{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:09:12Z","timestamp":1791295752761,"version":"4.1.0"},"reference-count":60,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Nutrition, Chemical Food Safety and Consumer Behaviour Department of the French National Institute for Agricultural Research (INRA)"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.jnutbio.2015.04.003","type":"journal-article","created":{"date-parts":[[2015,5,11]],"date-time":"2015-05-11T13:29:17Z","timestamp":1431350957000},"page":"949-959","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":81,"title":["DHA at nutritional doses restores insulin sensitivity in skeletal muscle by preventing lipotoxicity and inflammation"],"prefix":"10.1016","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0133-0277","authenticated-orcid":false,"given":"Fr\u00e9d\u00e9ric","family":"Capel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Acquaviva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elodie","family":"Pitois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Laillet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Paul","family":"Rigaudi\u00e8re","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chryst\u00e8le","family":"Jouve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Pouyet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e8cile","family":"Gladine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blandine","family":"Comte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Vianey Saban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e8atrice","family":"Morio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2015.04.003_bb0005","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.cell.2007.06.009","article-title":"AKT\/PKB signaling: navigating downstream","volume":"129","author":"Manning","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0010","doi-asserted-by":"crossref","first-page":"E577","DOI":"10.1152\/ajpendo.2000.279.3.E577","article-title":"Effects of individual fatty acids on glucose uptake and glycogen synthesis in soleus muscle in vitro","volume":"279","author":"Thompson","year":"2000","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0015","doi-asserted-by":"crossref","first-page":"11107","DOI":"10.1074\/jbc.M708700200","article-title":"Oleate reverses palmitate-induced insulin resistance and inflammation in skeletal muscle cells","volume":"283","author":"Coll","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0020","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0898-6568(00)00110-8","article-title":"Signalling aspects of insulin resistance in skeletal muscle: mechanisms induced by lipid oversupply","volume":"12","author":"Schmitz-Peiffer","year":"2000","journal-title":"Cell Signal"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0025","doi-asserted-by":"crossref","first-page":"10297","DOI":"10.1074\/jbc.M212307200","article-title":"A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids","volume":"278","author":"Chavez","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0030","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.cmet.2007.10.013","article-title":"Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance","volume":"7","author":"Koves","year":"2008","journal-title":"Cell Metab"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0035","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1172\/JCI43378","article-title":"Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice","volume":"121","author":"Holland","year":"2011","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0040","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1210\/en.2005-0440","article-title":"Palmitate induces tumor necrosis factor-alpha expression in C2C12 skeletal muscle cells by a mechanism involving protein kinase C and nuclear factor-kappaB activation","volume":"147","author":"Jove","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0045","doi-asserted-by":"crossref","first-page":"3087","DOI":"10.1210\/en.2004-1560","article-title":"Palmitate-induced interleukin 6 production is mediated by protein kinase C and nuclear-factor kappaB activation and leads to glucose transporter 4 down-regulation in skeletal muscle cells","volume":"146","author":"Jove","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0050","doi-asserted-by":"crossref","first-page":"R673","DOI":"10.1152\/ajpregu.00561.2007","article-title":"Skeletal muscle insulin resistance: role of inflammatory cytokines and reactive oxygen species","volume":"294","author":"Wei","year":"2008","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0055","doi-asserted-by":"crossref","first-page":"35617","DOI":"10.1074\/jbc.M007346200","article-title":"Ceramide directly activates protein kinase C zeta to regulate a stress-activated protein kinase signaling complex","volume":"275","author":"Bourbon","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0060","doi-asserted-by":"crossref","first-page":"50230","DOI":"10.1074\/jbc.M200958200","article-title":"Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle","volume":"277","author":"Yu","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0065","doi-asserted-by":"crossref","first-page":"4854","DOI":"10.1073\/pnas.91.11.4854","article-title":"Tumor necrosis factor alpha inhibits