{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T09:12:56Z","timestamp":1788599576528,"version":"build-2803163510"},"reference-count":87,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,8,3]],"date-time":"2015-08-03T00:00:00Z","timestamp":1438560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["SAF2011-24391"],"award-info":[{"award-number":["SAF2011-24391"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["SAF2014-53979-R"],"award-info":[{"award-number":["SAF2014-53979-R"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["BFU2009-08977"],"award-info":[{"award-number":["BFU2009-08977"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003529","name":"European Union","doi-asserted-by":"publisher","award":["FP7-AFHELO"],"award-info":[{"award-number":["FP7-AFHELO"]}],"id":[{"id":"10.13039\/501100003529","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003529","name":"European Union","doi-asserted-by":"publisher","award":["TARGEAR"],"award-info":[{"award-number":["TARGEAR"]}],"id":[{"id":"10.13039\/501100003529","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Puleva-LACTALIS"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.jnutbio.2015.07.011","type":"journal-article","created":{"date-parts":[[2015,7,31]],"date-time":"2015-07-31T23:41:00Z","timestamp":1438386060000},"page":"1424-1433","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["Long-term omega-3 fatty acid supplementation prevents expression changes in cochlear homocysteine metabolism and ameliorates progressive hearing loss in C57BL\/6J mice"],"prefix":"10.1016","volume":"26","author":[{"given":"Raquel","family":"Mart\u00ednez-Vega","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Partearroyo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00e9stor","family":"Vallecillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregorio","family":"Varela-Moreiras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda A.","family":"Pajares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3077-0500","authenticated-orcid":false,"given":"Isabel","family":"Varela-Nieto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2015.07.011_bb0005","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.arr.2014.09.003","article-title":"BioAge: toward a multi-determined, mechanistic account of cognitive aging","volume":"18","author":"DeCarlo","year":"2014","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0010","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"15","author":"Lopez-Otin","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0015","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1159\/000095129","article-title":"Sensory and cognitive association in older persons: findings from an older Australian population","volume":"52","author":"Tay","year":"2006","journal-title":"Gerontology"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0020","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1159\/000075557","article-title":"Biological age and 12-year cognitive change in older adults: findings from the Victoria Longitudinal Study","volume":"50","author":"MacDonald","year":"2004","journal-title":"Gerontology"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0025","series-title":"Features and challenges of population ageing using the European perspective","author":"Zaidi","year":"2008"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0030","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1093\/geront\/gnr159","article-title":"Age-related hearing loss: quality of care for quality of life","volume":"52","author":"Li-Korotky","year":"2012","journal-title":"The Gerontologist"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0035","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1007\/s00405-011-1597-8","article-title":"Prevalence of age-related hearing loss in Europe: a review","volume":"268","author":"Roth","year":"2011","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0040","first-page":"243","article-title":"Effect of vitamin B12 deficiency on otoacoustic emissions","volume":"33","author":"Karli","year":"2013","journal-title":"Acta Otorhinolaryngol Ital"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0045","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1093\/ajcn\/69.3.564","article-title":"Age-related hearing loss, vitamin B-12, and folate in elderly women","volume":"69","author":"Houston","year":"1999","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0050","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.otohns.2010.08.031","article-title":"Age-related hearing loss, vitamin B12, and folate in the elderly","volume":"143","author":"Lasisi","year":"2010","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0055","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1080\/00016480410016216","article-title":"Low serum folate levels: a risk factor for sudden sensorineural hearing loss?","volume":"124","author":"Cadoni","year":"2004","journal-title":"Acta Otolaryngol"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0060","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.anl.2003.09.001","article-title":"Comparative analysis of serum homocysteine, folic acid and vitamin B12 levels in patients with noise-induced hearing loss","volume":"31","author":"Gok","year":"2004","journal-title":"Auris Nasus Larynx"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7326\/0003-4819-146-1-200701020-00003","article-title":"Effects of folic acid supplementation on hearing in older adults: a randomized, controlled trial","volume":"146","author":"Durga","year":"2007","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0070","doi-asserted-by":"crossref","first-page":"242","DOI":"10.3109\/00016487009181884","article-title":"Dietary