{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T12:24:15Z","timestamp":1775651055821,"version":"3.50.1"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"European Union\u2019s Seventh Framework Programme","award":["259679"],"award-info":[{"award-number":["259679"]}]},{"name":"Alpe d\u2019Huzes\/Dutch Cancer Society","award":["2011-5234"],"award-info":[{"award-number":["2011-5234"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutritional Biochemistry"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.jnutbio.2018.01.001","type":"journal-article","created":{"date-parts":[[2018,3,20]],"date-time":"2018-03-20T19:23:58Z","timestamp":1521573838000},"page":"152-164","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Lifelong calorie restriction affects indicators of colonic health in aging C57Bl\/6J mice"],"prefix":"10.1016","volume":"56","author":[{"given":"Dieuwertje E.G.","family":"Kok","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fenni","family":"Rusli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benthe","family":"van der Lugt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolien","family":"Lute","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1593-7376","authenticated-orcid":false,"given":"Luca","family":"Laghi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Salvioli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianfranco","family":"Picone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9841-6386","authenticated-orcid":false,"given":"Claudio","family":"Franceschi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hauke","family":"Smidt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Vervoort","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen","family":"Kampman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5930-9905","authenticated-orcid":false,"given":"Michael","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3694-9261","authenticated-orcid":false,"given":"Wilma T.","family":"Steegenga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnutbio.2018.01.001_bb0005","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"L\u00f3pez-Ot\u00edn","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0010","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1146\/annurev-physiol-030212-183712","article-title":"Genetics of longevity in model organisms: debates and paradigm shifts","volume":"75","author":"Gems","year":"2013","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0015","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2318-11-47","article-title":"Recent trends in chronic disease, impairment and disability among older adults in the United States","volume":"11","author":"Hung","year":"2011","journal-title":"BMC Geriatr"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0020","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.cell.2015.02.020","article-title":"Promoting health and longevity through diet: from model organisms to humans","volume":"161","author":"Fontana","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0025","doi-asserted-by":"crossref","first-page":"14063","DOI":"10.1038\/ncomms14063","article-title":"Caloric restriction improves health and survival of rhesus monkeys","volume":"8","author":"Mattison","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0030","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.arr.2016.08.005","article-title":"Calorie restriction in humans: an update","volume":"39","author":"Most","year":"2017","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0035","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.exger.2012.11.007","article-title":"Recent advances in calorie restriction research on aging","volume":"48","author":"Chung","year":"2013","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0040","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1113\/JP270543","article-title":"Calorie restriction as an intervention in ageing","volume":"594","author":"L\u00f3pez-Lluch","year":"2016","journal-title":"J Physiol"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0045","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1093\/gerona\/glu057","article-title":"Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases","volume":"69","author":"Franceschi","year":"2014","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0050","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/j.1749-6632.2001.tb05662.x","article-title":"The inflammation hypothesis of aging: molecular modulation by calorie restriction","volume":"928","author":"Chung","year":"2001","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0055","doi-asserted-by":"crossref","first-page":"8426874","DOI":"10.1155\/2016\/8426874","article-title":"An update on inflamm-aging: mechanisms, prevention, and treatment","volume":"2016","author":"Xia","year":"2016","journal-title":"J Immunol Res"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0060","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1001\/jama.297.9.986","article-title":"Aging, adiposity, and calorie restriction","volume":"297","author":"Fontana","year":"2007","journal-title":"JAMA"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0065","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1097\/HCR.0b013e318295019e","article-title":"Caloric restriction: implications for human cardiometabolic health","volume":"33","author":"Bales","year":"2013","journal-title":"J Cardiopulm Rehabil Prev"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0070","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s11357-011-9217-5","article-title":"Ageing of the human metaorganism: the microbial counterpart","volume":"34","author":"Biagi","year":"2012","journal-title":"Age"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0075","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/nature11319","article-title":"Gut microbiota composition correlates with diet and health in the elderly","volume":"488","author":"Claesson","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0080","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.clnu.2015.01.012","article-title":"The role of immunomodulators on intestinal barrier homeostasis in experimental models","volume":"34","author":"Andrade","year":"2015","journal-title":"Clin Nutr"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0085","series-title":"Intestinal mucosal barrier function in health and disease","first-page":"799","volume":"9","author":"Turner","year":"2009"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0090","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1755-8794-5-38","article-title":"Structural, functional and molecular analysis of the