signaling from the insulin receptor","volume":"91","author":"Hotamisligil","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0070","doi-asserted-by":"crossref","first-page":"17070","DOI":"10.1074\/jbc.M312021200","article-title":"Tumor necrosis factor alpha produces insulin resistance in skeletal muscle by activation of inhibitor kappaB kinase in a p38 MAPK-dependent manner","volume":"279","author":"de Alvaro","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0075","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nature01137","article-title":"A central role for JNK in obesity and insulin resistance","volume":"420","author":"Hirosumi","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0080","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.2337\/diabetes.54.10.2939","article-title":"Tumor necrosis factor-alpha induces skeletal muscle insulin resistance in healthy human subjects via inhibition of Akt substrate 160 phosphorylation","volume":"54","author":"Plomgaard","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0085","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1126\/science.271.5249.665","article-title":"IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance","volume":"271","author":"Hotamisligil","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0090","doi-asserted-by":"crossref","first-page":"16683","DOI":"10.1074\/jbc.M011695200","article-title":"Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4","volume":"276","author":"Lee","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0095","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.2337\/db06-1491","article-title":"Metabolic endotoxemia initiates obesity and insulin resistance","volume":"56","author":"Cani","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0100","doi-asserted-by":"crossref","first-page":"280","DOI":"10.2337\/diab.40.2.280","article-title":"Influence of dietary fat composition on development of insulin resistance in rats. Relationship to muscle triglyceride and omega-3 fatty acids in muscle phospholipid","volume":"40","author":"Storlien","year":"1991","journal-title":"Diabetes"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0105","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1126\/science.3303333","article-title":"Fish oil prevents insulin resistance induced by high-fat feeding in rats","volume":"237","author":"Storlien","year":"1987","journal-title":"Science"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0110","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s13105-013-0303-2","article-title":"Capel F n-3 polyunsaturated fatty acids modulate metabolism of insulin-sensitive tissues: implication for the prevention of type 2 diabetes","volume":"70","author":"Pinel","year":"2014","journal-title":"J Physiol Biochem"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0115","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.plipres.2011.06.003","article-title":"Omega-3 fatty acids and metabolic syndrome: effects and emerging mechanisms of action","volume":"50","author":"Poudyal","year":"2011","journal-title":"Prog Lipid Res"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0120","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1194\/jlr.M500300-JLR200","article-title":"Eicosapentaenoic acid (20:5 n-3) increases fatty acid and glucose uptake in cultured human skeletal muscle cells","volume":"47","author":"Aas","year":"2006","journal-title":"J Lipid Res"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0125","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/jcp.21936","article-title":"Saturated fatty acid-induced insulin resistance is associated with mitochondrial dysfunction in skeletal muscle cells","volume":"222","author":"Hirabara","year":"2009","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0130","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1476-511X-11-36","article-title":"Ameliorative effects of polyunsaturated fatty acids against palmitic acid-induced insulin resistance in L6 skeletal muscle cells","volume":"11","author":"Sawada","year":"2012","journal-title":"Lipids Health Dis"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0135","first-page":"468","article-title":"Insulin-stimulated glucose uptake and pathways regulating energy metabolism in skeletal muscle cells: the effects of subcutaneous and visceral fat, and long-chain saturated, n-3 and n-6 polyunsaturated fatty acids","volume":"2011","author":"Lam","year":"1811","journal-title":"Biochim Biophys Acta"},{"issue":"Suppl. 