{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T14:37:25Z","timestamp":1781879845564,"version":"3.54.5"},"reference-count":76,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Coordenadoria de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior (CAPES)"},{"DOI":"10.13039\/501100003711","name":"S\u00e3o Paulo Research Foundation under grant agreements","doi-asserted-by":"publisher","award":["2010\/15014-9 and 2015\/09034-0"],"award-info":[{"award-number":["2010\/15014-9 and 2015\/09034-0"]}],"id":[{"id":"10.13039\/501100003711","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Financiadora de Estudos e Projetos-Apoio \u00e0 Infraestrutura (FINEP CT-INFRA)"},{"name":"Minist\u00e9rio da Ci\u00eancia, Tecnologia e Inova\u00e7\u00e3o (MCTI)"},{"name":"Secretaria da Ci\u00eancia, Tecnologia e Ensino Superior (SETI)"},{"name":"Departamento de Ci\u00eancia e Tecnologia \u2013 Minist\u00e9rio da Sa\u00fade (DECIT\/MS)"},{"name":"(CNPq), Funda\u00e7\u00e3o Arauc\u00e1ria, Secretaria de Sa\u00fade do Estado do Paran\u00e1 (SESA)"},{"name":"Governo do Estado do Paran\u00e1 (Brazil)"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.jnutbio.2017.10.010","type":"journal-article","created":{"date-parts":[[2017,11,5]],"date-time":"2017-11-05T02:46:00Z","timestamp":1509849960000},"page":"81-95","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":75,"special_numbering":"C","title":["The flavonoid quercetin inhibits titanium dioxide (TiO2)-induced chronic arthritis in mice"],"prefix":"10.1016","volume":"53","author":[{"given":"Sergio M.","family":"Borghi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra S.","family":"Mizokami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe A.","family":"Pinho-Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Fattori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jefferson","family":"Crespigio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana T.","family":"Clemente-Napimoga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo H.","family":"Napimoga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrius L.","family":"Pitol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o P.M.","family":"Issa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra Y.","family":"Fukada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rubia","family":"Casagrande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Waldiceu A.","family":"Verri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2017.10.010_bb0005","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/nrrheum.2011.128","article-title":"Mediators of the inflammatory response to joint replacement devices","volume":"7","author":"Cobelli","year":"2011","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0010","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s00264-007-0364-3","article-title":"Total hip arthroplasties: what are the reasons for revision?","volume":"32","author":"Ulrich","year":"2008","journal-title":"Int Orthop"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0015","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1016\/j.bmc.2015.05.010","article-title":"Anti-arthritic agents: progress and potential","volume":"23","author":"Laev","year":"2015","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0020","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0142-9612(01)00134-X","article-title":"Inflammatory responses to orthopaedic biomaterials in the murine air pouch","volume":"23","author":"Wooley","year":"2002","journal-title":"Biomaterials"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0025","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1002\/jor.21149","article-title":"Periprosthetic osteolysis: characterizing the innate immune response to titanium wear-particles","volume":"28","author":"St. Pierre","year":"2010","journal-title":"J Orthop Res"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0030","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.biomaterials.2009.09.017","article-title":"Over-expression of receptor activator of nuclear factor-\u03baB ligand (RANKL), inflammatory cytokines, and chemokines in periprosthetic osteolysis of loosened total hip arthroplasty","volume":"31","author":"Wang","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0035","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.tox.2005.05.007","article-title":"Ultrafine titanium dioxide particles in the absence of photoactivation can induce oxidative damage to human bronchial epithelial cells","volume":"213","author":"Gurr","year":"2005","journal-title":"Toxicology"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0040","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/0046-8177(91)90130-H","article-title":"Identification of titanium in human tissues: probable role in pathologic processes","volume":"22","author":"Moran","year":"1991","journal-title":"Hum Pathol"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0045","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0014-5793(97)01356-2","article-title":"Chemical oxidation and DNA damage catalysed by inorganic sunscreen ingredients","volume":"418","author":"Dunford","year":"1997","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0050","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1002\/jat.1414","article-title":"In vivo acute toxicity of titanium dioxide nanoparticles to mice after intraperitoneal