{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T05:57:10Z","timestamp":1789192630956,"version":"build-2803163510"},"reference-count":33,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.jnutbio.2015.07.020","type":"journal-article","created":{"date-parts":[[2015,8,8]],"date-time":"2015-08-08T21:03:08Z","timestamp":1439067788000},"page":"1502-1508","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"title":["Folic acid deficiency enhances abeta accumulation in APP\/PS1 mice brain and decreases amyloid-associated miRNAs expression"],"prefix":"10.1016","volume":"26","author":[{"given":"Huan","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanchun","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xumei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxia","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guowei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2015.07.020_bb0005","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.2147\/NDT.S3016","article-title":"An update on the toxicity of Abeta in Alzheimer's disease","volume":"4","author":"Gotz","year":"2008","journal-title":"Neuropsychiatr Dis Treat"},{"key":"10.1016\/j.jnutbio.2015.07.020_bb0010","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3233\/JAD-2008-14103","article-title":"Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways","volume":"14","author":"Cogswell","year":"2008","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.jnutbio.2015.07.020_bb0015","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1750-1326-3-10","article-title":"MicroRNAs can regulate human APP levels","volume":"3","author":"Patel","year":"2008","journal-title":"Mol Neurodegener"},{"key":"10.1016\/j.jnutbio.2015.07.020_bb0020","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.brainres.2014.04.026","article-title":"MicroRNA-135a and -200b, potential biomarkers for Alzheimer's disease, regulate \u03b2 secretase and amyloid precursor protein","volume":"1583","author":"Liu","year":"2014","journal-title":"Brain Res"},{"key":"10.1016\/j.jnutbio.2015.07.020_bb0025","doi-asserted-by":"crossref","first-page":"5184","DOI":"10.1074\/jbc.M113.518241","article-title":"MicroRNA-339-5p down-regulates protein expression of \u03b2-site amyloid precursor protein-cleaving enzyme 1 (BACE1) in human primary brain cultures and is reduced in brain tissue specimens of Alzheimer disease subjects","volume":"289","author":"Long","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jnutbio.2015.07.020_bb0030","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.brainresbull.2012.05.018","article-title":"MicroRNA-195 downregulates Alzheimer's disease amyloid-\u03b2 production by targeting BACE1","volume":"88","author":"Zhu","year":"2012","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.jnutbio.2015.07.020_bb0035","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.toxlet.2011.11.032","article-title":"The miR-124 regulates the expression of BACE1\/\u03b2-secretase correlated with cell death in Alzheimer's disease","volume":"209","author":"Fang","year":"2012","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.jnutbio.2015.07.020_bb0040","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.brainres.2011.04.035","article-title":"miR-29c regulates BACE1 protein expression","volume":"1395","author":"Zong","year":"2011","journal-title":"Brain Res"},{"key":"10.1016\/j.jnutbio.2015.07.020_bb0045","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1523\/JNEUROSCI.5065-07.2008","article-title":"The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1","volume":"28","author":"Wang","year":"2008","journal-title":"J Neurosci"},{"key":"10.1016\/j.jnutbio.2015.07.020_bb0050","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.3945\/jn.109.113670","article-title":"One-carbon metabolism-genome interactions in folate-associated pathologies","volume":"139","author":"Stover","year":"2009","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2015.07.020_bb0055","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1159\/000326301","article-title":"Folate and homocysteine in the cerebrospinal fluid of patients with Alzheimer's disease or dementia: a case control study","volume":"65","author":"Smach","year":"2011","journal-title":"Eur Neurol"},{"key":"10.1016\/j.jnutbio.2015.07.020_bb0060","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.3945\/jn.108.093641","article-title":"Cognitive impairment in folate-deficient rats corresponds to depleted brain phosphatidylcholine and is prevented by dietary methionine without lowering plasma homocysteine","volume":"138","author":"Troen","year":"2008","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2015.07.020_bb0065","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.exger.2009.12.005","article-title":"Acceleration of brain amyloidosis in an Alzheimer's disease mouse model by a folate, vitamin B6 and B12-deficient diet","volume":"45","author":"Zhuo","year":"2010","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.jnutbio.2015.07.020_bb0070","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.mcn.2007.12.018","article-title":"B-vitamin deprivation induces hyperhomocysteinemia and brain S-adenosylhomocysteine, depletes brain S-adenosylmethionine, and enhances PS1 and BACE expression and amyloid-beta deposition in mice","volume":"37","author":"Fuso","year":"2008","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.jnutbio.2015.07.020_bb0075","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1002\/jcb.20982","article-title":"Downregulation of miR-122 in the rodent and human hepatocellular carcinomas","volume":"99","author":"Kutay","year":"2006","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.jnutbio.2015.07.020_bb0080","first-page":"321","article-title":"From mild cognitive impairment to Alzheimer's disease \u2014 influence of homocysteine, vitamin B12 and folate on cognition over time: results from one-year follow-up","volume":"43","author":"Siuda","year":"2009","journal-title":"Neurol Neurochir