{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:56:06Z","timestamp":1790369766071,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.jnutbio.2016.11.012","type":"journal-article","created":{"date-parts":[[2016,11,27]],"date-time":"2016-11-27T04:45:16Z","timestamp":1480221916000},"page":"201-208","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"special_numbering":"C","title":["Soy protein concentrate mitigates markers of colonic inflammation and loss of gut barrier function in vitro and in vivo"],"prefix":"10.1016","volume":"40","author":[{"given":"Zachary T.","family":"Bitzer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy L.","family":"Wopperer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin J.","family":"Chrisfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy K.","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jairam","family":"Vanamala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan J.","family":"Elias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E.","family":"Hayes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua D.","family":"Lambert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2016.11.012_bb0005","doi-asserted-by":"crossref","first-page":"G7","DOI":"10.1152\/ajpgi.00079.2004","article-title":"Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation","volume":"287","author":"Itzkowitz","year":"2004","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jnutbio.2016.11.012_bb0010","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1185\/030079908X260790","article-title":"The costs of Crohn's disease in the United States and other western countries: a systematic review","volume":"24","author":"Yu","year":"2008","journal-title":"Curr Med Res Opin"},{"key":"10.1016\/j.jnutbio.2016.11.012_bb0015","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1111\/j.1365-2036.2010.04234.x","article-title":"Systematic review: the costs of ulcerative colitis in western countries","volume":"31","author":"Cohen","year":"2010","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.jnutbio.2016.11.012_bb0020","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.bbrc.2008.08.140","article-title":"Oxidative stress induces gastric epithelial permeability through claudin-3","volume":"376","author":"Hashimoto","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jnutbio.2016.11.012_bb0025","doi-asserted-by":"crossref","DOI":"10.1097\/MIB.0000000000000151","article-title":"Emerging significance of NLRs in inflammatory bowel disease","author":"Davis","year":"2014","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.jnutbio.2016.11.012_bb0030","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/ni0210-105","article-title":"NLRP3 has a sweet tooth","volume":"11","author":"Davis","year":"2010","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jnutbio.2016.11.012_bb0035","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.cell.2010.01.040","article-title":"The Inflammasomes","volume":"140","author":"Schroder","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.jnutbio.2016.11.012_bb0040","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1016\/S0002-9440(10)63051-9","article-title":"Neutrophil transmigration in inflammatory bowel disease is associated with differential expression of epithelial intercellular junction proteins","volume":"159","author":"Kucharzik","year":"2001","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jnutbio.2016.11.012_bb0045","doi-asserted-by":"crossref","first-page":"6164","DOI":"10.4049\/jimmunol.171.11.6164","article-title":"Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms","volume":"171","author":"Bruewer","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.jnutbio.2016.11.012_bb0050","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/j.1753-4887.2009.00213.x","article-title":"The effect of genistein aglycone on cancer and cancer risk: a review of in vitro, preclinical, and clinical studies","volume":"67","author":"Taylor","year":"2009","journal-title":"Nutr Rev"},{"key":"10.1016\/j.jnutbio.2016.11.012_bb0055","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1093\/jjco\/hyt203","article-title":"Soy intake and breast cancer risk: an evaluation based on a systematic review of epidemiologic evidence among the Japanese population","volume":"44","author":"Nagata","year":"2014","journal-title":"Jpn J Clin Oncol"},{"key":"10.1016\/j.jnutbio.2016.11.012_bb0060","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1080\/01635581.2013.795983","article-title":"Soy food consumption and lung cancer risk: a meta-analysis using a common measure across studies","volume":"65","author":"Wu","year":"2013","journal-title":"Nutr Cancer"},{"key":"10.1016\/j.jnutbio.2016.11.012_bb0065","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1258\/ebm.2009.009128","article-title":"Differential