{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T20:33:17Z","timestamp":1789936397039,"version":"4.0.1"},"reference-count":59,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1016\/j.jnutbio.2014.12.004","type":"journal-article","created":{"date-parts":[[2015,1,29]],"date-time":"2015-01-29T02:20:00Z","timestamp":1422498000000},"page":"476-483","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Dietary nitrite induces nitrosation of the gastric mucosa: the protective action of the mucus and the modulatory effect of red wine"],"prefix":"10.1016","volume":"26","author":[{"given":"Cassilda","family":"Pereira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui M.","family":"Barbosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4370-5177","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Laranjinha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2014.12.004_bb0005","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/368502a0","article-title":"Stomach NO synthesis","volume":"368","author":"Benjamin","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0010","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1136\/gut.35.11.1543","article-title":"Intragastric nitric oxide production in humans: measurements in expelled air","volume":"35","author":"Lundberg","year":"1994","journal-title":"Gut"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0015","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/nrmicro929","article-title":"Nitrate, bacteria and human health","volume":"2","author":"Lundberg","year":"2004","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0020","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.niox.2008.08.003","article-title":"The increase in plasma nitrite after a dietary nitrate load is markedly attenuated by an antibacterial mouthwash","volume":"19","author":"Govoni","year":"2008","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0025","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0015-6264(76)80006-5","article-title":"The effect of nitrate intake on nitrite formation in human saliva","volume":"14","author":"Tannenbaum","year":"1976","journal-title":"Food Cosmet Toxicol"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0030","article-title":"Chemical synthesis of nitric oxide in the stomach from dietary nitrate in humans","volume":"40","author":"McKnight","year":"1997","journal-title":"Br Med J"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0035","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0031-6997(25)06663-3","article-title":"Nitric oxide: physiology, pathophysiology, and pharmacology","volume":"43","author":"Moncada","year":"1991","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0040","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.cardiores.2007.03.016","article-title":"Signalling by NO-induced protein S-nitrosylation and S-glutathionylation: convergences and divergences","volume":"75","author":"Martinez-Ruiz","year":"2007","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0045","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1128\/AAC.40.6.1422","article-title":"Antimicrobial effect of acidified nitrite on gut pathogens: importance of dietary nitrate in host defense","volume":"40","author":"Dykhuizen","year":"1996","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0050","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1172\/JCI19019","article-title":"Nitrite in saliva increases gastric mucosal blood flow and mucus thickness","volume":"113","author":"Bjorne","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0055","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0014-2999(89)90324-5","article-title":"The vasodilator role of endogenous nitric oxide in the rat gastric microcirculation","volume":"174","author":"Pique","year":"1989","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0060","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.freeradbiomed.2006.11.018","article-title":"Protection from nonsteroidal anti-inflammatory drug (NSAID)-induced gastric ulcers by dietary nitrate","volume":"42","author":"Jansson","year":"2007","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0065","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/j.freeradbiomed.2007.06.007","article-title":"Red wine-dependent reduction of nitrite to nitric oxide in the stomach","volume":"43","author":"Gago","year":"2007","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0070","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.tox.2009.09.008","article-title":"Dietary polyphenols generate nitric oxide from nitrite in the stomach and induce smooth muscle relaxation","volume":"265","author":"Rocha","year":"2009","journal-title":"Toxicology"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0075","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.freeradbiomed.2005.04.021","article-title":"Apples increase nitric oxide production by human saliva at the acidic pH of the stomach: A new biological function for polyphenols with a catechol group?","volume":"39","author":"Peri","year":"2005","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0080","series-title":"Handbook of experimental pharmacology","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/978-3-642-57077-3_2","article-title":"The chemical biology of nitric oxide. Balancing nitric oxide with oxidative and nitrosative stress","author":"Wink","year":"2000"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/abio.1997.2129","article-title":"Chemistry, analysis, and biological roles of S-nitrosothiols","volume":"249","author":"Butler","year":"1997","journal-title":"Anal Biochem"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0090","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0092-8674(01)00495-0","article-title":"Nitrosylation. the prototypic redox-based signaling mechanism","volume":"106","author":"Stamler","year":"2001","journal-title":"Cell."