Pol"},{"key":"10.1016\/j.jnutbio.2015.07.020_bb0085","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1093\/ajcn\/80.1.114","article-title":"Homocysteine, folate, and vitamin B-12 in mild cognitive impairment, Alzheimer disease, and vascular dementia","volume":"80","author":"Quadri","year":"2004","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jnutbio.2015.07.020_bb0090","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.nbd.2014.08.004","article-title":"Folate deficiency-induced oxidative stress contributes to neuropathy in young and aged zebrafish \u2014 implication in neural tube defects and Alzheimer's diseases","volume":"71","author":"Kao","year":"2014","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.jnutbio.2015.07.020_bb0095","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1523\/JNEUROSCI.22-05-01752.2002","article-title":"Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease","volume":"22","author":"Kruman","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.jnutbio.2015.07.020_bb0100","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1038\/jcbfm.2011.13","article-title":"Cerebral perfusion and oxygenation are impaired by folate deficiency in rat: absolute measurements with noninvasive near-infrared spectroscopy","volume":"31","author":"Hallacoglu","year":"2011","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.jnutbio.2015.07.020_bb0105","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.neurobiolaging.2009.02.013","article-title":"Changes in Presenilin 1 gene methylation pattern in diet-induced B vitamin deficiency","volume":"32","author":"Fuso","year":"2011","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.jnutbio.2015.07.020_bb0110","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jnutbio.2010.01.010","article-title":"DNA methylase and demethylase activities are modulated by one-carbon metabolism in Alzheimer's disease models","volume":"22","author":"Fuso","year":"2011","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jnutbio.2015.07.020_bb0115","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.jnutbio.2015.03.009","article-title":"Folic acid administration inhibits amyloid \u03b2-peptide accumulation in APP\/PS1 transgenic mice","volume":"26","author":"Li","year":"2015","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jnutbio.2015.07.020_bb0120","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s12603-014-0514-4","article-title":"Folic acid inhibits tau phosphorylation through regulation of PP2A methylation in SH-SY5Y cells","volume":"19","author":"Li","year":"2015","journal-title":"J Nutr Health Aging"},{"key":"10.1016\/j.jnutbio.2015.07.020_bb0125","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1126\/science.8191290","article-title":"An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants","volume":"264","author":"Suzuki","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.jnutbio.2015.07.020_bb0130","doi-asserted-by":"crossref","first-page":"6316","DOI":"10.1021\/ja8092604","article-title":"Amyloid beta protein: Abeta40 inhibits Abeta42 oligomerization","volume":"131","author":"Murray","year":"2009","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.jnutbio.2015.07.020_bb0135","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1096\/fasebj.27.1_supplement.1077.8","article-title":"Folate deficiency accelerates Alzheimers disease related pathology in APP\/PS1 mice","volume":"27","author":"Crivello","year":"2013","journal-title":"FASEB J"},{"key":"10.1016\/j.jnutbio.2015.07.020_bb0140","doi-asserted-by":"crossref","first-page":"e101725","DOI":"10.1371\/journal.pone.0101725","article-title":"Genome-wide analysis of miRNA signature in the APPswe\/PS1\u0394E9 mouse model of alzheimer's disease","volume":"9","author":"Luo","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jnutbio.2015.07.020_bb0150","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1159\/000080982","article-title":"BACE1 and presenilin: two unusual aspartyl proteases involved in Alzheimer's disease","volume":"1","author":"Dominguez","year":"2004","journal-title":"Neurodegener Dis"},{"key":"10.1016\/j.jnutbio.2015.07.020_bb0155","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1001\/archneur.59.9.1381","article-title":"Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease","volume":"59","author":"Fukumoto","year":"2002","journal-title":"Arch Neurol"},{"key":"10.1016\/j.jnutbio.2015.07.020_bb0160","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1002\/ana.10208","article-title":"Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease","volume":"51","author":"Holsinger","year":"2002","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jnutbio.2015.07.020_bb0165","doi-asserted-by":"crossref","first-page":"3632","DOI":"10.1073\/pnas.0205689101","article-title":"Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients","volume":"101","author":"Li","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jnutbio.2015.07.020_bb9000","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ejphar.2011.11.039","article-title":"Ginsenoside Rg1 attenuates \u03b2-amyloid generation via suppressing PPAR\u03b3-regulated BACE1 activity in N2a-APP695 cells","volume":"675","author":"Chen","year":"2012","journal-title":"Eur J Pharmacol."}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286315001874?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286315001874?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T15:16:41Z","timestamp":1760627801000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286315001874"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":33,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["S0955286315001874"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2015.07.020","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Folic acid deficiency enhances abeta accumulation in APP\/PS1 mice brain and decreases amyloid-associated miRNAs expression","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2015.07.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}