effects of whole soy extract and soy isoflavones on apoptosis in prostate cancer cells","volume":"235","author":"Hsu","year":"2010","journal-title":"Exp Biol Med (Maywood)"},{"key":"10.1016\/j.jnutbio.2016.11.012_bb0070","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s10549-009-0321-5","article-title":"Soy isoflavones and risk of cancer recurrence in a cohort of breast cancer survivors: the life after cancer epidemiology study","volume":"118","author":"Guha","year":"2009","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.jnutbio.2016.11.012_bb0075","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1158\/1055-9965.EPI-09-0856","article-title":"Soy consumption and colorectal cancer risk in humans: a meta-analysis","volume":"19","author":"Yan","year":"2010","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.jnutbio.2016.11.012_bb0080","doi-asserted-by":"crossref","first-page":"577","DOI":"10.3945\/ajcn.2008.26742","article-title":"Prospective cohort study of soy food intake and colorectal cancer risk in women","volume":"89","author":"Yang","year":"2009","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jnutbio.2016.11.012_bb0085","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1080\/01635589709514526","article-title":"Effect of soya bean saponins on azoxymethane-induced preneoplastic lesions in the colon of mice","volume":"27","author":"Koratkar","year":"1997","journal-title":"Nutr Cancer"},{"key":"10.1016\/j.jnutbio.2016.11.012_bb0090","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1093\/carcin\/bgn182","article-title":"Effect of genistein on the bioavailability and intestinal cancer chemopreventive activity of (\u2212)-epigallocatechin-3-gallate","volume":"29","author":"Lambert","year":"2008","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.jnutbio.2016.11.012_bb0095","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1080\/10408390701425615","article-title":"Antioxidant activity of proteins and peptides","volume":"48","author":"Elias","year":"2008","journal-title":"Crit Rev Food Sci Nutr"},{"key":"10.1016\/j.jnutbio.2016.11.012_bb0100","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s11130-010-0185-1","article-title":"Antioxidant capacity of alcalase hydrolysates and protein profiles of two conventional and seven low glycinin soybean cultivars","volume":"65","author":"Darmawan","year":"2010","journal-title":"Plant Foods Hum Nutr"},{"key":"10.1016\/j.jnutbio.2016.11.012_bb0105","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1016\/j.peptides.2009.08.005","article-title":"Lunasin and lunasin-like peptides inhibit inflammation through suppression of NF-[kappa]B pathway in the macrophage","volume":"30","author":"de Mejia","year":"2009","journal-title":"Peptides"},{"key":"10.1016\/j.jnutbio.2016.11.012_bb0110","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.bbrc.2009.10.053","article-title":"Antioxidant and anti-inflammatory properties of cancer preventive peptide lunasin in RAW 264.7 macrophages","volume":"390","author":"Hernandez-Ledesma","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jnutbio.2016.11.012_bb0115","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.3945\/jn.110.137414","article-title":"Soy protein diet, but not lactobacillus rhamnosus GG, decreases mucin-1, trefoil factor-3, and tumor necrosis factor-alpha in colon of dextran sodium sulfate-treated C57BL\/6 mice","volume":"141","author":"Jiang","year":"2011","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2016.11.012_bb0120","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3945\/jn.111.149104","article-title":"Soy-derived di- and tripeptides alleviate Colon and Ileum inflammation in pigs with dextran sodium sulfate-induced colitis","volume":"142","author":"Young","year":"2012","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2016.11.012_bb0125","first-page":"1753","article-title":"The PepT1-transportable soy tripeptide VPY reduces intestinal inflammation","volume":"2012","author":"Kovacs-Nolan","year":"1820","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jnutbio.2016.11.012_bb0130","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1158\/1940-6207.CAPR-08-0099","article-title":"A gamma-tocopherol-rich mixture of tocopherols inhibits colon inflammation and carcinogenesis in azoxymethane and dextran sulfate sodium-treated mice","volume":"2","author":"Ju","year":"2009","journal-title":"Cancer Prev Res (Phila)"},{"key":"10.1016\/j.jnutbio.2016.11.012_bb0135","doi-asserted-by":"crossref","first-page":"4558","DOI":"10.1021\/jf035346i","article-title":"Role of continuous phase protein on the oxidative stability of fish oil-in-water emulsions","volume":"52","author":"Faraji","year":"2004","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.jnutbio.2016.11.012_bb0140","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","article-title":"Tissue