3","key":"10.1016\/j.jnutbio.2015.04.003_bb0140","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1046\/j.1365-2362.32.s3.3.x","article-title":"Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and beta-cell dysfunction","volume":"32","author":"Boden","year":"2002","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0145","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1056\/NEJM199301283280404","article-title":"The relation between insulin sensitivity and the fatty-acid composition of skeletal-muscle phospholipids","volume":"328","author":"Borkman","year":"1993","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0150","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.cell.2010.07.041","article-title":"GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects","volume":"142","author":"Oh da","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0155","doi-asserted-by":"crossref","first-page":"395757","DOI":"10.1155\/2012\/395757","article-title":"High physiological omega-3 fatty acid supplementation affects muscle fatty acid composition and glucose and insulin homeostasis in obese adolescents","volume":"2012","author":"Dangardt","year":"2012","journal-title":"J Nutr Metab"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0160","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1093\/ajcn\/76.6.1222","article-title":"Fatty acid composition of skeletal muscle reflects dietary fat composition in humans","volume":"76","author":"Andersson","year":"2002","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0165","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.jnutbio.2012.07.014","article-title":"Effects of ALA, EPA and DHA in high-carbohydrate, high-fat diet-induced metabolic syndrome in rats","volume":"24","author":"Poudyal","year":"2013","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0170","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1023\/A:1005306818025","article-title":"Diagnosis of inborn errors of metabolism by acylcarnitine profiling in blood using tandem mass spectrometry","volume":"20","author":"Vianey-Saban","year":"1997","journal-title":"J Inherit Metab Dis"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0175","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A simple method for the isolation and purification of total lipides from animal tissues","volume":"226","author":"Folch","year":"1957","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0180","doi-asserted-by":"crossref","first-page":"e89393","DOI":"10.1371\/journal.pone.0089393","article-title":"Lipid profiling following intake of the omega 3 fatty acid DHA identifies the peroxidized metabolites F4-neuroprostanes as the best predictors of atherosclerosis prevention","volume":"9","author":"Gladine","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0185","first-page":"5","article-title":"The ade4 package-I \u2014 one-table methods","volume":"4","author":"Chessel","year":"2004","journal-title":"R cNews"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0190","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1161\/01.ATV.19.5.1223","article-title":"Western-type diets induce insulin resistance and hyperinsulinemia in LDL receptor-deficient mice but do not increase aortic atherosclerosis compared with normoinsulinemic mice in which similar plasma cholesterol levels are achieved by a fructose-rich diet","volume":"19","author":"Merat","year":"1999","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0195","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1194\/jlr.M600146-JLR200","article-title":"Addition of dietary fat to cholesterol in the diets of LDL receptor knockout mice: effects on plasma insulin, lipoproteins, and atherosclerosis","volume":"47","author":"Wu","year":"2006","journal-title":"J Lipid Res"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0200","doi-asserted-by":"crossref","first-page":"4431","DOI":"10.1073\/pnas.91.10.4431","article-title":"The two-receptor model of lipoprotein clearance: tests of the hypothesis in \"knockout\" mice lacking the low density lipoprotein receptor, apolipoprotein E, or both proteins","volume":"91","author":"Ishibashi","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0205","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1476-511X-8-36","article-title":"Schilling BK Effect of eicosapentaenoic and docosahexaenoic acid on resting and exercise-induced inflammatory and oxidative stress biomarkers: a randomized, placebo controlled, cross-over study","volume":"8","author":"Bloomer","year":"2009","journal-title":"Lipids Health Dis"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0210","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1093\/jn\/136.1.83","article-title":"Flaxseed oil increases the plasma concentrations of cardioprotective (n-3) fatty acids in humans","volume":"136","author":"Harper","year":"2006","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0215","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3945\/ajcn.110.003871","article-title":"Dose-response effects of omega-3 fatty acids on triglycerides, inflammation, and endothelial function in healthy persons with moderate hypertriglyceridemia","volume":"93","author":"Skulas-Ray","year":"2011","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0220","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.3945\/ajcn.112.037432","article-title":"Long-chain n-3 PUFAs reduce adipose tissue and systemic inflammation in severely obese nondiabetic patients: a randomized controlled trial","volume":"96","author":"Itariu","year":"2012","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0225","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1194\/jlr.M004069","article-title":"Low dietary fish-oil threshold for myocardial membrane n-3 PUFA enrichment independent of n-6 PUFA intake in rats","volume":"51","author":"Slee","year":"2010","journal-title":"J Lipid Res"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0230","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1194\/jlr.M003319","article-title":"Metabolic switching of human myotubes is improved by n-3 