injection","volume":"29","author":"Chen","year":"2009","journal-title":"J Appl Toxicol"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0055","doi-asserted-by":"crossref","first-page":"4590","DOI":"10.1016\/j.biomaterials.2009.05.008","article-title":"TiO2 nanoparticles translocation and potential toxicological effect in rats after intraarticular injection","volume":"30","author":"Wang","year":"2009","journal-title":"Biomaterials"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0060","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1080\/15287394.2013.826567","article-title":"Biological response to nano-scale titanium dioxide (TiO2): role of particle dose, shape, and retention","volume":"76","author":"Silva","year":"2013","journal-title":"J Toxicol Environ Health A"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0065","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1743-8977-11-5","article-title":"Equivalent titanium dioxide nanoparticles deposition by intratracheal instillation and whole body inhalation: the effect of dose rate on acute respiratory tract inflammation","volume":"11","author":"Baisch","year":"2014","journal-title":"Part Fibre Toxicol"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0070","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/ncprheum0087","article-title":"Implant-related inflammatory arthritis","volume":"2","author":"D\u00f6rner","year":"2006","journal-title":"Nat Clin Pract Rheumatol"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0075","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/S0278-5846(03)00160-X","article-title":"Quercetin, a bioflavonoid, attenuates thermal hyperalgesia in a mouse model of diabetic neuropathic pain","volume":"27","author":"Anjaneyulu","year":"2003","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0080","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1111\/j.2042-7158.2012.01504.x","article-title":"Therapeutic properties of quercetin on monosodium urate crystal-induced inflammation in rats","volume":"64","author":"Huang","year":"2012","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0085","series-title":"In: Atta-ur-Rahman, editor. Studies in natural products chemistry","first-page":"297","author":"Verri","year":"2012"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0090","first-page":"933","article-title":"A review of flavonoid quercetin: metabolism, bioactivity and antioxidant properties","volume":"6","author":"Alrawaiq","year":"2014","journal-title":"Int J PharmTech Res"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0095","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1021\/np300670w","article-title":"Quercetin-loaded microcapsules ameliorate experimental colitis in mice by anti-inflammatory and antioxidant mechanism","volume":"76","author":"Guazelli","year":"2013","journal-title":"J Nat Prod"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0100","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1021\/np900259y","article-title":"Quercetin reduces inflammatory pain: inhibition of oxidative stress and cytokine production","volume":"72","author":"Val\u00e9rio","year":"2009","journal-title":"J Nat Prod"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0105","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.pbb.2006.05.008","article-title":"Hypernociception elicited by tibio-tarsal joint flexion in mice: a novel experimental arthritis model for pharmacological screening","volume":"84","author":"Guerrero","year":"2006","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0110","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1590\/1414-431x20144187","article-title":"The superoxide anion donor, potassium superoxide, induces pain and inflammation in mice through production of reactive oxygen species and cyclooxygenase-2","volume":"48","author":"Maioli","year":"2015","journal-title":"Braz J Med Biol Res"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0115","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1136\/ard.2009.122655","article-title":"IL-33 induces neutrophil migration in rheumatoid arthritis and is a target of anti-TNF therapy","volume":"69","author":"Verri","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0120","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1021\/acs.jnatprod.5b01115","article-title":"Anti-inflammatory effect of methyl gallate on experimental arthritis: inhibition of neutrophil recruitment, production of inflammatory mediators, and activation of macrophages","volume":"79","author":"Correa","year":"2016","journal-title":"J Nat Prod"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0125","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jphotobiol.2006.01.006","article-title":"Protective effect of topical formulations containing quercetin against UVB-induced oxidative stress in hairless mice","volume":"84","author":"Casagrande","year":"2006","journal-title":"J Photochem Photobiol B"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0130","first-page":"627046","article-title":"5-lypoxigenase deficiency reduces acetaminophen-induced hepatotoxicity and lethality","author":"Hohmann","year":"2013","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0135","doi-asserted-by":"crossref","first-page":"5116","DOI":"10.4049\/jimmunol.1004190","article-title":"Joint NOD2\/RIPK2 signaling regulates IL-17 axis and contributes to the development of experimental