effects of aging in the small intestine and colon of C57BL\/6J mice","volume":"5","author":"Steegenga","year":"2012","journal-title":"BMC Med Genomics"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0095","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/df45912f-d15c-44ab-8312-e7ec0607604d","article-title":"Through ageing, and beyond: gut microbiota and inflammatory status in seniors and centenarians","volume":"5","author":"Biagi","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0100","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s40168-014-0050-9","article-title":"Microbial shifts in the aging mouse gut","volume":"2","author":"Langille","year":"2014","journal-title":"Microbiome"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0105","doi-asserted-by":"crossref","first-page":"6113","DOI":"10.1128\/AEM.70.10.6113-6122.2004","article-title":"Comparison of compositions and metabolic activities of fecal microbiotas in young adults and in antibiotic-treated and non-antibiotic-treated elderly subjects","volume":"70","author":"Woodmansey","year":"2004","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0110","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms3163","article-title":"Structural modulation of gut microbiota in life-long calorie-restricted mice","volume":"4","author":"Zhang","year":"2013","journal-title":"Nat Commun"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0094765","article-title":"Effects of calorie restriction and diet-induced obesity on murine colon carcinogenesis, growth and inflammatory factors, and microRNA expression","volume":"9","author":"Olivo-Marston","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0120","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1002\/mc.21940","article-title":"Decreased systemic IGF-1 in response to calorie restriction modulates murine tumor cell growth, nuclear factor-kappaB activation, and inflammation-related gene expression","volume":"52","author":"Harvey","year":"2013","journal-title":"Mol Carcinog"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0125","doi-asserted-by":"crossref","first-page":"19083","DOI":"10.1038\/srep19083","article-title":"The impact of dietary energy intake early in life on the colonic microbiota of adult mice","volume":"6","author":"Xu","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0130","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/2046-2395-1-2","article-title":"Evidence of a metabolic memory to early-life dietary restriction in male C57BL\/6 mice","volume":"1","author":"Selman","year":"2012","journal-title":"Longev Healthspan"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0135","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/2046-2395-1-3","article-title":"Male mice retain a metabolic memory of improved glucose tolerance induced during adult onset, short-term dietary restriction","volume":"1","author":"Cameron","year":"2012","journal-title":"Longev Healthspan"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0140","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1002\/mnfr.201400621","article-title":"A weekly alternating diet between caloric restriction and medium fat protects the liver from fatty liver development in middle-aged C57BL\/6J mice","volume":"59","author":"Rusli","year":"2015","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0145","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/jcsm.12024","article-title":"Behavioural changes are a major contributing factor in the reduction of sarcopenia in caloric-restricted ageing mice","volume":"6","author":"van Norren","year":"2015","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0150","doi-asserted-by":"crossref","first-page":"30484","DOI":"10.1038\/srep30484","article-title":"Fibroblast growth factor 21 reflects liver fat accumulation and dysregulation of signalling pathways in the liver of C57BL\/6J mice","volume":"6","author":"Rusli","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0155","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1186\/1471-2164-15-1106","article-title":"Transcriptomic signatures of peroxisome proliferator-activated receptor alpha (PPARalpha) in different mouse liver models identify novel aspects of its biology","volume":"15","author":"Szalowska","year":"2014","journal-title":"BMC Genomics"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0160","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1152\/physiolgenomics.00115.2011","article-title":"Detailed transcriptomics analysis of the effect of dietary fatty acids on gene expression in the heart","volume":"44","author":"Georgiadi","year":"2012","journal-title":"Physiol Genomics"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0165","article-title":"Plasticity of life-long calorie restricted C57BL\/6J mice in adapting to a medium-fat diet intervention at old age","author":"Rusli","year":"2017","journal-title":"Aging Cell"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0170","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/biostatistics\/4.2.249","article-title":"Exploration, normalization, and summaries of high density oligonucleotide array probe level data","volume":"4","author":"Irizarry","year":"2003","journal-title":"Biostatistics"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0175","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gni179","article-title":"Evolving gene\/transcript definitions significantly alter the interpretation of GeneChip data","volume":"33","author":"Dai","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0180","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1186\/1471-2105-7-538","article-title":"Intensity-based hierarchical Bayes method improves testing for differentially expressed genes in microarray experiments","volume":"7","author":"Sartor","year":"2006","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0185","doi-asserted-by":"crossref","first-page":"D590","DOI":"10.1093\/nar\/gks1219","article-title":"The SILVA ribosomal RNA gene database project: improved data processing and web-based tools","volume":"41","author":"Quast","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0190","series-title":"Canoco 5: Canoco reference manual and user's guide: software for ordination (version 5)","author":"C.J.F. tB","year":"2012"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0195","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s004420100716","article-title":"Ecologically meaningful transformations for ordination of species data","volume":"129","author":"Legendre","year":"2001","journal-title":"Oecologia"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0200","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.3945\/jn.113.182154","article-title":"Resistant