fatty acids","volume":"51","author":"Hessvik","year":"2010","journal-title":"J Lipid Res"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0235","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/S0022-2275(20)34295-4","article-title":"Metabolism of n-3 polyunsaturated fatty acids and modification of phospholipids in cultured rabbit aortic smooth muscle cells","volume":"26","author":"Morisaki","year":"1985","journal-title":"J Lipid Res"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0240","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1017\/S1464793104006578","article-title":"Dietary fats and membrane function: implications for metabolism and disease","volume":"80","author":"Hulbert","year":"2005","journal-title":"Biol Rev Camb Philos Soc"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0245","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jnutbio.2010.01.006","article-title":"The function of porcine PPARgamma and dietary fish oil effect on the expression of lipid and glucose metabolism related genes","volume":"22","author":"Yu","year":"2011","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0250","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.plipres.2012.02.003","article-title":"Omega-3 fatty acids in anti-inflammation (pro-resolution) and GPCRs","volume":"51","author":"Im","year":"2012","journal-title":"Prog Lipid Res"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0255","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.abb.2003.08.020","article-title":"Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes","volume":"419","author":"Chavez","year":"2003","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0260","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.bbrc.2006.02.177","article-title":"PKCtheta is a key player in the development of insulin resistance","volume":"343","author":"Haasch","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0265","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1172\/JCI200422230","article-title":"PKC-theta knockout mice are protected from fat-induced insulin resistance","volume":"114","author":"Kim","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0270","doi-asserted-by":"crossref","first-page":"23942","DOI":"10.1074\/jbc.M312692200","article-title":"Palmitate, but not unsaturated fatty acids, induces the expression of interleukin-6 in human myotubes through proteasome-dependent activation of nuclear factor-kappaB","volume":"279","author":"Weigert","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0275","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1210\/en.2009-0874","article-title":"Cyclooxygenase 2 inhibition exacerbates palmitate-induced inflammation and insulin resistance in skeletal muscle cells","volume":"151","author":"Coll","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0280","doi-asserted-by":"crossref","first-page":"R1153","DOI":"10.1152\/ajpregu.00164.2003","article-title":"Lipopolysaccharide and proinflammatory cytokines stimulate interleukin-6 expression in C2C12 myoblasts: role of the Jun NH2-terminal kinase","volume":"285","author":"Frost","year":"2003","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0285","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1042\/CBI20120081","article-title":"TLR2 and TLR4 activation induces p38 MAPK-dependent phosphorylation of S6 kinase 1 in C2C12 myotubes","volume":"36","author":"Zbinden-Foncea","year":"2012","journal-title":"Cell Biol Int"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0290","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1007\/s00125-012-2652-8","article-title":"Skeletal muscle-specific overproduction of constitutively activated c-Jun N-terminal kinase (JNK) induces insulin resistance in mice","volume":"55","author":"Henstridge","year":"2012","journal-title":"Diabetologia"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0295","doi-asserted-by":"crossref","first-page":"4987","DOI":"10.1096\/fj.13-235333","article-title":"Cyclooxygenase-2 induction in macrophages is modulated by docosahexaenoic acid via interactions with free fatty acid receptor 4 (FFA4)","volume":"27","author":"Li","year":"2013","journal-title":"FASEB J"},{"key":"10.1016\/j.jnutbio.2015.04.003_bb0300","doi-asserted-by":"crossref","first-page":"e43764","DOI":"10.1371\/journal.pone.0043764","article-title":"Preservation of metabolic flexibility in skeletal muscle by a combined use of n-3 PUFA and rosiglitazone in dietary obese mice","volume":"7","author":"Horakova","year":"2012","journal-title":"PLoS One"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286315001023?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286315001023?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T15:15:52Z","timestamp":1760627752000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286315001023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":60,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["S0955286315001023"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2015.04.003","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DHA at nutritional doses restores insulin sensitivity in skeletal muscle by preventing lipotoxicity and inflammation","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2015.04.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}