arthritis","volume":"188","author":"Vieira","year":"2012","journal-title":"J Immunol"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0140","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1021\/np400222v","article-title":"Vitexin inhibits inflammatory pain in mice by targeting TRPV1, oxidative stress, and cytokines","volume":"76","author":"Borghi","year":"2013","journal-title":"J Nat Prod"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0145","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/BF01623458","article-title":"Tartrate-resistant acid phosphatase activity as osteoclastic marker: sensitivity of cytochemical assessment and serum assay in comparison with standardized osteoclast histomorphometry","volume":"7","author":"Ballanti","year":"1997","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0150","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jss.2009.03.034","article-title":"Effects of NF\u03baB inhibitor on titanium particulate-induced inflammation in a murine model","volume":"162","author":"Cheng","year":"2010","journal-title":"J Surg Res"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0155","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0891-5849(01)00560-3","article-title":"Diclofenac induced in vivo nephrotoxicity may involve oxidative stress-mediated massive genomic DNA fragmentation and apoptotic cell death","volume":"31","author":"Hickey","year":"2001","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0160","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.semcdb.2016.07.013","article-title":"Articular cartilage repair: current needs, methods and research directions","volume":"62","author":"Correa","year":"2016","journal-title":"Semin Cell Dev Biol"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0165","doi-asserted-by":"crossref","first-page":"e71156","DOI":"10.1371\/journal.pone.0071156","article-title":"CCN family member 2\/connective tissue growth fator (CCN2\/CTGF) has anti-aging effects that protect articular cartilage from age-related degenerative changes","volume":"8","author":"Itoh","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0170","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.1021\/np400691n","article-title":"Quercetin inhibits inflammatory bone resorption in a model periodontitis model","volume":"76","author":"Napimoga","year":"2013","journal-title":"J Nat Prod"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0175","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.pharmthera.2006.04.001","article-title":"Hypernociceptive role of cytokines and chemokines: target for analgesic drug development?","volume":"112","author":"Verri","year":"2006","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0180","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.tox.2009.03.005","article-title":"Induction of chronic inflammation in mice treated with titanium dioxide nanoparticles by intratracheal instillation","volume":"260","author":"Park","year":"2009","journal-title":"Toxicology"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0185","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1743-8977-10-4","article-title":"Intragastric exposure to titanium dioxide nanoparticles induced nephrotoxicity in mice, assessed by physiological and gene expression modifications","volume":"10","author":"Gui","year":"2013","journal-title":"Part Fibre Toxicol"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0190","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.neuroscience.2009.10.057","article-title":"Nanosized titanium dioxide enhanced inflammatory responses in the septic brain of mouse","volume":"165","author":"Shin","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0195","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12989-014-0047-3","article-title":"Mechanism of nanosized titanium dioxide-induced testicular oxidative stress and apoptosis in male mice","volume":"11","author":"Zhao","year":"2014","journal-title":"Part Fibre Toxicol"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0200","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1021\/tx500287f","article-title":"Titanium nanoparticle inhalation induces renal fibrosis in mice via an oxidative stress upregulated transforming growth factor-\u03b2 pathway","volume":"28","author":"Huang","year":"2015","journal-title":"Chem Res Toxicol"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0205","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.3109\/08958378.2010.528805","article-title":"Asian dust and titanium dioxide particles-induced inflammation and oxidative DNA damage in C57BL\/6 mice","volume":"22","author":"Hwang","year":"2010","journal-title":"Inhal Toxicol"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0210","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1021\/acs.jnatprod.5b00198","article-title":"Naringenin inhibits UVB irradiation-induced inflammation and oxidative stress in the skin of hairless mice","volume":"78","author":"Martinez","year":"2015","journal-title":"J Nat Prod"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0215","doi-asserted-by":"crossref","first-page":"e0146296","DOI":"10.1371\/journal.pone.0146296","article-title":"Topical formulation containing naringenin: efficacy against ultravioleta B irradiation-induced skin inflammation and oxidative stress in mice","volume":"11","author":"Martinez","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2015.11.050","article-title":"Quercetin