starch induces catabolic but suppresses immune and cell division pathways and changes the microbiome in the proximal colon of male pigs","volume":"143","author":"Haenen","year":"2013","journal-title":"J Nutr"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0205","doi-asserted-by":"crossref","first-page":"3411","DOI":"10.1128\/AAC.02469-14","article-title":"Rifaximin modulates the vaginal microbiome and metabolome in women affected by bacterial vaginosis","volume":"58","author":"Laghi","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0210","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1373\/49.10.1615","article-title":"Quality control and peak finding for proteomics data collected from nipple aspirate fluid by surface-enhanced laser desorption and ionization","volume":"49","author":"Coombes","year":"2003","journal-title":"Clin Chem"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0215","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1366\/000370210792434350","article-title":"Optimal choice of baseline correction for multivariate calibration of spectra","volume":"64","author":"Liland","year":"2010","journal-title":"Appl Spectrosc"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0220","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jmr.2009.11.012","article-title":"icoshift: a versatile tool for the rapid alignment of 1D NMR spectra","volume":"202","author":"Savorani","year":"2010","journal-title":"J Magn Reson"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0225","doi-asserted-by":"crossref","first-page":"4281","DOI":"10.1021\/ac051632c","article-title":"Probabilistic quotient normalization as robust method to account for dilution of complex biological mixtures. application in 1H NMR metabonomics","volume":"78","author":"Dieterle","year":"2006","journal-title":"Anal Chem"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0230","doi-asserted-by":"crossref","first-page":"D521","DOI":"10.1093\/nar\/gkl923","article-title":"HMDB: the Human Metabolome Database","volume":"35","author":"Wishart","year":"2007","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0235","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1756-0381-5-19","article-title":"Visualising associations between paired 'omics' data sets","volume":"5","author":"Gonzalez","year":"2012","journal-title":"BioData Min"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0240","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/2049-2618-2-15","article-title":"Unifying the analysis of high-throughput sequencing datasets: characterizing RNA-seq, 16S rRNA gene sequencing and selective growth experiments by compositional data analysis","volume":"2","author":"Fernandes","year":"2014","journal-title":"Microbiome"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0245","doi-asserted-by":"crossref","first-page":"W90","DOI":"10.1093\/nar\/gkw377","article-title":"Enrichr: a comprehensive gene set enrichment analysis web server 2016 update","volume":"44","author":"Kuleshov","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0250","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/1471-2105-14-128","article-title":"Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool","volume":"14","author":"Chen","year":"2013","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0255","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0260","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s11745-006-5008-7","article-title":"Single-step analysis of individual conjugated bile acids in human bile using 1H NMR spectroscopy","volume":"41","author":"Gowda","year":"2006","journal-title":"Lipids"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0265","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaa5680","article-title":"Urinary metabolic signatures of human adiposity","volume":"7","author":"Elliott","year":"2015","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0270","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.exger.2005.06.007","article-title":"Mice and flies and monkeys too: caloric restriction rejuvenates the aging immune system of non-human primates","volume":"40","author":"Nikolich-\u017dugich","year":"2005","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0275","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.mad.2006.11.016","article-title":"Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans","volume":"128","author":"Franceschi","year":"2007","journal-title":"Mech Ageing Dev"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0280","doi-asserted-by":"crossref","first-page":"14988","DOI":"10.1073\/pnas.232308999","article-title":"Transcriptional profiles associated with aging and middle age-onset caloric restriction in mouse hearts","volume":"99","author":"Lee","year":"2002","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0285","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s00262-014-1542-y","article-title":"Caloric restriction maintains OX40 agonist-mediated tumor immunity and CD4 T cell priming during aging","volume":"63","author":"Farazi","year":"2014","journal-title":"Cancer Immunol Immunother"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0290","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12866-016-0625-7","article-title":"Gut microbiota lipopolysaccharide accelerates inflamm-aging in mice","volume":"16","author":"Kim","year":"2016","journal-title":"BMC Microbiol"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0295","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0142521","article-title":"Orally administrated Lactobacillus pentosus var. plantarum C29 ameliorates age-dependent colitis by inhibiting the nuclear factor-kappa B signaling pathway via the regulation of lipopolysaccharide production by gut microbiota","volume":"10","author":"Jeong","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0300","doi-asserted-by":"crossref","first-page":"455-66.e4","DOI":"10.1016\/j.chom.2017.03.002","article-title":"Age-associated microbial dysbiosis promotes intestinal permeability, systemic inflammation, and macrophage dysfunction","volume":"21","author":"Thevaranjan","year":"2017","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0305","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s12866-016-0708-5","article-title":"Age-related changes in gut microbiota composition from newborn to centenarian: a cross-sectional study","volume":"16","author":"Odamaki","year":"2016","journal-title":"BMC Microbiol"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0310","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s12519-015-0025-3","article-title":"Effects