"Singh","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0225","doi-asserted-by":"crossref","first-page":"6226","DOI":"10.1021\/bi800351a","article-title":"Kinetic properties of polymorphic variants and pathogenic mutants in human cystathionine gamma-lyase","volume":"47","author":"Zhu","year":"2008","journal-title":"Biochemistry"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0230","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1093\/jn\/136.8.2141","article-title":"Vitamin B-6 deficiency suppresses the hepatic transsulfuration pathway but increases glutathione concentration in rats fed AIN-76A or AIN-93G diets","volume":"136","author":"Lima","year":"2006","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0235","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1093\/jn\/100.4.467","article-title":"Pyridoxine effects on cystathionine synthase in rat liver","volume":"100","author":"Finkelstein","year":"1970","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0240","doi-asserted-by":"crossref","first-page":"2738","DOI":"10.1021\/bi9826052","article-title":"Characterization of the heme and pyridoxal phosphate cofactors of human cystathionine beta-synthase reveals nonequivalent active sites","volume":"38","author":"Taoka","year":"1999","journal-title":"Biochemistry"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0245","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s12192-013-0416-0","article-title":"Inhibition of cystathionine beta-synthase is associated with glucocorticoids over-secretion in psychological stress-induced hyperhomocystinemia rat liver","volume":"18","author":"Zhao","year":"2013","journal-title":"Cell Stress Chaperones"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0250","doi-asserted-by":"crossref","first-page":"188","DOI":"10.3177\/jnsv.47.188","article-title":"Effect of vitamin B6 deficiency on the synthesis and accumulation of S-adenosylhomocysteine and S-adenosylmethionine in rat tissues","volume":"47","author":"Nguyen","year":"2001","journal-title":"J Nutr Sci Vitaminol (Tokyo)"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0255","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1093\/ajcn\/59.5.1033","article-title":"Vitamin B-6 deficiency vs folate deficiency: comparison of responses to methionine loading in rats","volume":"59","author":"Miller","year":"1994","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0260","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.neulet.2009.11.014","article-title":"Impaired transmethylation potential in Parkinson\u2019s disease patients treated with l-Dopa","volume":"468","author":"De Bonis","year":"2010","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0265","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1096\/fj.09-143651","article-title":"Regulation of homocysteine metabolism and methylation in human and mouse tissues","volume":"24","author":"Chen","year":"2010","journal-title":"FASEB J"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0270","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1017\/S0007114508159025","article-title":"Role of sulfur amino acids in controlling nutrient metabolism and cell functions: implications for nutrition","volume":"101","author":"Tesseraud","year":"2009","journal-title":"Br J Nutr"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0275","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1042\/BJ20131434","article-title":"The cystathionine gamma-lyase\/hydrogen sulfide system maintains cellular glutathione status","volume":"460","author":"Lee","year":"2014","journal-title":"Biochem J"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0280","first-page":"4","article-title":"Hydrogen sulfide (H2S) \u2014 the third gas of interest for pharmacologists","volume":"59","author":"\u0141owicka","year":"2007","journal-title":"Pharmacol Rep"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0285","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1053\/j.gastro.2005.02.034","article-title":"Cystathionine beta synthase deficiency promotes oxidative stress, fibrosis, and steatosis in mice liver","volume":"128","author":"Robert","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0290","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/jn\/72.1.81","article-title":"The effect of pyridoxine on cholesterol metabolism","volume":"72","author":"Shah","year":"1960","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0295","doi-asserted-by":"crossref","first-page":"3173","DOI":"10.1021\/jf981359y","article-title":"Isolation and characterization of the lignans, isolariciresinol and pinoresinol, in flaxseed meal","volume":"47","author":"Meagher","year":"1999","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0300","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1097\/FJC.0b013e3181af04e5","article-title":"Flaxseed and cardiovascular health","volume":"54","author":"Prasad","year":"2009","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0305","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jchromb.2012.10.030","article-title":"Supported liquid extraction in the quantitation of plasma enterolignans using isotope dilution GC\/MS with application to flaxseed consumption in healthy adults","volume":"912","author":"Edel","year":"2013","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0310","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/403076","article-title":"Flaxseed ingestion alters ratio of enterolactone enantiomers in human serum","author":"Saarinen","year":"2010","journal-title":"J Nutr Metab"},{"key":"10.1016\/j.jnutbio.2014.10.014_bb0315","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1139\/apnm-2013-0420","article-title":"Flaxseed and its lignan and oil components: can they play a role in reducing the risk of and improving the treatment of breast cancer?","volume":"39","author":"Mason","year":"2014","journal-title":"Appl Physiol Nutr Metab"},{"issue":"6","key":"10.1016\/j.jnutbio.2014.10.014_bb0320","doi-asserted-by":"crossref","first-page":"e63544","DOI":"10.1371\/journal.pone.0063544","article-title":"Metabolomic analysis reveals extended metabolic consequences of marginal vitamin B-6 deficiency in healthy human subjects","volume":"8","author":"Gregory","year":"2013","journal-title":"PLoS One"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286314002423?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286314002423?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T15:14:45Z","timestamp":1760627685000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286314002423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":64,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["S0955286314002423"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2014.10.014","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2015,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oral exposure to the anti-pyridoxine compound 1-amino d-proline further perturbs homocysteine metabolism through the transsulfuration pathway in moderately vitamin B6 deficient rats","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2014.10.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}