prevention of hearing loss","volume":"70","author":"Rosen","year":"1970","journal-title":"Acta Otolaryngol"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0075","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s12603-010-0078-x","article-title":"Plasma very long-chain n-3 polyunsaturated fatty acids and age-related hearing loss in older adults","volume":"14","author":"Dullemeijer","year":"2010","journal-title":"J Nutr Health Aging"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0080","doi-asserted-by":"crossref","first-page":"416","DOI":"10.3945\/ajcn.2010.29370","article-title":"Consumption of omega-3 fatty acids and fish and risk of age-related hearing loss","volume":"92","author":"Gopinath","year":"2010","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0085","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1744-9987.2012.01142.x","article-title":"Italian Multicenter Study on Low-Density Lipoprotein Apheresis Working Group. Italian Multicenter Study on Low-Density Lipoprotein Apheresis Working Group 2009 survey","volume":"17","author":"Stefanutti","year":"2013","journal-title":"Ther Apher Dial"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0090","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1001\/archotol.1993.01880140038006","article-title":"The relation of hearing in the elderly to the presence of cardiovascular disease and cardiovascular risk factors","volume":"119","author":"Gates","year":"1993","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0095","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1177\/000348947208100307","article-title":"Vascular changes in the human inner ear associated with aging","volume":"81","author":"Johnsson","year":"1972","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0100","doi-asserted-by":"crossref","first-page":"ORL322","DOI":"10.1177\/019459987808600225","article-title":"Arteriolar sclerosis as a cause of presbycusis","volume":"86","author":"Makishima","year":"1978","journal-title":"Otolaryngology"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0105","first-page":"1052","article-title":"Hearing loss and coronary heart disease","volume":"41","author":"Rosen","year":"1965","journal-title":"Bull N Y Acad Med"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0110","doi-asserted-by":"crossref","first-page":"800","DOI":"10.3109\/14992027.2012.705904","article-title":"Sudden sensorineural hearing loss: a vascular cause? Analysis of prothrombotic risk factors in head and neck","volume":"51","author":"Fusconi","year":"2012","journal-title":"Int J Audiol"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0115","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1288\/00005537-197410000-00012","article-title":"Atrophy of the stria vascularis, a common cause for hearing loss","volume":"84","author":"Schuknecht","year":"1974","journal-title":"Laryngoscope"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0120","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1002\/ar.22575","article-title":"Early development of the vertebrate inner ear","volume":"295","author":"Magarinos","year":"2012","journal-title":"Anat Rec (Hoboken)"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0125","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/0378-5955(94)00161-I","article-title":"Alterations in microvasculature are associated with atrophy of the stria vascularis in quiet-aged gerbils","volume":"82","author":"Gratton","year":"1995","journal-title":"Hear Res"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0130","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1001\/archotol.1990.01870080054015","article-title":"Cochlear microcirculation in young and old gerbils","volume":"116","author":"Prazma","year":"1990","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0135","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.1007\/s00018-006-6249-6","article-title":"Betaine homocysteine S-methyltransferase: just a regulator of homocysteine metabolism?","volume":"63","author":"Pajares","year":"2006","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0140","first-page":"473","article-title":"Plasma homocysteine, a risk factor for vascular disease: plasma levels in health, disease, and drug therapy","volume":"114","author":"Ueland","year":"1989","journal-title":"J Lab Clin Med"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0145","doi-asserted-by":"crossref","first-page":"355","DOI":"10.3390\/nu2030355","article-title":"Omega-3 fatty acids and inflammatory processes","volume":"2","author":"Calder","year":"2010","journal-title":"Nutrients"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0150","first-page":"469","article-title":"Marine omega-3 fatty acids and inflammatory processes: effects, mechanisms and clinical relevance","volume":"2015","author":"Calder","year":"1851","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0155","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1067\/mlc.2003.3","article-title":"Effect of fish oil on LDL oxidation and plasma homocysteine concentrations in health","volume":"141","author":"Piolot","year":"2003","journal-title":"J Lab Clin Med"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0160","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.nut.2010.12.011","article-title":"High consumption of Omega-3 polyunsaturated fatty acids decrease plasma homocysteine: a meta-analysis of randomized, placebo-controlled trials","volume":"27","author":"Huang","year":"2011","journal-title":"Nutrition"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0165","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.ntt.2008.09.001","article-title":"Abnormal neurological responses in young adult offspring caused by excess