of Bifidobacterium supplementation on intestinal microbiota composition and the immune response in healthy infants","volume":"12","author":"Wu","year":"2016","journal-title":"World J Pediatr"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0315","doi-asserted-by":"crossref","first-page":"979","DOI":"10.3389\/fmicb.2016.00979","article-title":"Bifidobacteria and butyrate-producing colon bacteria: importance and strategies for their stimulation in the human gut","volume":"7","author":"Riviere","year":"2016","journal-title":"Front Microbiol"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0320","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1093\/ecco-jcc\/jjv147","article-title":"Altered Fecal Microbiota in Paediatric Inflammatory Bowel Disease","volume":"9","author":"Maukonen","year":"2015","journal-title":"J Crohns Colitis"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0325","doi-asserted-by":"crossref","first-page":"e00271","DOI":"10.1128\/mBio.00271-10","article-title":"Colonization-induced host\u2013gut microbial metabolic interaction","volume":"2","author":"Claus","year":"2011","journal-title":"MBio"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0330","series-title":"Gut metagenome in European women with normal, impaired and diabetic glucose control","first-page":"99","volume":"498","author":"Karlsson","year":"2013"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0335","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.taap.2013.10.020","article-title":"Increased bile acids in enterohepatic circulation by short-term calorie restriction in male mice","volume":"273","author":"Fu","year":"2013","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0340","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/0959-8049(95)00216-6","article-title":"Role of bile acids in colorectal carcinogenesis","volume":"31a","author":"Nagengast","year":"1995","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0345","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1136\/gutjnl-2012-302578","article-title":"Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases","volume":"62","author":"Duboc","year":"2013","journal-title":"Gut"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0350","doi-asserted-by":"crossref","first-page":"H216","DOI":"10.1111\/1750-3841.13166","article-title":"High-fat diet-induced intestinal hyperpermeability is associated with increased bile acids in the large intestine of mice","volume":"81","author":"Murakami","year":"2016","journal-title":"J Food Sci"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0355","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/nrendo.2014.60","article-title":"Beyond intestinal soap \u2014 bile acids in metabolic control","volume":"10","author":"Kuipers","year":"2014","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0360","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/joim.12599","article-title":"Acute caloric restriction counteracts hepatic bile acid and cholesterol deficiency in morbid obesity","volume":"281","author":"Straniero","year":"2017","journal-title":"J Intern Med"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0365","first-page":"G836","article-title":"Effect of fasting on the enterohepatic circulation of bile acids in rats","volume":"267","author":"Dumaswala","year":"1994","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0370","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1096\/fj.03-0678fje","article-title":"Adipose tissue energy metabolism: altered gene expression profile of mice subjected to long-term caloric restriction","volume":"18","author":"Higami","year":"2004","journal-title":"FASEB J"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0375","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.exger.2004.04.009","article-title":"Krebs cycle enzymes from livers of old mice are differentially regulated by caloric restriction","volume":"39","author":"Hagopian","year":"2004","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0380","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1016\/0016-5085(93)90637-R","article-title":"Sucrose: a novel permeability marker for gastroduodenal disease","volume":"104","author":"Meddings","year":"1993","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0385","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1186\/s13059-015-0763-5","article-title":"Postnatal epigenetic regulation of intestinal stem cells requires DNA methylation and is guided by the microbiome","volume":"16","author":"Yu","year":"2015","journal-title":"Genome Biol"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0390","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.bbcan.2006.01.002","article-title":"Regulation of mucin expression: mechanistic aspects and implications for cancer and inflammatory diseases","volume":"1765","author":"Andrianifahanana","year":"2006","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0395","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/1479-5876-11-151","article-title":"Role of MUC20 overexpression as a predictor of recurrence and poor outcome in colorectal cancer","volume":"11","author":"Xiao","year":"2013","journal-title":"J Transl Med"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0400","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.arr.2017.05.008","article-title":"Calorie restriction in rodents: caveats to consider","volume":"39","author":"Ingram","year":"2017","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.jnutbio.2018.01.001_bb0405","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.arr.2017.08.002","article-title":"The science of nutritional modulation of aging","volume":"39","author":"Fontana","year":"2017","journal-title":"Ageing Res Rev"}],"container-title":["The Journal of Nutritional Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286317308264?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955286317308264?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T15:25:51Z","timestamp":1760628351000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955286317308264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":81,"alternative-id":["S0955286317308264"],"URL":"https:\/\/doi.org\/10.1016\/j.jnutbio.2018.01.001","relation":{},"ISSN":["0955-2863"],"issn-type":[{"value":"0955-2863","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lifelong calorie restriction affects indicators of colonic health in aging C57Bl\/6J mice","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutritional Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnutbio.2018.01.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}