phospholipid complex significantly protects against oxidative injury in ARPE-19 cells associated with activation of Nrf2 pathway","volume":"770","author":"Xu","year":"2016","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0225","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1007\/s12272-001-1217-2","article-title":"Quercetin: further investigation of its antinociceptive properties and mechanism of action","volume":"31","author":"Filho","year":"2008","journal-title":"Arch Pharm Res"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0230","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1039\/c2fo10268d","article-title":"Different cardiovascular protective effects of quercetin administered orally and intraperitoneally in spontaneously hypertensive rats","volume":"3","author":"Galindo","year":"2012","journal-title":"Food Funct"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0235","first-page":"580626","article-title":"Oral and intraperitoneal administration of quercetin decreased lymphocyte DNA damage and plasma lipid peroxidation induced by TSA in vivo","author":"Chan","year":"2014","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0240","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.phrs.2016.12.039","article-title":"Vinpocetine reduces diclofenac-induced acute kidney injury through inhibition of oxidative stress, apoptosis, cytokine production, and NF-\u03baB activation in mice","volume":"120","author":"Fattori","year":"2017","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0245","first-page":"659","article-title":"Phase I clinical trial of the flavonoid quercetin: pharmacokinetics and evidence for in vivo tyrosine kinase inhibition","volume":"2","author":"Ferry","year":"1996","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0250","first-page":"196","article-title":"Antioxidants and cancer, part 3: Quercetin","volume":"5","author":"Lamson","year":"2000","journal-title":"Altern Med Rev"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0255","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/art.1780260404","article-title":"Morphologic observations in the early phase of the cartilage-pannus junction. Light and electron microscopic studies of active cellular pannus","volume":"26","author":"Shiozawa","year":"1983","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0260","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-2776(08)60532-5","article-title":"Interleukin-6 in biology and medicine","volume":"54","author":"Akira","year":"1993","journal-title":"Adv Immunol"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0265","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.intimp.2011.03.007","article-title":"Titanium dioxide (TiO2) nanoparticles induce neutrophil influx and local production of several pro-inflammatory mediators in vivo","volume":"11","author":"Gon\u00e7alves","year":"2011","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0270","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1021\/np1003017","article-title":"Quercetin reduces neutrophil recruitment induced by CXCL8, LTB4 and fMLP: inhibition of actin polymerization","volume":"74","author":"Souto","year":"2011","journal-title":"J Nat Prod"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0275","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.tiv.2009.12.007","article-title":"Activation of human neutrophils by titanium dioxide (TiO2) nanoparticles","volume":"24","author":"Gon\u00e7alves","year":"2010","journal-title":"Toxicol in Vitro"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0280","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/nm1248","article-title":"Inflammatory arthritis requires Foxo3a to prevent Fas ligand-induced neutrophil apoptosis","volume":"11","author":"Jonsson","year":"2005","journal-title":"Nat Med"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0285","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nri3024","article-title":"Neutrophils in the activation and regulation of innate and adaptative immunity","volume":"11","author":"Mantovani","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0290","doi-asserted-by":"crossref","first-page":"569","DOI":"10.2174\/1381612053381927","article-title":"The role of macrophages in rheumatoid arthritis","volume":"11","author":"Ma","year":"2005","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0295","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1093\/rheumatology\/kes304","article-title":"Targeting monocytes\/macrophages in the treatment of rheumatoid arthritis","volume":"52","author":"Davignon","year":"2013","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0300","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1002\/art.10227","article-title":"Viral interleukin-10 gene inhibition of inflammation, osteoclastogenesis, and bone resorption in response to titanium particles","volume":"46","author":"Carmody","year":"2002","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0305","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1006\/bbrc.2000.3379","article-title":"Protein expression and functional difference of membrane-bound and soluble receptor activator of NF-kappaB ligand: modulation of the expression by osteotropic factors and cytokines","volume":"275","author":"Nakashima","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0310","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1248\/bpb.27.504","article-title":"Quercetin