omega-3 fatty acid (fish oil) consumption by the mother during pregnancy and lactation","volume":"31","author":"Church","year":"2009","journal-title":"Neurotoxicol Teratol"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0170","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ntt.2009.09.006","article-title":"Excess omega-3 fatty acid consumption by mothers during pregnancy and lactation caused shorter life span and abnormal ABRs in old adult offspring","volume":"32","author":"Church","year":"2010","journal-title":"Neurotoxicol Teratol"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0175","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ntt.2006.10.009","article-title":"Reduced auditory acuity in rat pups from excess and deficient omega-3 fatty acid consumption by the mother","volume":"29","author":"Church","year":"2007","journal-title":"Neurotoxicol Teratol"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0180","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/931626","article-title":"Effect of polyunsaturated fatty acids on homocysteine metabolism through regulating the gene expressions involved in methionine metabolism","author":"Huang","year":"2013","journal-title":"ScientificWorldJournal"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0185","doi-asserted-by":"crossref","first-page":"e17706","DOI":"10.1371\/journal.pone.0017706","article-title":"Effects of altered maternal folic acid, vitamin B12 and docosahexaenoic acid on placental global DNA methylation patterns in Wistar rats","volume":"6","author":"Kulkarni","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0190","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0378-5955(03)00365-4","article-title":"Age-related hearing loss and the ahl locus in mice","volume":"188","author":"Keithley","year":"2004","journal-title":"Hear Res"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0195","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s10162-007-0098-3","article-title":"Age-related hearing loss in C57BL\/6J mice has both frequency-specific and non-frequency-specific components that produce a hyperacusis-like exaggeration of the acoustic startle reflex","volume":"8","author":"Ison","year":"2007","journal-title":"J Assoc Res Otolaryngol"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0200","series-title":"Nutrient requirements of laboratory animals, Fourth revised edition","article-title":"C o A N, Board on Agriculture, National Research Council. Nutrient requirements of the laboratory mouse","author":"Subcommittee on Laboratory Animal Nutrition","year":"1995"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0205","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1111\/j.1460-9568.2005.04584.x","article-title":"Sensorineural hearing loss in insulin-like growth factor I-null mice: a new model of human deafness","volume":"23","author":"Cediel","year":"2006","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0210","doi-asserted-by":"crossref","first-page":"260","DOI":"10.2119\/molmed.2011.00328","article-title":"Insulin receptor substrate 2 (IRS2)-deficient mice show sensorineural hearing loss that is delayed by concomitant protein tyrosine phosphatase 1B (PTP1B) loss of function","volume":"18","author":"Murillo-Cuesta","year":"2012","journal-title":"Mol Med"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0215","doi-asserted-by":"crossref","DOI":"10.1002\/0471142301.ns0821cs34","article-title":"Assessment of cochlear function in mice: distortion-product otoacoustic emissions","author":"Martin","year":"2006","journal-title":"Curr Protoc Neurosci"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0220","doi-asserted-by":"crossref","first-page":"184","DOI":"10.3766\/jaaa.15.3.2","article-title":"Human frequency-following response correlates of the distortion product at 2F1-F2","volume":"15","author":"Pandya","year":"2004","journal-title":"J Am Acad Audiol"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0225","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1093\/jn\/111.3.442","article-title":"Properties of folic acid gamma-glutamyl hydrolase (conjugase) in rat bile and plasma","volume":"111","author":"Horne","year":"1981","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0230","series-title":"Folic acid metabolism in health and disease","first-page":"121","article-title":"Microbiological assays of folates","author":"Tamura","year":"1990"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0235","doi-asserted-by":"crossref","first-page":"e87536","DOI":"10.1371\/journal.pone.0087536","article-title":"Treatment with N- and C-terminal peptides of parathyroid hormone-related protein partly compensate the skeletal abnormalities in IGF-I deficient mice","volume":"9","author":"Rodriguez-de la Rosa","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0240","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1007\/s00018-008-8201-4","article-title":"Early effects of copper accumulation on methionine metabolism","volume":"65","author":"Delgado","year":"2008","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0245","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1096\/fj.14-259283","article-title":"Folic acid deficiency induces premature hearing loss through mechanisms involving cochlear oxidative stress and impairment of homocysteine metabolism","volume":"29","author":"Martinez-Vega","year":"2015","journal-title":"FASEB J"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0250","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0255","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0265","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1002\/path.2102","article-title":"Ageing and hearing