},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0095","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/S1471-4914(03)00028-5","article-title":"S-nitrosylation in health and disease","volume":"9","author":"Foster","year":"2003","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0100","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1161\/CIRCRESAHA.109.207381","article-title":"S-Nitrosylation in cardiovascular signaling","volume":"106","author":"Lima","year":"2010","journal-title":"Circ Res"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0014400","article-title":"Redox-sensitivity and site-specificity of S- and N-denitrosation in proteins","volume":"5","author":"Jourd'heuil","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0110","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.cardiores.2004.01.013","article-title":"S-nitrosylation: a potential new paradigm in signal transduction","volume":"62","author":"Martinez-Ruiz","year":"2004","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0115","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.freeradbiomed.2007.03.011","article-title":"Diet-induced endogenous formation of nitroso compounds in the GI tract","volume":"43","author":"Kuhnle","year":"2007","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0120","series-title":"Nitrosation reactions and the chemistry of nitric oxide","author":"Williams","year":"2004"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0125","article-title":"Nitrosation mechanisms","volume":"19","author":"Williams","year":"1983","journal-title":"Adv Phys Org Chem"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0130","doi-asserted-by":"crossref","first-page":"25859","DOI":"10.1074\/jbc.271.42.25859","article-title":"Bicarbonate Inhibits N-nitrosation in oxygenated nitric oxide solutions","volume":"271","author":"Singh","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0135","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1749-6632.1975.tb29277.x","article-title":"Blocking the formation of N-nitroso compounds with ascorbic acid in vitro and in vivo","volume":"258","author":"Mirvish","year":"1975","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0140","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1021\/tx00031a003","article-title":"Reactions of the bioregulatory agent nitric oxide in oxygenated aqueous media: Determination of the kinetics for oxidation and nitrosation by intermediates generated in the nitric oxide\/oxygen reaction","volume":"6","author":"Wink","year":"1993","journal-title":"Chem Res Toxicol"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0145","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1006\/abio.1997.2424","article-title":"A method to study kinetics of transnitrosation with nitrosoglutathione: reactions with hemoglobin and other thiols","volume":"254","author":"Rossi","year":"1997","journal-title":"Anal Biochem"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/S0022-3565(24)37255-6","article-title":"S-transnitrosation reactions are involved in the metabolic fate and biological actions of nitric oxide","volume":"284","author":"Liu","year":"1998","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0155","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1096\/fasebj.10.7.8635690","article-title":"The cellular and molecular basis of gastric mucosal defense","volume":"10","author":"Wallace","year":"1996","journal-title":"FASEB J"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0160","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2008.05.030","article-title":"Gastric mucosal defense and cytoprotection: bench to bedside","volume":"135","author":"Laine","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0165","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1152\/physrev.1993.73.4.823","article-title":"Gastroduodenal mucosal protection","volume":"73","author":"Allen","year":"1993","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0170","doi-asserted-by":"crossref","first-page":"G121","DOI":"10.1152\/ajpgi.2001.280.1.G121","article-title":"Intraluminal acid and gastric mucosal integrity: the importance of blood-borne bicarbonate","volume":"280","author":"Synnerstad","year":"2001","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0175","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/0016-5085(94)90075-2","article-title":"Hydrogen ion concentration in the mucus layer on top of acid-stimulated and -inhibited rat gastric mucosa","volume":"107","author":"Schade","year":"1994","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0180","doi-asserted-by":"crossref","first-page":"G211","DOI":"10.1152\/ajpgi.00223.2001","article-title":"The importance of mucus layers and bicarbonate transport in preservation of gastric juxtamucosal pH","volume":"282","author":"Phillipson","year":"2002","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0185","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0928-4257(01)00015-8","article-title":"Gastric mucosal integrity: gastric mucosal blood flow and microcirculation. An overview","volume":"95","author":"Abdel-Salam","year":"2001","journal-title":"J Physiol Paris"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0190","series-title":"Physiology of membrane disorders","first-page":"559","article-title":"Ion and water transport in the intestine","author":"Powell","year":"1987"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0195","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.addr.2008.09.008","article-title":"Barrier properties of mucus","volume":"61","author":"Cone","year":"2009","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0200","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1023\/B:DDAS.0000043371.12671.98","article-title":"The adherent gastric mucous layer is composed of alternating layers of MUC5AC and MUC6 mucin proteins","volume":"49","author":"Ho","year":"2004","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0205","doi-asserted-by":"crossref","first-page":"G806","DOI":"10.1152\/ajpgi.90252.2008","article-title":"The gastric mucus layers: constituents and regulation