sulfhydryl groups","volume":"82","author":"Ellman","year":"1959","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.jnutbio.2016.11.012_bb0145","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/S0887-2333(03)00095-X","article-title":"Permeability characteristics of parental and clonal human intestinal Caco-2 cell lines differentiated in serum-supplemented and serum-free media","volume":"17","author":"Ranaldi","year":"2003","journal-title":"Toxicol In Vitro"},{"key":"10.1016\/j.jnutbio.2016.11.012_bb0150","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1471-230X-12-57","article-title":"Protective role of 1,25(OH)2vitamin D3 in the mucosal injury and epithelial barrier disruption in DSS-induced acute colitis in mice","volume":"12","author":"Zhao","year":"2012","journal-title":"BMC Gastroenterol"},{"key":"10.1016\/j.jnutbio.2016.11.012_bb0155","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1136\/gut.2008.165886","article-title":"Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability","volume":"58","author":"Cani","year":"2009","journal-title":"Gut"},{"key":"10.1016\/j.jnutbio.2016.11.012_bb0160","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1136\/gutjnl-2012-303280","article-title":"Glucagon-like peptide-1 as a treatment for chemotherapy-induced mucositis","volume":"62","author":"Kissow","year":"2013","journal-title":"Gut"},{"key":"10.1016\/j.jnutbio.2016.11.012_bb0165","doi-asserted-by":"crossref","first-page":"2802","DOI":"10.1007\/s10620-011-1688-9","article-title":"Increase in the tight junction protein claudin-1 in intestinal inflammation","volume":"56","author":"Poritz","year":"2011","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.jnutbio.2016.11.012_bb0170","doi-asserted-by":"crossref","first-page":"3340","DOI":"10.4049\/jimmunol.161.7.3340","article-title":"Generation of biologically active IL-1\u03b2 by matrix metalloproteinases: a novel caspase-1-independent pathway of IL-1\u03b2 processing","volume":"161","author":"Sch\u00f6nbeck","year":"1998","journal-title":"J Immunol"},{"key":"10.1016\/j.jnutbio.2016.11.012_bb0175","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3389\/fphys.2013.00050","article-title":"TXNIP shuttling: missing link between oxidative stress and inflammasome activation","volume":"4","author":"Lane","year":"2013","journal-title":"Front Physiol"},{"key":"10.1016\/j.jnutbio.2016.11.012_bb0180","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.febslet.2012.02.045","article-title":"TLR-induced NF-kappaB activation regulates NLRP3 expression in murine macrophages","volume":"586","author":"Qiao","year":"2012","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jnutbio.2016.11.012_bb0185","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1111\/cei.12136","article-title":"Expression of toll-like receptor-3 is enhanced in active inflammatory bowel disease and mediates the excessive release of lipocalin 2","volume":"173","author":"\u00d8stvik","year":"2013","journal-title":"Clin Exper Immunol"},{"key":"10.1016\/j.jnutbio.2016.11.012_bb0190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vetimm.2014.03.003","article-title":"Expression profiling of pattern recognition receptors and selected cytokines in miniature dachshunds with inflammatory colorectal polyps","volume":"159","author":"Igarashi","year":"2014","journal-title":"Vet Immunol Immunopathol"},{"key":"10.1016\/j.jnutbio.2016.11.012_bb0195","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1053\/j.gastro.2008.06.064","article-title":"Guardians of the gut: newly appreciated role of epithelial toll-like receptors in protecting the intestine","volume":"135","author":"Vijay-Kumar","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jnutbio.2016.11.012_bb0200","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.taap.2014.10.002","article-title":"Suppression of NF-kappaB signaling and NLRP3 inflammasome activation in macrophages is responsible for the amelioration of experimental murine colitis by the natural compound fraxinellone","volume":"281","author":"Wu","year":"2014","journal-title":"Toxicol Appl Pharmacol"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286316307537?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286316307537?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T15:22:33Z","timestamp":1760628153000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286316307537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":40,"alternative-id":["S0955286316307537"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2016.11.012","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Soy protein concentrate mitigates markers of colonic inflammation and loss of gut barrier function in vitro and in vivo","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2016.11.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}