loss","volume":"211","author":"Liu","year":"2007","journal-title":"J Pathol"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0270","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1136\/pgmj.2005.039388","article-title":"Ageing and the auditory system","volume":"82","author":"Howarth","year":"2006","journal-title":"Postgrad Med J"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0275","first-page":"7","article-title":"A comparative study of age-related hearing loss in wild type and insulin-like growth factor I deficient mice","volume":"4","author":"Riquelme","year":"2010","journal-title":"Front Neuroanat"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0280","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3389\/fnmol.2011.00011","article-title":"The role of insulin-like growth factor-I in the physiopathology of hearing","volume":"4","author":"Murillo-Cuesta","year":"2011","journal-title":"Front Mol Neurosci"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0285","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jnutbio.2006.02.005","article-title":"Different ratios of eicosapentaenoic and docosahexaenoic omega-3 fatty acids in commercial fish oils differentially alter pro-inflammatory cytokines in peritoneal macrophages from C57BL\/6 female mice","volume":"8","author":"Bhattacharya","year":"2007","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0290","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1089\/ars.2011.4037","article-title":"Oxidative stress, inflammation, and autophagic stress as the key mechanisms of premature age-related hearing loss in SAMP8 mouse Cochlea","volume":"16","author":"Menardo","year":"2012","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0295","first-page":"134","article-title":"Continuous subcutaneous infusions of growth hormone (GH) releasing hormone 1\u201344 for 14 days increase GH and insulin-like growth factor-I levels in old men","volume":"76","author":"Corpas","year":"1993","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0300","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1097\/00003246-200007000-00031","article-title":"Decreased serum insulin-like growth factor-I in burn patients: relationship with serum insulin-like growth factor binding protein-3 proteolysis and the influence of lipid composition in nutritional support","volume":"28","author":"Abribat","year":"2000","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0305","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.plefa.2010.02.008","article-title":"Dietary fatty acids and arthritis","volume":"82","author":"Hurst","year":"2010","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0310","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1530\/JOE-11-0170","article-title":"Comparison of the effects of the n-3 polyunsaturated fatty acid eicosapentaenoic and fenofibrate on the inhibitory effect of arthritis on IGF1","volume":"210","author":"Castillero","year":"2011","journal-title":"J Endocrinol"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0315","doi-asserted-by":"crossref","first-page":"7630","DOI":"10.1523\/JNEUROSCI.21-19-07630.2001","article-title":"Delayed inner ear maturation and neuronal loss in postnatal Igf-1-deficient mice","volume":"21","author":"Camarero","year":"2001","journal-title":"J Neurosci"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0320","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/S0378-5955(02)00447-1","article-title":"Cochlear abnormalities in insulin-like growth factor-1 mouse mutants","volume":"70","author":"Camarero","year":"2002","journal-title":"Hear Res"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0325","doi-asserted-by":"crossref","first-page":"e58775","DOI":"10.1371\/journal.pone.0058775","article-title":"Time courses of changes in phospho- and total- MAP kinases in the cochlea after intense noise exposure","volume":"8","author":"Maeda","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0330","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.heares.2009.04.019","article-title":"Activation of cell death pathways in the inner ear of the aging CBA\/J mouse","volume":"254","author":"Sha","year":"2009","journal-title":"Hear Res"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0335","first-page":"7","article-title":"Swept-sine noise-induced damage as a hearing loss model for preclinical assays","volume":"7","author":"Sanz","year":"2015","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0340","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1177\/0148607103027003176","article-title":"Inhibition of activator protein-1 transcription factor activation by omega-3 fatty acid modulation of mitogen-activated protein kinase signaling kinases","volume":"27","author":"Babcock","year":"2003","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0345","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.bbrc.2014.04.118","article-title":"Alpha-lipoic acid protects against cisplatin-induced ototoxicity via the regulation of MAPKs and proinflammatory cytokines","volume":"449","author":"Kim","year":"2014","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0350","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.3945\/jn.110.122010","article-title":"Serum homocysteine and folate concentrations are associated with prevalent age-related hearing loss","volume":"140","author":"Gopinath","year":"2010","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0355","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1111\/jnc.12102","article-title":"Novel crosstalk between ERK MAPK and p38 MAPK leads to homocysteine-NMDA receptor-mediated neuronal cell death","volume":"124","author":"Poddar","year":"2013","journal-title":"J