of accumulation","volume":"295","author":"Phillipson","year":"2008","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0210","doi-asserted-by":"crossref","first-page":"G922","DOI":"10.1152\/ajpgi.2001.280.5.G922","article-title":"The adherent gastrointestinal mucus gel layer: thickness and physical state in vivo","volume":"280","author":"Atuma","year":"2001","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0215","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1365-201X.2005.01434.x","article-title":"An in vivo model for gastric physiological and pathophysiological studies in the mouse","volume":"184","author":"Henriksnas","year":"2005","journal-title":"Acta Physiol Scand"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0220","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/0006-291X(84)90213-4","article-title":"Effect of lipids and proteins on the viscosity of gastric mucus glycoprotein","volume":"121","author":"Murty","year":"1984","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0225","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1159\/000199341","article-title":"Effect of covalently bound fatty acids and associated lipids on the viscosity of gastric mucus glycoprotein in cystic fibrosis","volume":"34","author":"Slomiany","year":"1986","journal-title":"Digestion"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0230","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1073\/pnas.95.5.2175","article-title":"Accelerated reaction of nitric oxide with O2 within the hydrophobic interior of biological membranes","volume":"95","author":"Liu","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0235","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.niox.2010.01.003","article-title":"Diffusion of nitric oxide through the gastric wall upon reduction of nitrite by red wine: Physiological impact","volume":"22","author":"Rocha","year":"2010","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0240","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0245","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1096\/fj.02-0363com","article-title":"Concomitant S-, N-, and heme-nitros(yl)ation in biological tissues and fluids: implications for the fate of NO in vivo","volume":"16","author":"Feelisch","year":"2002","journal-title":"FASEB J"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0250","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1039\/tf9676300915","article-title":"Mechanism of chemiluminescent reaction between nitric oxide and ozone","volume":"63","author":"Clough","year":"1967","journal-title":"Trans Faraday Soc"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0255","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.freeradbiomed.2008.04.027","article-title":"The potent vasodilator ethyl nitrite is formed upon reaction of nitrite and ethanol under gastric conditions","volume":"45","author":"Gago","year":"2008","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0260","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.freeradbiomed.2011.11.011","article-title":"Intragastric nitration by dietary nitrite: implications for modulation of protein and lipid signaling","volume":"52","author":"Rocha","year":"2012","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0265","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.freeradbiomed.2012.12.017","article-title":"Pepsin is nitrated in the rat stomach, acquiring antiulcerogenic activity: a novel interaction between dietary nitrate and gut proteins","volume":"58","author":"Rocha","year":"2013","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0270","doi-asserted-by":"crossref","first-page":"3646","DOI":"10.1016\/j.fct.2012.07.062","article-title":"Ingested nitrate and nitrite and stomach cancer risk: an updated review","volume":"50","author":"Bryan","year":"2012","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0275","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0304-3835(95)03786-V","article-title":"Role of N-nitroso compounds (NOC) and N-nitrosation in etiology of gastric, esophageal, nasopharyngeal and bladder cancer and contribution to cancer of known exposures to NOC","volume":"93","author":"Mirvish","year":"1995","journal-title":"Cancer Lett"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0280","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.bpg.2006.03.005","article-title":"Cancer of the gastric cardia","volume":"20","author":"McColl","year":"2006","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0285","doi-asserted-by":"crossref","first-page":"25859","DOI":"10.1074\/jbc.271.42.25859","article-title":"Bicarbonate inhibits N-nitrosation in oxygenated nitric oxide solutions","volume":"271","author":"Caulfield","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0290","doi-asserted-by":"crossref","DOI":"10.1093\/ajcn\/53.1.247S","article-title":"Inhibition of nitrosamine formation by ascorbic acid","volume":"53","author":"Tannenbaum","year":"1991","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jnutbio.2014.12.004_bb0295","doi-asserted-by":"crossref","DOI":"10.3748\/wjg.v12.i3.354","article-title":"Epidemiology of gastric cancer","volume":"12","author":"Crew","year":"2006","journal-title":"World J Gastroenterol"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286315000182?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286315000182?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T15:15:38Z","timestamp":1760627738000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286315000182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":59,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["S0955286315000182"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2014.12.004","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dietary nitrite induces nitrosation of the gastric mucosa: the protective action of the mucus and the modulatory effect of red wine","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2014.12.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}