suppress bone resorption by inhibiting the differentiation and activation of osteoclasts","volume":"27","author":"Woo","year":"2004","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0315","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/jcb.20071","article-title":"Flavonoid quercetin decreases osteoclastic differentiation induced by RANKL via a mechanism involving NF\u03baB and AP-1","volume":"92","author":"Wattel","year":"2004","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0320","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1084\/jem.20111566","article-title":"TNF-induced osteoclatogenesis and inflammatory bone resorption are inhibited by transcription factor RBP-J","volume":"209","author":"Zhao","year":"2012","journal-title":"J Exp Med"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0325","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/0717-6287-47-41","article-title":"Ethyl acetate fraction from Angelica Sinensis inhibits IL-1\u03b2-induce rheumatoid synovial fibroblast proliferation and COX-2, PGE2, and MMPs production","volume":"47","author":"Lee","year":"2014","journal-title":"Biol Res"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0330","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1186\/s13075-014-0419-y","article-title":"Interleukin-10 regulates the inflammasome-driven augmentation of inflammatory arthritis and joint destruction","volume":"16","author":"Greenhill","year":"2014","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0335","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1113\/EP085026","article-title":"Interleukin-10 limits intense acute-swimming-induced muscle mechanical hyperalgesia in mice","volume":"100","author":"Borghi","year":"2015","journal-title":"Exp Physiol"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0340","first-page":"681","article-title":"Quercetin modulates OTA-induced oxidative stress and redox signaling in HepG2 cells \u2013 up regulation of Nrf2 expression and down regulation of NF-\u03baB and COX-2","volume":"2014","author":"Ramyaa","year":"1840","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0345","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1006\/excr.1993.1120","article-title":"Interleukin-1 differentially modulates chondrocyte expression of cyclooxygenase-2 and phospholipase A2","volume":"206","author":"Lyons-Giordano","year":"1993","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0350","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1189\/jlb.0408230","article-title":"Regulation of TNF-induced oxygen radical production in human neutrophils: role of delta-PKC","volume":"87","author":"Kilpatrick","year":"2010","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0355","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1002\/jbmr.5650110515","article-title":"Osteoclastic superoxide production and bone resorption: stimulation and inhibition by modulators of NADPH oxidase","volume":"11","author":"Darden","year":"1996","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0360","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/1744-8069-9-53","article-title":"The antioxidante effects of the flavonoids rutin and quercetin inhibit oxaliplatin-induced chronic painful peripheral neuropathy","volume":"9","author":"Azevedo","year":"2013","journal-title":"Mol Pain"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0365","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1002\/jbm.a.34190","article-title":"Oxidative damage of lung and its protective mechanism in mice caused by long-term exposure to titanium dioxide nanoparticles","volume":"100","author":"Sun","year":"2012","journal-title":"J Biomed Mater Res A"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0370","doi-asserted-by":"crossref","first-page":"8959","DOI":"10.1021\/jf402387e","article-title":"Renal injury and Nrf2 modulation in mouse kidney following chronic exposure to TiO2 nanoparticles","volume":"61","author":"Gui","year":"2013","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0375","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.abb.2015.08.008","article-title":"Quercetin reduces inflammation and increased antioxidante defense in rat adjuvante arthritis","volume":"583","author":"Gardi","year":"2015","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.jnutbio.2017.10.010_bb0380","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1002\/jcb.25141","article-title":"Quercetin metabolites up-regulate the antioxidant response in osteoblasts isolated from fetal rat calvaria","volume":"116","author":"Messer","year":"2015","journal-title":"J Cell Biochem"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095528631630804X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095528631630804X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T15:24:37Z","timestamp":1760628277000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S095528631630804X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":76,"alternative-id":["S095528631630804X"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2017.10.010","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The flavonoid quercetin inhibits titanium dioxide (TiO2)-induced chronic arthritis in mice","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2017.10.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}