Neurochem"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0360","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3389\/fnagi.2015.00058","article-title":"Mechanisms of sensorineural cell damage, death and survival in the cochlea","volume":"7","author":"Wong","year":"2015","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0365","first-page":"32","article-title":"Transforming growth factor beta1 inhibition protects from noise-induced hearing loss","volume":"7","author":"Murillo-Cuesta","year":"2015","journal-title":"Front AgingNeurosci"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0370","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3389\/fnagi.2015.00008","article-title":"Cochlear injury and adaptive plasticity of the auditory cortex","volume":"7","author":"Fetoni","year":"2015","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0375","doi-asserted-by":"crossref","first-page":"86","DOI":"10.3389\/fnagi.2015.00086","article-title":"Synergistic effects of free radical scavengers and cochlear vasodilators: a new otoprotective strategy for age-related hearing loss","volume":"7","author":"Alvarado","year":"2015","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0380","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1089\/ars.2013.5342","article-title":"Acute liver injury induces nucleocytoplasmic redistribution of hepatic methionine metabolism enzymes","volume":"20","author":"Delgado","year":"2014","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0385","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/nure.12050","article-title":"(2013) Nutritional essentiality of sulfur in health and disease","volume":"71","author":"Ingenbleek","year":"2013","journal-title":"Nutr Rev"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0390","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1146\/annurev-nutr-071813-105654","article-title":"Sulfur as a signaling nutrient through hydrogen sulfide","volume":"34","author":"Kabil","year":"2014","journal-title":"Annu Rev Nutr"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0395","first-page":"1355","article-title":"H2S and its role in redox signaling","volume":"2014","author":"Kabil","year":"1844","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0400","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.neuroscience.2014.03.020","article-title":"Therapeutic effect of sildenafil on blast-induced tinnitus and auditory impairment","volume":"69","author":"Mahmood","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0405","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0378-5955(97)00186-X","article-title":"The effect of prednisolone and non-steroidal anti-inflammatory agents on the normal and noise-damaged guinea pig inner ear","volume":"115","author":"Lamm","year":"1998","journal-title":"Hear Res"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0410","doi-asserted-by":"crossref","first-page":"2598","DOI":"10.1002\/jnr.22421","article-title":"Role of adenosine kinase in cochlear development and response to noise","volume":"88","author":"Vlajkovic","year":"2010","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0415","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.nut.2009.05.015","article-title":"Docosahexaenoic acid decreases plasma homocysteine via regulating enzyme activity and mRNA expression involved in methionine metabolism","volume":"26","author":"Huang","year":"2010","journal-title":"Nutrition"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0420","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1475-2891-11-6","article-title":"Effect of n-3 polyunsaturated fatty acid on gene expression of the critical enzymes involved in homocysteine metabolism","volume":"11","author":"Huang","year":"2012","journal-title":"Nutr J"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0425","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s10545-010-9088-4","article-title":"Choline and betaine in health and disease","volume":"34","author":"Ueland","year":"2011","journal-title":"J Inherit Metab Dis"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0430","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1743-7075-11-6","article-title":"Novel regulatory roles of omega-3 fatty acids in metabolic pathways: a proteomics approach","volume":"11","author":"Ahmed","year":"2014","journal-title":"Nutr Metab"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0435","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/ajcn\/85.1.19","article-title":"Methyl balance and transmethylation fluxes in humans","volume":"85","author":"Mudd","year":"2007","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jnutbio.2015.07.011_bb0440","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/1476-511X-13-82","article-title":"Phospholipids from herring roe improve plasma lipids and glucose tolerance in healthy, young adults","volume":"13","author":"Bjorndal","year":"2014","journal-title":"Lipids Health Dis"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286315001758?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286315001758?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T15:18:40Z","timestamp":1760627920000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286315001758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":87,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["S0955286315001758"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2015.07.011","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long-term omega-3 fatty acid supplementation prevents expression changes in cochlear homocysteine metabolism and ameliorates progressive hearing loss in C57BL\/6J mice","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2015.07.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}